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List of works by Simon Pearce

2013 ETA Guideline: Management of Subclinical Hypothyroidism

scientific article

2018 European Thyroid Association Guideline for the Management of Graves' Hyperthyroidism

scientific article published on 25 July 2018

A Review of the Clinical Consequences of Variation in Thyroid Function Within the Reference Range ⬇️

scientific article published on 03 July 2013

A Variant in the BACH2 Gene Is Associated With Susceptibility to Autoimmune Addison's Disease in Humans

scientific article published on 28 September 2016

A novel CLDN16 mutation in a large family with familial hypomagnesaemia with hypercalciuria and nephrocalcinosis

scientific article

AIRE is not essential for the induction of human tolerogenic dendritic cells

scientific article published on 25 February 2016

Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects

scientific article

Adjuvant rituximab, a potential treatment for the young patient with Graves' hyperthyroidism (RiGD): study protocol for a single-arm, single-stage, phase II trial

scientific article published on 21 January 2019

Adrenal insufficiency - recognition and management.

scientific article published on June 2017

Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease

scientific article

An ancient founder mutation in PROKR2 impairs human reproduction

scientific article

An unusual cause of adrenal insufficiency and bilateral adrenal masses.

scientific article published on 6 July 2018

Analysis of BAFF gene polymorphisms in UK Graves' disease patients

article

Anti-neutrophil cytoplasmic antibody (ANCA) associated small-vessel vasculitis in a patient with diabetic nephropathy and autoimmune polyendocrinopathy syndrome (APS) Type 2: a case report.

scientific article published in September 2013

Antidepressant augmentation with metyrapone for treatment-resistant depression (the ADD study): a double-blind, randomised, placebo-controlled trial.

scientific article published on 22 December 2015

Antigen-Specific Immunotherapy with Thyrotropin Receptor Peptides in Graves' Hyperthyroidism: A Phase I Study

scientific article published on 13 June 2019

Association analysis of the cytotoxic T lymphocyte antigen-4 (CTLA-4) and autoimmune regulator-1 (AIRE-1) genes in sporadic autoimmune Addison's disease

article

Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study

scientific article published on 21 February 2018

Autoimmune Addison disease: pathophysiology and genetic complexity.

scientific article published on 31 January 2012

Autoimmune Addison's disease.

scientific article

CTLA-4 as a genetic determinant in autoimmune Addison's disease.

scientific article

Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism

scientific article

Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders.

scientific article

Clinical review: The thyroid in mind: cognitive function and low thyrotropin in older people

scientific article

Clinical, behavioural and pharmacogenomic factors influencing the response to levothyroxine therapy in patients with primary hypothyroidism-protocol for a systematic review.

scientific article

Consensus statement of the European Group on Graves' orbitopathy (EUGOGO) on management of GO.

scientific article

Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency.

scientific article published on 16 December 2013

Current and emerging therapies for Addison's disease.

scientific article

Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy

scientific article published in The Lancet

Cytotoxic T-lymphocyte-associated antigen-4 single nucleotide polymorphisms and haplotypes in primary biliary cirrhosis

article

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice

scientific article

Diagnosis and management of thyrotoxicosis

scientific article published in the British Medical Journal

Diagnosis and management of vitamin D deficiency.

scientific article published on 11 January 2010

Diagnostic challenges due to phenocopies: lessons from Multiple Endocrine Neoplasia type1 (MEN1)

scientific article published on 01 January 2010

Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism

scientific article

Discordance for X-linked hypophosphataemic rickets in identical twin girls

scientific article published on 04 March 2009

Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cells.

scientific article

Do antithyroid drugs influence outcome after radioiodine therapy for hyperthyroidism?

scientific article published on 17 July 2007

Expanding the genotypic spectrum of Perrault syndrome.

scientific article published on 11 March 2016

Expression of melanocortin receptors in human endometrium.

scientific article

Extracellular calcium‐sensing receptor dysfunction is associated with two new phenotypes ⬇️

scientific article published on 01 October 2003

Follow-up of potential novel Graves' disease susceptibility loci, identified in the UK WTCCC genome-wide nonsynonymous SNP study

scientific article

Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement

scientific article published on 10 September 2015

Genetic progress towards the molecular basis of autoimmunity.

scientific article published on 18 January 2006

Genetic progress towards the molecular basis of common autoimmunity

scientific article published on 1 February 2006

Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility.

scientific article

High frequency of cytolytic 21-hydroxylase-specific CD8+ T cells in autoimmune Addison's disease patients

scientific article

How should I approach standard endocrine evaluation in patients with coeliac disease? ⬇️

scientific article published on August 9, 2013

How should we treat patients with low serum thyrotropin concentrations?

scientific article published on 10 September 2009

Impact of Month of Birth on the Risk of Development of Autoimmune Addison's Disease

scientific article published on 30 August 2016

Impact of month of birth on the development of autoimmune thyroid disease in the United Kingdom and Europe

scientific article published on 19 May 2014

Improving the prehospital safety of steroid-dependent patients in northern England: A hospital-initiated ambulance service registration pathway.

scientific article

In vivo and in vitro characterization of neonatal hyperparathyroidism resulting from a de novo, heterozygous mutation in the Ca2+-sensing receptor gene: normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial [...]

scientific article

Insufficient evidence to favour prednisolone over hydrocortisone in glucocorticoid replacement

scientific article published on 09 September 2014

Isolation of a multipotent mesenchymal stem cell-like population from human adrenal cortex.

scientific article

Left ventricular apical ballooning (takotsubo cardiomyopathy) in thyrotoxicosis

scientific article published on 01 February 2007

Levothyroxine treatment of subclinical hypothyroidism, fatal and nonfatal cardiovascular events, and mortality

scientific article published on 01 May 2012

Linkage Analysis in Autoimmune Addison's Disease: NFATC1 as a Potential Novel Susceptibility Locus.

scientific article published on 4 June 2015

Loperamide-induced hypopituitarism

scientific article

Low-dose levothyroxine did not improve symptoms in asymptomatic older people with subclinical hypothyroidism

scientific article published on 01 February 2018

MANAGEMENT OF ENDOCRINE DISEASE: Regenerative therapies in autoimmune Addison's disease

scientific article published on 3 November 2016

Management of hypothyroidism in adults.

scientific article

Many men are receiving unnecessary testosterone prescriptions

scientific article published on 21 August 2012

Medical therapy of macroprolactinomas in males: I. Prevalence of hypopituitarism at diagnosis. II. Proportion of cases exhibiting recovery of pituitary function

scientific article published on January 1, 2002

Mutational analysis of the adaptor protein 2 sigma subunit (AP2S1) gene: search for autosomal dominant hypocalcemia type 3 (ADH3).

scientific article published on 7 April 2014

Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.

scientific article published on 17 June 2008

No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease.

scientific article

Older patients' experience of primary hypothyroidism: A qualitative study

scientific article published on 21 February 2018

PREGO (presentation of Graves' orbitopathy) study: changes in referral patterns to European Group On Graves' Orbitopathy (EUGOGO) centres over the period from 2000 to 2012.

scientific article published on 7 May 2015

Patient knowledge of antithyroid drug-induced agranulocytosis

scientific article

Patients' attitudes and perceptions towards treatment of hypothyroidism in general practice: an in-depth qualitative interview study

scientific article published on 28 June 2017

Phaeochromocytoma and acth-dependent cushing's syndrome: Tumor crf-secretion can mimic pituitary cushing's disease.

scientific article published on 3 October 2015

Prevention and treatment of vitamin D deficiency.

scientific article

Primary hyperparathyroidism: just how 'primary' is it really?

scientific article

Programmed death ligand 1 (PD-L1) gene variants contribute to autoimmune Addison's disease and Graves' disease susceptibility

scientific article published on 22 October 2009

Rapid onset childhood cataracts leading to the diagnosis of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

scientific article published on 01 November 2003

Reply on the Letter by Stott et al. 'The Dilemma of Treating Subclinical Hypothyroidism: Risk that Current Guidelines Do More Harm than Good'.

scientific article

Residual Adrenal Function in Autoimmune Addison's Disease-Effect of Dual Therapy With Rituximab and Depot Tetracosactide

scientific article published on 01 April 2020

Residual adrenal function in autoimmune Addison's disease: improvement after tetracosactide (ACTH1-24) treatment.

scientific article

Rethinking antithyroid drugs in pregnancy.

scientific article published on 17 October 2014

Reversal of idiopathic hypogonadotropic hypogonadism

article

Role of the CD40 locus in Graves' disease.

scientific article published in July 2004

Role of the X-Linked GeneGPR174in Autoimmune Addison's Disease

scientific article published in January 2015

Saving lives of in-patients with adrenal insufficiency: implementation of an alert scheme within the Newcastle-upon-Tyne Hospitals e-Prescribing platform.

scientific article published on 5 May 2014

Serum 25-hydroxyvitamin D concentration and its determinants in the very old: the Newcastle 85+ Study.

scientific article

Serum Thyroid Function, Mortality and Disability in Advanced Old Age: The Newcastle 85+ Study ⬇️

scientific article published on 23 August 2016

Spontaneous and tetracosactide-induced anti-ACTH antibodies in man.

scientific article published on 16 April 2015

Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: study protocol for a randomized controlled tria

scientific article published on 22 March 2013

Study of Optimal Replacement of Thyroxine in the Elderly (SORTED) - results from the feasibility randomised controlled trial.

scientific article published on 10 October 2016

Subclinical Hypothyroidism and Cardiovascular Disease—Reply ⬇️

scientific article published on October 22, 2012

Subclinical Thyroid Disease: Time to Enter the Age of Evidence-Based Medicine ⬇️

scientific article published on 01 August 2012

Subclinical hyperthyroidism: first do no harm

scientific article published on 20 April 2016

Sun and melanoma: Time to go to get your hat

scientific article published on 06 August 2008

The cytotoxic T lymphocyte antigen-4 is a major Graves' disease locus.

scientific article

The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease

scientific article published in November 2003

The genetics of autoimmune thyroid disease.

scientific article

The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort.

scientific article published on 11 February 2010

The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis.

scientific article

The role of a nonsynonymous CD226 (DNAX-accessory molecule-1) variant (Gly 307Ser) in isolated Addison’s disease and autoimmune polyendocrinopathy type 2 pathogenesis

scientific article published on 6 July 2011

The tryptophan 620 allele of the lymphoid tyrosine phosphatase (PTPN22) gene predisposes to autoimmune Addison's disease.

scientific article

The voltage‐dependent Cl− channel ClC‐5 and plasma membrane Cl− conductances of mouse renal collecting duct cells (mIMCD‐3) ⬇️

scientific article published on November 1, 2001

Thyroid Hormone Therapy for Subclinical Hypothyroidism

scientific article published on 01 February 2019

Thyroid hormones and cardiovascular disease

scientific article published on 4 November 2016

Thyroxine in acute myocardial infarction (ThyrAMI) - levothyroxine in subclinical hypothyroidism post-acute myocardial infarction: study protocol for a randomised controlled trial.

scientific article

Toward precise forecasting of autoimmune endocrinopathy

scientific article published on 01 February 2004

Treatment for primary hypothyroidism: current approaches and future possibilities ⬇️

scientific article published on December 22, 2011

Tremelimumab-Induced Graves Hyperthyroidism.

scientific article published on 14 March 2017

Trends in thyroid hormone prescribing and consumption in the UK

scientific article

Unrecognised severe vitamin D deficiency

scientific article published on June 2008

Ventriculitis from a pituitary prolactinoma: bacterial or chemical?

scientific article published on 11 July 2016

Vitamin D testing

What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves’ disease

scientific article published in June 2006

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