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List of works by Leonard Girnita

Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation.

scientific article published on 23 January 2009

Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

scientific article published on 22 March 2018

Decrypting noncoding RNA interactions, structures, and functional networks

scientific article published on 21 August 2019

Expression of insulin-like growth factor-1 receptor (IGF-1R) and p27Kip1 in melanocytic tumors: a potential regulatory role of IGF-1 pathway in distribution of p27Kip1 between different cyclins

scientific article published on 01 January 2000

Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes.

scientific article published on 5 June 2017

Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene ⬇️

scientific article published on October 23, 2003

Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis

scientific article published on 2 November 2017

IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells.

scientific article published on 15 September 2005

Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis

scientific article

Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model.

scientific article published on 26 July 2005

Inhibition of G protein-coupled receptor kinase 2 promotes unbiased downregulation of IGF-1 receptor and restrains malignant cell growth

scientific article published on 06 November 2020

Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewing's sarcoma cells: therapeutic implications

scientific article published on 01 February 2000

Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor

scientific article

Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor

scientific article published on 01 November 2008

Insulin-like growth factor type 1 receptor expression correlates to good prognosis in highly malignant soft tissue sarcoma.

scientific article published on January 2005

Insulin-like growth factor-1 receptor in uveal melanoma: a predictor for metastatic disease and a potential therapeutic target ⬇️

scientific article published on January 1, 2002

Insulin/insulin-like growth factor (IGF) stimulation abrogates an association between a deubiquitinating enzyme USP7 and insulin receptor substrates (IRSs) followed by proteasomal degradation of IRSs.

scientific article

Malignant solitary fibrous tumour of the orbit.

scientific article

Molecular characterization of acquired tolerance of tumor cells to picropodophyllin (PPP)

scientific article (publication date: 14 March 2011)

New picropodophyllin analogs via palladium-catalyzed allylic alkylation-Hiyama cross-coupling sequences.

scientific article published on 25 June 2008

Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer

scientific article published on 14 December 2019

Non-coding RNAs: the cancer genome dark matter that matters!

scientific article published on 19 December 2016

Prediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification Networks

scientific article published on 16 October 2019

Receptors for the liver synthesized growth factors IGF-1 and HGF/SF in uveal melanoma: intercorrelation and prognostic implications

scientific article published on 01 December 2005

Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression.

scientific article published on July 2014

Role of ubiquitination in IGF-1 receptor signaling and degradation

scientific article published on 4 April 2007

Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm

scientific article published on 25 March 2019

Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor

scientific article

The coexistence of atypical intraductal hyperplasias with breast carcinoma

scientific article published on 01 January 1998

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling

scientific article published on 01 July 2007

The tale of a tail: The secret behind IGF-1R's oncogenic power

scientific article published on 26 May 2020

Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.

scientific article published on 16 January 2017

c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target?

scientific article

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