List of works - Chiara Zuccato

A microRNA-based gene dysregulation pathway in Huntington's disease

scientific article

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

scientific article published in May 2012

Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease

scientific article published on 23 December 2008

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

scientific article published on 19 July 2013

Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.

scientific article published on 10 May 2008

Brain-derived neurotrophic factor in neurodegenerative diseases

scientific article

Brain-derived neurotrophic factor in patients with Huntington's disease

scientific article

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

scientific article

Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

scientific article published on 21 December 2007

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

scientific article published on 27 August 2002

Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain

scientific article published on September 2003

Comparative expression profiles of ShcB and ShcC phosphotyrosine adapter molecules in the adult brain

scientific article published on January 2005

Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions.

scientific article published on 8 December 2007

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.

scientific article

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

scientific article published in October 2005

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

scientific article published in August 2002

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

scientific article published on 21 November 2014

Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data

scientific article

Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop

scientific article

From target identification to drug screening assays for neurodegenerative diseases

Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease

scientific article

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study

scientific article published on 11 July 2020

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

scientific article (publication date: September 2003)

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

scientific article published on 5 March 2001

Huntington's disease

scientific article published in January 2014

In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

scientific article published on 15 November 2012

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

scientific article published on 06 May 2019

Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

scientific article

Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators

scientific article

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

scientific article (publication date: 20 July 2001)

Loss of normal huntingtin function: new developments in Huntington's disease research

scientific article

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease ⬇️

scientific article published on July 1, 2010

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

scientific article

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

scientific article published on 10 July 2012

Normal huntingtin function: an alternative approach to Huntington's disease

scientific article

Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin

scientific article published on 28 November 2007

Pitfalls in the detection of cholesterol in Huntington's disease models

scientific article

Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease

scientific article published on August 2005

Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery

scientific article published in August 2005

Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones

scientific article published in December 2014

Role of brain-derived neurotrophic factor in Huntington's disease

scientific article published on 9 February 2007

Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes.

scientific article published on 6 May 2007

Shc3 affects human high-grade astrocytomas survival

scientific article

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

scientific article

The Huntington's Paradox

scientific article published in July 2016

The enigma of Huntington's disease.

scientific article published in December 2002

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

scientific article

The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases

scientific article

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

scientific article published on 17 February 2010

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

scientific article published on January 2009

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

scientific article

List of works by Chiara Zuccato

A microRNA-based gene dysregulation pathway in Huntington's disease

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease

Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models

Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347.

Brain-derived neurotrophic factor in neurodegenerative diseases

Brain-derived neurotrophic factor in patients with Huntington's disease

CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice

Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain

Comparative expression profiles of ShcB and ShcC phosphotyrosine adapter molecules in the adult brain

Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions.

Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington's disease.

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses

Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data

Forkhead transcription factor FOXO3a levels are increased in Huntington disease because of overactivated positive autofeedback loop

From target identification to drug screening assays for neurodegenerative diseases

Human accelerated region 1 noncoding RNA is repressed by REST in Huntington's disease

Huntingtin gene CAG repeat size affects autism risk: Family-based and case-control association study

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

Huntington's disease

In vivo delivery of DN:REST improves transcriptional changes of REST-regulated genes in HD mice

Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington's disease

Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death

Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

Loss of normal huntingtin function: new developments in Huntington's disease research

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease ⬇️

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease

Normal huntingtin function: an alternative approach to Huntington's disease

Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin

Pitfalls in the detection of cholesterol in Huntington's disease models

Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease

Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery

Repressor element-1 silencing transcription factor (REST) is present in human control and Huntington's disease neurones

Role of brain-derived neurotrophic factor in Huntington's disease

Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes.

Shc3 affects human high-grade astrocytomas survival

Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease

The Huntington's Paradox

The enigma of Huntington's disease.

The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity

The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.