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List of works by Fabiola Traina

A multicenter comparative acute myeloid leukemia study: can we explain the differences in the outcomes in resource-constrained settings?

scientific article published on 30 September 2020

ANKHD1 silencing inhibits Stathmin 1 activity, cell proliferation and migration of leukemia cells

scientific article published on 15 December 2014

ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells

scientific article published on 12 April 2014

ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells

scientific article

ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells

scientific article published on 28 November 2012

Abnormal Hedgehog pathway in myelodysplastic syndrome and its impact on patients' outcome.

scientific article published on 20 August 2015

Acute myeloid leukemia with e1a2 BCR-ABL1 fusion gene: two cases with peculiar molecular and clinical presentations.

scientific article published on 3 August 2017

Altered red cell and platelet adhesion in hemolytic diseases: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria and sickle cell disease.

scientific article published on 21 September 2013

Assessment of liver and cardiac iron overload using MRI in patients with chronic anemias in Latin American countries: results from ASIMILA study

scientific article published on 17 April 2018

BNIP3L in myelodysplastic syndromes and acute myeloid leukemia: impact on disease outcome and cellular response to decitabine

scientific article published on 21 July 2016

CXCR7 is highly expressed in acute lymphoblastic leukemia and potentiates CXCR4 response to CXCL12.

scientific article published on 31 January 2014

Characterization of Human AB Serum for Mesenchymal Stromal Cell Expansion

scientific article

Chronic liver abnormalities in sickle cell disease: a clinicopathological study in 70 living patients

scientific article published on 03 September 2007

Clinical features of JAK2V617F- or CALR-mutated essential thrombocythemia and primary myelofibrosis.

scientific article

Clofarabine for myelodysplastic syndromes ⬇️

scientific article published on May 19, 2011

Compound heterozygous RAG2 mutations mimicking hyper IgM syndrome

scientific article published on 31 October 2013

Conventional chemotherapy for acute myeloid leukemia: a Brazilian experience

scientific article published on 01 November 2000

Cytogenetic and molecular predictors of response in patients with myeloid malignancies without del[5q] treated with lenalidomide.

scientific article published on 5 March 2012

De novo AML exhibits greater microenvironment dysregulation compared to AML with myelodysplasia-related changes.

scientific article published on 13 January 2017

Differential profile of CDKN1A and TP53 expressions in bone marrow mesenchymal stromal cells from myeloid neoplasms.

scientific article published on 6 August 2016

Differential profile of PIP4K2A expression in hematological malignancies.

scientific article published on 30 June 2015

Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients.

scientific article

Downregulation of IRS2 in myelodysplastic syndrome: A possible role in impaired hematopoietic cell differentiation ⬇️

scientific article published on March 31, 2012

Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation

scientific article published on 18 November 2018

Effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: induction of IL-10 expression in the stromal layers.

scientific article published on 20 April 2011

Elevated hypercoagulability markers in hemoglobin SC disease.

scientific article

Elevated plasma levels and platelet-associated expression of the pro-thrombotic and pro-inflammatory protein, TNFSF14 (LIGHT), in sickle cell disease.

scientific article published on 6 July 2012

Endothelial activation by platelets from sickle cell anemia patients

scientific article

Expansion strategies for human mesenchymal stromal cells culture under xeno-free conditions

scientific article published on 9 May 2017

FMNL1 promotes proliferation and migration of leukemia cells

scientific article published on 25 June 2013

Familial systemic mastocytosis with germline KIT K509I mutation is sensitive to treatment with imatinib, dasatinib and PKC412.

scientific article published in August 2014

Fetal hemoglobin and hemolysis markers in sickle cell anemia.

scientific article published on May 2015

Hematopoietic cell kinase (HCK) is a potential therapeutic target for dysplastic and leukemic cells due to integration of erythropoietin/PI3K pathway and regulation of erythropoiesis: HCK in erythropoietin/PI3K pathway.

scientific article published on 10 November 2016

High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils

scientific article published on 17 June 2008

Hydroxyurea is associated with reductions in hypercoagulability markers in sickle cell anemia.

scientific article

IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells

scientific article published on 28 April 2019

IRAK1 expression in bone marrow cells does not impact patient outcomes in myelodysplastic syndromes.

scientific article published on 28 November 2017

IRS1/β-Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells

scientific article

IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms.

scientific article published on 9 January 2016

Identification of protein-coding and non-coding RNA expression profiles in CD34+ and in stromal cells in refractory anemia with ringed sideroblasts

scientific article

Identification of target genes using gene expression profile of granulocytes from patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors.

scientific article

Imatinib restores VASP activity and its interaction with Zyxin in BCR-ABL leukemic cells.

scientific article published on 15 November 2014

Immunophenotyping in myelodysplastic syndromes can add prognostic information to well-established and new clinical scores

scientific article

Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms

scientific article published on 18 September 2013

Improving the differential diagnosis between myelodysplastic syndromes and reactive peripheral cytopenias by multiparametric flow cytometry: the role of B-cell precursors

scientific article published on 29 April 2015

Inhibition of caspase-dependent spontaneous apoptosis via a cAMP-protein kinase A dependent pathway in neutrophils from sickle cell disease patients

scientific article published on 17 August 2007

Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals.

scientific article published on 20 February 2011

Insulin Substrate Receptor (IRS) proteins in normal and malignant hematopoiesis

scientific article published on 11 October 2018

Key endothelial cell angiogenic mechanisms are stimulated by the circulating milieu in sickle cell disease and attenuated by hydroxyurea

scientific article published on 13 March 2015

Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells.

scientific article published on 21 April 2011

Lack of association between MDM2 SNP309 and TP53 Arg72Pro polymorphisms with clinical outcomes in myelodysplastic syndrome.

scientific article published in January 2012

Low Ten-eleven-translocation 2 (TET2) transcript level is independent of TET2 mutation in patients with myeloid neoplasms.

scientific article published on 16 March 2016

Low bone mass density is associated with hemolysis in brazilian patients with sickle cell disease ⬇️

scientific article published on January 1, 2011

Low expression of tissue inhibitor of metalloproteinase-2 may be associated with high-risk myelodysplastic syndrome

scientific article published on 28 September 2012

MDR-1 and GST polymorphisms are involved in myelodysplasia progression.

scientific article published on 17 May 2013

MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model

scientific article published on 06 April 2021

Metaphase cytogenetics and single nucleotide polymorphism arrays in myeloid malignancies.

scientific article published on 30 January 2015

Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms

scientific article published on 22 February 2018

Molecular effects of the phosphatidylinositol-3-kinase inhibitor NVP-BKM120 on T and B-cell acute lymphoblastic leukaemia.

scientific article published on 31 July 2015

Molecular matching for Rh and K reduces red blood cell alloimmunisation in patients with myelodysplastic syndrome.

scientific article

Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

scientific article

Myelodysplastic syndrome with synchronous gastric cancer: when the symptoms suggest something else

scientific article published on 17 July 2014

NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2V617F-positive myeloproliferative neoplasm cells

scientific article published on 24 January 2020

NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia

scientific article published on 25 June 2020

PIP4K2A and PIP4K2C transcript levels are associated with cytogenetic risk and survival outcomes in acute myeloid leukemia

scientific article published on 11 April 2019

PTK2 and PTPN11 expression in myelodysplastic syndromes.

scientific article published on October 2013

Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells

scientific article published on 28 September 2017

Participation of Mac-1, LFA-1 and VLA-4 integrins in the in vitro adhesion of sickle cell disease neutrophils to endothelial layers, and reversal of adhesion by simvastatin

scientific article

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

scientific article published on 17 February 2018

Pyrimidine-5'-nucleotidase Campinas, a new mutation (p.R56G) in the NT5C3 gene associated with pyrimidine-5'-nucleotidase type I deficiency and influence of Gilbert's Syndrome on clinical expression.

scientific article

Reactive oxygen species overload promotes apoptosis in JAK2V617F-positive cell lines.

scientific article published on 14 May 2016

Reduced expression of FLIP SHORT in bone marrow of low risk myelodysplastic syndrome.

scientific article

Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms

scientific article published on 09 July 2019

Reversine triggers mitotic catastrophe and apoptosis in K562 cells.

scientific article published in July 2016

Rho Kinase Regulates the Survival and Transformation of Cells Bearing Oncogenic Forms of KIT, FLT3, and BCR-ABL ⬇️

scientific article published on September 13, 2011

SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes

scientific article

SF3B1 mutations are infrequently found in non-myelodysplastic bone marrow failure syndromes and mast cell diseases but, if present, are associated with the ring sideroblast phenotype

scientific article published on 5 July 2013

SF3B1, a splicing factor is frequently mutated in refractory anemia with ring sideroblasts

scientific article published on 02 September 2011

Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes.

scientific article

Serine protease inhibitor kunitz-type 2 is downregulated in myelodysplastic syndromes and modulates cell-cell adhesion

scientific article

Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.

scientific article

Single-nucleotide polymorphism array (SNP-A) improves the identification of chromosomal abnormalities by metaphase cytogenetics in myelodysplastic syndrome.

scientific article published on 11 November 2016

Somatic mutations of calreticulin in a Brazilian cohort of patients with myeloproliferative neoplasms

scientific article published on 15 April 2015

Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia

scientific article published on 6 July 2012

Stathmin 1 expression in plasma cell neoplasms

scientific article published on 11 March 2017

Stathmin 1 in normal and malignant hematopoiesis.

scientific article published on December 2014

Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells

scientific article published on 24 August 2015

Stathmin 1 is involved in the highly proliferative phenotype of high-risk myelodysplastic syndromes and acute leukemia cells.

scientific article

Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes

scientific article published on 01 October 2014

The U2AF homology motif kinase 1 (UHMK1) is upregulated upon hematopoietic cell differentiation

scientific article published on 4 January 2018

The impact of several phenotypic features at diagnosis on survival of patients with myelodysplastic syndromes

scientific article published on 01 January 2010

The prognostic relevance of apoptosis-related proteins in classical Hodgkin's lymphomas

scientific article published on 01 March 2003

Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties.

scientific article

Tissue factor-dependent coagulation activation by heme: A thromboelastometry study

scientific article

Updates in cytogenetics and molecular markers in MDS.

scientific article published on June 2011

Variation of bone marrow CD34+ cell subsets in myelodysplastic syndromes according to who types.

scientific article published in January 2009

YAP1 expression in myelodysplastic syndromes and acute leukemias.

scientific article published on 10 March 2014

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