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List of works by Patrick O. Humbert

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

scientific article

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

scientific article published on 01 June 2005

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization

scientific article

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

article

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

scientific article published on 20 September 2012

Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

scientific article published on 30 September 2020

Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression

scientific article

Asymmetric cell division during T cell development controls downstream fate

scientific article

Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms

scientific article published on 07 June 2010

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

scientific article published on 5 June 2017

Calcium Signaling Is Required for Erythroid Enucleation

scientific article published on 5 January 2016

Cell Polarity Regulation-From Atomic to Macroscopic Scale

scientific article published on 20 July 2018

Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.

scientific article published on 12 May 2010

Characterization of in vivo Dlg1 deletion on T cell development and function

scientific article

Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC

scientific article published on 02 February 2019

Discovery and analysis of consistent active sub-networks in cancers

scientific article

Dissecting the role of polarity regulators in cancer through the use of mouse models.

scientific article published on 30 August 2014

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

scientific article

E2F4 is essential for normal erythrocyte maturation and neonatal viability

scientific journal article

E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation

scientific article published on 01 August 2006

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

scientific article published on 20 May 2009

Epidermal wound repair is regulated by the planar cell polarity signaling pathway

scientific article published on 20 July 2010

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

scientific article

How to expel a bad tenant: Linking cyclin A2, enucleation and cell size

scientific article published on 19 January 2017

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis

scientific article

Increasing intracellular bioavailable copper selectively targets prostate cancer cells

scientific article published on 24 May 2013

Intermittent hypoxia induces a metastatic phenotype in breast cancer.

scientific article published in May 2018

Keratin 76 is required for tight junction function and maintenance of the skin barrier.

scientific article

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia

scientific article published on 27 January 2014

Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

scientific article published on 22 September 2015

Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers.

scientific article

Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

scientific article published in May 2015

Multiscale modeling of form and function

scientific article published in April 2009

Muscle stem cell fate is controlled by the cell-polarity protein Scrib

scientific article published on 19 February 2015

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors

scientific article (publication date: 2012)

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

scientific article published on 23 July 2015

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

scientific article published on January 2007

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition

scientific article

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

scientific article published in January 2013

Regulation of cellular and PCP signalling by the Scribble polarity module.

scientific article published on 14 November 2017

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

scientific article published on 3 October 2011

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

scientific article published on 25 November 2013

Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium

scientific article published on 18 August 2014

Scribble acts as an oncogene in Eμ-myc-driven lymphoma

scientific article published on 18 May 2015

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland

scientific article

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.

scientific article published on 26 June 2013

Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains

scientific article published on 18 July 2019

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.

scientific article

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

scientific article

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumourigenesis.

scientific article published on 30 January 2018

The polarity protein Scrib limits atherosclerosis development in mice

scientific article published on 01 December 2019

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

scientific article

The polarity protein Scribble regulates myelination and remyelination in the central nervous system

scientific article (publication date: March 2015)

Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines

scientific article

Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium

scientific article

VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland

scientific article published on 08 May 2019

Vimentin regulates scribble activity by protecting it from proteasomal degradation

scientific article published on 22 April 2009

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

scientific article (publication date: 18 December 2003)