List of works - Michael S. Christodoulou

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

scientific article

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

scientific article

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

scientific article published on 13 May 2013

A high-throughput screening of a chemical compound library in ovarian cancer stem cells

scientific article published on 23 January 2018

Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ

scientific article published on 12 May 2020

Application of the Ugi reaction with multiple amino acid-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics.

scientific article

Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds

scientific article published on 27 November 2020

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

scientific article published on 20 January 2015

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

scientific article

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

scientific article

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

scientific article published on 26 February 2019

Chemical approaches to targeting drug resistance in cancer stem cells.

scientific article published on 10 May 2014

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

scientific article published on 08 February 2012

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

scientific article published on 27 February 2015

Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy

scientific article published on 10 June 2015

Divergent Conversion of 4-Naphthoquinone-substituted 4H-Isoxazolones to Different Benzo-fused Indole Derivatives

scientific article published on 17 March 2020

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

scientific article

Farinose alpine Primula species: phytochemical and morphological investigations.

scientific article

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

scientific article published in August 2017

Microtubule-Directed Therapeutic Strategy for Neurodegenerative Disorders: Starting From the Basis and Looking on the Emergences

scientific article published on 14 December 2016

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

scientific article published on 20 August 2019

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

scientific article

Novel pyrazole derivatives: synthesis and evaluation of anti-angiogenic activity.

scientific article

Preparation of Fluorescent Tubulin Binders

Probing an Allosteric Pocket of CDK2 with Small Molecules

scientific article

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

scientific article

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

scientific article published on 19 September 2013

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

scientific article published on 17 January 2017

Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates

scientific article published on 04 January 2019

Self-assembly drug conjugates for anticancer treatment

scientific article published on 18 June 2016

Structure-Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

scientific article published on 20 November 2018

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

scientific article published on 25 January 2011

Synthesis and biological evaluation of novel tamoxifen analogues

scientific article published on 15 May 2013

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

article published in 2016

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

scientific article published on 01 January 2019

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.

scientific article published in July 2017

Tools for the rational design of bivalent microtubule-targeting drugs.

scientific article published on 6 September 2016

Vancomycin-Iridium (III) Interaction: An Unexplored Route for Enantioselective Imine Reduction

scientific article published on 30 July 2019

List of works by Michael S. Christodoulou

'Click' synthesis of a triazole-based inhibitor of Met functions in cancer cells.

4-(1,2-diarylbut-1-en-1-yl)isobutyranilide derivatives as inhibitors of topoisomerase II.

9-Fluorenone-2-Carboxylic Acid as a Scaffold for Tubulin Interacting Compounds

A high-throughput screening of a chemical compound library in ovarian cancer stem cells

Antiproliferative effects of chalcones on T cell acute lymphoblastic leukemia-derived cells: Role of PKCβ

Application of the Ugi reaction with multiple amino acid-derived components: synthesis and conformational evaluation of piperazine-based minimalist peptidomimetics.

Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds

Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2.

Camptothecin-7-yl-methanthiole: semisynthesis and biological evaluation

Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia

Chemical approaches to targeting drug resistance in cancer stem cells.

Chiral flavanones from Amygdalus lycioides Spach: structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation ⬇️

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

Cyclopamine-Paclitaxel-Containing Nanoparticles: Internalization in Cells Detected by Confocal and Super-Resolution Microscopy

Divergent Conversion of 4-Naphthoquinone-substituted 4H-Isoxazolones to Different Benzo-fused Indole Derivatives

Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis

Farinose alpine Primula species: phytochemical and morphological investigations.

Heteronanoparticles by self-Assembly of Doxorubicin and Cyclopamine Conjugates.

Microtubule-Directed Therapeutic Strategy for Neurodegenerative Disorders: Starting From the Basis and Looking on the Emergences

Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

New class of squalene-based releasable nanoassemblies of paclitaxel, podophyllotoxin, camptothecin and epothilone A.

Novel pyrazole derivatives: synthesis and evaluation of anti-angiogenic activity.

Preparation of Fluorescent Tubulin Binders

Probing an Allosteric Pocket of CDK2 with Small Molecules

Probing the binding site of abl tyrosine kinase using in situ click chemistry.

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

Self-assembling Releasable Thiocolchicine-Diphenylbutenylaniline Conjugates

Self-assembly drug conjugates for anticancer treatment

Structure-Activity Relationships of Hexahydrocyclopenta[c]quinoline Derivatives as Allosteric Inhibitors of CDK2 and EGFR

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Synthesis and biological evaluation of novel tamoxifen analogues

Synthesis of Pironetin-Dumetorine Hybrids as Tubulin Binders

Synthesis of Thicolchicine-Based Conjugates: Investigation towards Bivalent Tubulin/Microtubules Binders

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.

Tools for the rational design of bivalent microtubule-targeting drugs.

Vancomycin-Iridium (III) Interaction: An Unexplored Route for Enantioselective Imine Reduction