List of works - Lukas Mach

A plant-derived human monoclonal antibody induces an anti-carbohydrate immune response in rabbits

scientific article published on 18 January 2008

A proteomic study of the major allergens from yellow jacket venoms

scientific article

A unique beta1,3-galactosyltransferase is indispensable for the biosynthesis of N-glycans containing Lewis a structures in Arabidopsis thaliana

scientific article

Antibodies to rat procathepsin B recognize the active mature enzyme

scientific article published on 01 July 1992

Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins

scientific article published on 15 April 2014

Arabidopsis thaliana beta1,2-xylosyltransferase: an unusual glycosyltransferase with the potential to act at multiple stages of the plant N-glycosylation pathway.

scientific article published on June 2005

Arginine/lysine residues in the cytoplasmic tail promote ER export of plant glycosylation enzymes

scientific article published on November 2008

Biosynthesis and endocytosis of lysosomal enzymes in human colon carcinoma SW 1116 cells: impaired internalization of plasma membrane-associated cation-independent mannose 6-phosphate receptor

scientific article published on 01 October 1992

Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.

scientific article published on 28 June 2008

Characterizing the link between glycosylation state and enzymatic activity of the endo-β1,4-glucanase KORRIGAN1 from Arabidopsis thaliana.

scientific article published on 19 June 2013

Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana

scientific article

Construction of a functional CMP-sialic acid biosynthesis pathway in Arabidopsis

scientific article published on 7 March 2008

Designed SARS-CoV-2 receptor binding domain variants form stable monomers

scientific article published on 03 February 2022

Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development

scientific article

Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases

scientific article published on 20 July 2007

Folding competence of N-terminally truncated forms of human procathepsin B.

scientific article published on 18 January 2005

Generation of Arabidopsis thaliana plants with complex N-glycans lacking beta1,2-linked xylose and core alpha1,3-linked fucose.

scientific article published in March 2004

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

scientific article

Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

scientific article

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

scientific article

Identification of two subtilisin-like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana

scientific article published on 01 December 2020

Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile

scientific article published on 28 May 2009

Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis.

scientific article published on 8 April 2016

Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol.

scientific article published on 12 August 2015

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

scientific article published on 5 March 2015

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues ⬇️

scientific article published on April 17, 2012

Mannose trimming reactions in the early stages of the N-glycan processing pathway.

scientific article published on 4 April 2010

Mass + retention time = structure: a strategy for the analysis of N-glycans by carbon LC-ESI-MS and its application to fibrin N-glycans

scientific article

Molecular Insight into Propeptide–Protein Interactions in Cathepsins L and O ⬇️

scientific article published on October 16, 2012

Molecular cloning and characterization of Arabidopsis thaliana Golgi alpha-mannosidase II, a key enzyme in the formation of complex N-glycans in plants

scientific article published on March 2006

Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana.

scientific article

Molecular cloning and heterologous expression of beta1,2-xylosyltransferase and core alpha1,3-fucosyltransferase from maize

scientific article published on 22 August 2006

Molecular cloning of cDNA encoding N-acetylglucosaminyltransferase II from Arabidopsis thaliana

scientific article published in December 1999

Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease.

scientific article published on 9 July 2015

Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana

scientific article

Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana

scientific article

Proteolytic and N-glycan processing of human α1-antitrypsin expressed in Nicotiana benthamiana

scientific article published in 2014

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme ⬇️

scientific article published on March 1, 1992

Steric Accessibility of the Cleavage Sites Dictates the Proteolytic Vulnerability of the Anti-HIV-1 Antibodies 2F5, 2G12, and PG9 in Plants

scientific article published on 08 November 2019

The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes.

scientific article published on 14 November 2006

The Golgi localization of Arabidopsis thaliana beta1,2-xylosyltransferase in plant cells is dependent on its cytoplasmic and transmembrane sequences

scientific article published on 01 September 2002

The S-layer proteins of Tannerella forsythia are secreted via a type IX secretion system that is decoupled from protein O-glycosylation.

scientific article

The antigenicity of the carbohydrate moiety of an insect glycoprotein, honey-bee (Apis mellifera) venom phospholipase A2. The role of alpha 1,3-fucosylation of the asparagine-bound N-acetylglucosamine ⬇️

scientific article published on June 1, 1992

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

scientific article

The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

scientific article published on April 2014

The jiaoyao1 Mutant Is an Allele of korrigan1 That Abolishes Endoglucanase Activity and Affects the Organization of Both Cellulose Microfibrils and Microtubules in Arabidopsis.

scientific article published on 24 June 2014

The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells

scientific article published on April 2013

The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.

scientific article published in June 2009

The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B.

scientific article

Thyroid stimulating hormone upregulates secretion of cathepsin B from thyroid epithelial cells

scientific article published on May 2002

Two closely related forms of UDP-GlcNAc: alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II occur in the clawed frog Xenopus laevis

scientific article published in March 2002

List of works by Lukas Mach

A plant-derived human monoclonal antibody induces an anti-carbohydrate immune response in rabbits

A proteomic study of the major allergens from yellow jacket venoms

A unique beta1,3-galactosyltransferase is indispensable for the biosynthesis of N-glycans containing Lewis a structures in Arabidopsis thaliana

Antibodies to rat procathepsin B recognize the active mature enzyme

Arabidopsis Class I α-Mannosidases MNS4 and MNS5 Are Involved in Endoplasmic Reticulum-Associated Degradation of Misfolded Glycoproteins

Arabidopsis thaliana beta1,2-xylosyltransferase: an unusual glycosyltransferase with the potential to act at multiple stages of the plant N-glycosylation pathway.

Arginine/lysine residues in the cytoplasmic tail promote ER export of plant glycosylation enzymes

Biosynthesis and endocytosis of lysosomal enzymes in human colon carcinoma SW 1116 cells: impaired internalization of plasma membrane-associated cation-independent mannose 6-phosphate receptor

Cellular repressor of E1A-stimulated genes is a bona fide lysosomal protein which undergoes proteolytic maturation during its biosynthesis.

Characterizing the link between glycosylation state and enzymatic activity of the endo-β1,4-glucanase KORRIGAN1 from Arabidopsis thaliana.

Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana

Construction of a functional CMP-sialic acid biosynthesis pathway in Arabidopsis

Designed SARS-CoV-2 receptor binding domain variants form stable monomers

Drosophila melanogaster cellular repressor of E1A-stimulated genes is a lysosomal protein essential for fly development

Enzymatic properties and subcellular localization of Arabidopsis beta-N-acetylhexosaminidases

Folding competence of N-terminally truncated forms of human procathepsin B.

Generation of Arabidopsis thaliana plants with complex N-glycans lacking beta1,2-linked xylose and core alpha1,3-linked fucose.

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

Glycan modulation and sulfoengineering of anti-HIV-1 monoclonal antibody PG9 in plants.

Identification of Protease Specificity by Combining Proteome-Derived Peptide Libraries and Quantitative Proteomics

Identification of two subtilisin-like serine proteases engaged in the degradation of recombinant proteins in Nicotiana benthamiana

Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile

Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis.

Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol.

Introduction of germline residues improves the stability of anti-HIV mAb 2G12-IgM

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues ⬇️

Mannose trimming reactions in the early stages of the N-glycan processing pathway.

Mass + retention time = structure: a strategy for the analysis of N-glycans by carbon LC-ESI-MS and its application to fibrin N-glycans

Molecular Insight into Propeptide–Protein Interactions in Cathepsins L and O ⬇️

Molecular cloning and characterization of Arabidopsis thaliana Golgi alpha-mannosidase II, a key enzyme in the formation of complex N-glycans in plants

Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana.

Molecular cloning and heterologous expression of beta1,2-xylosyltransferase and core alpha1,3-fucosyltransferase from maize

Molecular cloning of cDNA encoding N-acetylglucosaminyltransferase II from Arabidopsis thaliana

Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease.

Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana

Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana

Proteolytic and N-glycan processing of human α1-antitrypsin expressed in Nicotiana benthamiana

Proteolytic processing and glycosylation of cathepsin B. The role of the primary structure of the latent precursor and of the carbohydrate moiety for cell-type-specific molecular forms of the enzyme ⬇️

Steric Accessibility of the Cleavage Sites Dictates the Proteolytic Vulnerability of the Anti-HIV-1 Antibodies 2F5, 2G12, and PG9 in Plants

The 46-kDa mannose 6-phosphate receptor does not depend on endosomal acidification for delivery of hydrolases to lysosomes.

The Golgi localization of Arabidopsis thaliana beta1,2-xylosyltransferase in plant cells is dependent on its cytoplasmic and transmembrane sequences

The S-layer proteins of Tannerella forsythia are secreted via a type IX secretion system that is decoupled from protein O-glycosylation.

The antigenicity of the carbohydrate moiety of an insect glycoprotein, honey-bee (Apis mellifera) venom phospholipase A2. The role of alpha 1,3-fucosylation of the asparagine-bound N-acetylglucosamine ⬇️

The death enzyme CP14 is a unique papain-like cysteine proteinase with a pronounced S2 subsite selectivity.

The human anti-HIV antibodies 2F5, 2G12, and PG9 differ in their susceptibility to proteolytic degradation: down-regulation of endogenous serine and cysteine proteinase activities could improve antibody production in plant-based expression platforms

The jiaoyao1 Mutant Is an Allele of korrigan1 That Abolishes Endoglucanase Activity and Affects the Organization of Both Cellulose Microfibrils and Microtubules in Arabidopsis.

The mannose 6-phosphate-binding sites of M6P/IGF2R determine its capacity to suppress matrix invasion by squamous cell carcinoma cells

The mannose 6-phosphate/insulin-like growth factor II receptor restricts the tumourigenicity and invasiveness of squamous cell carcinoma cells.

The papain-like cysteine proteinases NbCysP6 and NbCysP7 are highly processive enzymes with substrate specificities complementary to Nicotiana benthamiana cathepsin B.

Thyroid stimulating hormone upregulates secretion of cathepsin B from thyroid epithelial cells

Two closely related forms of UDP-GlcNAc: alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II occur in the clawed frog Xenopus laevis