List of works - Ben van Ommen

26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: evidence-based nutrition

scientific article

A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis ⬇️

scientific article published on August 12, 2011

A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice

scientific article

A network biology model of micronutrient related health

scientific article published on June 2008

A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans ⬇️

scientific article published on September 29, 2012

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

scientific article

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach

scientific article published on 24 February 2010

Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges

scientific article

Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study

scientific article

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

scientific article (publication date: 2007)

Bromobenzene-induced hepatotoxicity at the transcriptome level

scientific article published on 31 March 2004

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

scientific article (publication date: 3 February 2010)

Challenging homeostasis to define biomarkers for nutrition related health

scientific article published on July 2009

Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy

scientific article (publication date: 2012)

Connecting the Human Variome Project to nutrigenomics

scientific article

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life

scientific article (publication date: 2014)

Determinants of post-prandial plasma bile acid kinetics in human volunteers

scientific article

Developing computational model-based diagnostics to analyse clinical chemistry data

scientific article

Diagnostic markers based on a computational model of lipoprotein metabolism ⬇️

scientific article published on October 26, 2011

Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice ⬇️

scientific article published on February 15, 2013

Effect of body fat distribution on the transcription response to dietary fat interventions

scientific article published on 30 April 2009

Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial

scientific article

Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats ⬇️

scientific article published on December 1, 2003

Effects of n-6 and n-3 polyunsaturated fatty acids on gap junctional intercellular communication during spontaneous differentiation of the human colon adenocarcinoma cell line Caco-2.

scientific article published on January 2002

Establishing reporting standards for metabolomic and metabonomic studies: a call for participation

scientific article published on January 2006

Exploring the benefits and challenges of establishing a DRI-like process for bioactives

scientific article published on April 2014

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

scientific article

Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools

scientific article

How we will produce the evidence-based EURRECA toolkit to support nutrition and food policy

scientific article published on April 2008

Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice ⬇️

scientific article published on January 10, 2012

Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size

scientific article published on 10 June 2009

Improving the analysis of designed studies by combining statistical modelling with study design information

scientific article

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE).

scientific article

Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study

scientific article

Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro

scientific article

Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation

scientific article published in January 2006

Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation.

scientific article published on May 2017

Lipoprotein metabolism indicators improve cardiovascular risk prediction

scientific article

Looking back into the future: 30 years of metabolomics at TNO.

scientific article published on 29 April 2013

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

scientific article (publication date: 12 June 2009)

Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes

scientific article

Metabolomic biomarkers for personalised glucose lowering drugs treatment in type 2 diabetes

scientific article

Metabolomics in human nutrition: opportunities and challenges

scientific article

Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2.

scientific article published on 29 August 2005

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

scientific article published on 29 August 2017

Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters

scientific article

Nutrigenomics in efficacy and safety evaluation of food components

scientific article published in January 2004

Nutrigenomics: exploiting systems biology in the nutrition and health arena

scientific article

Nutrigenomics: exploiting systems biology in the nutrition and health arenas

scientific article published on January 2004

Nutrigenomics: the impact of biomics technology on nutrition research

scientific article published on 21 September 2005

Nutritional systems biology modeling: from molecular mechanisms to physiology

scientific article

Owner controlled data exchange in nutrigenomic collaborations: the NuGO information network

scientific article (publication date: June 2009)

Personalised nutrition: status and perspectives

scientific article published on 23 March 2007

Personalized nutrition from a health perspective: luxury or necessity?

scientific article published on October 2007

Phenotypic flexibility as a measure of health: the optimal nutritional stress response test

scientific article published on 21 April 2015

Phenotypic flexibility as key factor in the human nutrition and health relationship

scientific article

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status ⬇️

scientific article published on May 28, 2011

Predicting individual responses to pravastatin using a physiologically based kinetic model for plasma cholesterol concentrations

scientific article published on 9 August 2014

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

scientific article published in January 2005

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

scientific article published on 15 December 2017

Proteome analysis reveals novel proteins associated with proliferation and differentiation of the colorectal cancer cell line Caco-2.

scientific article published in August 2003

Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health

scientific article published on 21 July 2015

Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men

scientific article published on 26 November 2008

Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes

scientific article published on 20 February 2010

Systems biology of personalized nutrition

scientific article published in August 2017

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

scientific article

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

scientific article

The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation

scientific article (publication date: 26 November 2008)

The case for strategic international alliances to harness nutritional genomics for public and personal health

scientific article published in November 2005

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

scientific article published on July 2008

The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

scientific article

The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level

scientific article

The challenges for molecular nutrition research 4: the "nutritional systems biology level".

scientific article

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

scientific article published on 8 February 2017

The introduction of toxicogenomics; potential new markers of hepatotoxicity

scientific article published on January 2005

The nutrition researcher cohort: toward a new generation of nutrition research and health optimization ⬇️

scientific article published on June 7, 2013

The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines

scientific article published in March 2003

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

scientific article published on 23 January 2014

Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance

scientific article

Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure

scientific article published in August 2005

Toxicogenomics concepts and applications to study hepatic effects of food additives and chemicals

scientific article

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

scientific article published in March 2003

Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole

scientific journal article

Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health

scientific article

Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes ⬇️

scientific article published on January 6, 2012

Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study

scientific article published on February 2016

White adipose tissue reference network: a knowledge resource for exploring health-relevant relations

scientific article

List of works by Ben van Ommen

26th Hohenheim Consensus Conference, September 11, 2010 Scientific substantiation of health claims: evidence-based nutrition

A Systems Biology Strategy for Predicting Similarities and Differences of Drug Effects: Evidence for Drug-specific Modulation of Inflammation in Atherosclerosis ⬇️

A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosis in transgenic mice

A network biology model of micronutrient related health

A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans ⬇️

A systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach

Assessment of inflammatory resilience in healthy subjects using dietary lipid and glucose challenges

Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

Bromobenzene-induced hepatotoxicity at the transcriptome level

Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

Challenging homeostasis to define biomarkers for nutrition related health

Clustering by plasma lipoprotein profile reveals two distinct subgroups with positive lipid response to fenofibrate therapy

Connecting the Human Variome Project to nutrigenomics

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life

Determinants of post-prandial plasma bile acid kinetics in human volunteers

Developing computational model-based diagnostics to analyse clinical chemistry data

Diagnostic markers based on a computational model of lipoprotein metabolism ⬇️

Differential Effects of Drug Interventions and Dietary Lifestyle in Developing Type 2 Diabetes and Complications: A Systems Biology Analysis in LDLr−/− Mice ⬇️

Effect of body fat distribution on the transcription response to dietary fat interventions

Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial

Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats ⬇️

Effects of n-6 and n-3 polyunsaturated fatty acids on gap junctional intercellular communication during spontaneous differentiation of the human colon adenocarcinoma cell line Caco-2.

Establishing reporting standards for metabolomic and metabonomic studies: a call for participation

Exploring the benefits and challenges of establishing a DRI-like process for bioactives

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools

How we will produce the evidence-based EURRECA toolkit to support nutrition and food policy

Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice ⬇️

Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size

Improving the analysis of designed studies by combining statistical modelling with study design information

Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE).

Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study

Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro

Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation

Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation.

Lipoprotein metabolism indicators improve cardiovascular risk prediction

Looking back into the future: 30 years of metabolomics at TNO.

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes

Metabolomic biomarkers for personalised glucose lowering drugs treatment in type 2 diabetes

Metabolomics in human nutrition: opportunities and challenges

Modulatory effects of quercetin on proliferation and differentiation of the human colorectal cell line Caco-2.

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

Network signatures link hepatic effects of anti-diabetic interventions with systemic disease parameters

Nutrigenomics in efficacy and safety evaluation of food components

Nutrigenomics: exploiting systems biology in the nutrition and health arena

Nutrigenomics: exploiting systems biology in the nutrition and health arenas

Nutrigenomics: the impact of biomics technology on nutrition research

Nutritional systems biology modeling: from molecular mechanisms to physiology

Owner controlled data exchange in nutrigenomic collaborations: the NuGO information network

Personalised nutrition: status and perspectives

Personalized nutrition from a health perspective: luxury or necessity?

Phenotypic flexibility as a measure of health: the optimal nutritional stress response test

Phenotypic flexibility as key factor in the human nutrition and health relationship

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status ⬇️

Predicting individual responses to pravastatin using a physiologically based kinetic model for plasma cholesterol concentrations

Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

Proteome analysis reveals novel proteins associated with proliferation and differentiation of the colorectal cancer cell line Caco-2.

Quantifying phenotypic flexibility as the response to a high-fat challenge test in different states of metabolic health

Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men

Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes

Systems biology of personalized nutrition

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation

The case for strategic international alliances to harness nutritional genomics for public and personal health

The challenges for molecular nutrition research 1: linking genotype to healthy nutrition

The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level

The challenges for molecular nutrition research 4: the "nutritional systems biology level".

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

The introduction of toxicogenomics; potential new markers of hepatotoxicity

The nutrition researcher cohort: toward a new generation of nutrition research and health optimization ⬇️

The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE(2) synthesis and cytotoxicity in human colorectal carcinoma cell lines

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance