List of works - Vicent Casadó

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

scientific article

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer

scientific article published on 30 December 2011

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

scientific article published on 28 April 2015

A1 adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding

scientific article published in May 1994

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

scientific article published on 10 May 2013

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

scientific article published in May 2011

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors

scientific journal article

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function

scientific article

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers

scientific article published in September 2009

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

scientific article

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

scientific article published on July 2004

Adenosine/dopamine receptor-receptor interactions in the central nervous system

scholarly article by Rafael Franco et al published January 2001 in Drug Development Research

Allosteric modulation of dopamine D2 receptors by homocysteine

scientific article

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

scientific article published on 2 November 2007

Biotin Ergopeptide Probes for Dopamine Receptors ⬇️

scientific article published on January 31, 2011

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

scientific article published on 24 April 2012

Cell surface adenosine deaminase: much more than an ectoenzyme.

scientific article

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

scientific article

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

scientific article published on March 2014

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

scientific article

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

scientific article published on September 2004

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

scientific article

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

scientific article

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology

scientific article published in January 2013

Dimer-based model for heptaspanning membrane receptors

scientific article published on 01 July 2005

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

scientific article

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway

scientific article

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives

scientific article published on 10 February 2014

G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

scientific article published on 09 May 2014

G-protein-coupled receptor heteromers: function and ligand pharmacology

scientific article

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

scientific article published on 05 August 2009

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

scientific article published on 13 May 2010

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

scientific article

Heterodimeric adenosine receptors: a device to regulate neurotransmitter release.

scientific article published in November 2006

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine

scientific article

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

scientific article

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

scientific article

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

scientific article published on 4 August 2009

Immunological identification of A1adenosine receptors in brain cortex

scientific article published on 01 December 1995

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

scientific article published in September 2009

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

scientific article

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

scientific article (publication date: August 2008)

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

scientific article

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

scientific article published on 9 January 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

scientific article

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

scientific article

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

scientific article published on 13 February 2001

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

scientific article

Moonlighting adenosine deaminase: a target protein for drug development

scientific article

NCS-1 associates with adenosine A(2A) receptors and modulates receptor function.

scientific article published on 18 April 2012

Novel ergopeptides as dual ligands for adenosine and dopamine receptors

scientific article

Novel pharmacological targets based on receptor heteromers

scientific article

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

scientific article published on 14 June 2007

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

scientific article published on 22 April 2021

Partners for adenosine A1 receptors

scientific article

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

scientific article published on April 2010

Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone.

scientific article

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

scientific article

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

scientific article

Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins.

scientific article published on 6 October 2006

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction

scientific article

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

scientific article published on 01 May 2003

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

scientific article published on 22 November 2018

Solubilization of A1adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states

scientific article published on 01 August 1990

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

scientific journal article

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists

scientific article

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

scientific article

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

scientific article published on 27 November 2012

The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane

scientific journal article

The two-state dimer receptor model: a general model for receptor dimers

scientific article published on 24 February 2006

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

scientific article

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

scientific article published on 28 July 2009

List of works by Vicent Casadó

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer

A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D(1) and D(2) dopamine receptors.

A1 adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

Adenosine/dopamine receptor-receptor interactions in the central nervous system

Allosteric modulation of dopamine D2 receptors by homocysteine

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

Biotin Ergopeptide Probes for Dopamine Receptors ⬇️

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

Cell surface adenosine deaminase: much more than an ectoenzyme.

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology

Dimer-based model for heptaspanning membrane receptors

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway

G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives

G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

G-protein-coupled receptor heteromers: function and ligand pharmacology

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

Heterodimeric adenosine receptors: a device to regulate neurotransmitter release.

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

Immunological identification of A1adenosine receptors in brain cortex

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

Moonlighting adenosine deaminase: a target protein for drug development

NCS-1 associates with adenosine A(2A) receptors and modulates receptor function.

Novel ergopeptides as dual ligands for adenosine and dopamine receptors

Novel pharmacological targets based on receptor heteromers

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects

Partners for adenosine A1 receptors

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone.

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins.

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

Solubilization of A1adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane

The two-state dimer receptor model: a general model for receptor dimers

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.