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List of works by Jean-Noël Freund

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

scientific article published on 17 October 2018

Activity of the rat lactase gene promoter in transfected human colon cancer cells

scientific article published on 01 November 1995

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin

scientific article

Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells

scientific article (publication date: April 2006)

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

scientific article published on 17 December 2014

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype ⬇️

scientific article published on December 9, 2010

CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula

scientific article published on 02 August 2010

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos

scientific journal article

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer

scientific article published on 31 March 2008

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer Cells ⬇️

scientific article published on December 24, 2011

Cdx2 determines the fate of postnatal intestinal endoderm

scientific journal article

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

scientific article published on 20 December 2011

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

scientific article published on 29 October 2014

Cellular and molecular partners involved in gut morphogenesis and differentiation ⬇️

scientific article published on June 29, 1998

Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells

scientific article (publication date: June 1997)

Chromatin de-condensation by switching substrate elasticity

scientific article published in Scientific Reports

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice

scientific article

Comparative expression of the mRNA for three intestinal hydrolases during postnatal development in the rat

scientific article published on 01 January 1990

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

scientific article

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division

scientific article

Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha

scientific article

Dietary control of the lactase mRNA distribution along the rat small intestine

scientific article published on 01 June 1992

Different expression of the mRNA detected by the cDNA for fetal rat lactase in the jejunum and colon

scientific article

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

scientific article

Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2

scientific article

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization.

scientific article published on 26 January 2013

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults. Effect of starvation and thyroxine treatment.

scientific article published in May 1989

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

scientific article published on 19 February 2016

Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine?

scientific article published on 01 November 1992

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

scientific article published on 17 November 2003

Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras

scientific article published on 01 January 1999

Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat.

scientific article published in March 2003

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome

scientific article published on 21 June 2016

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi.

scientific article published in July 2012

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

scientific article

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

scientific article published on February 2015

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability

scientific article published on 30 May 2006

Functional diversity and interactions between the repeat domains of rat intestinal lactase ⬇️

scientific article published on October 1, 1997

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein

scientific article published on 7 December 2006

Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development.

scientific article published on July 2001

Gastric intestinal metaplasia revisited: function and regulation of CDX2.

scientific article published on 04 August 2012

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

scientific article published on 8 February 2013

Gradient expression of Cdx along the rat intestine throughout postnatal development

scientific article published on December 14, 1992

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

scientific article

Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.

scientific article published on February 2004

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

scientific article

Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs).

scientific article published on March 1997

Identity and intestinal pathologies: the Cdx2 homeotic gene

scientific article published on 12 October 2012

Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer ⬇️

scientific article published on September 2, 2010

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2 ⬇️

scientific article published on October 8, 2012

Intestinal epithelial-mesenchymal cell interactions.

scientific article published in November 1998

Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development

scientific article published on 01 June 1999

Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation ⬇️

scientific article published on December 15, 1997

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

scientific article

Lactase expression is controlled differently in the jejunum and ileum during development in rats

scientific article published on 01 February 1991

Lactase is unchanged in suckling mice fed with lactose-free milk

scientific article published on 01 November 1998

Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells.

scientific article

Mesenchyme-mediated effects of retinoic acid during rat intestinal development

scientific article published on 01 May 1997

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase ⬇️

scientific article published on February 14, 2013

Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase

scientific article published on December 1993

Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice

scientific article published on 07 September 2007

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

scientific article

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

scientific article published in December 2005

Precancerous lesions upon sporadic activation of beta-catenin in mice.

scientific article published on 21 January 2007

Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland

scientific article published on 01 February 1999

Promotion of intestinal carcinogenesis by dietary methionine

scientific article published on 01 March 1999

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

scientific article published on 01 January 1991

Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer

scientific article published on 17 September 2012

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

scientific article

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs

scientific article published on 24 October 2019

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

scientific article published on 29 June 2007

Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics.

scientific article published on May 1998

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

scientific article published on 3 February 2014

Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease

scientific article

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia

scientific article published on 08 April 2021

The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

scientific article published in October 2003

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

scientific article published on 8 February 2018

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

scientific article published on 13 November 2020

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity.

scientific article

The gene for intestinal sucrase-isomaltase as member of a gene family

scientific article published on 01 January 1989

The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells

scientific article (publication date: 27 September 2002)

The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells.

scientific article published on 6 June 2007

The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells

scientific article published on February 2007

The rat LPH gene 5' region: comparative structure with the human gene

scientific article published on January 1, 1992

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

scientific article

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

scientific article published on 2 November 2016

Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).

scientific article

Type IV collagen mRNA accumulates in the mesenchymal compartment at early stages of murine developing intestine.

scientific article

Ultrastructural study of intestinal lactase gene expression

scientific article published on 01 January 1995

Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies

scientific article

Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis

scientific article published on 01 October 1995

Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.

scientific article published on September 2000

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