List of works - Natalie J. Hannan

2D-DiGE analysis of the human endometrial secretome reveals differences between receptive and nonreceptive states in fertile and infertile women.

scientific article

A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage

scientific article

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid

scientific article

A wash step at collection of placental biopsies from preeclamptic pregnancies does not adversely affect levels of sFlt-1 or endoglin.

scientific article

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening.

scientific article

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta.

scientific article

Alternate roles for immune regulators: establishing endometrial receptivity for implantation

scientific article published in November 2011

Analysis of Fertility-Related Soluble Mediators in Human Uterine Fluid Identifies VEGF as a Key Regulator of Embryo Implantation

scientific article published in December 2011

CX3CL1 and CCL14 Regulate Extracellular Matrix and Adhesion Molecules in the Trophoblast: Potential Roles in Human Embryo Implantation1

scientific article published in July 2008

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin.

scientific article published on 7 October 2014

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

scientific article published on 23 January 2015

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

scientific article published in Scientific Reports

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

scientific article published on 10 February 2019

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.

scientific article published on 21 February 2018

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.

scientific article published on 21 February 2013

Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation.

scientific article published on November 2007

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

scientific article published on 24 September 2019

Defective soil for a fertile seed? Altered endometrial development is detrimental to pregnancy success

scientific article

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

scientific article published on 21 September 2018

Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol

scientific article

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

scientific article published on 05 September 2018

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion

scientific article published on 01 March 2019

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

scientific article published on 11 April 2018

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

scientific article published on 27 July 2015

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

scientific article

Endometrial signals improve embryo outcome: functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice.

scientific article published on 14 August 2014

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

scientific article published on 5 December 2016

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

scientific article published on 26 July 2018

Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice.

scientific article published on 4 August 2016

Fathers that are born small program alterations in the next-generation preimplantation rat embryos.

scientific article published on 25 March 2015

Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence.

scientific article

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion.

scientific article

Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity

scientific article published on 23 February 2011

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction.

scientific article published on 15 December 2017

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

scientific article published on 12 February 2019

Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation.

scientific article published in December 2004

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.

scientific article

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production.

scientific article published on 27 January 2016

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.

scientific article published on 4 January 2017

Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis

scientific article

Local regulation of implantation at the human fetal-maternal interface.

scientific article published on January 2010

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

scientific article

Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development

scientific article published on 9 February 2015

Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model.

scientific article

Measuring fetal brain and lung transcripts in amniotic fluid supernatant: a comparison of digital PCR and RT-qPCR methods.

scientific article

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia.

scientific article published on 11 April 2018

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

scientific article published on 22 December 2015

Models for study of human embryo implantation: choice of cell lines?

scientific article published on July 2009

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta.

scientific article published on 21 October 2016

PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility

scientific article published on 27 January 2011

PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

scientific article published on 24 March 2022

Paternal diet-induced obesity retards early mouse embryo development, mitochondrial activity and pregnancy health

scientific article

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner.

scientific article

Peptides do not prevent cleavage of endoglin to produce soluble endoglin.

scientific article published on 22 October 2014

Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation.

scientific article

Placental SEMA3B expression is not altered in severe early onset preeclampsia

scientific article published on 16 October 2014

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity.

scientific article published on 28 September 2015

Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE.

scientific article

Proteomic characterization of midproliferative and midsecretory human endometrium

scientific article published in April 2009

Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery

scientific article published on 06 October 2012

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

scientific article published on 23 January 2017

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women

scientific article published on 01 May 2019

Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction†.

scientific article published on 3 April 2017

Reply to L18-102AR1 Sandrim et al

scientific article published on 10 October 2018

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

scientific article published on 01 April 2019

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.

scientific article

Role of chemokines in the endometrium and in embryo implantation.

scientific article published on June 2007

Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity.

scientific article published in January 2009

Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia.

scientific article

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells

scientific article

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR.

scientific article published on 16 October 2014

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

scientific article published on 15 October 2016

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

scientific article published on 10 September 2019

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

scientific article published on 26 February 2019

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.

scientific article published on 20 February 2017

The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface.

scientific article published on February 2006

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

scientific article published on 04 February 2019

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14.

scientific article

Uterine Lavage or Aspirate: Which View of the Intrauterine Environment?

scientific article published on 27 April 2012

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy.

scientific article published on 2 February 2018

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

scientific article published on 6 July 2015

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

scientific article

List of works by Natalie J. Hannan

2D-DiGE analysis of the human endometrial secretome reveals differences between receptive and nonreceptive states in fertile and infertile women.

A bioplex analysis of cytokines and chemokines in first trimester maternal plasma to screen for predictors of miscarriage

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid

A wash step at collection of placental biopsies from preeclamptic pregnancies does not adversely affect levels of sFlt-1 or endoglin.

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening.

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta.

Alternate roles for immune regulators: establishing endometrial receptivity for implantation

Analysis of Fertility-Related Soluble Mediators in Human Uterine Fluid Identifies VEGF as a Key Regulator of Embryo Implantation

CX3CL1 and CCL14 Regulate Extracellular Matrix and Adhesion Molecules in the Trophoblast: Potential Roles in Human Embryo Implantation1

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin.

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia.

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.

Cytokines and chemokines during human embryo implantation: roles in implantation and early placentation.

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia

Defective soil for a fertile seed? Altered endometrial development is detrimental to pregnancy success

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Endometrial signals improve embryo outcome: functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice.

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

Evidence of proteinuria, but no other characteristics of pre-eclampsia, in relaxin-deficient mice.

Fathers that are born small program alterations in the next-generation preimplantation rat embryos.

Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence.

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion.

Human chorionic gonadotrophin regulates FGF2 and other cytokines produced by human endometrial epithelial cells, providing a mechanism for enhancing endometrial receptivity

IFPA meeting 2017 workshop report: Clinical placentology, 3D structure-based modeling of placental function, placental bed, and treating placental dysfunction.

IFPA meeting 2018 workshop report II: Abnormally invasive placenta; inflammation and infection; preeclampsia; gestational trophoblastic disease and drug delivery

Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation.

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production.

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.

Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis

Local regulation of implantation at the human fetal-maternal interface.

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

Low female birth weight and advanced maternal age programme alterations in next-generation blastocyst development

Male obesity is associated with changed spermatozoa Cox4i1 mRNA level and altered seminal vesicle fluid composition in a mouse model.

Measuring fetal brain and lung transcripts in amniotic fluid supernatant: a comparison of digital PCR and RT-qPCR methods.

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia.

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

Models for study of human embryo implantation: choice of cell lines?

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta.

PC6 levels in uterine lavage are closely associated with uterine receptivity and significantly lower in a subgroup of women with unexplained infertility

PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

Paternal diet-induced obesity retards early mouse embryo development, mitochondrial activity and pregnancy health

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner.

Peptides do not prevent cleavage of endoglin to produce soluble endoglin.

Placental Growth Factor Is Secreted by the Human Endometrium and Has Potential Important Functions during Embryo Development and Implantation.

Placental SEMA3B expression is not altered in severe early onset preeclampsia

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity.

Post-translational modifications and protein-specific isoforms in endometriosis revealed by 2D DIGE.

Proteomic characterization of midproliferative and midsecretory human endometrium

Proteomics of the human endometrium and uterine fluid: a pathway to biomarker discovery

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women

Relaxin treatment reduces angiotensin II-induced vasoconstriction in pregnancy and protects against endothelial dysfunction†.

Reply to L18-102AR1 Sandrim et al

Repurposing the selective estrogen receptor modulator to suppress gastrointestinal cancer growth

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.

Role of chemokines in the endometrium and in embryo implantation.

Society for Reproductive Biology Founders' Lecture 2009. Preparing fertile soil: the importance of endometrial receptivity.

Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia.

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR.

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

The angiotensin receptor blocker, Losartan, inhibits mammary tumor development and progression to invasive carcinoma.

The chemokines, CX3CL1, CCL14, and CCL4, promote human trophoblast migration at the feto-maternal interface.

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14.

Uterine Lavage or Aspirate: Which View of the Intrauterine Environment?