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List of works by Nicholas H. Oberlies

A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra. ⬇️

scientific article published on December 2005

A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII.

scientific article published on 16 April 2007

A systematic approach to evaluate herb-drug interaction mechanisms: investigation of milk thistle extracts and eight isolated constituents as CYP3A inhibitors.

scientific article published on 25 June 2013

A validated UHPLC-tandem mass spectrometry method for quantitative analysis of flavonolignans in milk thistle (Silybum marianum) extracts

scientific article published on 22 April 2016

Absolute Configuration of Isosilybin A by X-ray Crystallography of the Heavy Atom Analogue 7-(4-Bromobenzoyl)isosilybin A ⬇️

scientific article published on November 26, 2012

Acetophenone derivatives from a freshwater fungal isolate of recently described Lindgomyces madisonensis (G416). ⬇️

scientific article

Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis. ⬇️

scientific article published on 7 June 2007

An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics

scientific article published on 25 April 2019

Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR signaling

scientific article

Antimicrobial fungal endophytes from the botanical medicine goldenseal (Hydrastis canadensis).

scientific article published on 6 August 2016

Antimycobacterial furofuran lignans from the roots of Anemopsis californica

scientific article

Antioxidant activity and total phenolic content of aqueous and methanolic extracts of Jordanian plants: an ICBG project

scientific article

Apicidin Attenuates MRSA Virulence through Quorum-Sensing Inhibition and Enhanced Host Defense

scientific article published on 01 April 2019

Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

scientific article published on 9 January 2013

Bioactive Constituents of the Roots ofLicaniaintrapetiolaris

scientific article published on 01 April 2001

Bioactive constituents of the stem bark of Mitrephora glabra. ⬇️

scientific article

Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds

scientific article (publication date: 26 February 2016)

Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach

scientific article

Biosynthetic gene clusters and the evolution of fungal chemodiversity

scientific article published on 03 January 2020

Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris ⬇️

scientific article

Calothrixamides A and B from the Cultured CyanobacteriumCalothrixsp. UIC 10520 ⬇️

scientific article published on 07 September 2018

Camptothecin and taxol: historic achievements in natural products research.

scientific article published on February 2004

Characterizing the Pathogenic, Genomic, and Chemical Traits of , a Close Relative of the Major Human Fungal Pathogen

scientific article published on 20 February 2019

Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.

scientific article

Chemoenzymatic Synthesis, Characterization, and Scale-Up of Milk Thistle Flavonolignan Glucuronides.

scientific article

Chemoinformatic expedition of the chemical space of fungal products

scientific article published on 3 August 2016

Chemoselective fluorination and chemoinformatic analysis of griseofulvin: Natural vs fluorinated fungal metabolites

scholarly article by Noemi D Paguigan published in October 2017

Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.

scientific article published on February 2007

Colchicinoids from Colchicum crocifolium Boiss. (Colchicaceae).

scientific article

Colchicinoids from Colchicum crocifolium Boiss.: a case study in dereplication strategies for (-)-Colchicine and related analogues using LC-MS and LC-PDA techniques

scientific article published on 01 September 2008

Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study. ⬇️

scientific article

Comparison of the chemistry and diversity of endophytes isolated from wild-harvested and greenhouse-cultivated yerba mansa (Anemopsis californica). ⬇️

scientific article

Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

scientific article

Conventional and accelerated-solvent extractions of green tea (camellia sinensis) for metabolomics-based chemometrics

scientific article published on 29 July 2017

Correction to Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

scientific article published on 14 December 2020

Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

scientific article published on 23 November 2018

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320). ⬇️

scientific article published on 6 October 2011

Cytotoxic Homoisoflavones from the Bulbs of Bellevalia eigii ⬇️

scientific article

Cytotoxic Naphthoquinone Analogues, Including Heterodimers, and Their Structure Elucidation Using LR-HSQMBC NMR Experiments

scientific article published on 02 October 2020

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

scientific article published in July 2004

Cytotoxic and insecticidal constituents of the unripe fruit of Persea americana.

scientific article published on June 1998

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae

scientific article

Cytotoxic homoisoflavonoids from the bulbs of Bellevalia flexuosa.

scientific article published on 19 February 2018

Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)

scientific article published on 9 November 2011

DNA barcoding for identification of consumer-relevant mushrooms: A partial solution for product certification?

scientific article published on 9 July 2016

Delitpyrones: α-Pyrone Derivatives from a Freshwater Delitschia sp ⬇️

scholarly article by José Rivera-Chávez et al published 17 July 2018 in Planta Medica

Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.

scientific article

Dereplicating and Spatial Mapping of Secondary Metabolites from Fungal Cultures in Situ.

scientific article

Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.

scientific article

Detection of adulteration in Hydrastis canadensis (goldenseal) dietary supplements via untargeted mass spectrometry-based metabolomics

scientific article published on 19 July 2018

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles

article

Development of a consensus approach for botanical safety evaluation - A roundtable report

scientific article published on 10 May 2019

Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma associated herpesvirus

scientific article published on August 2007

Differential in vitro effects of intravenous versus oral formulations of silibinin on the HCV life cycle and inflammation

scientific article

Discovery of Anticancer Agents of Diverse Natural Origin

scientific article

Discovery of anticancer agents of diverse natural origin.

scientific article published on January 2009

Diterpene glycosides from Egletes viscosa.

scientific article

Draft Genome Sequence of the Griseofulvin-Producing Fungus Xylaria flabelliformis Strain G536

scientific article published on 19 September 2019

Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature

scientific article published on 21 May 2019

Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis

scientific article published on 21 October 2019

Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones

scientific article published on 10 August 2020

Enhanced bioactivity of silybin B methylation products

scientific article published on 5 December 2012

Enhanced dereplication of fungal cultures via use of mass defect filtering

scientific article

Epigenetic Manipulation of a Filamentous Fungus by the Proteasome-Inhibitor Bortezomib Induces the Production of an Additional Secondary Metabolite.

scientific article

Ethanolic Echinacea purpurea Extracts Contain a Mixture of Cytokine-Suppressive and Cytokine-Inducing Compounds, Including Some That Originate from Endophytic Bacteria

scientific article

Evaluation of culture media for the production of secondary metabolites in a natural products screening program.

scientific article published on 17 December 2013

Evolving moldy murderers: Aspergillus section Fumigati as a model for studying the repeated evolution of fungal pathogenicity

scientific article published on 27 February 2020

Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite

scientific article

Five New Monotetrahydrofuran Ring Acetogenins from the Leaves of Annona muricata

scientific article published on 01 November 1996

Flavonolignans from Aspergillus iizukae, a fungal endophyte of milk thistle (Silybum marianum).

scientific article published on 23 January 2014

Freshwater Fungi as a Source of Chemical Diversity: A Review

scientific article published in 2021

Freshwater ascomycetes: Minutisphaera (Dothideomycetes) revisited, including one new species from Japan.

scientific article

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community.

scientific article published on 15 February 2017

Fungal Planet description sheets: 371-399. ⬇️

scientific article

Fungal Planet description sheets: 716–784 ⬇️

article

Fungal–fungal co-culture: a primer for generating chemical diversity

scientific article published in 2022

Genomic and Phenotypic Trait Variation of the Opportunistic Human Pathogen Aspergillus flavus and Its Close Relatives

scientific article published in 2022

Genomic and phenotypic analysis of COVID-19-associated pulmonary aspergillosis isolates of Aspergillus fumigatus

scientific article published on 06 November 2020

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri

scientific article published on 11 February 2020

Gram-Scale Purification of Flavonolignan Diastereoisomers from Silybum marianum (Milk Thistle) Extract in Support of Preclinical in vivo Studies for Prostate Cancer Chemoprevention

scientific article published on 18 October 2007

Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity

scientific article published on 16 March 2016

Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines

scientific article published on 29 March 2019

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines

scholarly article by Kirti S Prabhu et al published 2018 in Frontiers in Pharmacology

Greensporones: resorcylic acid lactones from an aquatic Halenospora sp. ⬇️

scientific article

H3K9 Trimethylation Silences Fas Expression To Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance.

scientific article

H3K9me3 represses G6PD expression to suppress the pentose phosphate pathway and ROS production to promote human mesothelioma growth

scientific article published in 2022

HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case

scientific article published on 5 March 2013

High-resolution MS, MS/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products.

scientific article published on 16 August 2013

Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation

scientific article published on 21 February 2018

Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.

scientific article published on 29 December 2008

Identification of diet-derived constituents as potent inhibitors of intestinal glucuronidation

scientific article

Identification of hepatoprotective flavonolignans from silymarin

scientific article

Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma

scientific article

Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells.

scientific article

In situ mass spectrometry monitoring of fungal cultures led to the identification of four peptaibols with a rare threonine residue ⬇️

article

Influence of dietary substances on intestinal drug metabolism and transport.

scientific article

Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance

scientific article

Isochromenones, isobenzofuranone, and tetrahydronaphthalenes produced by Paraphoma radicina, a fungus isolated from a freshwater habitat. ⬇️

scientific article

Isolation and identification of intestinal CYP3A inhibitors from cranberry (Vaccinium macrocarpon) using human intestinal microsomes.

scientific article

Isolation, semisynthesis, covalent docking and transforming growth factor beta-activated kinase 1 (TAK1)-inhibitory activities of (5Z)-7-oxozeaenol analogues

scientific article

Isosilibinin inhibits advanced human prostate cancer growth in athymic nude mice: comparison with silymarin and silibinin.

scientific article

Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling

scientific article published on October 2010

Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostate cancer LNCaP and 22Rv1 cells.

scientific article published on 26 March 2007

Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway

scientific article

Labeled content of two furanocoumarins in dietary supplements correlates with neither actual content nor CYP3A inhibitory activity

scientific article

Mapping of Sample Collection Data: GIS Tools for the Natural Product Researcher

scientific article

Mapping the Fungal Battlefield: Using Chemistry and Deletion Mutants to Monitor Interspecific Chemical Interactions Between Fungi

scientific article published on 19 February 2019

Mechanisms underlying food-drug interactions: inhibition of intestinal metabolism and transport.

scientific article

Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis

scientific article published on 21 June 2021

Media studies to enhance the production of verticillins facilitated by in situ chemical analysis

scientific article published on 27 September 2018

Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression ⬇️

scientific article published on 08 January 2019

Microbial-mediated release of bisphenol A from polycarbonate vessels.

scientific article published on 7 December 2007

Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction

scientific article

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. ⬇️

scientific article

Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies ⬇️

scientific article

Minutisphaerales (Dothideomycetes, Ascomycota): a new order of freshwater ascomycetes including a new family, Minutisphaeraceae, and two new species from North Carolina, USA.

scientific article

Multiple effects of silymarin on the hepatitis C virus lifecycle

scientific article

Mycopyranone: a 8,8'-binaphthopyranone with potent anti-MRSA activity from the fungus Phialemoniopsis sp

scientific article published on 17 January 2019

Nanoparticle drug-delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle

scientific article published on 9 February 2017

New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.

scientific article published on February 2005

New diketopiperazine dimer from a filamentous fungal isolate of Aspergillus sydowii

scientific article

New tricks for old dogs: Two new macrocyclic trichothecene epimers and absolute configuration of 16-hydroxyverrucarin B

scientific article published on 10 January 2020

Non-Destructive Chemical Analysis of a Garcinia mangostana L. (Mangosteen) Herbarium Voucher Specimen

scientific article published on 12 October 2018

Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

article

Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales ⬇️

scientific article published on October 5, 2011

Optimizing production and evaluating biosynthesis in situ of a herbicidal compound, mevalocidin, from Coniolariella sp.

scientific article

Orthogonal Method for Double-Bond Placement via Ozone-Induced Dissociation Mass Spectrometry (OzID-MS)

scientific article published on 11 December 2019

Pannorin B, a new naphthopyrone from an endophytic fungal isolate of Penicillium sp.

scientific article published on 14 September 2015

Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities ⬇️

scientific article published on June 29, 2012

Phylogenetic and chemical diversity of fungal endophytes isolated from Silybum marianum (L) Gaertn. (milk thistle)

scientific article published on January 2015

Physiologically based pharmacokinetic modeling framework for quantitative prediction of an herb-drug interaction

scientific article

Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.

scientific article published on May 2006

Plasma pharmacokinetics and bioavailability of verticillin A following different routes of administration in mice using liquid chromatography tandem mass spectrometry.

scientific article

Polyhydroxyanthraquinones as quorum sensing inhibitors from the guttates of Penicillium restrictum and their analysis by desorption electrospray ionization mass spectrometry ⬇️

scientific article

Prealamethicin F50 and related peptaibols from Trichoderma arundinaceum: Validation of their authenticity via in situ chemical analysis.

scientific article published on 25 September 2017

Prenylated Diresorcinols Inhibit Bacterial Quorum Sensing

scientific article published on 07 February 2019

Proliferation of antibiotic-producing bacteria and concomitant antibiotic production as the basis for the antibiotic activity of Jordan's red soils

scientific article published on 13 March 2009

Pyrrolizidine alkaloids from Echium glomeratum (Boraginaceae). ⬇️

scientific article published on 6 August 2008

Quantitative prediction and clinical evaluation of an unexplored herb-drug interaction mechanism in healthy volunteers.

scientific article published on 28 November 2015

Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography

scientific article published on 18 June 2013

Reinforcement of polymeric nanoassemblies for ultra-high drug loadings, modulation of stiffness and release kinetics, and sustained therapeutic efficacy

article

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships ⬇️

scientific article

Revisiting the enniatins: a review of their isolation, biosynthesis, structure determination and biological activities ⬇️

scientific article published on September 19, 2012

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma ⬇️

scientific article published on May 18, 2011

SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion

scientific article published on 04 January 2019

Safety assessment of mushrooms in dietary supplements by combining analytical data with in silico toxicology evaluation

scientific article

Scaffold Diversity of Fungal Metabolites

scientific article

Secondary Metabolites from the Leaves of the Medicinal Plant Goldenseal (Hydrastis canadensis).

scientific article

Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach

scientific article published on 01 August 2019

Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages.

scientific article

Silymarin Prevents Memory Impairments, Anxiety, and Depressive-Like Symptoms in a Rat Model of Post-Traumatic Stress Disorder

scientific article published on 28 August 2018

Silymarin Suppresses Cellular Inflammation By Inducing Reparative Stress Signaling

scientific article

Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album ⬇️

scientific article

Spatial and Temporal Profiling of Griseofulvin Production in Xylaria cubensis Using Mass Spectrometry Mapping

scientific article (publication date: 2016)

Special Issue in Honor of Professor Rachel Mata

scientific article published on 01 March 2019

Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum. ⬇️

scientific article

Structural Diversity of Perylenequinones Is Driven by Their Redox Behavior

scientific article published on 25 January 2022

Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.

scientific article published on June 1997

Synergy-directed fractionation of botanical medicines: a case study with goldenseal (Hydrastis canadensis) ⬇️

scientific article

Synthesis of poly(1,2-glycerol carbonate)-paclitaxel conjugates and their utility as a single high-dose replacement for multi-dose treatment regimens in peritoneal cancer

scientific article published on 20 October 2017

Talarolutins A-D: Meroterpenoids from an endophytic fungal isolate of Talaromyces minioluteus. ⬇️

scientific article published on 2 April 2016

The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells.

scientific article published in May 1997

The Chemistry of Kratom [Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids

scientific article published on 29 June 2020

The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion

scientific article published on 28 January 2017

The most widely recognized mushroom: chemistry of the genus Amanita

scientific article

The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

article by James B. McAlpine et al published 13 July 2018 in Natural Product Reports

Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales

scientific article

Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay.

scientific article

Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations

scientific article

Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.)

scientific article published on 25 January 2007

Verticillin A Causes Apoptosis and Reduces Tumor Burden in High-Grade Serous Ovarian Cancer by Inducing DNA Damage

scientific article published on 01 January 2020

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species. ⬇️

scientific article published on August 2013

Wheldone: Characterization of a Unique Scaffold from the Coculture of Aspergillus fischeri and Xylaria flabelliformis ⬇️

scientific article published on 25 February 2020

qNMR for profiling the production of fungal secondary metabolites

scientific article published on 26 December 2016

α-Pyrone derivatives, tetra/hexahydroxanthones, and cyclodepsipeptides from two freshwater fungi. ⬇️

scientific article published on December 2016

ω-Hydroxyemodin limits staphylococcus aureus quorum sensing-mediated pathogenesis and inflammation.

scientific article

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