List of works - Vuk Stambolic

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy

scientific article published on 22 August 2019

A unified nomenclature and amino acid numbering for human PTEN.

scientific article

Akt is activated in response to an apoptotic signal.

scientific article published on 8 June 2001

An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

scientific article

Association of Obesity-Related Metabolic Disruptions With Cancer Risk and Outcome

scientific article published on 7 November 2016

Cancer: Precise control of localized signals

scientific article

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

scientific article

Characterization of nuclear PTEN and its post translational modifications

scientific article

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

scientific article published on 27 January 2009

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

scientific article

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

scientific article published on 24 May 2019

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

scientific article published in December 2001

Diabetes, Metformin, and Breast Cancer: Lilac Time?

scientific article published on 11 June 2012

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

scientific article

Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32.

scientific article

Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32.

scientific article published on 26 April 2017

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

scientific article published on 24 February 2014

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

scientific article published on 26 October 2010

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

scientific article published on 15 February 2015

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

scientific article published on 25 July 2006

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

article

Impact of the obesity epidemic on cancer

scientific article

Localization of Rheb to the endomembrane is critical for its signaling function

scientific article (publication date: 9 June 2006)

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

scientific article

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

scientific article published in April 2016

Metformin and Exercise in Cancer: Better Together

scientific article published on 20 November 2019

Metformin in breast cancer: time for action

scientific article (publication date: 10 July 2009)

Metformin in cancer: translational challenges

scientific article

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

scientific article published on 30 August 2012

NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity

scientific article published on 19 June 2020

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

scientific journal article

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)

scientific article

Nek family of kinases in cell cycle, checkpoint control and cancer

scientific article

Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation

scientific article

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

scientific article published on July 2013

Obesity and cancer, a case for insulin signaling

scientific article

Obesity and insulin resistance in breast cancer – Chemoprevention strategies with a focus on metformin ⬇️

scientific article published on October 1, 2011

PTEN at 18: Still Growing

scientific article published on January 2016

PTEN function in mammalian cell size regulation

scientific article

PTEN, here, there, everywhere

scientific article published on December 2013

PTEN: a new twist on β-catenin?

scientific article published on 01 March 2002

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

scientific article published on 22 December 2016

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

scientific article

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

scientific article published on 28 June 2012

Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity

scientific article

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

scientific article published on 17 December 2009

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

scientific article published on 14 December 2009

Regulation of PTEN transcription by p53

scientific journal article

Regulation of adipocyte differentiation by distinct subcellular pools of protein kinase B (PKB/Akt).

scientific article

Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos

scientific article published on July 1999

Reply to A. Vazquez-Martin et al

Reply to R.M. Memmott et al

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

scientific journal article

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)

scientific article

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila

scientific article

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

scientific article

The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair

scientific article published on 26 February 2016

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

scientific article

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

scientific article published on 10 August 2019

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions

scientific article published on 10 August 2019

Understanding the benefit of metformin use in cancer treatment

scientific article

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

scientific article published on 26 April 2008

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice

scientific article

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

scientific article published on 4 April 2016

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

scientific article published on 3 May 2017

List of works by Vuk Stambolic

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy

A unified nomenclature and amino acid numbering for human PTEN.

Akt is activated in response to an apoptotic signal.

An autoinhibited noncanonical mechanism of GTP hydrolysis by Rheb maintains mTORC1 homeostasis

Association of Obesity-Related Metabolic Disruptions With Cancer Risk and Outcome

Cancer: Precise control of localized signals

Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: a prospective window of opportunity neoadjuvant study

Characterization of nuclear PTEN and its post translational modifications

Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR.

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila

Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

Diabetes, Metformin, and Breast Cancer: Lilac Time?

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

Effect of metformin vs placebo on and metabolic factors in NCIC CTG MA.32.

Effects of metformin versus placebo on vitamin B12 metabolism in non-diabetic breast cancer patients in CCTG MA.32.

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

Evaluation of metformin in early breast cancer: a modification of the traditional paradigm for clinical testing of anti-cancer agents

Evidence for biological effects of metformin in operable breast cancer: biomarker analysis in a pre-operative window of opportunity randomized trial

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

Impact of the obesity epidemic on cancer

Localization of Rheb to the endomembrane is critical for its signaling function

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc

Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy.

Metformin and Exercise in Cancer: Better Together

Metformin in breast cancer: time for action

Metformin in cancer: translational challenges

Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study

NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)

Nek family of kinases in cell cycle, checkpoint control and cancer

Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress

Obesity and cancer, a case for insulin signaling

Obesity and insulin resistance in breast cancer – Chemoprevention strategies with a focus on metformin ⬇️

PTEN at 18: Still Growing

PTEN function in mammalian cell size regulation

PTEN, here, there, everywhere

PTEN: a new twist on β-catenin?

Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice

Probing the GTPase cycle with real-time NMR: GAP and GEF activities in cell extracts

Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

Real-time NMR study of three small GTPases reveals that fluorescent 2'(3')-O-(N-methylanthraniloyl)-tagged nucleotides alter hydrolysis and exchange kinetics.

Regulation of PTEN transcription by p53

Regulation of adipocyte differentiation by distinct subcellular pools of protein kinase B (PKB/Akt).

Regulation of the protein kinase activity of Shaggy(Zeste-white3) by components of the wingless pathway in Drosophila cells and embryos

Reply to A. Vazquez-Martin et al

Reply to R.M. Memmott et al

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes

The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions

Understanding the benefit of metformin use in cancer treatment

Utility of metformin in breast cancer treatment, is neoangiogenesis a risk factor?

grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models