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List of works by William S. Powell

12-Oxo-LTB4, a Key Pivotal Intermediate in LTB4 Metabolism

article

15-deoxy-Δ12,14-PGJ2: endogenous PPARγ ligand or minor eicosanoid degradation product?

article

15R-methyl-prostaglandin D2 is a potent and selective CRTH2/DP2 receptor agonist in human eosinophils.

scientific article

5-Oxo-ETE and the OXE receptor

scientific article (publication date: September 2009)

5-Oxo-ETE receptor antagonists

scientific article published on 26 April 2013

5-Oxo-ETE regulates tone of guinea pig airway smooth muscle via activation of Ca2+ pools and Rho-kinase pathway

scientific article

5-oxo-15-HETE: total synthesis and bioactivity

scientific article

5-oxo-6,8,11,14-Eicosatetraenoic Acid Is a Potent Stimulator ofl-Selectin Shedding, Surface Expression of CD11b, Actin Polymerization, and Calcium Mobilization in Human Eosinophils

article

5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin

scientific article

5-oxo-6,8,11,14-eicosatetraenoic acid stimulates the release of the eosinophil survival factor granulocyte/macrophage colony-stimulating factor from monocytes.

scientific article

5-oxo-ETE induces pulmonary eosinophilia in an integrin-dependent manner in Brown Norway rats.

scientific article published on December 1998

5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes

scientific article published on 18 February 2011

58 Rapid extraction of arachidonic acid metabolites from biological samples using octadecylsilyl silica

scientific article published on January 1, 1982

A convenient strategy for the synthesis of β,γ-unsaturated aldehydes and acids. A construction of skipped dienes

article published in 1999

A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI.

scientific article published on 29 September 2009

A new method for the preparation of olefins from vicinal diols

article published in 1999

A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis

article

A novel PGD(2) receptor expressed in eosinophils

scientific article

A photoaffinity probe for 5-hydroxyeicosanoid dehydrogenase suitable for radioiodination

AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury

scientific article

Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and 11-Methylene-PGD2 on Human Eosinophils and Basophils

scientific article published on 13 October 2006

Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress

scientific article published on 14 December 2006

An efficient approach to the synthesis of LTB4 and ω-substituted LTB4 metabolites

An efficient preparation of stereospecific β-hydroxy nitriles

Analysis of Leukotrienes, Lipoxins, and Monooxygenated Metabolites of Arachidonic Acid by Reversed-Phase High-Pressure Liquid Chromatography

scientific article published on 01 April 1995

Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists

scientific article published on 04 June 2014

Binding of prostaglandin E2 to cultured bovine adrenal chromaffin cells and its effect on catecholamine secretion

article

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE

scientific article

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes

scientific article

Biosynthesis of prostaglandins and thromboxane B2 by fetal lung homogenates

scientific article published on 01 February 1978

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

scientific article

C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

scientific article

Calcium/Calmodulin-dependent Conversion of 5-Oxoeicosanoids to 6,7-Dihydro Metabolites by a Cytosolic Olefin Reductase in Human Neutrophils ⬇️

scientific article published on August 14, 1998

Cellular infiltration and eicosanoid synthesis in brown Norway rat lungs after allergen challenge

scientific article published on 01 October 1995

Chapter 3 High Pressure Liquid Chromatography of Arachidonic Acid Metabolites Involved in Inflammation

Conversion of 8,11,14-eicosatrienoic acid to 11,12-epoxy-10-hydroxy-8-heptadecenoic acid by aorta.

scientific article published on February 1983

Conversion of leukotriene B4 to dihydro and 19-hydroxy metabolites by rat polymorphonuclear leukocytes

article

Conversion of stereoisomers of leukotriene B4 to dihydro and tetrahydro metabolites by porcine leukocytes

scientific article published on 01 May 1990

CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma

scientific article published on 25 May 2016

Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase

scientific article

Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma

scientific article

Distribution of prostaglandin ω-hydroxylases in different tissues

scientific article published on 01 May 1980

Effects of Phorbol Myristate Acetate on the Synthesis of 5-Oxo-6,8,11,14-eicosatetraenoic Acid by Human Polymorphonuclear Leukocytes

article

Effects of Prostaglandins on the Adenylate Cyclase Activity of Lungs from Fetal Rabbits*

article

Effects of changing educational requirements on teaching psychiatry

scientific article published in August 1974

Effects of dietary vitamin E on the biosynthesis of 5-lipoxygenase products by rat polymorphonuclear leukocytes (PMNL)

scientific article published on 01 October 1989

Effects of prostaglandin D(2) and 5-lipoxygenase products on the expression of CD203c and CD11b by basophils.

scientific article published on 23 September 2004

Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats

scientific article published on 8 December 2004

Effects of protein deficiency on the metabolism of arachidonic acid by rat pleural polymorphonuclear leukocytes

scientific article published on 01 May 1983

Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae

article

Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes

scientific article published on 06 September 2008

Enantio- and Stereospecific Syntheses of 15(R)-Me-PGD2, A Potent and Selective DP2−Receptor Agonist

scientific article published on 14 August 2008

Endotoxemia in transgenic mice overexpressing human glutathione peroxidases

Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid

scientific article

Fluorescent Functional Recognition Sites through Molecular Imprinting. A Polymer-Based Fluorescent Chemosensor for Aqueous cAMP

article published in 1998

Fluorescent Functional Recognition Sites through Molecular Imprinting. A Polymer-Based Fluorescent Chemosensor for Aqueous cAMP

article by Petra Turkewitsch et al published May 1998 in Analytical Chemistry

Formation of 6-oxoprostaglandin F1α by arteries of the fetal calf

scientific article published on 01 April 1977

High-Pressure Liquid Chromatography of Oxo-Eicosanoids Derived from Arachidonic Acid

scientific article published in 1997

Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant ⬇️

scientific article

IL-2 enhances allergic airway responses in rats by increased inflammation but not through increased synthesis of cysteinyl leukotrienes☆☆☆★

article

IL‐3 does not affect the allergic airway responses and leukotriene production after allergen challenge in rats

article

In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

scientific article published on 2 May 2017

Increased levels of monohydroxy metabolites of arachidonic acid and linoleic acid in LDL and aorta from atherosclerotic rabbits ⬇️

scientific article published on July 9, 1991

Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice.

scientific article published on 12 November 2016

Inhibition of 5-Oxo-6,8,11,14-eicosatetraenoic Acid-Induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor Antagonists

article

Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates

scientific article published on 17 January 2020

Inhibition of leukotriene B4 synthesis in human polymorphonuclear leukocytes after exposure to meningococcal lipopolysaccharide

scientific article published on 01 February 1982

Inositol (1,4,5)Trisphosphate Metabolism and Enhanced Calcium Mobilization in Airway Smooth Muscle of Hyperresponsive Rats

article

Interactions between Prostaglandin Analogues and a Receptor in Bovine Corpora lutea. Correlation of Dissociation Constants with Luteolytic Potencies in Hamsters ⬇️

scientific article (publication date: November 1975)

Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration

article

Intramolecular sulfur-assisted NaBH4 reduction of esters synthesis of 5-oxo-ETE and 5-oxo-12-HETE

Leukotrienes in bile during the early and the late airway responses after allergen challenge of sensitized rats.

scientific article

Marked improvement of the basophil activation test by detecting CD203c instead of CD63.

scientific article published in February 2003

Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys

scientific article published on 12 January 2018

Metabolism of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid and other hydroxylated fatty acids by the reductase pathway in porcine polymorphonuclear leukocytes.

scientific article published in October 1990

Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells

article

Metabolism of linoleic acid by prostaglandin endoperoxide synthase from adult and fetal blood vessels

article

Metabolism of prostaglandins, prostaglandin analogs and thromboxane B2 by lung and liver microsomes from pregnant rabbits ⬇️

scientific article published on December 18, 1979

Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite

scientific article published on 31 January 2008

Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)

scientific article published on 17 July 2018

Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys

scientific article published on 17 January 2020

Novel pathway for the metabolism of 6-trans-leukotriene B4 by human polymorphonuclear leukocytes.

scientific article published on April 1986

Nucleotides enhance the fluorescence of trans-4-(p-N,N-dimethylaminostyryl)-N-vinylbenzylpyridinium chloride

Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells.

scientific article published on 2 July 2004

Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.

scientific article published on 17 April 2009

Oxidized derivatives of ω-3 fatty acids: identification of IPF3α-VI in human urine

article

PROSTAGLANDIN-F2α RECEPTOR IN HUMAN CORPORA LUTEA

scientific article published in The Lancet

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

scientific article published on 21 October 2016

Precolumn extraction and reversed-phase high-pressure liquid chromatography of prostaglandins and leukotrienes

article

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

scientific article published on 01 September 2001

Prostaglandin E-Binding Sites in the Fetal Adrenal*

Rapid extraction of oxygenated metabolites of arachidonic acid from biological samples using octadecylsilyl silica ⬇️

scientific article published on November 1, 1980

Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane

scientific article

Regional variability in the response of collateral resistance to histamine in the dog: effects of cyclooxygenase inhibition.

scientific article

Regulation of 5-hydroxyeicosanoid dehydrogenase activity in monocytic cells

scientific article published on April 2007

Reversed-phase high-pressure liquid chromatography of arachidonic acid metabolites formed by cyclooxygenase and lipoxygenases

article

Separation of icosenoic acids, monohydroxyicosenoic acids, and prostaglandins by high-pressure liquid chromatography on a silver ion-loaded cation-exchange column ⬇️

scientific article published on 01 August 1981

Separation of unlabeled metabolites of arachidonic acid from their deuterium- and tritium-labeled analogs by argentation high-pressure liquid chromatography

scientific article published on 01 January 1983

Silyl group deprotection by Pd/C/H2. A facile and selective method

Stereochemistry of leukotriene B4 metabolites formed by the reductase pathway in porcine polymorphonuclear leukocytes: inversion of stereochemistry of the 12-hydroxyl group

scientific article published on 01 February 1990

Stereoselective synthesis of two highly potent 5-oxo-ETE receptor antagonists

Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.

scientific article

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

scientific article

Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids.

scientific article published on 22 January 2009

Synthesis of 10,11-Dihydro-12-oxo-LTB4, a Key Biochemical Intermediate

scientific article published on 01 January 1997

Synthesis of 12-KETE and its 8,9-trans-isomer

Synthesis of 15R-PGD2: a potential DP2 receptor agonist

scientific article published on 01 April 2005

Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.

scientific article

The Total Synthesis of 5-Oxo-12(S)-hydroxy-6(E),8(Z),10(E),14(Z)-eicosatetraenoic Acid and Its 8,9-trans-Isomer and Their Identification in Human Platelets

The Total Synthesis of Tritiated and Deuterated 5-Oxo-ETE, a Novel Inflammatory Mediator

article published in 1998

The design and synthesis of a 5-HETE affinity chromatography ligand for 5-hydroxyeicosanoid dehydrogenase

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor

scientific article

The immunomodulatory actions of prostaglandin E2 on allergic airway responses in the rat.

scientific article published in October 2002

The metabolism of arachidonic and eicosapentaenoic acids in human neutrophils stimulated by A23187 and FMLP

article

The synthesis of a 5-HETE photoaffinity ligand

Total Synthesis of a Potent Proinflammatory 5-Oxo-ETE and Its 6,7-Dihydro Biotransformation Product

article

Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center.

scientific article published in February 2006

Total synthesis of isoprostanes: discovery and quantitation in biological systems.

scientific article published on March 2004

Total synthesis of proinflammatory dihydro-12-KETE metabolites

Two Potent OXE-R Antagonists: Assignment of Stereochemistry

scientific article

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7

scientific article

[28] Measurement of prostaglandin ω-hydroxylase activity

scientific article published on 01 January 1982

[63] Argentation—high-pressure liquid chromatography of prostaglandins and monohydroxyeicosenoic acids

iPF2α-III-17,18,19,20-d4: Total synthesis and metabolism

article

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