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List of works by Darren J Hart

A new plasmid display technology for the in vitro selection of functional phenotype-genotype linked proteins.

scientific article

A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

scientific article published in March 2017

A universal mini-vector and an annealing of PCR products (APP)-based cloning strategy for convenient molecular biological manipulations

scientific article published on 12 February 2018

Auxin sensing is a property of an unstructured domain in the Auxin Response Factor ETTIN of Arabidopsis thaliana

scientific article published in Scientific Reports

Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.

scientific article published in March 2010

CoESPRIT: a library-based construct screening method for identification and expression of soluble protein complexes

scientific article

Combinatorial library approaches for improving soluble protein expression in Escherichia coli

scientific article published on 14 December 2005

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

scientific article

Death-Associated Protein Kinase Activity Is Regulated by Coupled Calcium/Calmodulin Binding to Two Distinct Sites

scientific article published on 20 April 2016

Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells

scientific article

ESPRIT: A Method for Defining Soluble Expression Constructs in Poorly Understood Gene Sequences

scientific article published in January 2017

ESPRIT: an automated, library-based method for mapping and soluble expression of protein domains from challenging targets

scientific article

Expression and Characterization of Levansucrase from Clostridium acetobutylicum.

scientific article published on 11 January 2017

Expression of Helicobacter pylori CagA domains by library-based construct screening

scientific article

Expression of soluble, active fragments of the morphogenetic protein SpoIIE from Bacillus subtilis using a library-based construct screen

scientific article

Fabrication of protein function microarrays for systems-oriented proteomic analysis

scientific article published on 01 January 2005

Host Determinant Residue Lysine 627 Lies on the Surface of a Discrete, Folded Domain of Influenza Virus Polymerase PB2 Subunit

scientific article

Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE.

scientific article published on 19 September 2006

Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

scientific article

Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains

scientific article published on 16 December 2015

Interaction of the influenza A virus polymerase PB2 C-terminal region with importin alpha isoforms provides insights into host adaptation and polymerase assembly.

scientific article

Large-Scale Conformational Dynamics Control H5N1 Influenza Polymerase PB2 Binding to Importin α.

scientific article

Library methods for structural biology of challenging proteins and their complexes

scientific article

Library-based methods for identification of soluble expression constructs ⬇️

scientific article published on June 23, 2011

Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7.

scientific article published on 15 January 2015

Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).

scientific article published on 18 May 2017

ORF-selector ESPRIT: a second generation library screen for soluble protein expression employing precise open reading frame selection.

scientific article

Recent advances in universal TA cloning methods for use in function studies.

scientific article

Solubility survey of fragments of the neurofibromatosis type 1 protein neurofibromin

scientific article

Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7.

scientific article

Structural and biophysical characterization of murine rif1 C terminus reveals high specificity for DNA cruciform structures.

scientific article published on 14 March 2014

Structural basis for the oligomerization of the MADS domain transcription factor SEPALLATA3 in Arabidopsis

scientific article

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

scientific article

Structural insights into the architecture of the Shigella flexneri virulence factor IcsA/VirG and motifs involved in polar distribution and secretion.

scientific article

Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit

scientific article

Structure of the Phosphatase Domain of the Cell Fate Determinant SpoIIE from Bacillus subtilis

scientific article

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

scientific article

The structural basis for cap binding by influenza virus polymerase subunit PB2

scientific article

Three Novel Escherichia coli Vectors for Convenient and Efficient Molecular Biological Manipulations

scientific article published on 11 June 2018

Towards an atomic resolution understanding of the influenza virus replication machinery

scientific article published on 12 January 2010

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