List of works - Daniel Růžek

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

scientific article published on 04 September 2020

A Review of Methods for Detecting Tick-Borne Encephalitis Virus Infection in Tick, Animal, and Human Specimens.

scientific article

A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties

scientific article published on 15 June 2017

A deep phylogeny of viral and cellular right-hand polymerases.

scientific article

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

scientific article (publication date: November 2016)

Advanced Therapeutics, Vaccinations, and Precision Medicine in the Treatment and Management of Chronic Hepatitis B Viral Infections; Where Are We and Where Are We Going?

scientific article published on 07 September 2020

An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein

scientific article

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

scientific article published on 30 July 2019

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

scientific article published on 01 March 2019

An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases.

scientific article published on August 2016

Analysis of serum levels of cytokines, chemokines, growth factors, and monoamine neurotransmitters in patients with tick-borne encephalitis: identification of novel inflammatory markers with implications for pathogenesis.

scientific article published on 11 February 2015

Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

scientific article published on 04 January 2021

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

scientific article published on 21 March 2019

Antiviral activities of 2,6-diaminopurine-based acyclic nucleoside phosphonates against herpesviruses: In vitro study results with pseudorabies virus (PrV, SuHV-1).

scientific article published on 18 January 2016

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses

scientific article (publication date: June 2017)

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses.

scientific article published on 10 April 2018

Arbidol (Umifenovir): A Broad-spectrum Antiviral Drug that Inhibits Medically Important Arthropod-borne Flaviviruses

Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients

scientific article published in 2024

Breakdown of the blood-brain barrier during tick-borne encephalitis in mice is not dependent on CD8+ T-cells

scientific article

Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic

scientific article published on 3 October 2017

Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection.

scientific article published on 7 November 2019

Characterisation of Zika virus infection in primary human astrocytes.

scientific article published on 20 February 2018

Comparative analysis of complete genome sequences of European subtype tick-borne encephalitis virus strains isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the Asian part of Russia.

scientific article

Detection of Borrelia bissettii in Cardiac Valve Tissue of a Patient with Endocarditis and Aortic Valve Stenosis in the Czech Republic

scientific article

Detection of Diverse Novel Bat Astrovirus Sequences in the Czech Republic.

scientific article

Detection panel for identification of twelve hemorrhagic viruses using real-time RT-PCR.

scientific article published on September 2014

Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use

scholarly article by Jiří Salát et al published November 2018 in Vaccine

Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons

scientific article

Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness

scientific article published on 16 August 2017

Europe-Wide Meta-Analysis of Borrelia burgdorferi Sensu Lato Prevalence in Questing Ixodes ricinus Ticks

scientific article published on 26 May 2017

Evolution of tertiary structure of viral RNA dependent polymerases

scientific article (publication date: 2014)

FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells

scientific article published on 20 April 2020

Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient.

scientific article published on 27 November 2015

Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.

scientific article

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients.

scientific article published on 11 October 2014

Full-length genome analysis of Čalovo strains of Batai orthobunyavirus (Bunyamwera serogroup): implications to taxonomy

scientific article published on 11 July 2014

Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology

scientific article published on 01 May 2022

Hedgehogs, Squirrels, and Blackbirds as Sentinel Hosts for Active Surveillance of <i>Borrelia miyamotoi</i> and <i>Borrelia burgdorferi</i> Complex in Urban and Rural Environments

scientific article published on 30 November 2020

High variability in viral load in cerebrospinal fluid from patients with herpes simplex and varicella-zoster infections of the central nervous system

article

Infection and injury of human astrocytes by tick-borne encephalitis virus

scientific article published on 7 July 2014

Japanese encephalitis virus: from genome to infectome.

scientific article published on 14 January 2011

Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells

scientific article published on 07 November 2018

Mannitol treatment is not effective in therapy of rabies virus infection in mice

scientific article published on 20 December 2017

May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis?

scientific article

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate)

article

Molecular characterization of the African orthobunyavirus Ilesha virus.

scientific article published on 26 August 2013

Molecular phylogeography of tick-borne encephalitis virus in central Europe.

scientific article published on 19 June 2013

Morphological changes in human neural cells following tick-borne encephalitis virus infection.

scientific article

Multiple Lineages of Usutu Virus (Flaviviridae, Flavivirus) in Blackbirds (Turdus merula) and Mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016-2019)

scientific article published on 16 November 2019

Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.

scientific article published on 14 March 2008

Novel hantavirus identified in European bat species Nyctalus noctula

scientific article published on 23 December 2016

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

scientific article

Nucleoside inhibitors of tick-borne encephalitis virus

scientific article

Omsk haemorrhagic fever.

scientific article

Phylogenetic Analysis of Lednice Orthobunyavirus

scientific article published on 13 October 2019

Phylogenetic and virulence analysis of tick-borne encephalitis virus field isolates from Switzerland.

scientific article published in May 2011

Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

scientific article published on 18 May 2011

Seroprevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus in zoo animal species in the Czech Republic.

scientific article published on 13 May 2014

Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis

scientific article published on October 2013

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody.

scientific article published on 30 January 2018

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.

scientific article published on 27 July 2016

Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection

scientific article

The occurrence of Ixodes ricinus ticks and important tick-borne pathogens in areas with high tick-borne encephalitis prevalence in different altitudinal levels of the Czech Republic Part I. Ixodes ricinus ticks and tick-borne encephalitis virus

scientific article

The supposedly attenuated hy-HK variant of highly virulent Hypr strain of tick-borne encephalitis virus is obviously a strain of Langat virus.

scientific article published in January 2006

The variability of the large genomic segment of Ťahyňa orthobunyavirus and an all-atom exploration of its anti-viral drug resistance.

scientific article published on 30 September 2013

Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells

scientific article published on February 2015

Tick-Borne Encephalitis in Sheep, Romania

scientific article published in December 2017

Tick-borne encefalitis - pathogenesis and -therapeutic approaches

scientific article published on January 2015

Tick-borne encephalitis virus infection of cultured mouse macrophages.

scientific article

Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity.

scientific article published on 19 April 2017

Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin

scientific article

Tick-borne encephalitis: Pathogenesis and clinical implications ⬇️

scientific article published on July 21, 2010

Tick-borne encephalitis: What travelers should know when visiting an endemic country.

scientific article published on 15 August 2016

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection

scientific article published on 26 February 2019

Klíšťová encefalitida

book edition published in 2015

Metoda detekce protilátek proti viru klíšťové encefalitidy v séru malých přežvýkavců

book edition published in 2017

Metoda detekce viru klíšťové encefalitidy v mléku

book edition published in 2019

List of works by Daniel Růžek

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

A Review of Methods for Detecting Tick-Borne Encephalitis Virus Infection in Tick, Animal, and Human Specimens.

A comparative analysis on the physicochemical properties of tick-borne encephalitis virus envelope protein residues that affect its antigenic properties

A deep phylogeny of viral and cellular right-hand polymerases.

Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

Advanced Therapeutics, Vaccinations, and Precision Medicine in the Treatment and Management of Chronic Hepatitis B Viral Infections; Where Are We and Where Are We Going?

An Approach for Zika Virus Inhibition Using Homology Structure of the Envelope Protein

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

An E460D substitution in the NS5 protein of tick-borne encephalitis virus confers resistance to the inhibitor Galidesivir (BCX4430) and also attenuates the virus for mice

An all-atom, active site exploration of antiviral drugs that target Flaviviridae polymerases.

Analysis of serum levels of cytokines, chemokines, growth factors, and monoamine neurotransmitters in patients with tick-borne encephalitis: identification of novel inflammatory markers with implications for pathogenesis.

Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus

Antiviral activities of 2,6-diaminopurine-based acyclic nucleoside phosphonates against herpesviruses: In vitro study results with pseudorabies virus (PrV, SuHV-1).

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses

Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses.

Arbidol (Umifenovir): A Broad-spectrum Antiviral Drug that Inhibits Medically Important Arthropod-borne Flaviviruses

Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients

Breakdown of the blood-brain barrier during tick-borne encephalitis in mice is not dependent on CD8+ T-cells

Broad-range survey of vector-borne pathogens and tick host identification of Ixodes ricinus from Southern Czech Republic

Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection.

Characterisation of Zika virus infection in primary human astrocytes.

Comparative analysis of complete genome sequences of European subtype tick-borne encephalitis virus strains isolated from Ixodes persulcatus ticks, long-tailed ground squirrel (Spermophilus undulatus), and human blood in the Asian part of Russia.

Detection of Borrelia bissettii in Cardiac Valve Tissue of a Patient with Endocarditis and Aortic Valve Stenosis in the Czech Republic

Detection of Diverse Novel Bat Astrovirus Sequences in the Czech Republic.

Detection panel for identification of twelve hemorrhagic viruses using real-time RT-PCR.

Development and testing of a new tick-borne encephalitis virus vaccine candidate for veterinary use

Electron Tomography Analysis of Tick-Borne Encephalitis Virus Infection in Human Neurons

Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness

Europe-Wide Meta-Analysis of Borrelia burgdorferi Sensu Lato Prevalence in Questing Ixodes ricinus Ticks

Evolution of tertiary structure of viral RNA dependent polymerases

FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells

Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient.

Flaviviridae viruses use a common molecular mechanism to escape nucleoside analogue inhibitors.

Full genome sequences and molecular characterization of tick-borne encephalitis virus strains isolated from human patients.

Full-length genome analysis of Čalovo strains of Batai orthobunyavirus (Bunyamwera serogroup): implications to taxonomy

Guanine quadruplexes in the RNA genome of the tick-borne encephalitis virus: their role as a new antiviral target and in virus biology

Hedgehogs, Squirrels, and Blackbirds as Sentinel Hosts for Active Surveillance of <i>Borrelia miyamotoi</i> and <i>Borrelia burgdorferi</i> Complex in Urban and Rural Environments

High variability in viral load in cerebrospinal fluid from patients with herpes simplex and varicella-zoster infections of the central nervous system

Infection and injury of human astrocytes by tick-borne encephalitis virus

Japanese encephalitis virus: from genome to infectome.

Kyasanur Forest disease virus infection activates human vascular endothelial cells and monocyte-derived dendritic cells

Mannitol treatment is not effective in therapy of rabies virus infection in mice

May early intervention with high dose intravenous immunoglobulin pose a potentially successful treatment for severe cases of tick-borne encephalitis?

Model of Risk of Exposure to Lyme Borreliosis and Tick-Borne Encephalitis Virus-Infected Ticks in the Border Area of the Czech Republic (South Bohemia) and Germany (Lower Bavaria and Upper Palatinate)

Molecular characterization of the African orthobunyavirus Ilesha virus.

Molecular phylogeography of tick-borne encephalitis virus in central Europe.

Morphological changes in human neural cells following tick-borne encephalitis virus infection.

Multiple Lineages of Usutu Virus (Flaviviridae, Flavivirus) in Blackbirds (Turdus merula) and Mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016-2019)

Mutations in the NS2B and NS3 genes affect mouse neuroinvasiveness of a Western European field strain of tick-borne encephalitis virus.

Novel hantavirus identified in European bat species Nyctalus noctula

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Nucleoside inhibitors of tick-borne encephalitis virus

Omsk haemorrhagic fever.

Phylogenetic Analysis of Lednice Orthobunyavirus

Phylogenetic and virulence analysis of tick-borne encephalitis virus field isolates from Switzerland.

Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

Seroprevalence of Borrelia burgdorferi sensu lato and tick-borne encephalitis virus in zoo animal species in the Czech Republic.

Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in patients with tick-borne encephalitis

Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody.

Structure-activity relationships of nucleoside analogues for inhibition of tick-borne encephalitis virus.

Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection

The occurrence of Ixodes ricinus ticks and important tick-borne pathogens in areas with high tick-borne encephalitis prevalence in different altitudinal levels of the Czech Republic Part I. Ixodes ricinus ticks and tick-borne encephalitis virus

The supposedly attenuated hy-HK variant of highly virulent Hypr strain of tick-borne encephalitis virus is obviously a strain of Langat virus.

The variability of the large genomic segment of Ťahyňa orthobunyavirus and an all-atom exploration of its anti-viral drug resistance.

Tick salivary cystatin sialostatin L2 suppresses IFN responses in mouse dendritic cells

Tick-Borne Encephalitis in Sheep, Romania

Tick-borne encefalitis - pathogenesis and -therapeutic approaches

Tick-borne encephalitis virus infection of cultured mouse macrophages.

Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity.

Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin

Tick-borne encephalitis: Pathogenesis and clinical implications ⬇️

Tick-borne encephalitis: What travelers should know when visiting an endemic country.

Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection

Klíšťová encefalitida

Metoda detekce protilátek proti viru klíšťové encefalitidy v séru malých přežvýkavců

Metoda detekce viru klíšťové encefalitidy v mléku