Search filters

List of works by Fiona Powrie

A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages

scientific article published in December 2017

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

scientific article (publication date: 6 August 2007)

A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

scientific article

Accurate identification and quantification of commensal microbiota bound by host immunoglobulins

scientific article published on 30 January 2021

Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

scientific article published in Nature Communications

An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer ⬇️

scientific article published on August 2, 2010

Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level

scientific article published on 01 June 2005

Animal models of intestinal inflammation: clues to the pathogenesis of inflammatory bowel disease.

scientific article

Author Correction: Pathogenic stromal cells as therapeutic targets in joint inflammation

scientific article published on 01 January 2019

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo

scientific article published on 01 October 2006

CD4+ T‐cell subsets in intestinal inflammation ⬇️

scientific article published on March 1, 2013

CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms

scientific article

CTLA-4 expression on antigen-specific cells but not IL-10 secretion is required for oral tolerance

article by Sanna Fowler & Fiona Powrie published October 2002 in European Journal of Immunology

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

scientific article published on 01 November 2006

Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation

scientific article published on 3 August 2017

Colitogenic Th1 cells are present in the antigen-experienced T cell pool in normal mice: control by CD4+ regulatory T cells and IL-10.

scientific article published in July 2003

Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease

scientific article published in July 2018

Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19

scientific article published in 2022

Control of immune pathology by regulatory T cells

scientific article published on January 2003

Controlling the frontier: regulatory T-cells and intestinal homeostasis

scientific article

Correction: Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling

scientific article published on 01 March 2020

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases

scientific article published in 2022

Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells

scientific article

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells

scientific article

Cytokine Networks in the Pathophysiology of Inflammatory Bowel Disease

scientific article published on 01 April 2019

Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance

scientific article published on 09 October 2020

Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling

scientific article published on 22 March 2016

Dendritic cells and the intestinal bacterial flora: a role for localized mucosal immune responses

scientific article published on September 2003

Dendritic cells in intestinal immune regulation.

scientific article published on June 2008

Dendritic-cell genealogy

scientific article published in Nature

Depletion of CD25+ regulatory cells results in suppression of melanoma growth and induction of autoreactivity in mice

scientific article published on 22 February 2002

Depletion of CD25+ regulatory cells uncovers immune responses to shared murine tumor rejection antigens

article

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology

scientific article published in August 2006

Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

scientific article

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation ⬇️

scientific article published on November 29, 2012

E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis.

scientific article published on 15 April 2010

Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection

scientific article published on 18 December 2012

Emerging challenges in regulatory T cell function and biology

scientific article published on 01 August 2007

Emerging cytokine networks in colorectal cancer.

scientific article published on 11 September 2015

Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.

scientific article published on 21 December 2012

Eosinophilic bowel disease controlled by the BB rat-derived lymphopenia/Gimap5 gene

scientific article published on 05 October 2006

Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease

scientific article

Essential role for CD103 in the T cell-mediated regulation of experimental colitis

scientific article

FOXP3+ regulatory T cells: Current controversies and future perspectives

scientific article published on November 2006

Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

scientific article

Fiona Powrie: Gut diplomacy. Interview by Amy Maxmen

scientific article published on January 2010

Foxp3 T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8 T cell response

scientific article published on 06 July 2018

Fueling regulation: IL-2 keeps CD4+ Treg cells fit

scientific article published on 01 November 2005

Functional analysis of rat T cell subsets

DPhil Thesis of Fiona Powrie

Gender equality: Is it real?

scientific article published on 01 December 2012

Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis.

scientific article published on 09 May 2008

Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis

scientific article published in July 2015

Gut reactions: immune pathways in the intestine in health and disease ⬇️

scientific article published on January 25, 2012

Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis

scientific article published on 4 March 2015

Helicobacter hepaticus polysaccharide induces an anti-inflammatory response in intestinal macrophages

scientific article published on 22 March 2018

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

scientific article published on 16 December 2019

Homeostasis of intestinal immune regulation

scientific article

Homing of intestinal immune cells.

scientific article

Host-microbiota maladaptation in colorectal cancer

scientific article published on 23 September 2020

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells

scientific article published on 15 November 2011

Hybrid Treg cells: steel frames and plastic exteriors

scientific article published in June 2009

IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies

scientific article published on 21 October 2021

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells

scientific article published on 13 August 2012

IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis.

scientific article

IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease

scientific article published on 16 May 2011

IL-33 promotes anemia during chronic inflammation by inhibiting differentiation of erythroid progenitors

scientific article published on 01 September 2020

ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation

scientific article published on 18 January 2016

IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation

scientific article published on 01 May 2020

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation

scientific article

Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells

scientific article published on 18 June 2016

Immune regulation in the intestine: a balancing act between effector and regulatory T cell responses

scientific article

Immunology. Feed your Tregs more fiber

scientific article

Immunology. Regulating the regulators.

scientific article published in February 2003

Immunology. The gut's Clostridium cocktail

scientific article published on 01 January 2011

Immunology: Malnutrition promotes rogue bacteria

scientific article published on 25 July 2012

Immunotherapy Not Working? Check Your Microbiota.

scientific article published in December 2015

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

scientific article published on 7 March 2016

Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens

scientific article published on 6 May 2015

Innate Lymphoid Cells: 10 Years On

scientific article published on 01 August 2018

Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

scientific article published on April 2010

Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model

scientific article published on May 2013

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes

scientific article published on 15 April 2016

Interleukin-10 in the regulation of T cell-induced colitis

scientific article

Interleukin-22 promotes phagolysosomal fusion to induce protection against Typhimurium in human epithelial cells

article published in the Proceedings of the National Academy of Sciences of the United States of America

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells.

scientific article published in March 2011

Interleukin-23 drives innate and T cell-mediated intestinal inflammation

scientific article

Interleukin-23 drives intestinal inflammation through direct activity on T cells

scientific article published on August 2010

Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis

scientific article published on April 2008

Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity

scientific article published on 27 July 2020

Intestinal inflammation abrogates the tolerogenic properties of MLN CD103+ dendritic cells.

scientific article published in July 2010

Involvement of innate immunity in the development of inflammatory and autoimmune diseases.

scientific article

Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2

scientific article published on 01 February 2020

Lymphoid microenvironments and innate lymphoid cells in the gut ⬇️

scientific article published on May 10, 2012

MICROBIOME. Microbiota RORgulates intestinal suppressor T cells

scientific article

Microbiota, Disease, and Back to Health: A Metastable Journey ⬇️

scientific article published on June 6, 2012

Mouse models of intestinal inflammation as tools to understand the pathogenesis of inflammatory bowel disease

scientific article published on 01 August 2009

Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

scientific article

OX40 is required for regulatory T cell-mediated control of colitis

scientific article

Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

scientific article published on 3 April 2017

Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis

scientific article published on 01 July 2021

Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease.

scientific article published on 28 April 2010

Pathogenic stromal cells as therapeutic targets in joint inflammation

scientific article published on 01 December 2018

Prenatal tolerance--a role for regulatory T cells?

scientific article published on 01 February 2005

RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

scientific article published on 20 November 2015

Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development

scientific article published on November 2007

Re-establishing immunological self-tolerance in autoimmune disease ⬇️

scientific article published on 06 January 2012

Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2

scientific article published on March 2013

Regulatory T Cells and Immune Tolerance in the Intestine

Regulatory T cell adaptation in the intestine and skin

scientific article published on 19 March 2019

Regulatory T cells

scientific article published in August 2004

Regulatory T cells and immune tolerance in the intestine

scientific article

Regulatory T cells and intestinal homeostasis

scientific article

Regulatory T cells reinforce intestinal homeostasis

scientific article published on September 2009

Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation

scientific article published on August 2006

Regulatory lymphocytes and intestinal inflammation.

scientific article published on January 2009

Regulatory mechanisms in graft-versus-host responses

scientific article published on January 2009

Segmented filamentous bacteria in a defined bacterial cocktail induce intestinal inflammation in SCID mice reconstituted with CD45RBhigh CD4+ T cells

scientific article published on 01 October 2007

Single-Cell Transcriptomics of Regulatory T Cells Reveals Trajectories of Tissue Adaptation

scholarly article by Ricardo J Miragaia et al published 19 February 2019 in Immunity

Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans.

scientific article

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier.

scientific article published on January 2008

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells

scientific article

T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine

scientific article published on 19 May 2016

TCR and Inflammatory Signals Tune Human MAIT Cells to Exert Specific Tissue Repair and Effector Functions

scientific article published on 01 September 2019

TLR2-independent induction and regulation of chronic intestinal inflammation.

scientific article published on February 2010

Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease

scientific article published on 5 April 2017

The IL23 axis plays a key role in the pathogenesis of IBD.

scientific article published on October 2007

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

scientific article published on 23 January 2019

The alarmin IL-33 promotes regulatory T-cell function in the intestine

scientific article

The interleukin 22 pathway interacts with mutant KRAS to promote poor prognosis in colon cancer

scientific article published on 19 May 2020

The interleukin-23 axis in intestinal inflammation

scientific article published on December 2008

The role of mucosal T lymphocytes in regulating intestinal inflammation

scientific article

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

scientific article published on 30 July 2015

Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease

scientific article published in April 2018

Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies

scientific article published on 03 December 2019

Paulina is supported by:

About Paulina

Help