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List of works by Scott A. Waldman

A 56 kDa binding protein for Escherichia coli heat-stable enterotoxin isolated from the cytoskeleton of rat intestinal membrane does not possess guanylate cyclase activity.

scientific article

A common antigenic determinant found in two functionally unrelated toxins ⬇️

scientific article published on October 1, 1984

A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer.

scientific article

A novel CDX2 isoform regulates alternative splicing

scientific article

A simple, sensitive, and specific assay for the heat-stable enterotoxin of Escherichia coli

scientific article published on 01 January 1984

A splice variant of the transcript for guanylyl cyclase C is expressed in human colon and colorectal cancer cells.

scientific article

A survey of physician receptivity to molecular diagnostic testing and readiness to act on results for early-stage colon cancer patients

scientific article

A two-step procedure for obtaining highly purified particulate guanylate cyclase from rat lung

scientific article published on 01 January 1985

A uroguanylin-GUCY2C endocrine axis regulates feeding in mice

scientific article published on 25 August 2011

A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer

scientific article

Acquired and innate cardioprotection

scientific article published on 09 August 2007

Adiponectin receptor and adiponectin signaling in human tissue among patients with end-stage renal disease.

scientific article

Advancing Pharmacometrics and Systems Pharmacology ⬇️

scientific article published on November 1, 2012

Affinity purification of functional receptors for Escherichia coli heat-stable enterotoxin from rat intestine.

scientific article published in January 1992

Allosteric regulation by calcium of rabbit polyclonal anti-cyclic GMP antibody

scientific article published on 01 February 1995

An intracellular adenine nucleotide binding site inhibits guanyly cyclase C by a guanine nucleotide-dependent mechanism

scientific article

Antiobesity pharmacotherapy: new drugs and emerging targets

scientific article

Applications of microRNA in cancer: Exploring the advantages of miRNA.

scientific article published on June 2009

Aprepitant for the prevention of nausea and vomiting associated with chemotherapy and postoperative recovery

scientific article published on 01 January 2008

Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer

scientific article published on February 2009

Association of Inflammation prior to Kidney Transplantation with Post-Transplant Diabetes Mellitus.

scientific article published on 18 May 2016

Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle ⬇️

scientific article published on December 1, 1984

Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures.

scientific article published in February 1987

Atrial natriuretic peptide, oxytocin, and vasopressin increase guanosine 3',5'-monophosphate in LLC-PK1 kidney epithelial cells.

scientific article

Bacterial enterotoxins are associated with resistance to colon cancer.

scholarly article

Bacterial heat-stable enterotoxins: translation of pathogenic peptides into novel targeted diagnostics and therapeutics

scientific article

Big Data Transforms Discovery-Utilization Therapeutics Continuum.

scientific article published in March 2016

Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells

scientific article (publication date: April 2006)

Bile acids initiate lineage-addicted gastroesophageal tumorigenesis by suppressing the EGF receptor-AKT axis

scientific article

Bioactivity of Oral Linaclotide in Human Colorectum for Cancer Chemoprevention

scientific article published on 10 April 2017

Bioinnovation Enterprise: An engine driving breakthrough therapies

scientific article published on January 2016

Biomarker development, commercialization, and regulation: individualization of medicine lost in translation

scientific article published on 01 February 2007

Bionic Technologies Transforming the Science of Healthcare Delivery ⬇️

scientific article published on April 1, 2011

Bridging the therapeutic continuum of drug development, regulation and use

scientific article published on 01 January 2008

CD19-Targeted Nanodelivery of Doxorubicin Enhances Therapeutic Efficacy in B-Cell Acute Lymphoblastic Leukemia

scientific article

Calorie-induced ER stress suppresses uroguanylin satiety signaling in diet-induced obesity

scientific article

Cancer mucosa antigens as a novel immunotherapeutic class of tumor-associated antigen.

scientific article published on 26 September 2007

Cardiopoietic Stem Cell Therapy in Heart Failure

article

Cardiopoietic cell therapy for advanced ischaemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

scientific article published on 23 December 2016

Cardiovascular health: the global challenge

scientific article published on 01 October 2011

Chemiluminescence-based detection of gastrointestinal malignancies.

scientific article published on 13 October 2009

Chimeric adenoviral (Ad5.F35) and listeria vector prime-boost immunization is safe and effective for cancer immunotherapy

scientific article published in 2022

Chronic diseases: the emerging pandemic.

scientific article

Clinical Pharmacology & Therapeutics: Past, Present, and Future

scientific article published in March 2017

Clinical Pharmacology & Therapeutics: the next five years

scientific article published on 05 December 2014

Clinical and translational science: from bench-bedside to global village

scientific article

Clinical and translational sciences: at the intersection of molecular and individualized medicine.

scientific article

Clinical pharmacology as a foundation for translational science

scientific article published on 01 July 2011

Clinical pharmacology at the core of translational science

scientific article published on 01 May 2011

Clinical pharmacology: a paradigm for individualized medicine

scientific article published on 01 December 2009

Clinical pharmacology: the science of therapeutics

scientific article published on 01 January 2007

Clinical translational science 2020: disruptive innovation redefines the discovery-application enterprise

scientific article

Colorectal cancer stem cells as biomarkers: where it all starts?

scientific article published on 19 March 2013

Companion diagnostics at the intersection of personalized medicine and healthcare delivery.

scientific article published on January 2015

Comparison of particulate guanylate cyclase in cells with and without atrial natriuretic peptide receptor binding activity

scientific article published on 01 October 1989

Copurification of atrial natriuretic peptide receptor and particulate guanylyl cyclase

scientific article published on 01 January 1991

Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity

scientific article

Cytokine adjuvanation of therapeutic anti-tumor immunity targeted to cancer mucosa antigens

scientific article published on December 2008

Cytoplasmic domains mediate the ligand-induced affinity shift of guanylyl cyclase C.

scientific article published on October 1997

Dexamethasone-Loaded Block Copolymer Nanoparticles Induce Leukemia Cell Death and Enhance Therapeutic Efficacy: A Novel Application in Pediatric Nanomedicine ⬇️

scientific article published on November 29, 2012

Does obesity promote the development of colorectal cancer?

scientific article published on 4 March 2016

Editorial (Thematic Issue: Ferid Murad, at 80: A Legacy of Science, Medicine, and Mentorship).

scientific article published in January 2016

Effect of Mibefradil on CYP3A4 In Vivo ⬇️

scientific article published on October 1, 2003

Effects of atriopeptin on particulate guanylate cyclase from rat adrenal

scientific article published on 01 May 1985

Effects of atriopeptins on relaxation and cyclic GMP levels in human coronary artery in vitro

scientific article published on 01 May 1986

Effects of atriopeptins on relaxation and cyclic GMP levels in rat and rabbit aortas

scientific article published on 01 January 1986

Effects of food on the bioequivalence of different verapamil sustained-release formulations.

scientific article published in February 1995

Epitope-targeted cytotoxic T cells mediate lineage-specific antitumor efficacy induced by the cancer mucosa antigen GUCY2C.

scientific article

Escherichia coli heat-stable enterotoxin receptors. A novel marker for colorectal tumors.

scientific article published on 01 February 1996

Evidence-based Guidelines for Precision Risk Stratification-Based Screening (PRSBS) for Colorectal Cancer: Lessons learned from the US Armed Forces: Consensus and Future Directions

scientific article published on March 2013

Exisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells

scientific article published on 01 May 2006

Experimental therapeutics: a paradigm for personalized medicine.

scientific article published on December 2009

Exposure-dependent inhibition of intestinal and hepatic CYP3A4 in vivo by grapefruit juice

scientific article (publication date: August 2003)

Expression of the intestinal biomarkers Guanylyl cyclase C and CDX2 in poorly differentiated colorectal carcinomas.

scientific article published on October 2009

First do no harm: managing antihistamine impairment in patients with allergic rhinitis.

scientific article

GCC signaling in colorectal cancer: Is colorectal cancer a paracrine deficiency syndrome?

scientific article published on July 2009

GUCY2C Molecular Staging Personalizes Colorectal Cancer Patient Management ⬇️

scientific article published on June 1, 2012

GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome

scientific article published on September 2017

GUCY2C ligand replacement to prevent colorectal cancer.

scientific article published on 22 April 2016

GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress

scientific article published on 26 October 2017

GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity

scientific article (publication date: 2012)

GUCY2C reverse transcriptase PCR to stage pN0 colorectal cancer patients

scientific article

GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity

scientific article published on 2 September 2016

GUCY2C-targeted cancer immunotherapy: past, present and future.

scientific article published on December 2011

GUCY2C: at the intersection of obesity and cancer

scientific article published on 29 January 2013

Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association

scientific article published on 02 December 2013

Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer

scientific article published on 4 February 2017

Guanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer

scientific article published on June 2016

Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells.

scientific article published on July 2001

Guanylyl cyclase C as a biomarker in colorectal cancer

scientific article

Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract

scientific article

Guanylyl cyclase C is a selective marker for metastatic colorectal tumors in human extraintestinal tissues

scientific article published on December 1996

Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms

scientific article

Guanylyl cyclase C signaling axis and colon cancer prevention

scientific article

Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity

scientific journal article

Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity

scientific article

Guanylyl cyclase C: a molecular marker for staging and postoperative surveillance of patients with colorectal cancer.

scientific article

Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism.

scholarly article

H-ras inhibits RhoA/ROCK leading to a decrease in the basal tone in the internal anal sphincter.

scientific article

Highly purified particulate guanylate cyclase from rat lung: characterization and comparison with soluble guanylate cyclase ⬇️

scientific article published on January 1, 1983

Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine.

scientific article

Human cholecystokinin-A receptor is not an oncofetal protein

scientific article published on 01 March 2000

Hypotensive mechanisms of amifostine

scientific article published on April 1996

Identification and characterization of a new family of high-affinity receptors for Escherichia coli heat-stable enterotoxin in rat intestinal membranes.

scientific article

Identification of atrial natriuretic peptide receptors in cultured cells

scientific article published on 01 January 1991

Immunotherapeutic strategies to target prognostic and predictive markers of cancer

scientific article published on February 2013

Individualized medicine and the imperative of global health.

scientific article published in November 2007

Information Hierarchies Optimize Patient-Centered Solutions

scientific article published on January 1, 2013

Internalization of E. coli ST mediated by guanylyl cyclase C in T84 human colon carcinoma cells.

scientific article

Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins.

scientific article published on December 2005

Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins

scientific article

Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer

scientific article published on October 2013

Intestinal kinetics and dynamics of Escherichia coli heat-stabile enterotoxin in suckling mice.

scientific article

Intestine-specific activity of the human guanylyl cyclase C promoter is regulated by Cdx2.

scientific article published on July 2000

Knowledge cycle transforms therapeutic innovation

scientific article published on 01 January 2012

Lineage-specific T-cell responses to cancer mucosa antigen oppose systemic metastases without mucosal inflammatory disease

scientific article

Losartan does not affect the pharmacokinetics and pharmacodynamics of warfarin

scientific article published on 01 October 1995

Managing Innovation to Maximize Value Along the Discovery-Translation-Application Continuum

scientific article

Managing the innovation supply chain to maximize personalized medicine.

scientific article published in February 2014

Markers of cell cycle-mediated drug resistance and prognosis of patients receiving preoperative combined modality therapy for rectal cancer.

scientific article published in November 2004

Mechanisms of Weight Regain following Weight Loss

scientific article

MicroRNA signatures as diagnostic and therapeutic targets.

scientific article published in June 2008

Molecular Staging Estimates Occult Tumor Burden in Colorectal Cancer ⬇️

scientific article published on January 1, 2010

Molecular Staging of Node Negative Patients with Colorectal Cancer ⬇️

scientific article published on January 1, 2013

Molecular diagnostics. At the nexus of individualized medicine, health care delivery, and public policy.

scientific article published on February 2009

Molecular insights provide the critical path to disease mitigation

scientific article published in January 2014

Molecular medicine hones therapeutic arts to science

scientific article published on 01 October 2007

Molecular staging individualizing cancer management.

scientific article published in April 2012

Molecular therapeutics from knowledge to delivery

scientific article published on 01 June 2010

Multiregion whole-exome sequencing of matched primary and metastatic tumors revealed genomic heterogeneity and suggested polyclonal seeding in colorectal cancer metastasis

scientific article published in September 2017

New advances in models and strategies for developing anti-obesity drugs

scientific article

Nitric oxide activation of soluble guanylyl cyclase reveals high and low affinity sites that mediate allosteric inhibition by calcium.

scientific article published in March 2002

Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine-specific expression of guanylyl cyclase C.

scientific article published in October 2001

Obesity pharmacotherapy: what is next?

scientific article

Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis

scientific article published on January 2016

Occult tumor burden contributes to racial disparities in stage-specific colorectal cancer outcomes.

scientific article published on September 2011

Occult tumor burden predicts disease recurrence in lymph node-negative colorectal cancer

scientific article

Opportunities for near-infrared thermal ablation of colorectal metastases by guanylyl cyclase C-targeted gold nanoshells.

scientific article published on December 2006

Patient-centric clinical pharmacology advances the path to personalized medicine.

scientific article published in December 2011

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics.

scientific article

Pharmacoeconomics in the era of individualized medicine

scientific article published on 01 August 2008

Pharmacokinetics and pharmacodynamics of tepoxalin after single oral dose administration to healthy volunteers

scientific article published on 01 May 1996

Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study.

scientific article

Pharmacokinetics of aprepitant after single and multiple oral doses in healthy volunteers.

scientific article published in March 2006

Pharmacokinetics of ertapenem in healthy young volunteers.

scientific article

Pharmacokinetics of intramuscularly administered ertapenem

scientific article

Phosphorylation of vasodilator-stimulated phosphoprotein Ser239 suppresses filopodia and invadopodia in colon cancer.

scientific article published on 12 August 2011

Plp1 gene duplication inhibits airway responsiveness and induces lung inflammation.

scientific article published on 4 November 2014

Preclinical Evaluation of a Replication-Deficient Recombinant Adenovirus Serotype 5 Vaccine Expressing Guanylate Cyclase C and the PADRE T-helper Epitope

scientific article published on 30 November 2016

Previstage GCC test for staging patients with colorectal cancer.

scientific article

Prime-Boost Immunization Eliminates Metastatic Colorectal Cancer by Producing High-Avidity Effector CD8+ T Cells

scientific article published on 24 March 2017

Rat guanylyl cyclase C expressed in COS-7 cells exhibits multiple affinities for Escherichia coli heat-stable enterotoxin.

scientific article published on July 1995

Rat intestinal cell atrial natriuretic peptide receptor coupled to guanylate cyclase.

scientific article published in July 1990

Reciprocal regulation and integration of signaling by intracellular calcium and cyclic GMP.

scientific article published on January 2004

Regulation of appetite to treat obesity

scientific article

Regulation of guanylate cyclase by atrial natriuretic factor and the role of cyclic GMP in vasodilation.

scientific article published on September 1987

Regulation of nitric oxide-responsive recombinant soluble guanylyl cyclase by calcium.

scientific article published on May 1999

Regulation of particulate guanylate cyclase by Escherichia coli heat-stable enterotoxin: receptor binding and enzyme kinetics

scientific article published on 01 January 1989

Reply

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice

scientific article published on 12 September 2017

STa peptide analogs for probing guanylyl cyclase C.

scientific article

Selection of optimal reference genes for normalization in quantitative RT-PCR.

scientific article

Selective antigen-specific CD4(+) T-cell, but not CD8(+) T- or B-cell, tolerance corrupts cancer immunotherapy

scientific article

Sex modulates intestinal transformation by the tumor-suppressor GCC

scientific article published on 01 September 2008

Single- and multiple-dose pharmacokinetics of caspofungin in healthy men.

scientific article published on March 2002

Sizing up pharmacotherapy for obesity

scientific article

Solubilization and characterization of functionally coupled Escherichia coli heat-stable toxin receptors and particulate guanylate cyclase associated with the cytoskeleton compartment of intestinal membranes.

scientific article

Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides.

scientific article

Systems approaches evolve clinical pharmacology.

scientific article published on 21 August 2013

Systems-based discovery advances drug development.

scientific article

Taking a lesson from microbial diarrheagenesis in the management of chronic constipation.

scientific article published on 27 January 2010

The Molecular Therapeutics Section of the American Society for Clinical Pharmacology and Therapeutics

scientific article published on 01 October 1999

The Value Proposition of Molecular Medicine ⬇️

scientific article published on February 23, 2012

The adipose tissue production of adiponectin is increased in end-stage renal disease ⬇️

scientific article published on January 2, 2013

The effects of modifying in vivo cytochrome P450 3A (CYP3A) activity on etoricoxib pharmacokinetics and of etoricoxib administration on CYP3A activity.

scientific article published in October 2004

The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.

scientific article

The involvement of catalytic site thiol groups in the activation of soluble guanylate cyclase by sodium nitroprusside

scientific article published on 01 December 1986

The orl rat is more responsive to methacholine challenge than wild type

scientific article

The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer

scientific article

The paracrine hormone hypothesis of colorectal cancer.

scientific article published on 8 August 2007

The pharmacokinetics of nebulized nanocrystal budesonide suspension in healthy volunteers.

scientific article published in January 2004

The pharmacokinetics of taurolidine metabolites in healthy volunteers

scientific article

The putative tumor suppressor Cdx2 is overexpressed by human colorectal adenocarcinomas.

scientific article published in December 2005

The roadmap to personalized medicine

scientific article

Therapeutic targeting: a crucible for individualized medicine

scientific article published on 01 May 2008

Transitioning biomarkers into the clinic.

scientific article

Translating MicroRNA discovery into clinical biomarkers in cancer

scientific article published on 01 May 2007

Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis

scientific article

Translational medicine in the era of health care reform.

scientific article published on April 2009

Translational medicine individualizes healthcare discovery, development and delivery. Foreword.

scientific article published in February 2013

Translational medicine: path to personalized and public health.

scientific article published in December 2010

Tumor epithelial cell matrix metalloproteinase 9 is a target for antimetastatic therapy in colorectal cancer

scientific article published in March 2006

Tumor radiation therapy creates therapeutic vaccine responses to the colorectal cancer antigen GUCY2C.

scientific article published on April 2014

Tumor-targeting peptide-PNA-peptide chimeras for imaging overexpressed oncogene mRNAs.

scientific article published on January 2005

Use of guanylyl cyclase C for detecting micrometastases in lymph nodes of patients with colon cancer

scientific article published on 01 March 1998

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