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List of works by John F Marshall

A framework for the development of effective anti-metastatic agents

scientific article published on 01 March 2019

A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo ⬇️

scientific article published on October 29, 2012

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

scientific article

Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma

scientific article published on 25 July 2013

Activation status and function of the VLA-4 (α4β1) integrin expressed on human melanoma cell lines ⬇️

scientific article published on 01 October 1997

AlphaV integrins play an important role in myofibroblast differentiation

scientific article

Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis

scientific article

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence

scientific article published on 22 October 2013

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

scientific article published on 25 October 2010

Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer

scientific article

Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion

scientific article published on 01 January 2018

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

scientific article published on November 2006

DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single-Molecule Control

scientific article published on 31 December 2018

Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes.

scientific article published on 2 September 2003

Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines

scientific article

Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus

scientific article

Evaluation of [64Cu]Cu-DOTA and [64Cu]Cu-CB-TE2A chelates for targeted positron emission tomography with an alphavbeta6-specific peptide

scientific article

Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues

scientific article

Expression of αv integrins and vitronectin receptor identity in breast cancer cells ⬇️

scientific article published on February 1, 1998

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

scientific article (publication date: December 2007)

Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness

scientific article published on 28 November 2007

Generation and characterization of a diabody targeting the αvβ6 integrin

scientific article published on 4 September 2013

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

article

Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer

High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.

scientific article published on September 2010

High-throughput in vivo screening of targeted molecular imaging agents

scientific article

Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability ⬇️

scientific article published on June 1, 1998

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

scientific article published on 15 April 2009

Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis.

scientific article published on 22 January 2010

Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro ⬇️

scientific article published on September 15, 1991

Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16 ⬇️

scientific article published on August 1, 1997

Integrin trafficking and its role in cancer metastasis

scientific article published on December 2007

Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus

scientific article published on 12 February 2020

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

scientific article published on 21 August 2019

Integrins as Therapeutic Targets: Successes and Cancers.

scientific article published on 23 August 2017

Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy.

scientific article published on 18 April 2017

Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability

scientific article (publication date: 15 August 2003)

Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells ⬇️

scientific article published on October 9, 1997

Modulation of the urokinase-type plasminogen activator receptor by the beta6 integrin subunit.

scientific article published in April 2004

NMR relaxation and structural elucidation of peptides in the presence and absence of trifluoroethanol illuminates the critical molecular nature of integrin αvβ6 ligand specificity

scientific article

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.

scientific article

Pancreatic cancer organotypic cultures.

scientific article published on 18 January 2010

Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2.

scientific article published on 7 January 2016

Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis

scientific article published on 28 October 2013

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

scientific article published on 13 June 2017

Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control

scientific article published on 01 October 2019

Rapid solid phase synthesis and biodistribution of 18F-labelled linear peptides

scientific article published on 26 March 2002

Rigidity sensing and adaptation through regulation of integrin types.

scientific article

S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.

scientific article published on 11 February 2012

Stromal features are predictive of disease mortality in oral cancer patients

scientific article published on 05 January 2011

Structural guided scaffold phage display libraries as a source of bio-therapeutics

scientific article

Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality

scientific article published on 3 May 2017

Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function.

scientific article published on 29 April 2014

TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?

scientific article

Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model

scientific article

Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?

scientific article published on 30 October 2017

Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

scientific article published on 04 January 2017

Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

scientific article published on 22 September 2017

The ITGB6 gene: its role in experimental and clinical biology

scientific article

The Integrins α3β1and α6β1 Physically and Functionally Associate with CD36 in Human Melanoma Cells

scientific article published in Journal of Biological Chemistry

The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells.

scientific article published on 24 January 2018

The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.

scientific article published on 2 April 2004

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

scientific article published on 30 July 2019

The role of α9β1 integrin in modulating epithelial cell behaviour.

scientific article published on 25 May 2011

Therapeutic targeting of integrin αvβ6 in breast cancer

scientific article

Transwell® Invasion Assays ⬇️

scientific article published on January 1, 2011

Tumor cell migration in three dimensions

scientific article published on January 2006

Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein-peptide interactions.

scientific article published on 13 September 2010

Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomograp

scientific article published on August 2007

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation

scientific article published on May 2008

αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential

scientific article published on 15 October 2014

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