List of works - Brigitte Meunier

A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria

scientific article published on 14 April 2020

A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy

scientific journal article

A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast

scientific article

A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease

scientific article

A rapid in vivo colorimetric library screen for inhibitors of microbial respiration.

scientific article

A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione

scientific article published on 21 November 2020

Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy

scientific article published on 3 March 2015

An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae ⬇️

scientific article published on October 25, 2011

Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.

scientific article

Assignment of the CO-sensitive carboxyl group in mitochondrial forms of cytochrome c oxidase using yeast mutants

scientific article published on 05 April 2012

CO recombination as a probe of the Fe/Cu binuclear centre of terminal protonmotive oxidases.

scientific article

COX10 mutations resulting in complex multisystem mitochondrial disease that remains stable into adulthood.

scientific article

Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.

scientific article published on December 2014

Construction of histidine-tagged yeast mitochondrial cytochrome c oxidase for facile purification of mutant forms

scientific article published on 01 June 2012

Deleterious effect of the Qo inhibitor compound resistance-conferring mutation G143A in the intron-containing cytochrome b gene and mechanisms for bypassing it

scientific article

Design, synthesis, and biological evaluation of multiple targeting antimalarials

scientific article published on 20 May 2021

Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models.

scientific article published in March 2003

Disruption of the interaction between the Rieske iron-sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b.

scientific article published in April 2004

Effect of inhibition of the bc1 complex on gene expression profile in yeast.

scientific article published on 20 June 2005

Effects of mutation of residue I67 on redox-linked protonation processes in yeast cytochrome c oxidase.

scientific article published on March 1998

Effects of mutation of the conserved glutamic acid-286 in subunit I of cytochrome c oxidase from Rhodobacter sphaeroides

scientific article published on 01 April 1999

Effects of mutation of the conserved lysine-362 in cytochrome c oxidase from Rhodobacter sphaeroides

scientific article published on 01 November 1997

Effects of mutations in mitochondrial cytochrome b in yeast and man. Deficiency, compensation and disease.

scientific article

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

scientific article

Formation of the redox cofactor centers during Cox1 maturation in yeast cytochrome oxidase.

scientific article

Functional mapping reveals the importance of yeast cytochrome b C-terminal region in assembly and function of the bc1 complex

scientific article published on 01 March 1997

Genetic screening in Saccharomyces cerevisiae for large numbers of mitochondrial point mutations which affect structure and function of catalytic subunits of cytochrome-c oxidase

scientific article published on 01 April 1993

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.

scientific article

Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms.

scientific article published on 13 June 2016

Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.

scientific article published in February 1989

Insight into the interactions between subunits I and II of the cytochrome c oxidase of the yeast Saccharomyces cerevisiae by means of extragenic complementation

scientific article published on 01 December 1993

Insight into topological and functional relationships of cytochrome c oxidase subunit I of Saccharomyces cerevisiae by means of intragenic complementation

scientific article published on 01 April 1993

Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

scientific article published on 09 July 2019

Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex - Analysis of Plasmodium-like mutations in the yeast enzyme

scientific article published on 21 August 2015

Laser Photolysis Behavior of Ferrous Horseradish Peroxidase with Carbon Monoxide and Cyanide: Effects of Mutations in the Distal Heme Pocket ⬇️

scientific article published on November 14, 1995

Mitochondrial complex III Qi -site inhibitor resistance mutations found in laboratory selected mutants and field isolates

scientific article published on 24 December 2018

MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase.

scientific article

Multiple defects in the respiratory chain lead to the repression of genes encoding components of the respiratory chain and TCA cycle enzymes.

scientific article

Mutations of cytochrome c oxidase subunits 1 and 3 in Saccharomyces cerevisiae: assembly defect and compensation

scientific article published in April 2002

New inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd.

scientific article

Nuclearly inherited diuron-resistant mutations conferring a deficiency in the NADH--or succinate--ubiquinone oxidoreductase activity in Saccharomyces cerevisiae.

scientific article

Probing the Role of E272 in Quinol Oxidation of Mitochondrial Complex III†

scientific article published on 01 August 2006

Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.

scientific article published on 2 August 2006

Proton transfer and reactive oxygen species in the cytochrome bc1 complex

Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase

scientific article published on 27 December 2019

Protonmotive mechanism of heme-copper oxidases

scientific article published on February 1, 1998

Quantitation and Characterization of CytochromecOxidase in Complex Systems ⬇️

scientific article published on July 1, 1998

Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain ⬇️

scientific article published on October 19, 2011

Random deficiency mutations and reversions in the cytochrome c oxidase subunits I, II and III of Saccharomyces cerevisiae.

scientific article published on August 1994

Rapid screening of cytochromes of respiratory mutants of Saccharomyces cerevisiae. Application to the selection of strains containing novel forms of cytochrome-c oxidase

scientific article published on 01 April 1993

Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes

scientific article published on 14 April 2020

Re-examination of inhibitor resistance conferred by Qo-site mutations in cytochrome b using yeast as a model system.

scientific article published in October 2005

Reaction of wild-type and Glu243Asp variant yeast cytochrome c oxidase with O2

scientific article published on 28 March 2014

Reconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzyme

scientific article (publication date: 2013)

Redox- and anion-linked protonation sites in horseradish peroxidase: analysis of distal haem pocket mutants.

scientific article published on February 1998

Respiratory complex III dysfunction in humans and the use of yeast as a model organism to study mitochondrial myopathy and associated diseases ⬇️

scientific article published on 05 December 2012

S15.10 The role of glu272 in ubiquinol oxidation of mitochondrial cytochrome bc1 complex

Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.

scientific article published on 27 April 2015

Second-site reversion analysis is not a reliable method to determine distances in membrane proteins: an assessment using mutations in yeast cytochrome c oxidase subunits I and II

scientific article published on 01 November 1998

Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase.

scientific article

Structural and functional analysis of deficient mutants in subunit I of cytochrome c oxidase from Saccharomyces cerevisiae.

scientific article

Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1

scientific article published on 31 December 2018

The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth

scientific article published on 26 November 2015

The topology of CuA in relation to the other metal centres in cytochrome-c oxidase of Saccharomyces cerevisiae as determined by analysis of second-site reversions

scientific article published on 01 November 1995

Transcriptional response to nitrosative stress in Saccharomyces cerevisiae.

scientific article

Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae.

scientific article

Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily

scientific article published on 07 September 2011

List of works by Brigitte Meunier

A common coupling mechanism for A-type heme-copper oxidases from bacteria to mitochondria

A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy

A mitochondrial cytochrome b mutation causing severe respiratory chain enzyme deficiency in humans and yeast

A nonsense mutation in COQ9 causes autosomal-recessive neonatal-onset primary coenzyme Q10 deficiency: a potentially treatable form of mitochondrial disease

A rapid in vivo colorimetric library screen for inhibitors of microbial respiration.

A role for the succinate dehydrogenase in the mode of action of the redox-active antimalarial drug, plasmodione

Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy

An in silico approach combined with in vivo experiments enables the identification of a new protein whose overexpression can compensate for specific respiratory defects in Saccharomyces cerevisiae ⬇️

Assembly factors monitor sequential hemylation of cytochrome b to regulate mitochondrial translation.

Assignment of the CO-sensitive carboxyl group in mitochondrial forms of cytochrome c oxidase using yeast mutants

CO recombination as a probe of the Fe/Cu binuclear centre of terminal protonmotive oxidases.

COX10 mutations resulting in complex multisystem mitochondrial disease that remains stable into adulthood.

Comparisons of subunit 5A and 5B isoenzymes of yeast cytochrome c oxidase.

Construction of histidine-tagged yeast mitochondrial cytochrome c oxidase for facile purification of mutant forms

Deleterious effect of the Qo inhibitor compound resistance-conferring mutation G143A in the intron-containing cytochrome b gene and mechanisms for bypassing it

Design, synthesis, and biological evaluation of multiple targeting antimalarials

Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models.

Disruption of the interaction between the Rieske iron-sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b.

Effect of inhibition of the bc1 complex on gene expression profile in yeast.

Effects of mutation of residue I67 on redox-linked protonation processes in yeast cytochrome c oxidase.

Effects of mutation of the conserved glutamic acid-286 in subunit I of cytochrome c oxidase from Rhodobacter sphaeroides

Effects of mutation of the conserved lysine-362 in cytochrome c oxidase from Rhodobacter sphaeroides

Effects of mutations in mitochondrial cytochrome b in yeast and man. Deficiency, compensation and disease.

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Formation of the redox cofactor centers during Cox1 maturation in yeast cytochrome oxidase.

Functional mapping reveals the importance of yeast cytochrome b C-terminal region in assembly and function of the bc1 complex

Genetic screening in Saccharomyces cerevisiae for large numbers of mitochondrial point mutations which affect structure and function of catalytic subunits of cytochrome-c oxidase

HDQ, a potent inhibitor of Plasmodium falciparum proliferation, binds to the quinone reduction site of the cytochrome bc1 complex.

Human Mitochondrial Cytochrome b Variants Studied in Yeast: Not All Are Silent Polymorphisms.

Increased diuron resistance in the joint expression of mutations located at the DIU2, DIU3 and DIU4 loci of Saccharomyces cerevisiae.

Insight into the interactions between subunits I and II of the cytochrome c oxidase of the yeast Saccharomyces cerevisiae by means of extragenic complementation

Insight into topological and functional relationships of cytochrome c oxidase subunit I of Saccharomyces cerevisiae by means of intragenic complementation

Integrated Approach Reveals Role of Mitochondrial Germ-Line Mutation F18L in Respiratory Chain, Oxidative Alterations, Drug Sensitivity, and Patient Prognosis in Glioblastoma

Interplay between the hinge region of iron sulphur protein and the Qo site in the bc1 complex - Analysis of Plasmodium-like mutations in the yeast enzyme

Laser Photolysis Behavior of Ferrous Horseradish Peroxidase with Carbon Monoxide and Cyanide: Effects of Mutations in the Distal Heme Pocket ⬇️

Mitochondrial complex III Qi -site inhibitor resistance mutations found in laboratory selected mutants and field isolates

MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase.

Multiple defects in the respiratory chain lead to the repression of genes encoding components of the respiratory chain and TCA cycle enzymes.

Mutations of cytochrome c oxidase subunits 1 and 3 in Saccharomyces cerevisiae: assembly defect and compensation

New inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd.

Nuclearly inherited diuron-resistant mutations conferring a deficiency in the NADH--or succinate--ubiquinone oxidoreductase activity in Saccharomyces cerevisiae.

Probing the Role of E272 in Quinol Oxidation of Mitochondrial Complex III†

Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants.

Proton transfer and reactive oxygen species in the cytochrome bc1 complex

Proton-transfer pathways in the mitochondrial S. cerevisiae cytochrome c oxidase

Protonmotive mechanism of heme-copper oxidases

Quantitation and Characterization of CytochromecOxidase in Complex Systems ⬇️

Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain ⬇️

Random deficiency mutations and reversions in the cytochrome c oxidase subunits I, II and III of Saccharomyces cerevisiae.

Rapid screening of cytochromes of respiratory mutants of Saccharomyces cerevisiae. Application to the selection of strains containing novel forms of cytochrome-c oxidase

Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes

Re-examination of inhibitor resistance conferred by Qo-site mutations in cytochrome b using yeast as a model system.

Reaction of wild-type and Glu243Asp variant yeast cytochrome c oxidase with O2

Reconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzyme

Redox- and anion-linked protonation sites in horseradish peroxidase: analysis of distal haem pocket mutants.

Respiratory complex III dysfunction in humans and the use of yeast as a model organism to study mitochondrial myopathy and associated diseases ⬇️

S15.10 The role of glu272 in ubiquinol oxidation of mitochondrial cytochrome bc1 complex

Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.

Second-site reversion analysis is not a reliable method to determine distances in membrane proteins: an assessment using mutations in yeast cytochrome c oxidase subunits I and II

Site-directed mutations in the mitochondrially encoded subunits I and III of yeast cytochrome oxidase.

Structural and functional analysis of deficient mutants in subunit I of cytochrome c oxidase from Saccharomyces cerevisiae.

Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc1

The antimalarial drug primaquine targets Fe-S cluster proteins and yeast respiratory growth

The topology of CuA in relation to the other metal centres in cytochrome-c oxidase of Saccharomyces cerevisiae as determined by analysis of second-site reversions

Transcriptional response to nitrosative stress in Saccharomyces cerevisiae.

Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae.

Yeast cytochrome c oxidase: a model system to study mitochondrial forms of the haem-copper oxidase superfamily