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List of works by Giuseppe Toffoli

'Genetic profiling' and ovarian cancer therapy (review).

scientific article published on 17 June 2011

2-D gel electrophoresis: constructing 2D-gel proteome reference maps

scientific article

A Clinical-Genetic Score to Identify Surgically Resected Colorectal Cancer Patients Benefiting From an Adjuvant Fluoropyrimidine-Based Therapy

scientific article published on 04 October 2018

A New Genetic Risk Score to Predict the Outcome of Locally Advanced or Metastatic Breast Cancer Patients Treated With First-Line Exemestane: Results From a Prospective Study

scientific article published on 24 November 2018

A Pan-Cancer Approach to Predict Responsiveness to Immune Checkpoint Inhibitors by Machine Learning

scientific article published on 15 October 2019

A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long Term Side Effects after Finasteride Discontinuation

article

A TGF-β associated genetic score to define prognosis and platinum sensitivity in advanced epithelial ovarian cancer

scientific article published on 09 November 2019

A fast method for the detection of irinotecan in plasma samples by combining solid phase extraction and differential pulse voltammetry

scientific article published on 25 January 2020

A liquid chromatography-tandem mass spectrometry method for the simultaneous determination of exemestane and its metabolite 17-dihydroexemestane in human plasma.

scientific article published in June 2009

A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study

scientific article published on 23 February 2018

A novel CDH1 germline missense mutation in a sporadic gastric cancer patient in north-east of Italy

scientific article published on 29 April 2012

A novel UGT1 marker associated with better tolerance against irinotecan-induced severe neutropenia in metastatic colorectal cancer patients

scientific article published on 17 March 2015

A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen

scientific article published on 07 August 2012

A surface enhanced Raman scattering based colloid nanosensor for developing therapeutic drug monitoring

scientific article published on 29 August 2018

ABCC5 and ABCG1 polymorphisms predict irinotecan-induced severe toxicity in metastatic colorectal cancer patients.

scientific article published on 8 September 2015

Adipose mesenchymal stromal/stem cells expanded by a GMP compatible protocol displayed improved adhesion on cancer cells in flow conditions

scientific article published on 01 April 2020

An Effective Multi-Stage Liposomal DNA Origami Nanosystem for In Vivo Cancer Therapy

scientific article published on 12 December 2019

Analytical aspects of sunitinib and its geometric isomerism towards therapeutic drug monitoring in clinical routine

scientific article published on 08 August 2018

Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia.

scientific article published on 23 December 2016

Androgen receptor serine 81 mediates Pin1 interaction and activity

scientific article

Association of STAT-3 rs1053004 and VDR rs11574077 With FOLFIRI-Related Gastrointestinal Toxicity in Metastatic Colorectal Cancer Patients.

scientific article published on 13 April 2018

Association of theHLA-G3′UTR polymorphisms with colorectal cancer in Italy: a first insight

scientific article (publication date: 21 December 2015)

Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants.

scientific article published on 4 April 2019

Biocompatible tailored zirconia mesoporous nanoparticles with high surface area for theranostic applications

scientific article published on 24 August 2015

Biosensing Technologies for Therapeutic Drug Monitoring.

scientific article

Bottom-up synthesis of carbon nanoparticles with higher doxorubicin efficacy.

scientific article published on 13 January 2017

Brief report: prognostic importance of cellular DNA content in T1-2 N0 laryngeal squamous cell carcinomas treated with radiotherapy

scientific article published on 01 June 1995

C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation

scientific article

CDK4/6 Inhibitors in Breast Cancer Treatment: Potential Interactions with Drug, Gene, and Pathophysiological Conditions

scientific article published on 01 September 2020

CORRIGENDUM: Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium

scientific article published on 01 July 2017

Candidate germline polymorphisms of genes belonging to the pathways of four drugs used in osteosarcoma standard chemotherapy associated with risk, survival and toxicity in non-metastatic high-grade osteosarcoma

scientific article published on 22 August 2016

Carbon Dots from Sugars and Ascorbic Acid: Role of the Precursors on Morphology, Properties, Toxicity, and Drug Uptake

scientific article published on 16 July 2018

Carboplatin and topotecan combination and myelosuppression

scientific article published in August 2002

Carboxylesterase isoform 2 mRNA expression in peripheral blood mononuclear cells is a predictive marker of the irinotecan to SN38 activation step in colorectal cancer patients.

scientific article

Characterization of antibodies directed against the immunoglobulin light kappa chain variable chain region (VK) of hepatitis C virus-related type-II mixed cryoglobulinemia and B-cell proliferations

scientific article published on September 2009

Circulating-Free DNA Analysis in Hepatocellular Carcinoma: A Promising Strategy to Improve Patients' Management and Therapy Outcomes ⬇️

scientific article published on 05 November 2019

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy

scientific article published on 22 April 2022

Clinical implications of genetic polymorphisms on stomach cancer drug therapy

scientific article published on 27 June 2006

Clinical predictive circulating peptides in rectal cancer patients treated with neoadjuvant chemoradiotherapy

scientific article published on August 2015

Clinical validity of a DPYD-based pharmacogenetic test to predict severe toxicity to fluoropyrimidines

scientific article published on 23 June 2015

Clonal Evolution of TP53 c.375+1G>A Mutation in Pre- and Post- Neo-Adjuvant Chemotherapy (NACT) Tumor Samples in High-Grade Serous Ovarian Cancer (HGSOC)

scientific article published on 01 October 2019

Clonal Selection of a Novel Deleterious TP53 Somatic Mutation Discovered in ctDNA of a KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumor Resistant to Imatinib

scientific article published on 07 February 2020

Combination antibiotic treatment of chemotherapy-induced neutropenia in non-leukemic patients.

scientific article

Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients

scientific article published on 08 November 2019

Comparison of mechanisms responsible for resistance to idarubicin and daunorubicin in multidrug resistant LoVo cell lines.

scientific article published on November 1994

Correction: Genetic Diversity of the KIR/HLA System and Outcome of Patients with Metastatic Colorectal Cancer Treated with Chemotherapy

Correlation between the retinal nerve fiber layer thickness and the pattern electroretinogram amplitude

scientific article

Corrigendum to “Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma” [Biosens. Bioelectron. 86 (2016) 913–919]

scientific article published on 23 March 2017

Cost Evaluation of Irinotecan-Related Toxicities Associated With the UGT1A1*28 Patient Genotype.

scientific article published on 11 January 2017

Critical choices for modeling breast cancer in transgenic mouse models.

scientific article published on August 2012

Cross-validation of a mass spectrometric-based method for the therapeutic drug monitoring of irinotecan: implementation of matrix-assisted laser desorption/ionization mass spectrometry in pharmacokinetic measurements

scientific article

Cyclosporin A as a multidrug-resistant modulator in patients with renal cell carcinoma treated with teniposide.

scientific article

DNA Nanotechnology for Cancer Therapy

scientific article

DNA flow cytometric evaluation of cell cycle distribution in ulcerative colitis: a proposed method for assessing severity of disease.

scientific article

Detection of low-quantity anticancer drugs by surface-enhanced Raman scattering.

scientific article published on 4 February 2016

Determination of unbound etoposide concentration in ultrafiltered plasma by high-performance liquid chromatography with fluorimetric detection

scientific article published on 01 November 1996

Development and validation of a high-performance liquid chromatography-tandem mass spectrometry method for the simultaneous determination of irinotecan and its main metabolites in human plasma and its application in a clinical pharmacokinetic study

scientific article

Development and validation of a microRNA-based signature (MiROvaR) to predict early relapse or progression of epithelial ovarian cancer: a cohort study.

scientific article published on 8 July 2016

Diagnostic value of plasma and urinary 2-hydroxyglutarate to identify patients with isocitrate dehydrogenase-mutated glioma.

scientific article published on 10 April 2015

Dissecting Pin1 and phospho-pRb regulation.

scientific article published on January 2013

Do gliadin and tissue transglutaminase mediate PPAR downregulation in intestinal cells of patients with coeliac disease?

scientific article published on 30 August 2010

Drug interactions among the epidermal growth factor receptor inhibitors, other biologics and cytotoxic agents

scientific article published on 11 June 2010

ELISA assay employing epitope-specific monoclonal antibodies to quantify circulating HER2 with potential application in monitoring cancer patients undergoing therapy with trastuzumab

scientific article published on 20 February 2020

Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate

scientific article published on 01 May 1988

Effect of TP53 Arg72Pro and MDM2 SNP309 polymorphisms on the risk of high-grade osteosarcoma development and survival

scientific article published in May 2009

Effect of cyclosporin A on protein binding of teniposide in cancer patients

scientific article published on 01 July 1999

Effect of cyclosporine on teniposide pharmacokinetics and pharmacodynamics in patients with renal cell cancer

scientific article published on 01 June 1995

Effect of highly active antiretroviral therapy (HAART) on pharmacokinetics and pharmacodynamics of doxorubicin in patients with HIV-associated non-Hodgkin's lymphoma.

scientific article published in December 2004

Effect of hyperthermia on intracellular drug accumulation and chemosensitivity in drug-sensitive and drug-resistant P388 leukaemia cell lines.

scientific article

Effect of methylenetetrahydrofolate reductase 677C-->T polymorphism on toxicity and homocysteine plasma level after chronic methotrexate treatment of ovarian cancer patients.

scientific article published on January 2003

Effect of short- and long-term treatment with omeprazole on cell cycle distribution in the gastric mucosa. Results of a flow cytometric study

scientific article published on 01 July 1993

Enhanced Chemotherapeutic Behavior of Open-Caged DNA@Doxorubicin Nanostructures for Cancer Cells

scientific article published on 29 May 2015

Enzyme-Based Electrochemical Biosensor for Therapeutic Drug Monitoring of Anticancer Drug Irinotecan

scientific article published on 16 April 2018

Estimating the Effectiveness of DPYD Genotyping in Italian Individuals Suffering from Cancer Based on the Cost of Chemotherapy-Induced Toxicity

scientific article published on 30 May 2019

Exceptional Chemotherapy Response in Metastatic Colorectal Cancer Associated With Hyper-Indel-Hypermutated Cancer Genome and Comutation of POLD1 and MLH1

scientific article published on 27 April 2017

Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin

scientific article published on 30 September 2015

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models.

scientific article published on 25 August 2016

Expression of MDR1 and GST-pi in human soft tissue sarcomas: relation to drug resistance and biological aggressiveness

scientific article published on 01 January 1992

Expression of folate binding protein as a prognostic factor for response to platinum-containing chemotherapy and survival in human ovarian cancer ⬇️

scientific article published on April 17, 1998

Expression of glutathione-S-transferase-pi in human tumours.

scientific article published in January 1992

Expression of the mdr1 gene in human colorectal carcinomas: relationship with multidrug resistance inferred from analysis of human colorectal carcinoma cell lines

scientific article published on January 1992

FARMAPRICE: A Pharmacogenetic Clinical Decision Support System for Precise and Cost-Effective Therapy.

scientific article published on 4 April 2019

Fast liquid chromatography-tandem mass spectrometry method for routine assessment of irinotecan metabolic phenotype

scientific article published on October 2010

Field-assisted paper spray mass spectrometry for the quantitative evaluation of imatinib levels in plasma

scientific article

Field-assisted paper spray mass spectrometry for therapeutic drug monitoring: 1. the case of imatinib in plasma

scientific article

Fluorescent carbon nanoparticles in medicine for cancer therapy

scientific article

Fluorescent molecularly imprinted nanogels for the detection of anticancer drugs in human plasma

scientific article published on 26 July 2016

Galectin-10, eosinophils, and celiac disease

scientific article published in September 2009

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study

scientific article published on 20 April 2020

Genetic Variants of the TERT Gene, Telomere Length, and Circulating TERT as Prognostic Markers in Rectal Cancer Patients

scientific article published on 25 October 2020

Genetic biomarkers for hepatocellular cancer risk in a caucasian population.

scientific article published on September 2017

Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy.

scientific article published on 31 January 2014

Genetic markers of the host to predict the efficacy of colorectal cancer targeted therapy

scientific article published on 12 July 2019

Genotype-Guided Dosing Study of FOLFIRI plus Bevacizumab in Patients with Metastatic Colorectal Cancer.

scientific article published on 9 August 2016

Genotype-driven phase I study of irinotecan administered in combination with fluorouracil/leucovorin in patients with metastatic colorectal cancer

scientific article published on 28 December 2009

Germline Polymorphisms in the Nuclear Receptors PXR and VDR as Novel Prognostic Markers in Metastatic Colorectal Cancer Patients Treated With FOLFIRI

scientific article published on 26 November 2019

Germline and Somatic Pharmacogenomics to Refine Rectal Cancer Patients Selection for Neo-Adjuvant Chemoradiotherapy

scientific article published on 17 June 2020

Germline variability and tumor expression level of ribosomal protein gene RPL28 are associated with survival of metastatic colorectal cancer patients

scientific article published on 10 September 2019

Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies

scientific article published on 23 June 2020

HCV inhibits antigen processing and presentation and induces oxidative stress response in gastric mucosa

scientific article published on 21 July 2008

HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia

scientific article published on 9 December 2009

HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment.

scientific article published on 3 December 2015

HLA-G 3'UTR Polymorphisms Predict Drug-Induced G3-4 Toxicity Related to Folinic Acid/5-Fluorouracil/Oxaliplatin (FOLFOX4) Chemotherapy in Non-Metastatic Colorectal Cancer.

scientific article

High throughput screening of genetic polymorphisms by matrix-assisted laser desorption ionization time-of-flight mass spectrometry

scientific article

High-throughput plasma docetaxel quantification by liquid chromatography-tandem mass spectrometry

scientific article published on 12 November 2010

Highly selective salicylketoxime-based estrogen receptor β agonists display antiproliferative activities in a glioma model

scientific article

Homocysteine accumulation in human ovarian carcinoma ascitic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in ovarian carcinoma cells

scientific article published on 01 July 1997

Host genetic profiling to increase drug safety in colorectal cancer from discovery to implementation

scientific article published on 10 July 2018

Hypoxic Modulation of HLA-G Expression through the Metabolic Sensor HIF-1 in Human Cancer Cells

scientific article published on 11 July 2017

Identification and characterization of a new reversible MAGL inhibitor

scientific article

Identification of Novel Somatic TP53 Mutations in Patients with High-Grade Serous Ovarian Cancer (HGSOC) Using Next-Generation Sequencing (NGS).

scientific article published on 18 May 2018

Immune Checkpoint Inhibitors as Monotherapy or Within a Combinatorial Strategy in Advanced Hepatocellular Carcinoma

scientific article published on 31 August 2020

Immunogenetic markers in IL17F predict the risk of metastases spread and overall survival in rectal cancer patients treated with neoadjuvant chemoradiotherapy

scientific article published on 05 May 2020

Immunogenetics of prostate cancer: a still unexplored field of study

scientific article published on 12 January 2018

Impact of DNA repair gene polymorphisms on the risk of biochemical recurrence after radiotherapy and overall survival in prostate cancer

scientific article

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.

scientific article published on 27 December 2016

Improved Doxorubicin Encapsulation and Pharmacokinetics of Ferritin-Fusion Protein Nanocarriers Bearing Proline, Serine, and Alanine Elements

scientific article published on 19 December 2015

Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L.

scientific article published on 10 October 2017

Improving decision making on DPYD and UGT1A1*28 patients' profiling with an innovative reimbursement strategy.

scientific article published on 14 February 2018

In K562 leukemia cells treated with doxorubicin and hemin, a decrease in c-myc mRNA expression correlates with loss of self-renewal capability but not with erythroid differentiation

scientific article

Increased chemosensitivity to doxorubicin of intrinsically multidrug-resistant human colon carcinoma cells by prolonged exposure to verapamil.

scientific article

Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line

scientific article published on August 1996

Inhibition of host immune response in colorectal cancer: human leukocyte antigen-G and beyond.

scientific article published on April 2014

Innovative schedule of oral idarubicin in elderly patients with metastatic breast cancer: comprehensive results of a phase II multi-institutional study with pharmacokinetic drug monitoring

scientific article published on 23 February 2006

Inorganic Nanoparticles for Cancer Therapy: A Transition from Lab to Clinic

scientific article published on 01 January 2018

Interactions of antineoplastic chemotherapy with zidovudine pharmacokinetics in patients with HIV-related neoplasms

scientific article published on 01 November 1999

Irinotecan in the adjuvant treatment of colon cancer: is the story finished or does personalized therapy open new opportunities?

scientific article published on 22 March 2010

Is tailored therapy feasible in oncology?

scientific article

KIR Molecules: Recent Patents of Interest for the Diagnosis and Treatment of Several Autoimmune Diseases, Chronic Inflammation, and B-cell Malignancies ⬇️

scientific article published on 01 December 2011

KIR/HLA Combination Associated with the Risk of Complications in Celiac Disease

scientific article published on 01 October 2011

Label-Free Quantification of Anticancer Drug Imatinib in Human Plasma with Surface Enhanced Raman Spectroscopy

scientific article published in 2018

Lack of association of CYP1 B1*3 polymorphism and ovarian cancer in a Caucasian population.

scientific article published in April 2004

Liquid chromatography tandem mass spectrometry assay for fast and sensitive quantification of estrone-sulfate.

scientific article published on 21 January 2010

Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma

scientific article published on 22 August 2007

MTHFR and ALL risk: a challenge

scientific article published on 01 July 2006

MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF)

scientific article published on 01 March 2000

MTHFR polymorphisms in gastric cancer and in first-degree relatives of patients with gastric cancer.

scientific article

MTHFR-1298 A>C (rs1801131) is a predictor of survival in two cohorts of stage II/III colorectal cancer patients treated with adjuvant fluoropyrimidine chemotherapy with or without oxaliplatin

scientific article published on 21 October 2014

Mass spectrometry in the pharmacokinetic studies of anticancer natural products

scientific article published on 17 August 2015

Matrix-assisted laser desorption/ionization, nanostructure-assisted laser desorption/ionization and carbon nanohorns in the detection of antineoplastic drugs. 1. The cases of irinotecan, sunitinib and 6-alpha-hydroxy paclitaxel

scientific article published on January 2014

Mechanism of multidrug resistance in human tumour cell lines and complete reversion of cellular resistance.

scientific article

Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review

scientific article published on 21 October 2009

Metabolomics biomarkers of frailty in elderly breast cancer patients.

scientific article published in July 2014

Methylenetetrahydrofolate reductase genotype in diffuse large B-cell lymphomas with and without hypermethylation of the DNA repair gene O6-methylguanine DNA methyltransferase

scientific article published in July 2003

Mixed cryoglobulinemia syndrome as an additional autoimmune disorder associated with risk for lymphoma development

scientific article published on 01 June 2008

Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

scientific article published on August 2017

Nanocarriers in cancer clinical practice: a pharmacokinetic issue.

scientific article published on 9 August 2016

New Challenges in Tumor Mutation Heterogeneity in Advanced Ovarian Cancer by a Targeted Next-Generation Sequencing (NGS) Approach

scientific article published on 14 June 2019

New Insight into Therapies Targeting Angiogenesis in Hepatocellular Carcinoma

scientific article published on 31 July 2019

New insights into the pharmacological, immunological, and CAR-T-cell approaches in the treatment of hepatocellular carcinoma

scientific article published on 19 April 2020

New oral drugs in older patients: a review of idarubicin in elderly patients.

scientific article published on February 2004

Non-linear pharmacokinetics of high-dose intravenous verapamil

scientific article published in September 1997

Novel immunotherapeutic approaches for hepatocellular carcinoma treatment

scientific article published on 14 April 2019

Nuclear receptors and drug metabolism for the personalization of cancer therapy

scientific article

Nucleotide excision repair gene variants and association with survival in osteosarcoma patients treated with neoadjuvant chemotherapy.

scientific article

On the possibility of low cost, adherent therapeutic drug monitoring in oncology

Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients

scientific article published on 17 March 2020

Oral etoposide in elderly patients with advanced non small cell lung cancer: a clinical and pharmacological study

scientific article published on 01 April 2006

Overexpression of folate binding protein in ovarian cancers.

scientific article

P-451 HIV-protease inhibitors as antitumoral therapy in advanced NSCLC patients

article

P-glycoprotein but not topoisomerase II and glutathione-S-transferase-pi accounts for enhanced intracellular drug-resistance in LoVo MDR human cell lines

scientific article published on June 30, 1992

P53 overexpression in human soft tissue sarcomas: relation to biological aggressiveness

scientific article published on 01 February 1994

PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage

scientific article

Peptide biosensors for anticancer drugs: Design in silico to work in denaturizing environment

scientific article published on 14 September 2017

Pharmaco-metabolomics: an emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets

scientific article

Pharmacogenetic relevance of MTHFR polymorphisms

scientific article published on September 2008

Pharmacogenetic score predicts overall survival, progression-free survival and platinum sensitivity in ovarian cancer

scientific article published on 08 September 2020

Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients.

scientific article published on 05 September 2016

Pharmacogenetics and stomach cancer: an update.

scientific article published on May 2007

Pharmacogenetics of ABC and SLC transporters in metastatic colorectal cancer patients receiving first-line FOLFIRI treatment.

scientific article published in October 2013

Pharmacogenetics of irinotecan.

scientific article

Pharmacogenetics of the nuclear hormone receptors: the missing link between environment and drug effects?

scientific article published on December 2013

Pharmacogenetics of the systemic treatment in advanced hepatocellular carcinoma

scientific article published on 01 August 2019

Pharmacogenomics and stomach cancer.

scientific article published in September 2004

Pharmacogenomics of Targeted Agents for Personalization of Colorectal Cancer Treatment

scientific article published on 14 July 2017

Pharmacogenomics of intrinsic and acquired pharmacoresistance in colorectal cancer: Toward targeted personalized therapy.

scientific article published on 22 May 2015

Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit

scientific article published on 01 February 1999

Pharmacokinetic comparison of 120-hour infusion versus hyperfractionated oral administration of idarubicin.

scientific article

Pharmacokinetic interaction between etoposide and tamoxifen in patients with hepatocellular carcinoma

scientific article published on 01 October 1999

Pharmacokinetic optimisation of treatment with oral etoposide.

scientific article published on January 2004

Pharmacokinetics of doxorubicin co-administered with high-dose verapamil

scientific article

Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma.

scientific article published in January 1999

Pharmacology of chronic oral daily administration of idarubicin ⬇️

scientific article published on 01 September 1997

Pharmacology of epidermal growth factor inhibitors.

scientific article published in January 2007

Phase I trial of docetaxel, oxaliplatin, and capecitabine (DOC) in untreated gastric cancer patients

scientific article published on 05 June 2012

Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines

scientific article published on January 1991

Polymer-Mediated Delivery of siRNAs to Hepatocellular Carcinoma: Variables Affecting Specificity and Effectiveness

scientific article published on 28 March 2018

Polymorphic thymidylate synthase gene impacts on overall survival of patients with epithelial ovarian cancer after platinum-based chemotherapy

scientific article published on 01 November 2012

Population pharmacokinetics and pharmacodynamics of oral etoposide

scientific article

Potential hazard drug-drug interaction between boosted protease inhibitors and vinblastine in HIV patients with Hodgkin's lymphoma.

scientific article published in March 2013

Potential hazard of pharmacokinetic interactions between lopinavir-ritonavir protease inhibitors and irinotecan

article published in 2005

Practical fluorimetric assay for the detection of anticancer drug SN-38 in human plasma

scientific article published on 21 June 2018

Predictive role of microRNA-related genetic polymorphisms in the pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

scientific article published on 26 February 2016

Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan.

scientific article

Pregnane X receptor, constitutive androstane receptor and hepatocyte nuclear factors as emerging players in cancer precision medicine.

scientific article

Prevalence of Methylenetetrahydrofolate Reductase Polymorphisms in Young Patients with Inflammatory Bowel Disease

scientific article published on 01 March 2006

Prognostic Role of Serum Antibody Immunity to p53 Oncogenic Protein in Ovarian Cancer: A Systematic Review and a Meta-Analysis

scientific article

Proof-of-Concept Multistage Biomimetic Liposomal DNA Origami Nanosystem for the Remote Loading of Doxorubicin

scientific article published on 31 January 2019

Radiation treatment of glottic squamous cell carcinoma, stage I and II: analysis of factors affecting prognosis

scientific article published on 01 February 1998

Rapid and sensitive analysis of vincristine in human plasma using on-line extraction combined with liquid chromatography/tandem mass spectrometry

scientific article

Recent patents relating to HCV molecules like putative targets for therapeutic intervention.

scientific article published on January 2007

Recent prognostic factors in diffuse large B-cell lymphoma indicate NF-kappaB pathway as a target for new therapeutic strategies.

scientific article

Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens.

scientific article published on 05 February 2013

Research Highlights

Research highlights. Overcoming BRAF resistance to PLX4032 by AKT inhibition in PTEN-deficient melanoma cells

Research highlights. PI3K/AKT/mTOR inhibitors would require PI3KCA-mutation analysis

Research highlights. Protein kinase D3 is the genetic sensitizer of RAF inhibitor RAF265 in melanoma cells

Resistance to methotrexate in SKOV-3 cell lines after chronic exposure to carbamazepine is associated with a decreased expression of folate receptor

scientific article

Reversal activity of cyclosporin A and its metabolites M1, M17 and M21 in multidrug-resistant cells

scientific article published on 01 May 1997

Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells ⬇️

scientific article published on January 5, 1998

Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).

scientific article published on 16 December 2010

SERRS multiplexing with multivalent nanostructures for the identification and enumeration of epithelial and mesenchymal cells

scientific article published on 25 September 2020

SNCA 3'UTR genetic variants in patients with Parkinson's disease and REM sleep behavior disorder

scientific article published on 13 April 2017

Safe core-satellite magneto-plasmonic nanostructures for efficient targeting and photothermal treatment of tumor cells

scientific article

Sarcomas and pharmacogenetics

scientific article

Sensitivity pattern of normal and Ha-ras transformed NIH3T3 fibroblasts to antineoplastic drugs

scientific article published in October 1989

Soluble HLA-G expression levels and HLA-G/irinotecan association in metastatic colorectal cancer treated with irinotecan-based strategy

scientific article published on 29 May 2020

Standard fluoropyrimidine dosages in chemoradiation therapy result in an increased risk of severe toxicity in DPYD variant allele carriers

article

Strategies to optimize siRNA delivery to hepatocellular carcinoma cells.

scientific article published on 17 February 2017

Structure-activity relationship of verapamil analogs and reversal of multidrug resistance.

scientific article

Surface-enhanced Raman spectroscopy of the anti-cancer drug irinotecan in presence of human serum albumin

scientific article published on 22 January 2015

Tailored therapy of colorectal cancer: results, challenges and future directions

scientific article

The Clinical translation of Organic Nanomaterials for Cancer Therapy: A Focus on Polymeric Nanoparticles, Micelles, Liposomes and Exosomes.

scientific article published on 29 August 2017

The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target

scientific article published on 24 February 2020

The International HIV Dementia Scale: a new rapid screening test for HIV dementia

scientific article published on September 2005

The Role of UGT1A1*28 Polymorphism in the Pharmacodynamics and Pharmacokinetics of Irinotecan in Patients With Metastatic Colorectal Cancer

scientific article published on 01 July 2006

The development of a matrix-assisted laser desorption/ionization (MALDI)-based analytical method for determination of irinotecan levels in human plasma: preliminary results

scientific article published on 01 July 2015

The effect of the UGT1A1*28 allele on survival after irinotecan-based chemotherapy: a collaborative meta-analysis

scientific article published on 08 April 2014

The genotype for DPYD risk variants in colorectal cancer patients and the related toxicity management costs in clinical practice

article

The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer

scientific article

Thymidylate synthetase mRNA levels are increased in liver metastases of colorectal cancer patients resistant to fluoropyrimidine-based chemotherapy

scientific article

Topoisomerase I inhibitors combination chemotherapy in non-small cell lung cancer

scientific article

Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy

scientific article published on 06 April 2010

Two-dimensional gel proteome reference map of human small intestine

scientific article published on 19 March 2009

UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population

scientific article published on 12 March 2017

UGT1A1*28 and other UGT1A polymorphisms as determinants of irinotecan toxicity.

scientific article published on April 2008

Ubiquitous Pharmacogenomics (U-PGx): The time for implementation is now. An Horizon2020 program to drive pharmacogenomics into clinical practice

scientific article published on 02 January 2017

Uridine diphosphoglucuronosyl transferase and methylenetetrahydrofolate reductase polymorphisms as genomic predictors of toxicity and response to irinotecan-, antifolate- and fluoropyrimidine-based chemotherapy.

scientific article

c-myc overexpression is a tumor-specific phenomenon in a subset of human colorectal carcinomas

scientific article published on January 1990

miRNA Pharmacogenomics: The New Frontier for Personalized Medicine in Cancer? ⬇️

scientific article published on November 1, 2012

pRb controls estrogen receptor alpha protein stability and activity.

scientific article published on June 2013

rs4143815-PDL1, a New Potential Immunogenetic Biomarker of Biochemical Recurrence in Locally Advanced Prostate Cancer after Radiotherapy.

scientific article published on 27 April 2019

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