List of works - Frances Ashcroft

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

scientific article

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

scientific article

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes

scientific article

A high-throughput assay for modulators of NNT activity in permeabilized yeast cells

scientific article

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

scientific article

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes

scientific article

ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer

scholarly article

ATP-sensitive potassium channelopathies: focus on insulin secretion

scientific article published in August 2005

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

scientific article

Activation mechanism of ATP-sensitive K channels explored with real-time nucleotide binding

scientific article published on 21 February 2019

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

scientific article (publication date: 2013)

An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression ⬇️

scientific article published on 30 June 2017

Asymmetric switching in a homodimeric ABC transporter: a simulation study

scientific article

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5

scientific article

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

scientific article published on 17 May 2018

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease

scientific article

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

scientific article published on 2 April 2018

Changes in gene expression associated with FTO overexpression in mice

scientific article published on 19 May 2014

Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'

scientific article published on September 2016

Crystal structure of the potassium channel KirBac1.1 in the closed state

scientific article (publication date: 20 June 2003)

Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy

scientific article published on 20 September 2007

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies

scientific article

Dissection-independent production of <i>Plasmodium</i> sporozoites from whole mosquitoes

scientific article published on 16 June 2021

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

scientific article published on 08 November 2018

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

scientific article

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice

scientific article published in December 2017

FTO influences adipogenesis by regulating mitotic clonal expansion

scientific article

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting

scientific article

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

scientific article published on September 2017

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

scientific article

Functional identification of islet cell types by electrophysiological fingerprinting

scientific article published on March 2017

Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking

scientific article

How ATP inhibits the open K(ATP) channel

scientific article

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

scientific article

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2

scientific article published on 13 November 2018

Influences: Find a friend

scientific article published on 21 June 2018

Inhibition of ATP-sensitive potassium channels by haloperidol

scientific article

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

scientific article published in Nature Communications

Introduction. The blurred boundary between channels and transporters

scientific article published in January 2009

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

scientific article

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions

scientific journal article

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

scientific article

Magnesium deficiency prevents high-fat-diet-induced obesity in mice

scientific article published on 09 July 2018

Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux

scientific article

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

scientific article

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

scientific article published on 01 September 2018

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease

scientific article

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding

scientific article

Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes

scientific article

Neonatal Diabetes and the KATP Channel: From Mutation to Therapy

scientific article published on 2 March 2017

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk

scientific article

New insights into KATP channel gene mutations and neonatal diabetes mellitus

scientific article published on 06 May 2020

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

scientific article published on 07 January 2020

Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain

scientific article

Overexpression of Fto leads to increased food intake and results in obesity

scientific article

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism

scientific article

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

scientific article published in January 2018

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

scientific article published on 18 November 2016

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

scientific article

Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment

scientific article published on 13 June 2018

Potassium channel regulation

scientific article

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

scientific article

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KATP channels by MgADP and metabolism.

scientific article published on 14 October 2018

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance

scientific journal article

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels

scientific article

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

scientific article published on 31 March 2016

Sulfonylurea stimulation of insulin secretion

scientific article

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents

scientific article (publication date: 2015)

Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

scientific journal article

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits

scientific article published on 29 March 2007

The Nucleotide-Binding Sites of SUR1: A Mechanistic Model

scientific article

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter

scientific article

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

scientific article

Type 2 diabetes mellitus: not quite exciting enough?

scientific article published on 20 January 2004

Women in Metabolism: Part 3.

scientific article published in December 2015

β-Cell dysfunction in diabetes: a crisis of identity?

scientific article published on September 2016

List of works by Frances Ashcroft

3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1.

A gating mutation at the internal mouth of the Kir6.2 pore is associated with DEND syndrome

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes

A high-throughput assay for modulators of NNT activity in permeabilized yeast cells

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes

ATP-dependent interaction of the cytosolic domains of the inwardly rectifying K+ channel Kir6.2 revealed by fluorescence resonance energy transfer

ATP-sensitive potassium channelopathies: focus on insulin secretion

Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes

Activation mechanism of ATP-sensitive K channels explored with real-time nucleotide binding

Adult onset global loss of the fto gene alters body composition and metabolism in the mouse

An ABCC8 Nonsense Mutation Causing Neonatal Diabetes Through Altered Transcript Expression ⬇️

Asymmetric switching in a homodimeric ABC transporter: a simulation study

Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5

Binding of sulphonylureas to plasma proteins - A KATP channel perspective.

CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease

Cardiac Dysfunction and Metabolic Inflexibility in a Mouse Model of Diabetes Without Dyslipidemia.

Changes in gene expression associated with FTO overexpression in mice

Correction to 'Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels'

Crystal structure of the potassium channel KirBac1.1 in the closed state

Direct visualization of KirBac3.1 potassium channel gating by atomic force microscopy

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies

Dissection-independent production of <i>Plasmodium</i> sporozoites from whole mosquitoes

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

FTO demethylase activity is essential for normal bone growth and bone mineralization in mice

FTO influences adipogenesis by regulating mitotic clonal expansion

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes.

Functional identification of islet cell types by electrophysiological fingerprinting

Gain-of-function mutations in the K(ATP) channel (KCNJ11) impair coordinated hand-eye tracking

How ATP inhibits the open K(ATP) channel

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2

Influences: Find a friend

Inhibition of ATP-sensitive potassium channels by haloperidol

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion

Introduction. The blurred boundary between channels and transporters

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Kir6.2 mutations causing neonatal diabetes provide new insights into Kir6.2-SUR1 interactions

Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane

Magnesium deficiency prevents high-fat-diet-induced obesity in mice

Metabolic regulation of the pancreatic beta-cell ATP-sensitive K+ channel: a pas de deux

Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological features

Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis

Mutational analysis of CLC-5, cofilin and CLC-4 in patients with Dent's disease

Mutations in the linker domain of NBD2 of SUR inhibit transduction but not nucleotide binding

Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes

Neonatal Diabetes and the KATP Channel: From Mutation to Therapy

Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk

New insights into KATP channel gene mutations and neonatal diabetes mellitus

Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry

Nucleotide-dependent conformational changes in HisP: molecular dynamics simulations of an ABC transporter nucleotide-binding domain

Overexpression of Fto leads to increased food intake and results in obesity

PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.

Pancreatic β-Cells Express the Fetal Islet Hormone Gastrin in Rodent and Human Diabetes

Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Permanent neonatal diabetes: combining sulfonylureas with insulin may be an effective treatment

Potassium channel regulation

Reversible changes in pancreatic islet structure and function produced by elevated blood glucose

Role of the C-terminus of SUR in the differential regulation of β-cell and cardiac KATP channels by MgADP and metabolism.

Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes.

Sulfonylurea stimulation of insulin secretion

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents

Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits

The Nucleotide-Binding Sites of SUR1: A Mechanistic Model

The ligand-sensitive gate of a potassium channel lies close to the selectivity filter

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase

Type 2 diabetes mellitus: not quite exciting enough?

Women in Metabolism: Part 3.

β-Cell dysfunction in diabetes: a crisis of identity?