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List of works by Fiona Watt

(More) women in science

scholarly article by Fiona Watt published in March 2018

2009 winner: Ravi Desai

scientific article

?1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum

scholarly article by Wai Jing Kee published in July 2000

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data

scientific article

A blueprint for translational regenerative medicine

scientific article published on 01 December 2020

A central role for alpha beta T cells in the pathogenesis of murine lupus

scientific article published on 01 June 1999

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

scientific article published on 01 May 2002

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

scientific article

A high-content platform to characterise human induced pluripotent stem cell lines

scientific article published on 19 November 2015

A model for in vitro studies of epidermal homeostasis: proliferation and involucrin synthesis by cultured human keratinocytes during recovery after stripping off the suprabasal layers

scientific article published on May 1988

A new technology for revealing the flow profile in integrated lab-on-a-chip

scientific article published in August 2012

A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

scientific article published on 18 October 2017

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

scientific article

A stem cell gene expression profile of human squamous cell carcinomas

scientific article

A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control

scientific article

A year in the life of eLife

scientific article

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis

scientific article

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

scientific article published on 27 June 2010

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.

scientific article published in November 2007

Adhesion of human epidermal keratinocytes to laminin

scientific article published on 01 August 1994

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

scientific article

Advancing research

scientific article published on 13 August 2014

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

scientific article published on 29 April 2016

Altered expression of CD44 isoforms in squamous-cell carcinomas and cell lines derived from them

scientific article published on 01 May 1996

Amparo Cano

scientific article published in July 2004

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

scientific article published on 01 March 2022

An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.

scientific article published on 03 February 2009

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.

scientific article published on 11 April 2018

An unusual strain of human keratinocytes which do not stratify or undergo terminal differentiation in culture

scientific article published on November 1988

Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

scientific article published on February 1999

Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis

scientific article

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

scientific article published in November 2017

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium

scientific article

Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis

scientific article published in July 2013

Autophagy mediates the mitotic senescence transition

scientific article

BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions

scientific article

Balancing work and life: a conversation with Fiona Watt. Interview by Majlinda Lako and Susan Daher

scientific article

Bench to bedside: Current advances in regenerative medicine

scientific article published on 11 July 2018

Best Paper Award 2003.

scientific article published in April 2004

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells

scientific article

Biochemical specificity of Xenopus notochord

scientific article published on 01 January 1985

Biosynthesis of EGF receptor, transferrin receptor and colligin by cultured human keratinocytes and the effect of retinoic acid

scientific article published on 01 July 1985

CD44 is the major peanut lectin-binding glycoprotein of human epidermal keratinocytes and plays a role in intercellular adhesion

scientific article published on 01 May 1995

CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.

scientific article published in July 2016

Calcium-induced changes in cytoskeleton and motility of cultured human keratinocytes

scientific article published on September 1987

Calcium-induced changes in distribution and solubility of cadherins, integrins and their associated cytoplasmic proteins in human keratinocytes.

scientific article

Calcium-induced intercellular adhesion of keratinocytes does not involve accumulation of beta 1 integrins at cell-cell contacts and does not involve changes in the levels or phosphorylation of catenins

scientific article published in March 1998

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes

scientific article published on December 1984

Carboxylate microsphere-induced cellular toxicity in human lung fibroblasts

article

Cell Biology of Tissues and Tumors ⬇️

scientific article (publication date: 15 November 2010)

Cell adhesion. Fibronectin and integrin knockouts come unstuck

scientific article

Cell culture models of differentiation

scientific article published on March 1991

Cell shape controls terminal differentiation of human epidermal keratinocytes

scientific article

Cell-extracellular matrix interactions in normal and diseased skin

scientific article published on April 2011

Changes in cell-surface carbohydrate during terminal differentiation of human epidermal keratinocytes

scientific article

Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes

scientific article published in October 1995

Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface

scientific article published on October 1990

Changes in the abundance and distribution of actin and associated proteins during terminal differentiation of human epidermal keratinocytes.

scientific article

Changes in the distribution of actin-associated proteins during epidermal wound healing

scientific article

Changes in the expression of alpha v integrins in oral squamous cell carcinomas

scientific article published on February 1997

Changes in type I keratin expression associated with HPV16 transformation of human epidermal keratinocytes

scientific article published on April 1992

Characterisation of eight monoclonal antibodies to involucrin

scientific article published in June 1992

Characterisation of the peanut lectin-binding glycoproteins of human epidermal keratinocytes

scientific article published on April 1990

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin

scientific article

Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25.

scientific article

Clinically-relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis

scientific article published on 12 September 2020

Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo

scientific article

Common genetic variation drives molecular heterogeneity in human iPSCs

scientific article published on 10 May 2017

Common genetic variation drives molecular heterogeneity in human iPSCs

Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas

scientific article published on October 1993

Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity

scientific article published on 01 September 1998

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

scientific article

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis

scientific article published on 20 October 2020

Contribution of stem cells and differentiated cells to epidermal tumours

scientific article

Correction: Rac1 Deletion Causes Thymic Atrophy.

scientific article

Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture

scientific article published on October 1997

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs

scientific article published in Nature

Cutting edge: amelioration of kidney disease in a transgenic mouse model of lupus nephritis by administration of the caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-(beta-o-methyl)-fluoromethylketone

scientific article

DNA amplification is rare in normal human cells

scientific article published on March 1990

Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns.

scientific article published in June 2013

Decreased expression of fibronectin and the alpha 5 beta 1 integrin during terminal differentiation of human keratinocytes

scientific article published on February 1991

Defining Adult Stem Cells by Function, Not by Phenotype.

scientific article published in March 2018

Defining dermal adipose tissue

scientific article

Delta regulates keratinocyte spreading and motility independently of differentiation

scientific article published on 01 September 2001

Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture

scientific article published on 25 July 2019

Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth

scientific article published on 28 June 2017

Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes.

scientific article

Designer skin: lineage commitment in postnatal epidermis

scientific article

Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication.

scientific article

Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation

scientific article

Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient Cells

article by Claudia Bagutti et al published October 1996 in Developmental Biology

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

scientific article

Diverse epigenetic strategies interact to control epidermal differentiation

scientific article

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

scientific article published in Nature

Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation

scientific article published on January 2010

Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse.

scientific article

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

scientific article

Dynamic culture substrates that mimic the topography of the epidermal-dermal junction

article

Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling

scientific article

ERK MAPK activation bursts and propagation in adult and embryonic mouse skin

Effect of growth environment on spatial expression of involucrin by human epidermal keratinocytes

scientific article published on January 1987

Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling

scientific article

Elaine Fuchs

scientific article published in October 2004

Employing core regulatory circuits to define cell identity

Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution

scientific article published on September 2016

Envoplakin and Periplakin are Components of the Paraneoplastic Pemphigus Antigen Complex

scientific article published on 01 December 1998

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin

scientific article

Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.

scientific article

Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity

scientific article published on 30 December 2011

Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood

Epidermal Notch signalling: differentiation, cancer and adhesion

scientific article

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells.

scientific article published on 15 January 2018

Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

scientific article

Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

scientific article

Epidermal label-retaining cells: background and recent applications

scientific article

Epidermal stem cell diversity and quiescence

scientific article

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation

scientific article

Epidermal stem cells are retained in vivo throughout skin aging ⬇️

scientific article published on 21 January 2008

Epidermal stem cells as targets for gene transfer

scientific article

Epidermal stem cells in culture

scientific article published on January 1988

Epidermal stem cells: an update

scientific article published on 17 August 2006

Epidermal stem cells: markers, patterning and the control of stem cell fate ⬇️

scientific article published on June 29, 1998

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

scientific article published on 3 February 2016

Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression

scientific article

Epithelial stem cells, wound healing and cancer ⬇️

scientific article published on February 24, 2012

Erratum: Extracellular-matrix tethering regulates stem-cell fate

scientific article published in August 2012

Erratum: MYC in mammalian epidermis: how can an oncogene stimulate differentiation? (Erratum)

scholarly article published in Nature Reviews Cancer

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes

article

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

scientific article published on June 2003

Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes

article

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

scientific article

Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis

scientific article

Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale

scientific article

Expression and function of the keratinocyte integrins

scientific article published on 01 January 1993

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture

scientific article published on July 1991

Expression of Notch pathway genes in mammalian epidermis and modulation by β-Catenin

article

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

scientific article published on 27 December 2016

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

scientific article

Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes

scientific article published on 01 December 2000

Extracellular-matrix tethering regulates stem-cell fate

scientific article

FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis

scientific article

Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation

scientific article

Fibroblast heterogeneity: implications for human disease

scientific article published on 2 January 2018

Fibroblast state switching orchestrates dermal maturation and wound healing

scientific article published on 29 August 2018

Fibroblast state switching orchestrates dermal maturation and wound healing

Fibronectin inhibits the terminal differentiation of human keratinocytes

scientific article

Fibrotic enzymes modulate wound-induced skin tumorigenesis

scientific article published on 29 March 2021

Fiona Watt

scientific article published in April 2003

Fran Balkwill

scientific article published in April 2005

Functional down-regulation of alpha 5 beta 1 integrin in keratinocytes is reversible but commitment to terminal differentiation is not.

scientific article published in December 1993

Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes

scientific article published on November 1996

Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome

scientific article published on 23 June 2016

Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope

scientific article

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

scientific article published on 08 March 2019

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

scientific article

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

scientific article

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

scientific article published on 09 November 2020

HAN11 binds mDia1 and controls GLI1 transcriptional activity

scientific article

Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation

Hair follicle dermal papilla cells at a glance

scientific article

Hair follicle epidermal stem cells define a niche for tactile sensation

scientific article published on 25 October 2018

Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress

scientific article published on 01 December 2019

Heterogeneous expression of keratin, involucrin, and extracellular matrix among subpopulations of a poorly differentiated human cervical carcinoma: possible relationships to patterns of invasion

scientific article

High-throughput micro-patterning platform reveals Nodal-dependent dissection of peri-gastrulation-associated versus pre-neurulation associated fate patterning

High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation-associated versus preneurulation-associated fate patterning

scientific article published on 21 October 2019

High-throughput stem-cell niches

Homeostasis, regeneration and tumour formation in the mammalian epidermis

Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP

Human epidermal stem cell differentiation is modulated by specific lipid subspecies

scientific article published on 25 August 2020

Human sebaceous tumors harbor inactivating mutations in LEF1.

scientific article published on 26 March 2006

IMMUNOMODULATORY ROLE OF KERATIN 76 IN ORAL AND GASTRIC CANCER

scholarly article published 21 April 2018

Identification of Novel Keratinocyte Differentiation Modulating Compounds by High-Throughput Screening

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs

scientific article (publication date: May 2005)

Identification of an 80kD protein associated with the alpha 3 beta 1 integrin as a proteolytic fragment of the alpha 3 subunit: studies with human keratinocytes

scientific article published on 01 August 1995

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse

scientific journal article

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors

Identifying extrinsic versus intrinsic drivers of variation in cell behaviour in human iPS cell lines from healthy donors

Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis

article

Immunolocalization of keratan sulphate in the human embryonic cornea and other human foetal organs

scientific article published on 01 February 1986

Immunomodulatory role of Keratin 76 in oral and gastric cancer

scientific article published in Nature Communications

Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility

scientific article published in January 2016

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis

scientific article

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion

scientific article

Influence of cell shape and adhesiveness on stratification and terminal differentiation of human keratinocytes in culture

scientific article published on January 1987

Influence of cytochalasin d-induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes

scientific article published on 01 October 1988

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

scientific article published on 10 June 2016

Innate sensing of microbial products promotes wound-induced skin cancer

scientific article

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation

scientific article published on 28 September 2016

Integrin expression and function in HPV 16-immortalised human keratinocytes in the presence or absence of v-Ha-ras. Comparison with cervical intraepithelial neoplasia

scientific article published on 01 March 1994

Integrin expression by human epidermal keratinocytes can be modulated by interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and culture on a dermal equivalent

scientific article published on February 1995

Integrin expression during human epidermal development in vivo and in vitro

scientific article

Integrin expression in normal, hyperplastic, dysplastic, and malignant oral epithelium

scientific article

Integrin special issue

scientific article

Interaction of periplakin and envoplakin with intermediate filaments

scientific article (publication date: 15 December 2002)

Involucrin and Other Markers of Keratinocyte Terminal Differentiation ⬇️

scientific article published on July 1, 1983

Involucrin synthesis is correlated with cell size in human epidermal cultures

scientific article

JCS Prize. 2006 winner: Satomi Matsuoka.

scientific article published in May 2007

JCS in 2010 - Ringing in the Changes

scientific article published on 01 January 2010

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

scientific article published on 11 October 2006

Julia Polak

scientific article published in October 2004

Kalinin, epiligrin and GB3 antigen: kalinepiligrinin-3?

scientific article published on 01 February 1992

Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation

scientific article published on 07 October 2008

Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane

scientific article

KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis

scientific article published in June 2008

KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules

scientific article published on 20 October 2009

Keratinocyte culture club

scientific article published in Nature

Keratinocyte cultures: an experimental model for studying how proliferation and terminal differentiation are co-ordinated in the epidermis

article

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway

scientific article published on December 2003

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.

scientific article published on March 2013

Lack of intrinsic polarity in the ligand-binding ability of keratinocyte beta1 integrins

scientific article

Lack of keratan sulphate in the human notochord

scientific article published on April 1988

Launching eLife, Part 1 ⬇️

scientific article published on October 15, 2012

Launching eLife, Part 2.

scientific article

Lineage Tracing ⬇️

scientific article published on January 20, 2012

Loss of alpha 6 and beta 4 integrin subunits coincides with loss of basement membrane components in oral squamous cell carcinomas

scientific article

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

scientific article published on 28 June 2018

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

scientific article

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

scientific article published on May 2009

Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro

scientific article published in Scientific Reports

MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

scientific article published on March 2008

Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis

scientific article published on 11 January 2016

Mammalian skin cell biology: at the interface between laboratory and clinic

scientific article

Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis

scientific article published on 3 September 2003

Map clusters of diseases to tackle multimorbidity

scientific article published on 01 March 2020

Markers of epidermal stem cell subpopulations in adult mammalian skin

scientific article

Measurement of the rate of epidermal terminal differentiation: expression of involucrin by S-phase keratinocytes in culture and in psoriatic plaques

scientific article

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence

scientific article published on 01 June 2019

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

scientific article published on December 2007

Micro-scaled topographies direct differentiation of human epidermal stem cells

scientific article published on 05 December 2018

Microtubule organizing centres in cells in culture and in hybrids derived from them

DPhil Thesis of Fiona Watt

Microtubule-organizing centres in binucleate cells and homosynkaryons

scientific article published on 01 August 1980

Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis

scientific article

Mimicking the topography of the epidermal-dermal interface with elastomer substrates.

scientific article published on 11 December 2015

Mitogens induce calcium transients in both dividing and terminally differentiating keratinocytes ⬇️

scientific article published on June 1, 1991

Modulating the stem cell niche for tissue regeneration

scientific article

Monodisperse collagen-gelatin beads as potential platforms for 3D cell culturing

scientific article published on 29 August 2013

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer

scientific article published on 18 March 2019

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

scientific article

Myosin 10 is involved in murine pigmentation.

scientific article published on 6 March 2018

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis

scientific article published on 26 November 2019

Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.

scientific article

Necl2 regulates epidermal adhesion and wound repair

scientific article published on October 2009

New roles for integrins in squamous-cell carcinoma

scientific article

Non-profit publishing: open access and the end of copyright transfer.

scientific article published in January 2004

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

scientific article

Onset of expression of peanut lectin-binding glycoproteins is correlated with stratification of keratinocytes during human epidermal development in vivo and in vitro

scientific article

Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice

scientific article published on July 1998

Out of Eden: stem cells and their niches

scientific article

PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation

scientific article (publication date: 8 December 2000)

PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation

scientific article published on March 2009

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial ⬇️

scientific article

Paraneoplastic Pemphigus Sera React Strongly with Multiple Epitopes on the Various Regions of Envoplakin and Periplakin, Except for the C-Terminal Homologous Domain of Periplakin

article published in 2001

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness

scientific article published on 30 January 2019

Patterns of junctional communication in animal tissues

scientific article published on 01 January 1987

Patterns of junctional communication in skin: studies on cultured keratinocytes

scientific article published on December 1987

Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways

scientific article

Pentapeptide inhibitor of epidermal mitosis: production and responsiveness in cultures of normal, transformed and neoplastic human keratinocytes.

scientific article published in December 1989

Poised cell circuits in human skin are activated in disease ⬇️

journal article from 'bioRxiv' published in 2020

Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin

scientific article

Production of scatter factor by ndk, a strain of epithelial cells, and inhibition of scatter factor activity by suramin

scientific article published on March 1991

Professor Sir Henry Harris (1925-2014).

scientific article

Proliferation and terminal differentiation of human epidermal keratinocytes in culture

article

Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells.

scientific article

Prolonged expression of differentiated phenotype by chondrocytes cultured at low density on a composite substrate of collagen and agarose that restricts cell spreading

scientific article published on 01 July 1988

Rac1 deletion causes thymic atrophy

scientific article published on 29 April 2011

Recognizing the importance of new tools and resources for research

scientific article published on 31 March 2015

Regulation by vitamin A of envelope cross-linking in cultured keratinocytes derived from different human epithelia

scientific article published on September 1982

Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis

scientific article published on 10 July 2020

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation

scientific article published on March 1995

Regulation of development and differentiation by the extracellular matrix

scientific article published on April 1993

Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease

scientific article published on 22 March 2003

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways

scientific article published on August 2003

Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions

scientific article published on 01 September 1993

Repeal and Replace: Adipocyte Regeneration in Wound Repair

scientific article published in April 2017

Reply to Chi et al.

scientific article published on 13 September 2016

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

scientific article published on 26 October 2011

Restoration of alpha v beta 5 integrin expression in neoplastic keratinocytes results in increased capacity for terminal differentiation and suppression of anchorage-independent growth.

scientific article

Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis

scientific article

Role of LIM kinases in normal and psoriatic human epidermis

scientific article published on 8 February 2006

Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer

scientific article

Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion

article

Role of integrins in regulating epidermal adhesion, growth and differentiation

scientific article

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

scientific article (publication date: December 2003)

Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis

scientific journal article

Role of the extracellular matrix in regulating stem cell fate

scientific article published on 10 July 2013

Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.

scientific article published on 13 January 2016

Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis

scientific article published on January 1984

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

scientific article published on 01 May 1993

Sequence variation in the I-like domain of the beta1 integrin subunit in human oral squamous cell carcinomas

scientific article

Seven actionable strategies for advancing women in science, engineering, and medicine

scientific article

Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation ⬇️

scientific article published on November 2, 2011

Sic transit gloria: farewell to the epidermal transit amplifying cell?

article by Fiona Watt, Philip H. Jones and Benjamin D. Simons published in 2007

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro

scientific article

Sin3a is essential for the genome integrity and viability of pluripotent cells

scientific article published on 20 December 2011

Single-cell electroporation using proton beam fabricated biochips

scientific article

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

scientific article

Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells

scientific article published on April 2013

Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

article

Sox2 modulates the function of two distinct cell lineages in mouse skin

scientific article published on 13 August 2013

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

scientific article

Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations.

scientific article

Spatial constraints govern competition of mutant clones in human epidermis.

scientific article published on 24 October 2017

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

scientific article published on 4 February 2013

Stem cell depletion through epidermal deletion of Rac1.

scientific article

Stem cell fate and patterning in mammalian epidermis

scientific article

Stem cell heterogeneity and plasticity in epithelia

scientific article published on May 2015

Stem cell patterning and fate in human epidermis

scientific article published on 01 January 1995

Stem cells are dispensable for lung homeostasis but restore airways after injury

scholarly article

Stem cells: on the front line

scientific article published on 01 November 2011

Stem cells: the generation and maintenance of cellular diversity

scientific article

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

scientific article

Stratification and terminal differentiation of cultured epidermal cells

scientific article published in Nature

Structure and regulation of the envoplakin gene

scientific article

Studies with cultured human epidermal keratinocytes: Potential relevance to corneal wound healing

Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope

scientific article

Subpopulations of chondrocytes from different zones of pig articular cartilage. Isolation, growth and proteoglycan synthesis in culture

scientific article published in October 1990

Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors

scientific article published in September 2005

Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling

scientific article published on 5 August 2003

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

scientific article

Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis

scientific article published on August 2004

Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture

scientific article published on 31 July 2007

Terminal differentiation of epidermal keratinocytes

scientific article published on December 1989

The 5' noncoding region of the mouse involucrin gene: comparison with the human gene and genes encoding other cornified envelope precursors

scientific article

The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

scientific article

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

scientific article

The Human Cell Atlas

scientific article

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

journal article from 'arXiv:1810.05192 [q-bio]' published in 2018

The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors

scientific article

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate

scientific article published on December 2011

The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

scientific article published on 19 June 2017

The basement membrane of hair follicle stem cells is a muscle cell niche

scientific article

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

scientific article

The distribution of actin cables and microtubules in hybrids between malignant and non-malignant cells, and in tumours derived from them

scientific article published on August 1978

The eLife approach to peer review

scientific article published on 30 April 2013

The epidermal keratinocyte

scientific article published on May 1988

The epidermal stem cell compartment: variation in expression levels of E-cadherin and catenins within the basal layer of human epidermis

scientific article published on June 1997

The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.

scientific article published on 4 June 2013

The peanut lectin-binding glycoproteins of human epidermal keratinocytes

scientific article published in August 1988

The plakin family: versatile organizers of cytoskeletal architecture ⬇️

scientific article published on June 1, 1997

The reward of great collaborations

The role of keratins in modulating carcinogenesis via communication with cells of the immune system

scientific article published on 23 March 2019

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis

scientific article published on June 1999

The stem cell compartment in human interfollicular epidermis

scientific article

The therapeutic potential of stem cells

scientific article published on January 2010

The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis

scientific article

The vitamin D receptor is required for mouse hair cycle progression but not for maintenance of the epidermal stem cell compartment

scientific article published on 13 March 2008

The α2 and α5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes

article

Topo II alpha reporter mice reveal proliferative regions in the epidermis and small intestine

scientific article published on 2 November 2005

Towards gene therapy for haemophilia B using primary human keratinocytes

scientific article published in February 1993

Transcriptional and post-translational regulation of beta 1 integrin expression during keratinocyte terminal differentiation ⬇️

scientific article published on July 25, 1992

Transfection of beta 4 integrin subunit into a neoplastic keratinocyte line fails to restore terminal differentiation capacity or influence proliferation

scientific article published on November 1996

Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

article

Transgenic mice expressing IFN-gamma in the epidermis are a model of inflammatory skin disease and systemic lupus erythematosus.

scientific article

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

scientific article

Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

scientific article

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

scientific article

Two strains of human keratinocytes transfected with HPV16 DNA: comparison with the normal parental cells

scientific article

Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate

scientific article published on July 1985

Type XVII collagen coordinates proliferation in the interfollicular epidermis

scientific article published on 11 July 2017

UK funders learn from COVID-19 'white-water ride'

scientific article published on 01 July 2020

Understanding allergy and cancer risk: what are the barriers?

Understanding allergy and cancer risk: what are the barriers?

Understanding fibroblast heterogeneity in the skin

scientific article

Unexpected Hedgehog-Wnt interactions in epithelial differentiation

scientific article

Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation.

scientific article

What does it take to recruit and retain senior women faculty?

scientific article published on 5 March 2013

What is AI? Applications of artificial intelligence to dermatology

scientific article published on 20 January 2020

What is the point of large-scale collections of human induced pluripotent stem cells?

scientific article published on October 2013

Women in cell biology: getting to the top

Women in cell biology: how personal lives shape careers

article published in 2006

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

scientific article published on 15 May 2017

Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity

scientific article

Zena Werb [interview by Fiona M Watt].

scientific article published in February 2004

beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

scientific article published on May 1999

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms

scientific article published on February 2000

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum

scientific article published on 01 April 2000

c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis

scientific article published on 09 February 2013

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

scientific article

c-Myc promotes differentiation of human epidermal stem cells

scientific article

eLife and early career researchers

scientific article published on 22 October 2013

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

scientific article published on February 2001

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

scientific article published on 19 February 2016

β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition

scientific article

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