List of works - Rafael Pulido

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

scientific article

A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity

scientific article

A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

scientific article

A novel loss-of-function mutation (N48K) in the PTEN gene in a Spanish patient with Cowden disease

scientific article published on 01 December 2003

A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity

scientific article published on 11 October 2007

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

scientific article

A one-step method to identify MAP kinase residues involved in inactivation by tyrosine- and dual-specificity protein phosphatases.

scientific article

A rapid guide to PTEN function

scientific article published on 01 May 2015

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

Assessing PTEN Subcellular Localization

scientific article published on January 2016

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

scientific article published on September 2008

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

scientific article

CD34 immunostaining enhances a distinct pattern of intratumor angiogenesis with prognostic implications in clear cell renal cell carcinoma.

scientific article published on February 2017

Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function.

scientific article

Comparative biochemical and tissue distribution study of four distinct CD45 antigen specificities

scientific article published on 01 June 1988

Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.

scientific article published on 20 October 2011

Differential expression of VLA-4 integrin by resident and peripheral blood B lymphocytes. Acquisition of functionally active α4β1-fibronectin receptors upon B cell activation ⬇️

scholarly article by Antonio A. Postigo et al published October 1991 in European Journal of Immunology

Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils

scientific article (publication date: November 1991)

Dual-specificity MAP kinase phosphatases as targets of cancer treatment.

scientific article published on January 2011

Dual-specificity phosphatases as molecular targets for inhibition in human disease

scientific article published on 11 March 2014

Fibroblast activation protein predicts prognosis in clear cell renal cell carcinoma.

scientific article published on 7 April 2016

Functional assignment of MAPK phosphatase domains

scientific article

Functional definition of relevant epitopes on the tumor suppressor PTEN protein

scientific article published on 10 November 2004

Global RT-PCR and RT-qPCR Analysis of the mRNA Expression of the Human PTPome.

scientific article published on January 2016

Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues

scientific article published on 01 January 2001

Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages

scientific article published on 01 April 1994

Identification of amino acids at the junction of exons 3 and 7 that are used for the generation of glycosylation-related human CD45RO and CD45RO-like antigen specificities.

scientific article

In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN.

scientific article

Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model

scientific article published on 31 January 2017

Low-grade metastases in high-grade clear cell renal cell carcinomas: A clinicopathologic study of 4 cases with an insight into the role of mesenchymal-to-epithelial transition process.

scientific article published on 30 October 2015

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution

scientific article published on 27 January 2021

Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity

scientific article published on 17 November 2007

Nuclear PTEN: a tale of many tails

scientific article published on 22 December 2006

Oligometastatic Prostate Adenocarcinoma. Clinical-Pathologic Study of a Histologically Under-Recognized Prostate Cancer

scientific article published on 04 December 2020

One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections

scientific article

PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells ⬇️

scientific article published on October 23, 2010

PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1

scientific journal article

PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase

scientific article published on 21 November 2006

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

scientific article published on 18 January 2016

PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.

scientific article

PTEN: a yin-yang master regulator protein in health and disease

scientific article published on May 2015

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

scientific article

Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways

scientific article

Phosphorylation-dephosphorylation of the CD6 glycoprotein renders two isoforms of 130 and 105 kilodaltons. Effect of serum and protein kinase C activators

scientific article published on 01 September 1990

Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms.

scientific article published on 16 March 2011

Protein tyrosine phosphatases as novel targets in breast cancer therapy.

scientific article published on 10 June 2013

Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7.

scientific article published on 27 November 2006

Regulation of ICAM-3 (CD50) membrane expression on human neutrophils through a proteolytic shedding mechanism

scientific article published on 01 November 1994

Regulation of MAPK cascades by protein tyrosine phosphatases.

scientific article published on January 2004

Role of ICAM-3 in intercellular adhesion and activation of T lymphocytes

scientific article published on 01 July 1994

Snail heterogeneity in clear cell renal cell carcinoma.

scientific article

Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR.

scientific article published in December 2004

Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases In Vitro and in Cell Systems ⬇️

scientific article published on January 1, 2010

Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B.

scientific article published in January 2016

The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases

scientific article

The Extended Family of Protein Tyrosine Phosphatases.

scientific article published in January 2016

The extended human PTPome: a growing tyrosine phosphatase family

scientific article published on 17 November 2015

The extended human PTPome: a growing tyrosine phosphatase family

scientific article published on 20 May 2016

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

scientific article

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo.

scientific article

List of works by Rafael Pulido

A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes

A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity

A functional network of the tumor suppressors APC, hDlg, and PTEN, that relies on recognition of specific PDZ-domains.

A novel loss-of-function mutation (N48K) in the PTEN gene in a Spanish patient with Cowden disease

A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity

A novel regulatory mechanism of MAP kinases activation and nuclear translocation mediated by PKA and the PTP-SL tyrosine phosphatase

A one-step method to identify MAP kinase residues involved in inactivation by tyrosine- and dual-specificity protein phosphatases.

A rapid guide to PTEN function

A unified nomenclature and amino acid numbering for human PTEN.

Assessing PTEN Subcellular Localization

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast.

Binding of PTEN to specific PDZ domains contributes to PTEN protein stability and phosphorylation by microtubule-associated serine/threonine kinases

CD34 immunostaining enhances a distinct pattern of intratumor angiogenesis with prognostic implications in clear cell renal cell carcinoma.

Caspase-3 cleavage of DUSP6/MKP3 at the interdomain region generates active MKP3 fragments that regulate ERK1/2 subcellular localization and function.

Comparative biochemical and tissue distribution study of four distinct CD45 antigen specificities

Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.

Differential expression of VLA-4 integrin by resident and peripheral blood B lymphocytes. Acquisition of functionally active α4β1-fibronectin receptors upon B cell activation ⬇️

Differentially regulated cell surface expression of leukocyte adhesion receptors on neutrophils

Dual-specificity MAP kinase phosphatases as targets of cancer treatment.

Dual-specificity phosphatases as molecular targets for inhibition in human disease

Fibroblast activation protein predicts prognosis in clear cell renal cell carcinoma.

Functional assignment of MAPK phosphatase domains

Functional definition of relevant epitopes on the tumor suppressor PTEN protein

Global RT-PCR and RT-qPCR Analysis of the mRNA Expression of the Human PTPome.

Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues

Human CD45RC specificity. A novel marker for T cells at different maturation and activation stages

Identification of amino acids at the junction of exons 3 and 7 that are used for the generation of glycosylation-related human CD45RO and CD45RO-like antigen specificities.

In vivo functional analysis of the counterbalance of hyperactive phosphatidylinositol 3-kinase p110 catalytic oncoproteins by the tumor suppressor PTEN.

Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model

Low-grade metastases in high-grade clear cell renal cell carcinomas: A clinicopathologic study of 4 cases with an insight into the role of mesenchymal-to-epithelial transition process.

MMADHC premature termination codons in the pathogenesis of cobalamin D disorder: Potential of translational readthrough reconstitution

Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity

Nuclear PTEN: a tale of many tails

Oligometastatic Prostate Adenocarcinoma. Clinical-Pathologic Study of a Histologically Under-Recognized Prostate Cancer

One-Tube-Only Standardized Site-Directed Mutagenesis: An Alternative Approach to Generate Amino Acid Substitution Collections

PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells ⬇️

PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1

PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase

PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

PTEN-PDZ domain interactions: binding of PTEN to PDZ domains of PTPN13.

PTEN: a yin-yang master regulator protein in health and disease

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.

Phosphorylation of the kinase interaction motif in mitogen-activated protein (MAP) kinase phosphatase-4 mediates cross-talk between protein kinase A and MAP kinase signaling pathways

Phosphorylation-dephosphorylation of the CD6 glycoprotein renders two isoforms of 130 and 105 kilodaltons. Effect of serum and protein kinase C activators

Phylogenetic and genetic linkage between novel atypical dual-specificity phosphatases from non-metazoan organisms.

Protein tyrosine phosphatases as novel targets in breast cancer therapy.

Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7.

Regulation of ICAM-3 (CD50) membrane expression on human neutrophils through a proteolytic shedding mechanism

Regulation of MAPK cascades by protein tyrosine phosphatases.

Role of ICAM-3 in intercellular adhesion and activation of T lymphocytes

Snail heterogeneity in clear cell renal cell carcinoma.

Stimulated regeneration of the crushed adult rat optic nerve correlates with attenuated expression of the protein tyrosine phosphatases RPTPalpha, STEP, and LAR.

Studying the Regulation of MAP Kinase by MAP Kinase Phosphatases In Vitro and in Cell Systems ⬇️

Tailor-Made Protein Tyrosine Phosphatases: In Vitro Site-Directed Mutagenesis of PTEN and PTPRZ-B.

The Expression of Fibroblast Activation Protein in Clear Cell Renal Cell Carcinomas Is Associated with Synchronous Lymph Node Metastases

The Extended Family of Protein Tyrosine Phosphatases.

The extended human PTPome: a growing tyrosine phosphatase family

The extended human PTPome: a growing tyrosine phosphatase family

Two clusters of residues at the docking groove of mitogen-activated protein kinases differentially mediate their functional interaction with the tyrosine phosphatases PTP-SL and STEP.

Yeast-based methods to assess PTEN phosphoinositide phosphatase activity in vivo.