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List of works by Eleonora Grandi

A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources

scientific article published on 27 July 2019

A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII.

scientific article published on 13 January 2014

Anti-arrhythmic strategies for atrial fibrillation: The role of computational modeling in discovery, development, and optimization.

scientific article published on 6 September 2016

Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing.

scientific article published in January 2017

Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes

scientific article published on August 2015

Ca/calmodulin kinase II differentially modulates potassium currents

scientific article published on 17 April 2009

CaMKII comes of age in cardiac health and disease.

scientific article

CaMKII-dependent regulation of cardiac Na(+) homeostasis

scientific article

Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis

scientific article published on 28 November 2007

Cardiac response to hemodialysis with different cardiovascular tolerance: heart rate variability and QT interval analysis

scientific article published in July 2006

Correction: Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

scientific article published on 21 September 2017

Different paths, same destination: divergent action potential responses produce conserved cardiac fight-or-flight response in mouse and rabbit hearts

scientific article published on 11 July 2019

Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)].

scientific article published in October 2017

FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility

scientific article

How does β-adrenergic signalling affect the transitions from ventricular tachycardia to ventricular fibrillation?

scientific article published on March 2014

Human Atrial Fibrillation: Insights From Computational Electrophysiological Models ⬇️

scientific article published on July 1, 2011

Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation

scientific article published on 15 September 2011

In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. ⬇️

scientific article published on 7 November 2017

In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes

article

In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia.

scientific article published on 30 October 2015

Induction of NO synthase 2 in ventricular cardiomyocytes incubated with a conventional bicarbonate dialysis bath

scientific article

Interplay of voltage and Ca-dependent inactivation of L-type Ca current.

scientific article

Ion Channels in the Heart

scientific article

Keeping it short and (not so) simple: characterizing hERG kinetics with sinusoidal waves

scientific article published on 01 April 2018

Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization

scientific article

Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk

scientific article published on 23 December 2016

Na+ channel function, regulation, structure, trafficking and sequestration

scientific article

Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use?

scientific article published on 24 October 2017

Nonequilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

scientific article

Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal

scientific article published on 08 December 2007

Post-translational modifications of the cardiac Na channel: contribution of CaMKII-dependent phosphorylation to acquired arrhythmias

scientific article

Potassium channels in the heart: structure, function and regulation.

scientific article published on 13 November 2016

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

scientific article published on 3 November 2016

Predominant contribution of L-type Cav1.2 channel stimulation to impaired intracellular calcium and cerebral artery vasoconstriction in diabetic hyperglycemia.

scientific article published on 10 February 2017

Quantitative analysis of the Ca2+ -dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes

scientific article published on 23 December 2016

Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening.

scientific article published on 29 July 2013

Reactive oxygen species-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload.

scientific article published on 20 January 2011

Recent advances in the synthesis of analogues of phytohormones strigolactones with ring-closing metathesis as a key step

scientific article published on 7 September 2017

Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity.

scientific article published on September 2017

Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.

scientific article published on 24 January 2017

Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials

scientific article

Size matters, proportion too: coupling of experiments and theory reveals relative roles of K+ channels in action potential stability

scientific article published on 22 December 2016

Slow [Na]i Changes and Positive Feedback Between Membrane Potential and [Ca]i Underlie Intermittent Early Afterdepolarizations and Arrhythmias.

scientific article

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

scientific article published on 11 December 2008

β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

scientific article published on 25 February 2015

β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets ⬇️

scientific article published on February 26, 2013

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