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List of works by Upendra A Argikar

A numerical method for analysis of in vitro time-dependent inhibition data. Part 2. Application to experimental data

scientific article

An experimental approach to enhance precursor ion fragmentation for metabolite identification studies: application of dual collision cells in an orbital trap

scientific article published on 01 May 2011

An in vitro approach to investigate ocular metabolism of a topical, selective β1-adrenergic blocking agent, betaxolol.

scientific article published on 5 December 2014

Case study 2. Practical analytical considerations for conducting in vitro enzyme kinetic studies

scientific article

Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.

scientific article published on 5 August 2016

Compound Property Optimization in Drug Discovery Using Quantitative Surface Sampling Micro Liquid Chromatography with Tandem Mass Spectrometry.

scientific article published on 31 October 2016

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.

scientific article

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.

scientific article

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

scientific article published on 30 April 2019

Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

scientific article published on 19 February 2020

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.

scientific article published on 16 June 2017

Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet?

scientific article published on 17 March 2017

Enzyme kinetics in drug metabolism: fundamentals and applications

scientific article published on 01 January 2014

Evaluation of pharmaceutical excipients as cosolvents in 4-methyl umbelliferone glucuronidation in human liver microsomes: applications for compounds with low solubility

scientific article published on 12 November 2010

Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation.

scientific article published on 6 December 2006

Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes

scientific article published on 02 November 2011

Genotoxicity of 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazine, a Potent H4 Receptor Antagonist for the Treatment of Allergy : Evidence of glyoxal intermediate involvement.

scientific article published on 6 November 2017

Identification of a novel N-carbamoyl glucuronide: in vitro, in vivo, and mechanistic studies.

scientific article published on 11 December 2009

Identification of domperidone metabolites in plasma and urine of gastroparesis patients with LC-ESI-MS/MS.

scientific article

Identification of saturated and unsaturated fatty acids released during microsomal incubations

scientific article published on 06 February 2014

Implications for Metabolite Quantification by Mass Spectrometry in the Absence of Authentic Standards.

scientific article published on 2 March 2017

Investigation of Ocular Bioactivation Potential and the Role of Cytochrome P450 2D Enzymes in Rat.

scientific article

In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human.

scientific article published on 19 November 2016

Metabolism of bromopride in mouse, rat, rabbit, dog, monkey, and human hepatocytes

scientific article published on 23 April 2013

Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route

scientific article published on 15 August 2018

Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways.

scientific article published on 17 May 2016

Ocular non-P450 oxidative, reductive, hydrolytic, and conjugative drug metabolizing enzymes

scientific article

Optimization of Allosteric With-No-Lysine (WNK) Kinase Inhibitors and Efficacy in Rodent Hypertension Models

scientific article published on 3 August 2017

Oxidative ipso substitution of 2,4-difluoro-benzylphthalazines: identification of a rare stable quinone methide and subsequent GSH conjugate

scientific article published on 30 July 2012

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.

scientific article

Predicting phospholipidosis: a fluorescence noncell based in vitro assay for the determination of drug-phospholipid complex formation in early drug discovery

scientific article published on 19 August 2011

Rapid, large-scale formation of porcine hepatocyte spheroids in a novel spheroid reservoir bioartificial liver.

scientific article published in August 2005

Saccharolactone: the History, the Myth, and the Practice.

scientific article published on 29 December 2017

Strategies and chemical design approaches to reduce the potential for formation of reactive metabolic species.

scientific article published on January 2011

Structure based design of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors from a phenotypic screen

scientific article published on 18 December 2017

Studies on induction of lamotrigine metabolism in transgenic UGT1 mice.

scientific article

The mesentery: an ADME perspective on a 'new' organ

scientific article published on 16 July 2018

Tissue-specific, inducible, and hormonal control of the human UDP-glucuronosyltransferase-1 (UGT1) locus.

scientific article published on 9 September 2005

Understanding metabolism related differences in ocular efficacy of MGV354

scientific article published on 14 July 2020

Unusual glucuronides.

scientific article published on 19 April 2012

Update on tools for evaluation of uridine diphosphoglucuronosyltransferase polymorphisms

scientific article published on 01 July 2008

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