List of works - David Kavanagh

A national specialized service in England for atypical haemolytic uraemic syndrome-the first year's experience

scientific article

A non-synonymous polymorphism (arg240his) in C4b-binding protein is associated with atypical haemolytic uraemic syndrome and leads to impaired alternative pathway cofactor activity

A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome

scientific article

Acute respiratory infection in a renal transplant recipient

scientific article

Advances in understanding of pathogenesis of aHUS and HELLP.

scientific article

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

scientific article

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

scientific article

Atypical aHUS: State of the art.

scientific article

Atypical haemolytic uraemic syndrome

scientific article

Atypical hemolytic uremic syndrome

scientific article published in November 2013

Atypical hemolytic uremic syndrome

scientific article published on 01 September 2010

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

scientific article published on 15 December 2016

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

scientific article

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

scientific article

C3 glomerulopathy - understanding a rare complement-driven renal disease

scientific article published on 01 March 2019

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

scientific article

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

scientific article

Chromosomal rearrangement-A rare cause of complement factor I associated atypical haemolytic uraemic syndrome

scientific article published on 10 May 2016

Complement factor h autoantibodies and age-related macular degeneration

scientific article

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

scientific article published on 20 August 2020

Complement regulatory genes and hemolytic uremic syndromes

scientific article

Complement therapy in atypical haemolytic uraemic syndrome (aHUS).

scientific article

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

scientific article

Determining the population frequency of the CFHR3/CFHR1 deletion at 1q32.

scientific article

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

scientific article

Diseases of complement dysregulation-an overview

scientific article

Does complement factor B have a role in the pathogenesis of atypical HUS?

scientific article

Eculizumab in children with hemolytic uremic syndrome

scientific article

Electrocardiogram and Outcome following Renal Transplantation

scientific article published on 01 January 1999

Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

scientific article published in 2022

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

scientific article

Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome

scholarly article by David Kavanagh et al published August 2010 in Molecular Immunology

Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?

scientific article

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome

scientific article

Genetics and complement in atypical HUS.

scientific article

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome

scientific article

Haemolytic Uraemic Syndrome

scientific article published on 11 November 2010

Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue

scientific article

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

scholarly article by Kate Smith-Jackson et al published 4 February 2019 in Journal of Clinical Investigation

Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome

scientific article

Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degen

scientific article

Interference of urinary amino acid analysis by pregabalin

scientific article published on 16 February 2012

Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome

scientific article

Membrane cofactor protein and factor I: mutations and transplantation

scientific article

Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome

scientific article

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort

scientific article (publication date: March 2011)

New roles for the major human 3'-5' exonuclease TREX1 in human disease

scientific article

Pathogenesis of Thrombotic Microangiopathy: Insights from Animal Models

scientific article published on 13 August 2009

Peritoneal dialysis-associated peritonitis in Scotland (1999-2002).

scientific article published on 10 August 2004

Protecting the kidney from complement: atypical haemolytic uraemic syndrome

scientific article

Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy

scientific article published on 15 April 2010

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

scientific article published on 15 September 2013

Restless legs syndrome in patients on dialysis

scientific article published on May 2004

Risk factors for restless legs syndrome in dialysis patients

scientific article published on 14 July 2005

Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome

scientific article

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

scientific article published on 01 December 2019

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

scientific article published on 2 March 2018

Structural and functional characterization of the product of disease-related factor H gene conversion

scientific article

Structural basis for engagement by complement factor H of C3b on a self surface

scientific article

Structural basis for sialic acid-mediated self-recognition by complement factor H

scientific article

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

scientific article

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

scientific article

The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation.

scientific article

The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies

scientific article

Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease

scientific article

Thrombotic microangiopathy associated with interferon beta

scientific article

Transplantation in atypical hemolytic uremic syndrome

scientific article

Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1).

scientific article

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

scientific article published on 23 September 2016

Update on evaluating complement in hemolytic uremic syndrome

scientific article

Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration

scientific article

List of works by David Kavanagh

A national specialized service in England for atypical haemolytic uraemic syndrome-the first year's experience

A non-synonymous polymorphism (arg240his) in C4b-binding protein is associated with atypical haemolytic uraemic syndrome and leads to impaired alternative pathway cofactor activity

A novel hybrid CFH/CFHR3 gene generated by a microhomology-mediated deletion in familial atypical hemolytic uremic syndrome

Acute respiratory infection in a renal transplant recipient

Advances in understanding of pathogenesis of aHUS and HELLP.

Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome

Atypical aHUS: State of the art.

Atypical haemolytic uraemic syndrome

Atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference.

Autoantibodies to CD59, CD55, CD46 or CD35 are not associated with atypical haemolytic uraemic syndrome (aHUS).

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

C3 glomerulopathy - understanding a rare complement-driven renal disease

Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.

Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome

Chromosomal rearrangement-A rare cause of complement factor I associated atypical haemolytic uraemic syndrome

Complement factor h autoantibodies and age-related macular degeneration

Complement modulation reverses pathology in Y402H-retinal pigment epithelium cell model of age-related macular degeneration by restoring lysosomal function

Complement regulatory genes and hemolytic uremic syndromes

Complement therapy in atypical haemolytic uraemic syndrome (aHUS).

Crystallographic determination of the disease-associated T1184R variant of complement regulator factor H.

Determining the population frequency of the CFHR3/CFHR1 deletion at 1q32.

Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities

Diseases of complement dysregulation-an overview

Does complement factor B have a role in the pathogenesis of atypical HUS?

Eculizumab in children with hemolytic uremic syndrome

Electrocardiogram and Outcome following Renal Transplantation

Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications

Factor I autoantibodies are associated with atypical haemolytic uraemic syndrome

Factor I autoantibodies in patients with atypical hemolytic uremic syndrome: disease-associated or an epiphenomenon?

Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome

Genetics and complement in atypical HUS.

Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome

Haemolytic Uraemic Syndrome

Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue

Hyperfunctional complement C3 promotes C5-dependent atypical hemolytic uremic syndrome in mice

Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome

Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degen

Interference of urinary amino acid analysis by pregabalin

Interpretation of genetic variants of uncertain significance in atypical hemolytic uremic syndrome

Membrane cofactor protein and factor I: mutations and transplantation

Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome

Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort

New roles for the major human 3'-5' exonuclease TREX1 in human disease

Pathogenesis of Thrombotic Microangiopathy: Insights from Animal Models

Peritoneal dialysis-associated peritonitis in Scotland (1999-2002).

Protecting the kidney from complement: atypical haemolytic uraemic syndrome

Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

Restless legs syndrome in patients on dialysis

Risk factors for restless legs syndrome in dialysis patients

Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2

Statistical Validation of Rare Complement Variants Provides Insights into the Molecular Basis of Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Structural and functional characterization of the product of disease-related factor H gene conversion

Structural basis for engagement by complement factor H of C3b on a self surface

Structural basis for sialic acid-mediated self-recognition by complement factor H

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

The decay accelerating factor mutation I197V found in hemolytic uraemic syndrome does not impair complement regulation.

The role of ADAMTS-13 activity and complement mutational analysis in differentiating acute thrombotic microangiopathies

Thrombotic Microangiopathy in Inverted Formin 2-Mediated Renal Disease

Thrombotic microangiopathy associated with interferon beta

Transplantation in atypical hemolytic uremic syndrome

Triggering of atypical hemolytic uremic syndrome by influenza A (H1N1).

Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature.

Update on evaluating complement in hemolytic uremic syndrome

Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration