List of works - Sandra Galic

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

scientific article published on 25 April 2018

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

scientific article

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.

scientific article

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

scientific article published on 13 February 2018

AMPK β1 reduces tumor progression and improves survival in p53 null mice.

scientific article published on 24 May 2017

Absence of the β1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes

scientific article published on 26 April 2019

Activation of AMPK reduces the co-transporter activity of NKCC1.

scientific article published on March 2014

Adipose tissue as an endocrine organ

article

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

scientific article published on 18 April 2019

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

scientific journal article

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

scientific article

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

scientific article published on 13 October 2011

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway.

scientific article published on 09 September 2016

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

scientific article published on 25 March 2020

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

scientific article published on March 2016

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

scientific article published on 14 November 2011

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

scientific article published on June 2015

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

scientific article

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

scientific article

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

scientific article published on November 2010

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

scientific article

Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.

scientific article

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

scientific article published on 05 July 2018

Reactive oxygen species enhance insulin sensitivity

scientific article

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance.

scientific article published on 08 August 2012

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

scientific article

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

scientific article

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.

scientific article published on 5 May 2015

Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT).

scientific article published on 10 August 2012

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

scientific article

Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise.

scientific article published on July 2015

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

scientific article

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.

scientific article published on July 2014

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

scientific article

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

scientific article published in December 2011

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis ⬇️

scientific journal article

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

scientific article published on 18 September 2017

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

scientific article

List of works by Sandra Galic

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965.

AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance

AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice.

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

AMPK β1 reduces tumor progression and improves survival in p53 null mice.

Absence of the β1 subunit of AMP-activated protein kinase reduces myofibroblast infiltration of the kidneys in early diabetes

Activation of AMPK reduces the co-transporter activity of NKCC1.

Adipose tissue as an endocrine organ

Allosteric regulation of AMP-activated protein kinase by adenylate nucleotides and small-molecule drugs

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway.

Functional analysis of an R311C variant of Ca2+ -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson's Disease

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance.

Novel mechanisms of Na+ retention in obesity: phosphorylation of NKCC2 and regulation of SPAK/OSR1 by AMPK.

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin

Reactive oxygen species enhance insulin sensitivity

Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance.

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis.

Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT).

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Skeletal muscle ACC2 S212 phosphorylation is not required for the control of fatty acid oxidation during exercise.

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis ⬇️

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.