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List of works by F. Peter Guengerich

14 Expression of mammalian cytochrome P450 enzymes using yeast-based vectors

scientific article published on 01 January 1991

16 Production and application of antibodies to rat liver cytochrome P-450

scientific article published on 01 January 1981

20-Hydroxyeicosatetraenoic Acid (HETE)-dependent Hypertension in Human Cytochrome P450 (CYP) 4A11 Transgenic Mice: NORMALIZATION OF BLOOD PRESSURE BY SODIUM RESTRICTION, HYDROCHLOROTHIAZIDE, OR BLOCKADE OF THE TYPE 1 ANGIOTENSIN II RECEPTOR.

scientific article published on 13 June 2016

7-Ethoxycoumarin O-deethylation catalyzed by cytochromes P450 1A2 and 2E1 in human liver microsomes

scientific article

7-Ketocholesterol induces P-glycoprotein through PI3K/mTOR signaling in hepatoma cells

scientific article

A Role for the Orphan Human Cytochrome P450 2S1 in Polyunsaturated Fatty Acid ω-1 Hydroxylation Using an Untargeted Metabolomic Approach

scientific article published on 11 September 2019

A comparison of levels of glutathione transferases, cytochromes P450 and acetyltransferases in human livers

scientific article published on 01 February 1991

A history of the roles of cytochrome P450 enzymes in the toxicity of drugs

scientific article published on 18 August 2020

A new Salmonella typhimurium NM5004 strain expressing rat glutathione S-transferase 5-5: use in detection of genotoxicity of dihaloalkanes using an SOS/umu test system

scientific article published in February 1996

A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis

scientific article published on 03 June 2020

Activation and detoxication of aflatoxin B1

scientific journal article

Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains

scientific article published on 25 October 2006

Activation of bis-electrophiles to mutagenic conjugates by human O6-alkylguanine-DNA alkyltransferase

scientific article published in July 2004

Activation of carcinogens by human liver cytochromes P-450.

scientific article published on January 1990

Activation of procarcinogens by human cytochrome P450 enzymes ⬇️

scientific article published on May 25, 1998

Activation of toxic chemicals by cytochrome P450 enzymes: regio- and stereoselective oxidation of aflatoxin B1.

scientific article published on January 1996

Adduct size limits efficient and error-free bypass across bulky N2-guanine DNA lesions by human DNA polymerase eta.

scientific article

Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase

scientific article published on 25 February 2004

Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases

scientific article published in November 2003

Aryl hydrocarbon receptor response to indigoids in vitro and in vivo

scientific article published on March 2004

Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry.

scientific article published on 27 July 2016

Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA

scientific article published on 01 January 2018

Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51

scientific article published in Journal of Biological Chemistry

Binding of diverse environmental chemicals with human cytochromes P450 2A13, 2A6, and 1B1 and enzyme inhibition

scientific article

Binding of two flaviolin substrate molecules, oxidative coupling, and crystal structure of Streptomyces coelicolor A3(2) cytochrome P450 158A2

scientific journal article

Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1.

scientific article

Biochemical analysis of six genetic variants of error-prone human DNA polymerase ι involved in translesion DNA synthesis

scientific article

Biochemical basis of genotoxicity of heterocyclic arylamine food mutagens: Human DNA polymerase eta selectively produces a two-base deletion in copying the N2-guanyl adduct of 2-amino-3-methylimidazo[4,5-f]quinoline but not the C8 adduct at the NarI

scientific article

Biochemical characterization of eight genetic variants of human DNA polymerase κ involved in error-free bypass across bulky N(2)-guanyl DNA adducts.

scientific article

CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes

scientific article published on January 2013

Calcium is a cofactor of polymerization but inhibits pyrophosphorolysis by the Sulfolobus solfataricus DNA polymerase Dpo4

scientific article published on 01 May 2006

Carcinogenesis of urethane: simulation versus experiment

scientific article published on 16 February 2015

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

scientific article

Catalytic properties of polymorphic human cytochrome P450 1B1 variants

scientific article published in August 1999

Celebrating the scientific legacy of Herbert Tabor

scientific article published on 01 February 2019

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase

scientific article

Chemical reactivity as a tool to study carcinogenicity: reaction between chloroethylene oxide and guanine.

scientific article

Chromatographic assays of drug oxidation by human cytochrome P450 3A4

scientific article published on 6 August 2009

Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

scholarly article

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology.

scientific article published on 23 June 2016

Comparative metabolism of 1-, 2-, and 4-nitropyrene by human hepatic and pulmonary microsomes

scientific article published on 01 April 1999

Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses

scientific article

Comparison of the inhibitory profiles of itraconazole and cimetidine in cytochrome P450 3A4 genetic variants

scientific article (publication date: April 2011)

Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes ⬇️

scientific article published on 01 August 1983

Composition of cytochrome P-450 isozymes from hepatic microsomes of C57BL/6 and DBA/2 mice assessed by warfarin metabolism, immunoinhibition, and immunoelectrophoresis with anti-(rat cytochrome P-450)

scientific article published on 01 May 1984

Conformational changes during nucleotide selection by Sulfolobus solfataricus DNA polymerase Dpo4.

scientific article published on 10 June 2009

Conformational selection dominates binding of steroids to human cytochrome P450 17A1

scientific article published on 09 May 2019

Conjugation of Butadiene Diepoxide with Glutathione Yields DNA Adducts in Vitro and in Vivo ⬇️

scientific article published on January 9, 2012

Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4′-methylene-bis(2-chloroaniline) ⬇️

scientific article published on February 1, 1992

Conversion of 7-Dehydrocholesterol to 7-Ketocholesterol Is Catalyzed by Human Cytochrome P450 7A1 and Occurs by Direct Oxidation without an Epoxide Intermediate ⬇️

scientific article published on 03 August 2011

Cooperativity in oxidation reactions catalyzed by cytochrome P450 1A2: highly cooperative pyrene hydroxylation and multiphasic kinetics of ligand binding

scientific article

Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene

scientific article published on 29 February 2008

Correction: Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

scientific article published on 01 October 2019

Cyclization of a cellular dipentaenone by Streptomyces coelicolor cytochrome P450 154A1 without oxidation/reduction ⬇️

scientific article published on November 3, 2010

Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

scientific article

Cytochrome P-450 isozyme/isozyme functional interactions and NADPH-cytochrome P-450 reductase concentrations as factors in microsomal metabolism of warfarin

scientific article published on 01 June 1985

Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids

scientific article published in Journal of Biological Chemistry

Cytochrome P450 107U1 is required for sporulation and antibiotic production in Streptomyces coelicolor

scientific article published on 25 January 2013

Cytochrome P450 1B1 (CYP1B1) pharmacogenetics: association of polymorphisms with functional differences in estrogen hydroxylation activity

scientific article published on 01 July 2000

Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies

scientific article

Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone.

scientific article

Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes

scientific article published on October 1, 1992

Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase ⬇️

scientific article published on March 23, 2011

Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis

scientific article

Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics

scientific article published on 01 July 1993

Cytochrome P450 research and The Journal of Biological Chemistry

scientific article published on 01 February 2019

Cytochromes P450 and drug discovery

scientific article

D-amino acid oxidase generates agonists of the aryl hydrocarbon receptor from D-tryptophan

scientific article

Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 by phenobarbital and other xenobiotics in the rat

scientific article published on 01 April 1985

Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).

scientific article published in November 2003

Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone

scientific article published on 31 July 2008

Destruction of highly purified cytochromes P-450 associated with metabolism of fluorinated ether anesthetics

scientific article published in December 1981

Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase

scientific article

Development of a mass spectrometric assay for 5,6,7,9-tetrahydro-7-hydroxy-9-oximidazo[1,2-alpha] purine in DNA modified by 2-chloro-oxirane

scientific article published on 01 January 1996

Development of a new genotoxicity test system with Salmonella typhimurium OY1001/1A2 expressing human CYP1A2 and NADPH-P450 reductase

scientific article published in June 1999

Differences in the functional interaction of two purified cytochrome P-450 isozymes with epoxide hydrolase

scientific article published on 01 June 1981

Different Mechanisms for Inhibition of Human Cytochromes P450 1A1, 1A2, and 1B1 by Polycyclic Aromatic Inhibitors

scientific article published on 10 February 2007

Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples ⬇️

scientific article published on 01 November 1997

Different patterns of benzo[a]pyrene metabolism of purified cytochromes P-450 from methylcholanthrene, β-naphthoflavone and phenobarbital treated rats ⬇️

scientific article published on 01 January 1982

Differential DNA recognition and cleavage by EcoRI dependent on the dynamic equilibrium between the two forms of the malondialdehyde-deoxyguanosine adduct

scientific article

Differential inhibition of individual human liver cytochromes P-450 by cimetidine

scientific article published on 01 December 1991

Direct detection and mapping of sites of base modification in DNA fragments by tandem mass spectrometry

scientific article published on 01 January 2008

Diterpene quinone tanshinone IIA selectively inhibits mouse and human cytochrome p4501A2.

scientific article

Drug Metabolism and Toxicology Special Issue Call for Papers

scientific article published on 11 January 2019

Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A5

scientific article

Effect of suicide substrate on the metabolism of steroids and xenobiotics and on cytochrome P-450 apoproteins

scientific article published on 01 January 1986

Effects of N2-Alkylguanine, O6-Alkylguanine, and Abasic Lesions on DNA Binding and Bypass Synthesis by the Euryarchaeal B-Family DNA Polymerase Vent (exo–) ⬇️

scientific article published on July 31, 2012

Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.

scientific article published on 25 February 2016

Effects of acetone administration on cytochrome P-450-dependent monooxygenases in hamster liver, kidney, and lung

scientific article published on 01 January 1991

Effects of motorcycle exhaust on cytochrome P-450-dependent monooxygenases and glutathione S-transferase in rat tissues ⬇️

scientific article published on 01 August 1998

Efficient and high fidelity incorporation of dCTP opposite 7,8-dihydro-8-oxodeoxyguanosine by Sulfolobus solfataricus DNA polymerase Dpo4.

scientific article

Electron transport pathway for a Streptomyces cytochrome P450: cytochrome P450 105D5-catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2).

scientific article published on 19 April 2007

Elucidation of catalytic specificities of human cytochrome P450 and glutathione S-transferase enzymes and relevance to molecular epidemiology ⬇️

scientific article published on November 1, 1992

Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications

scientific article published on 06 December 2019

Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding

scientific article published in December 2004

Ethnic-related differences in coumarin 7-hydroxylation activities catalyzed by cytochrome P4502A6 in liver microsomes of Japanese and Caucasian populations

scientific article published on 01 April 1996

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

scientific article

Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.

scientific article published on March 2005

Exploiting Streptomyces coelicolor A3(2) P450s as a model for application in drug discovery

scientific article published on February 2006

Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide

scientific article published on July 2008

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

scientific article published on 01 March 1995

Expression of cytochrome P450 2D6 in Escherichia coli, purification, and spectral and catalytic characterization

scientific article published on 01 June 1995

Expression of human cytochrome P450 2B6 in Escherichia coli: characterization of catalytic activity and expression levels in human liver

scientific article published on 01 April 2000

Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity.

scientific article

Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes

scientific article published on September 1993

Expression of modified human cytochrome P450 1A1 in Escherichia coli: effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties

scientific article published on 01 August 1994

Expression of modified human cytochrome P450 2E1 in Escherichia coli, purification, and spectral and catalytic properties.

scientific article

Fluorescence in situ hybridization analysis of chromosomal localization of three human cytochrome P450 2C genes (CYP2C8, 2C9, and 2C10) at 10q24.1

scientific article

Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions

scientific article published on 22 June 2018

Formation and mass spectrometric analysis of DNA and nucleoside adducts by S-(1-acetoxymethyl)glutathione and by glutathione S-transferase-mediated activation of dihalomethanes

scientific article

Formation and reduction of aryl and heterocyclic nitroso compounds and significance in the flux of hydroxylamines

scientific article published in April 2004

Formation of 1,N2- and N2,3-ethenoguanine from 2-halooxiranes: isotopic labeling studies and isolation of a hemiaminal derivative of N2-(2-oxoethyl)guanine

scientific article published on 01 September 1993

Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases

scientific article

Formation of the DNA adduct S-[2-(N7-guanyl)ethyl]glutathione from ethylene dibromide: effects of modulation of glutathione and glutathione S-transferase levels and lack of a role for sulfation

scientific article published on 01 March 1990

Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures

scientific article published in January 2007

Frameshift deletion by Sulfolobus solfataricus P2 DNA polymerase Dpo4 T239W is selective for purines and involves normal conformational change followed by slow phosphodiester bond formation

scientific article published on 16 October 2009

Function of human cytochrome P450s: characterization of the orphans

scientific article

Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.

scientific article published on 24 May 2017

Functional characterization of four allelic variants of human cytochrome P450 1A2.

scientific article

Glutamine-451 Confers Sensitivity to Oxidative Inhibition and Heme-Thiolate Sulfenylation of Cytochrome P450 4B1

scientific article published on 11 February 2019

Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations

scientific article published on 13 July 2007

Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.

scientific article published on 22 May 2017

Heterologous expression, purification, and properties of human cytochrome P450 27C1.

scientific article published on 28 November 2005

High rates of substrate hydroxylation by human cytochrome P450 3A4 in reconstituted membranous vesicles: influence of membrane charge

scientific article published on 01 April 1996

High-throughput fluorescence assay of cytochrome P450 3A4.

scientific article

Human DNA polymerase η accommodates RNA for strand extension

scientific article published on 26 September 2017

Human DNA polymerase η has reverse transcriptase activity in cellular environments

scientific article published on 06 March 2019

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

scientific article

Human cytochrome P450 11B2 produces aldosterone by a processive mechanism due to the lactol form of the intermediate 18-hydroxycorticosterone

scientific article published on 11 July 2019

Human cytochrome P450 4F11: heterologous expression in bacteria, purification, and characterization of catalytic function

scientific article published on 20 November 2009

Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

scientific article published on 30 May 2019

Human cytochrome P450 oxidation of 5-hydroxythalidomide and pomalidomide, an amino analogue of thalidomide

scientific article published on 24 December 2013

Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

scientific article published on January 1996

Human liver debrisoquine 4-hydroxylase: test for specificity toward various monooxygenase substrates and model of the active site

scientific article published on 01 January 1987

Human liver mephenytoin 4'-hydroxylase cytochrome P-450 proteins and genes

scientific article

Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction

scientific article published on 01 January 1986

Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate

scientific article published on June 2010

Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturates trans-retinol to 3,4-dehydroretinol

scientific article published on 12 July 2017

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

scientific article published on 16 June 2016

Identification and quantitation of a 2.0-kilobase messenger ribonucleic acid coding for 3-methylcholanthrene-induced cytochrome P-450 using cloned cytochrome P-450 complementary deoxyribonucleic acid

scientific article published on 01 December 1982

Identification of genetic variants of human cytochrome P450 2D6 with impaired mitochondrial targeting

scientific article published on January 2010

Identification of rat and human cytochrome P450 forms involved in the metabolism of the thromboxane A2 receptor antagonist (+)-S-145.

scientific article published in January 1997

Impact of 1,N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair

scientific article published on 25 March 2020

In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

scientific article published on 03 November 2019

In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1.

scientific article published on September 2010

In vitro cytochrome P450 46A1 (CYP46A1) activation by neuroactive compounds

scientific article published on 22 June 2017

In vitro inhibition of dihydropyridine oxidation and aflatoxin B1 activation in human liver microsomes by naringenin and other flavonoids

scientific article

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

scientific article

In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice

scientific article published on 7 February 2011

In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice.

scientific article

Induction and inhibition of cytochrome P-450-dependent monooxygenases in hamster tissues by ethanol

scientific article published on 01 July 1993

Induction and suppression of renal and hepatic cytochrome P450-dependent monooxygenases by acute and chronic streptozotocin diabetes in hamsters

scientific article published on 01 January 1996

Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity

scientific article published in January 2017

Induction of rat liver GSH transferases by 1,2-dithiole-3-thione illustrates both anticarcinogenic and tumor-promoting properties

scientific article published on 01 January 1993

Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.

scientific article published on 6 December 2017

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study

scientific article published on 01 July 1998

Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons

Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane

scientific article

Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors

scientific article published on January 2009

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity

scientific article published on December 2008

Interactions of ingested food, beverage, and tobacco components involving human cytochrome P4501A2, 2A6, 2E1, and 3A4 enzymes ⬇️

scientific article published on November 1, 1994

Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes

scientific article

Interpretations of cytochrome P450 mechanisms from kinetic studies

scientific article published on 01 January 1995

Introduction to Metals in Biology 2017: Iron transport, storage, and the ramifications.

scientific article published on 14 June 2017

Introduction: Drug Metabolism and Toxicology Special Issue

scientific article published on 02 June 2020

Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer

scientific article published on May 1996

Isotope-Labeling Studies Support the Electrophilic Compound I Iron Active Species, FeO(3+), for the Carbon-Carbon Bond Cleavage Reaction of the Cholesterol Side-Chain Cleavage Enzyme, Cytochrome P450 11A1

scientific article published on 29 August 2016

Isotopic tagging of oxidized and reduced cysteines (iTORC) for detecting and quantifying sulfenic acids, disulfides, and free thiols in cells

scientific article published on 08 March 2019

Kinetic Modeling of Steady-State Situations in Cytochrome P450 Enzyme Reactions

scientific article published on 19 August 2019

Kinetic analysis of correct nucleotide insertion by a Y-family DNA polymerase reveals conformational changes both prior to and following phosphodiester bond formation as detected by tryptophan fluorescence

scientific article published on 4 November 2008

Kinetic analysis of steps in the repair of damaged DNA by human O6-alkylguanine-DNA alkyltransferase

scientific article

Kinetic analysis of the three-step steroid aromatase reaction of human cytochrome P450 19A1.

scientific article

Kinetic analysis of translesion synthesis opposite bulky N2- and O6-alkylguanine DNA adducts by human DNA polymerase REV1.

scientific article

Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase ι.

scientific article

Kinetic evidence for inefficient and error-prone bypass across bulky N2-guanine DNA adducts by human DNA polymerase iota

scientific article published on 08 March 2006

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1.

scientific article

Kinetics of Ferric Cytochrome P450 Reduction by NADPH−Cytochrome P450 Reductase: Rapid Reduction in the Absence of Substrate and Variations among Cytochrome P450 Systems ⬇️

scientific article published on December 2, 1997

Kinetics of nucleotide incorporation opposite DNA bulky guanine N2 adducts by processive bacteriophage T7 DNA polymerase (exonuclease-) and HIV-1 reverse transcriptase

scientific article published on 8 November 2004

Kinetics of nucleotide incorporation opposite polycyclic aromatic hydrocarbon-DNA adducts by processive bacteriophage T7 DNA polymerase

scientific article

Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2´-, 3´-, 4´-, and 6-hydroxyflavanones by human cytochrome P450 enzymes

scientific article published on 13 October 2020

Low frequency of CYP2A6 gene polymorphism as revealed by a one-step polymerase chain reaction method

scientific article published in June 1999

Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase

scientific article published on 6 August 2009

Mechanism of 17α,20-Lyase and New Hydroxylation Reactions of Human Cytochrome P450 17A1: 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.

scientific article published on 23 June 2016

Mechanism of 17α,20-lyase and new hydroxylation reactions of human cytochrome P450 17A1. 18O LABELING AND OXYGEN SURROGATE EVIDENCE FOR A ROLE OF A PERFERRYL OXYGEN.

scientific article published on December 2016

Mechanism of C8 alkylation of guanine residues by activated arylamines: evidence for initial adduct formation at the N7 position ⬇️

scientific article published on September 1, 1992

Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde

scientific article published on 01 March 1994

Mechanism of the third oxidative step in the conversion of androgens to estrogens by cytochrome P450 19A1 steroid aromatase

scientific article

Mechanism-based inhibition profiles of erythromycin and clarithromycin with cytochrome P450 3A4 genetic variants.

scientific article published on 19 March 2013

Mechanisms of hydroxylation by cytochrome P-450: exchange of iron-oxygen intermediates with water

scientific article published on 01 January 1982

Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage ⬇️

scientific article published on September 26, 2010

Metabolic activation of carcinogenic 1-nitropyrene by human cytochrome P450 1B1 in Salmonella typhimurium strain expressing an O-acetyltransferase in SOS/umu assay

scientific article published in October 2001

Metabolic activation of polycyclic aromatic hydrocarbons and aryl and heterocyclic amines by human cytochromes P450 2A13 and 2A6.

scientific article published on 13 March 2013

Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.

scientific article

Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by mitochondrion-targeted cytochrome P450 2D6: implications in Parkinson disease

scientific article published on 20 December 2012

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by human cytochrome P450 1A2 and its inhibition by phenethyl isothiocyanate.

scientific article

Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells ⬇️

scientific article published on April 1, 1992

Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes

scientific article published on 01 January 1996

Metabolism of benzo[a]pyrene to trans-7,8-dihydroxy-7, 8-dihydrobenzo[a]pyrene by recombinant human cytochrome P450 1B1 and purified liver epoxide hydrolase.

scientific article published in July 1999

Metabolism of dichlorobiphenyls by highly purified isozymes of rat liver cytochrome P-450

scientific article published on 01 December 1981

Metabolism of the food mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in human hepatocytes

scientific article published in January 2001

Metabolomic analysis and identification of a role for the orphan human cytochrome P450 2W1 in selective oxidation of lysophospholipids ⬇️

scientific article published on May 16, 2012

Misincorporation of dNTPs opposite 1,N2-ethenoguanine and 5,6,7,9-tetrahydro-7-hydroxy-9-oxoimidazo[1,2-a]purine in oligonucleotides by Escherichia coli polymerases I exo- and II exo-, T7 polymerase exo-, human immunodeficiency virus-1 reverse trans

scientific article published in May 1997

Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction

scientific article published on 04 February 2014

Mitochondrially targeted cytochrome P450 2D6 is involved in monomethylamine-induced neuronal damage in mouse models

scientific article published on 20 May 2019

Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA.

scientific article published in April 2005

Modulation of the structure, catalytic activity, and fidelity of African swine fever virus DNA polymerase X by a reversible disulfide switch.

scientific article published on 05 May 2009

Multi-step oxidations catalyzed by cytochrome P450 enzymes: Processive vs. distributive kinetics and the issue of carbonyl oxidation in chemical mechanisms

scientific article published on 04 September 2010

Multistep Binding of the Non-Steroidal Inhibitors Orteronel and Seviteronel to Human Cytochrome P450 17A1 and Relevance to Inhibition of Enzyme Activity

scientific article published on 09 April 2020

Mutagenicity of a glutathione conjugate of butadiene diepoxide

scientific article published on 29 September 2010

Mutation Spectra of S-(2-Hydroxy-3,4-epoxybutyl)glutathione: Comparison with 1,3-Butadiene and Its Metabolites in the Escherichia coli rpoB Gene ⬇️

scientific article published on June 15, 2012

N-nitroso-N-methylvinylamine: reaction of the epoxide with guanyl and adenyl moieties to yield adducts derived from both parts of the molecule

scientific article published on 01 March 1993

On ‘Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions’ by Alfred Hildebrandt and Ronald W. Estabrook

scientific article published in 2022

Organic solvents as modifiers of aldrin epoxidase in reconstituted monooxygenase systems and in microsomes

scientific article published on 01 December 1989

Oxidation kinetics of ethanol by human cytochrome P450 2E1. Rate-limiting product release accounts for effects of isotopic hydrogen substitution and cytochrome b5 on steady-state kinetics

scientific article published on 01 November 1997

Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants.

scientific article published on 21 July 2017

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.

scientific article

Oxidation of Acenaphthene and Acenaphthylene by Human Cytochrome P450 Enzymes

scientific article published on 02 February 2015

Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes

scientific article published on 17 April 2019

Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps

scientific article

Oxidation of benzo[a]pyrene by recombinant human cytochrome P450 enzymes

scientific article published on 01 January 1995

Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.

scientific article

Oxidation of endogenous N-arachidonoylserotonin by human cytochrome P450 2U1.

scientific article

Oxidation of methyl and ethyl nitrosamines by cytochrome P450 2E1 and 2B1

scientific article

Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13

scientific article published on 6 August 2015

Oxidation of the angiotensin II receptor antagonist losartan (DuP 753) in human liver microsomes. Role of cytochrome P4503A(4) in formation of the active metabolite EXP3174

scientific article published on 01 February 1995

Oxidation of troglitazone to a quinone-type metabolite catalyzed by cytochrome P-450 2C8 and P-450 3A4 in human liver microsomes

scientific article

Oxidation of xenobiotics by recombinant human cytochrome P450 1B1.

scientific article

Paradoxical enhancement of the toxicity of 1,2-dibromoethane by O6-alkylguanine-DNA alkyltransferase

scientific article

Polymorphism of human cytochrome P-450.

scientific article published on March 1987

Preference for O-demethylation reactions in the oxidation of 2´-, 3´-, and 4´-methoxyflavones by human cytochrome P450 enzymes

scientific article published on 21 April 2020

Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes

scientific article published in September 1995

Purification and characterization of liver microsomal cytochromes p-450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone

scientific article published on 01 November 1982

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

scientific article published on 01 June 1984

Purification of cytochrome P-450, NADPH-cytochrome P-450 reductase, and epoxide hydratase from a single preparation of rat liver microsomes

scientific article published on 01 December 1980

Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products

scientific article

Rat liver cytochrome P-450 isozymes as catalysts of aldrin epoxidation in reconstituted monooxygenase systems and microsomes

scientific article published on 01 August 1987

Reaction of aflatoxin B(1) oxidation products with lysine

scientific journal article

Reaction of aflatoxin B1 exo-8,9-epoxide with DNA: kinetic analysis of covalent binding and DNA-induced hydrolysis

scientific article

Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1

scientific article

Recombinant human cytochrome P450 1B1 expression in Escherichia coli

scientific article published on 01 September 1998

Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: effects of cytochrome P450-P450 and cytochrome P450-b5 interactions.

scientific article

Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations

scientific article published on April 1997

Replication past the N5-methyl-formamidopyrimidine lesion of deoxyguanosine by DNA polymerases and an improved procedure for sequence analysis of in vitro bypass products by mass spectrometry

scientific article published on June 2009

Replication past the butadiene diepoxide-derived DNA adduct S-[4-(N(6)-deoxyadenosinyl)-2,3-dihydroxybutyl]glutathione by DNA polymerases

scientific article

Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine

scientific article

Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes

scientific article published on 01 July 1996

Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study

scientific article published on July 2009

Role of active site water molecules and substrate hydroxyl groups in oxygen activation by cytochrome P450 158A2: a new mechanism of proton transfer

scientific article

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

scientific article

Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects

scientific article (publication date: 1991)

Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl

scientific article published on 13 September 2016

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli

scientific article published in April 2002

Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P450 1B1 variants in Escherichia coli.

scientific article

Roles of human hepatic and pulmonary cytochrome P450 enzymes in the metabolism of the environmental carcinogen 6-nitrochrysene

scientific article published on 01 May 1993

Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons

scientific article (publication date: 15 November 1989)

Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions

scientific article published in 2022

Roles of the Four DNA Polymerases of the Crenarchaeon Sulfolobus solfataricus and Accessory Proteins in DNA Replication ⬇️

scientific article published on July 22, 2011

Roles of the four DNA polymerases of the crenarchaeon and accessory proteins in DNA replication

scientific article published in 2011

Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

article

Similarities and differences in the regulation of hepatic cytochrome P-450 enzymes by diabetes and fasting in male rats

scientific article published in October 1989

Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice.

scientific article

Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes

scientific article published on 28 September 2018

Six Germline Genetic Variations Impair the Translesion Synthesis Activity of Human DNA Polymerase κ.

scientific article published on 7 September 2016

Specificity of 17beta-oestradiol and benzo[a]pyrene oxidation by polymorphic human cytochrome P4501B1 variants substituted at residues 48, 119 and 432.

scientific article published in March 2001

Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells ⬇️

scientific article

Spectral Modification and Catalytic Inhibition of Human Cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by Four Chemopreventive Organoselenium Compounds ⬇️

scientific article published on July 20, 2011

Spectroscopic and thermodynamic characterization of the interaction of N7-guanyl thioether derivatives of d(TGCTG*CAAG) with potential complements

scientific article published on 01 November 1994

Steric and electrostatic effects at the C2 atom substituent influence replication and miscoding of the DNA deamination product deoxyxanthosine and analogs by DNA polymerases

scientific article published on 14 July 2009

Sterol 14α-Demethylase Structure-Based Design of VNI (( R)- N-(1-(2,4-Dichlorophenyl)-2-(1 H-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallogr

scientific article published on 25 June 2018

Sterol 14α-Demethylase Structure-Based Optimization of Drug Candidates for Human Infections with the Protozoan Trypanosomatidae

scientific article published on 30 November 2018

Stimulation of cytochrome P450 reactions by apo-cytochrome b5: evidence against transfer of heme from cytochrome P450 3A4 to apo-cytochrome b5 or heme oxygenase

scientific article published on 18 June 2001

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

scientific article published on 3 March 2017

Structural identification of Diindole agonists of the aryl hydrocarbon receptor derived from degradation of indole-3-pyruvic acid

scientific article published on December 2009

Structure and function of cytochrome P-450.

scientific article published in January 1986

Structure of the aflatoxin B(1) dialdehyde adduct formed from reaction with methylamine

scientific article

Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6.

scientific article published on 3 May 2016

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

scientific article

Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives

scientific article published on December 2010

Sulfenylation of Human Liver and Kidney Microsomal Cytochromes P450 and Other Drug Metabolizing Enzymes as a Response to Redox Alteration.

scientific article published on 26 January 2018

Sulfolobus solfataricus DNA polymerase Dpo4 is partially inhibited by "wobble" pairing between O6-methylguanine and cytosine, but accurate bypass is preferred

scientific article published on 14 November 2006

Synthesis and Characterization of Site-Specific O6 -Alkylguanine DNA-Alkyl Transferase-Oligonucleotide Crosslinks

scientific article published on 18 January 2019

Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments

scientific article published on July 2009

Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction

scientific article

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

scientific article published on 5 February 2014

The Cytochrome P450 Slow Metabolizers CYP2C9*2 and CYP2C9*3 Directly Regulate Tumorigenesis via Reduced Epoxyeicosatrienoic Acid Production

scientific article published on 16 July 2018

The Dihydroxy Metabolite of the Teratogen Thalidomide Causes Oxidative DNA Damage.

scientific article published on 26 July 2017

The abundant DNA adduct N 7-methyl deoxyguanosine contributes to miscoding during replication by human DNA polymerase η

scientific article published on 17 May 2019

The alkaloid rutaecarpine is a selective inhibitor of cytochrome P450 1A in mouse and human liver microsomes

scientific article published in March 2002

The safety evaluation of food flavouring substances: the role of metabolic studies

scientific article published on 28 March 2018

Three Human Pol ι Variants with Impaired Polymerase Activity Fail to Rescue H2O2 Sensitivity in POLI-Deficient Cells

scientific article published on 08 July 2020

Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

scientific article

Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase

scientific article published on 30 October 2007

Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, ι, κ, and REV1 ⬇️

scientific article published on November 19, 2010

Translesion Synthesis acrossO6-Alkylguanine DNA Adducts by Recombinant Human DNA Polymerases

scientific article published in Journal of Biological Chemistry

Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases

scientific article

Translesion synthesis across 1,N6-(2-hydroxy-3-hydroxymethylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases

scientific article

Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase kappa

scientific article published on June 2006

Translesion synthesis across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine by Sulfolobus solfataricus DNA polymerase Dpo4

scientific article published on 01 June 2006

Translesion synthesis past the C8- and N2-deoxyguanosine adducts of the dietary mutagen 2-Amino-3-methylimidazo[4,5-f]quinoline in the NarI recognition sequence by prokaryotic DNA polymerases

scientific article

Twenty one novel single nucleotide polymorphisms (SNPs) of the CYP2A6 gene in Japanese and Caucasians

scientific article published on 01 January 2002

Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/umu assay

scientific article

Use of heterologously-expressed cytochrome P450 and glutathione transferase enzymes in toxicity assays.

scientific article

Validation of Human Sterol 14α-Demethylase (CYP51) Druggability: Structure-Guided Design, Synthesis, and Evaluation of Stoichiometric, Functionally Irreversible Inhibitors

scientific article published on 11 November 2019

Xenobiotic-metabolizing cytochromes P450 convert prostaglandin endoperoxide to hydroxyheptadecatrienoic acid and the mutagen, malondialdehyde.

scientific article

mRNA distribution and heterologous expression of orphan cytochrome P450 20A1

scientific article

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