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List of works by Helena Nader

2,3-Di-O-sulfo glucuronic acid: An unmodified and unusual residue in a highly sulfated chondroitin sulfate from Litopenaeus vannamei.

scientific article published on 13 December 2017

A Brazilian perspective for the use of bovine heparin in open heart surgery.

scientific article

A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation

scientific article published on 28 June 2019

A heparin mimetic isolated from a marine shrimp suppresses neovascularization.

scientific article

A heparin-like compound isolated from a marine crab rich in glucuronic acid 2-O-sulfate presents low anticoagulant activity

scientific article published on 29 January 2013

A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence

scientific article published on 12 March 2014

A low-molecular-weight galactofucan from the seaweed, Spatoglossum schröederi, binds fibronectin and inhibits capillary-like tube formation in vitro.

scientific article published on 20 January 2018

A new approach for heparin standardization: combination of scanning UV spectroscopy, nuclear magnetic resonance and principal component analysis.

scientific article

A non-anticoagulant heterofucan has antithrombotic activity in vivo.

scientific article

A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential.

scientific article

A novel approach for the characterisation of proteoglycans and biosynthetic enzymes in a snail model

article

A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.

scientific article published on 19 July 2010

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

scientific article

A preponderantly 4-sulfated, 3-linked galactan from the green alga Codium isthmocladum.

scientific article published on 3 January 2008

A xylogalactofucan from the brown seaweed Spatoglossum schröederi stimulates the synthesis of an antithrombotic heparan sulfate from endothelial cells.

scientific article published in April 2005

Abundance of MMPs and cysteine cathepsins in caries-affected dentin

scientific article published on 19 December 2013

Acquisition of anoikis resistance promotes alterations in the Ras/ERK and PI3K/Akt signaling pathways and matrix remodeling in endothelial cells.

scientific article

Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells.

scientific article published on 30 December 2014

Activation of the low molecular weight protein tyrosine phosphatase in keratinocytes exposed to hyperosmotic stress

scientific article published on 17 March 2015

Active site mapping of Loxosceles phospholipases D: Biochemical and biological features

scientific article published on 24 May 2016

Adult bone marrow-derived mononuclear cells expressing chondroitinase AC transplanted into CNS injury sites promote local brain chondroitin sulphate degradation.

scientific article

Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis

scientific article published on 24 February 2015

Analysis of glycosaminoglycans in the parametrium and vaginal apex of women with and without uterine prolapse

scientific article published on 01 July 2010

Analysis of heparanase isoforms and cathepsin B in the plasma of patients with gastrointestinal carcinomas: analytical cross-sectional study

scientific article published on 01 February 2015

Analysis of hyaluronic acid in the endometrium of women with polycystic ovary syndrome

scientific article published on 06 January 2019

Analysis of proteoglycan expression in human dental pulp

scientific article published on 10 March 2018

Anti-IIa activity and antitumor properties of a hybrid heparin/heparan sulfate-like compound from Litopenaeus vannamei shrimp

scientific article published on 30 June 2018

Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp

scientific article published on 12 September 2008

Antiangiogenic activity and direct antitumor effect from a sulfated polysaccharide isolated from seaweed ⬇️

scientific article published on March 16, 2013

Bradykinin release avoids high molecular weight kininogen endocytosis.

scientific article published on 30 March 2015

Brown spider (Loxosceles intermedia) venom triggers endothelial cells death by anoikis

scientific article published on 19 April 2012

Brown spider dermonecrotic toxin directly induces nephrotoxicity.

scientific article published on 11 July 2005

Brown spider venom toxins interact with cell surface and are endocytosed by rabbit endothelial cells.

scientific article published on June 2010

CASE SERIES OF PATIENTS UNDER BIWEEKLY TREATMENT WITH LARONIDASE: A REPORT OF A SINGLE CENTER EXPERIENCE

scientific article published on 09 May 2019

Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex

scientific article published on 20 February 2020

CdSe magic-sized quantum dots incorporated in biomembrane models at the air-water interface composed of components of tumorigenic and non-tumorigenic cells

scientific article published on 20 April 2016

Cell-permeable gomesin peptide promotes cell death by intracellular Ca(2+) overload.

scientific article

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age

scientific article published in PLoS ONE

Characterization of Brown spider (Loxosceles intermedia) hemolymph: cellular and biochemical analyses.

scientific article published on 24 February 2015

Chemical reduction of carboxyl groups in heparin abolishes its vasodilatory activity

scientific article published on 01 April 2012

Chemistry of heparitin sulfate and heparin from normal tissues and from patients with hunter syndrome ⬇️

scientific article published on January 4, 1979

Chondroitin sulfate and kallikrein in saliva: markers for glossodynia.

scientific article published on 28 March 2008

Colorectal cancer desmoplastic reaction up-regulates collagen synthesis and restricts cancer cell invasion ⬇️

scientific article published on October 11, 2011

Concentration and distribution of hyaluronic acid in human vocal folds.

scientific article published in April 2007

Concentration and distribution of hyaluronic acid in mouse uterus throughout the estrous cycle.

scientific article

Concentration of hyaluronic acid in human vocal folds in young and old subjects.

scientific article published on 26 August 2011

Concentration of hyaluronic acid in primary open-angle glaucoma aqueous humor

scientific article published on 26 January 2005

Concentration of sulfated glycosaminoglycans in the mammary tissue of female rats with the aging and about hormonal influence.

scientific article

Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan

scientific article

Crosstalk between tumor cells and lymphocytes modulates heparanase expression

scientific article published on 29 March 2019

Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans.

scientific article published on 9 May 2007

Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants

scientific article published on 17 August 2019

Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization.

scientific article published on 10 July 2008

DNA and bone structure preservation in medieval human skeletons.

scientific article published on 13 April 2015

Determination of sulfate after chromatography and toluidine blue complex formation

scientific article published on March 1, 1977

Development of an enzyme-linked immunosorbent assay (ELISA)-like fluorescence assay to investigate the interactions of glycosaminoglycans to cells.

scientific article

Development of new methods for determining the heparanase enzymatic activity.

scientific article

Different doses of strontium ranelate and mechanical vibration modulate distinct responses in the articular cartilage of ovariectomized rats.

scientific article published on 18 February 2017

Distribution and composition of glycosaminoglycans in the left human coronary arterial branches under myocardial bridge

scientific article published on 01 April 1999

Does mobilization for autologous stem cell transplantation damage stromal layer formation?

scientific article published in April 2009

Effect of collagen cross-linking in stromal fibril organization in edematous human corneas.

scientific article published in July 2010

Effect of corneal epithelium on ultraviolet-A and riboflavin absorption

scientific article published on 01 September 2011

Effect of monensin on the sulfation of heparan sulfate proteoglycan from endothelial cells

scientific article published on September 1, 1992

Effects of Training and Overtraining on Intervertebral Disc Proteoglycans.

scientific article

Effects of different doses of soy isoflavones on bone tissue of ovariectomized rats ⬇️

scientific article published on October 1, 2013

Effects of shock wave therapy on glycosaminoglycan expression during bone healing

scientific article published on 30 September 2015

Effects of soy isoflavones and mechanical vibration on rat bone tissue.

scientific article published on 27 February 2013

Electrofocusing of heparin: Fractionation of heparin into 21 components distinguishable from other acidic mucopolysaccharides ⬇️

scientific article published on July 1, 1975

Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways. ⬇️

scientific article

Evaluation of Chitosan-Based Films Containing Gelatin, Chondroitin 4-Sulfate and ZnO for Wound Healing.

scientific article published on 27 March 2017

Evaluation of anti-nociceptive and anti-inflammatory activities of a heterofucan from Dictyota menstrualis.

scientific article

Evaluation of the metabolism of glycosaminoglycans in patients with interstitial cystis

scientific article

Expression and inactivation of osteopontin-degrading PHEX enzyme in squamous cell carcinoma.

scientific article published on 3 June 2016

Extracellular matrix alterations in the Peyronie's disease.

scientific article

Fibroblast and prostate tumor cell cross-talk: Fibroblast differentiation, TGF-β, and extracellular matrix down-regulation ⬇️

scientific article published on August 18, 2010

Fucan effect on CHO cell proliferation and migration.

scientific article

Fucan inhibits Chinese hamster ovary cell (CHO) adhesion to fibronectin by binding to the extracellular matrix.

scientific article

Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes ⬇️

scientific article

GLYCOSAMINOGLYCANS AND PROTEOGLYCANS IN PALMAR FASCIA OF PATIENTS WITH DUPUYTREN

scientific article published on March 2016

Genetic polymorphism in the sulfotransferase SULT1A1 gene in cancer

scientific article published on 01 July 2005

Glycosaminoglycan backbone is not required for the modulation of hemostasis: effect of different heparin derivatives and non-glycosaminoglycan analogs.

scientific article

Glycosaminoglycan chains from alpha5beta1 integrin are involved in fibronectin-dependent cell migration.

scientific article published in August 2009

Glycosaminoglycan profiles in the uterus of adult ovariectomized rats treated with estrogen and progestagen

scientific article published on 16 September 2012

Glycosaminoglycan synthesis and shedding induced by growth factors are cell and compound specific

scientific article published on 01 February 2007

Glycosaminoglycans affect heparanase location in CHO cell lines.

scientific article published in June 2015

Glycosaminoglycans of Abdominal Skin After Massive Weight Loss in Post-bariatric Female Patients ⬇️

scientific article published on June 1, 2011

Gradual strenuous running regimen predisposes to osteoarthritis due to cartilage cell death and altered levels of glycosaminoglycans.

scientific article published on 18 April 2013

Growth inhibitory activity of a novel lectin from Cliona varians against K562 human erythroleukemia cells. ⬇️

scientific article

Heparan Sulfate Proteoglycan Deficiency Up-Regulates the Intracellular Production of Nitric Oxide in Chinese Hamster Ovary Cell Lines.

scientific article

Heparan sulfate and cell division

scientific article published on 01 May 1999

Heparan sulfate and control of endothelial cell proliferation: increased synthesis during the S phase of the cell cycle and inhibition of thymidine incorporation induced by ortho-nitrophenyl-beta-D-xylose.

scientific article published on August 2004

Heparan sulfate mediates trastuzumab effect in breast cancer cells

scientific article

Heparan sulfate proteoglycans as trastuzumab targets in anoikis-resistant endothelial cells

scientific article published on 04 April 2019

Heparanase expression and glycosaminoglycans profile in renal cell carcinoma.

scientific article published on 27 June 2012

Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma.

scientific article

Heparin affects the interaction of kininogen on endothelial cells.

scientific article

Heparin and heparan sulfate disaccharides bind to the exchanger inhibitor peptide region of Na+/Ca2+ exchanger and reduce the cytosolic calcium of smooth muscle cell lines. Requirement of C4-C5 unsaturation and 1--> 4 glycosidic linkage for activity

scientific article

Heparin induces rat aorta relaxation via integrin-dependent activation of muscarinic M3 receptors.

scientific article published on 30 August 2010

Heparin modulation of human plasma kallikrein on different substrates and inhibitors

scientific article published in January 2006

Heparin-integrin interaction in endothelial cells: Downstream signaling and heparan sulfate expression

scientific article published on 01 June 2012

High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra

scientific article published on 31 January 2011

Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-d-hexosaminidases hydrolases.

scientific article published on 2 December 2006

Identification and partial characterisation of hyaluronidases in Lonomia obliqua venom.

scientific article published on March 2005

Identification of proteases in the extract of venom glands from brown spiders.

scientific article published in June 2002

Impact of birth in the presence and absence of simulated birth injury on vaginal glycosaminoglycan content.

scientific article published on 18 August 2011

Inhibition of heparin synthesis by methotrexate in rats in vivo.

scientific article

Inhibitory peptides of the sulfotransferase domain of the heparan sulfate enzyme, N-deacetylase-N-sulfotransferase-1.

scientific article

Insights into the N-Sulfation Mechanism: Molecular Dynamics Simulations of the N-Sulfotransferase Domain of Ndst1 and Mutants ⬇️

scientific article published on August 5, 2013

Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis.

scientific article

Interaction of Trastuzumab with biomembrane models at air-water interfaces mimicking cancer cell surfaces

scientific article published on 23 May 2019

Ionic and biochemical characterization of bovine intervertebral disk

scientific article published on 04 March 2016

Leptospira interrogans shotgun phage display identified LigB as a heparin-binding protein.

scientific article

Long-term and short-term effects of simulated birth trauma, cesarean and vaginal delivery on sulfated glycosaminoglycans in the urethra of female rats.

scientific article published on 14 January 2010

Lumican Peptides: Rational Design Targeting ALK5/TGFBRI.

scientific article

Lumican expression, localization and antitumor activity in prostate cancer

scientific article published on 8 February 2013

Mechanical stretch implications for vascular endothelial cells: Altered extracellular matrix synthesis and remodeling in pathological conditions

scientific article published on 18 October 2018

Mechanism of heparin acceleration of tissue inhibitor of metalloproteases-1 (TIMP-1) degradation by the human neutrophil elastase

scientific article

Melanocyte transformation associated with substrate adhesion impediment.

scientific article

Metabolic profile of glycosaminoglycans in bladder and urethra of female rats during and after pregnancy.

scientific article published on 2 October 2009

Mitogenic activity of acidic fibroblast growth factor is enhanced by highly sulfated oligosaccharides derived from heparin and heparan sulfate ⬇️

scientific article published on July 21, 1993

Modifications in bone matrix of estrogen-deficient rats treated with intermittent PTH

scientific article

Modulation of Hyaluronan Synthesis by the Interaction between Mesenchymal Stem Cells and Osteoarthritic Chondrocytes

scientific article

New index for the diagnosis of liver fibrosis in Schistosomiasis mansoni.

scientific article published on January 2017

New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and glycuronidases in the mollusc Tagelus gibbus

scientific article published on 01 March 1998

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+

article

On the structure of heparitin sulfates Analyses of the products formed from heparitin sulfates by two heparitinases and a heparinase from Flavobacterium heparinum ⬇️

scientific article published on June 23, 1976

P2X7-induced apoptosis decreases by aging in mice myeloblasts

scientific article published on 22 December 2006

PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells

scientific article published in July 2017

Participation of heparin binding proteins from the surface of Leishmania (Viannia) braziliensis promastigotes in the adhesion of parasites to Lutzomyia longipalpis cells (Lulo) in vitro.

scientific article

Pharmacological prospection and structural characterization of two purified sulfated and pyruvylated homogalactans from green algae Codium isthmocladum

scientific article published on 20 June 2019

Probing the interaction between heparan sulfate proteoglycan with biologically relevant molecules in mimetic models for cell membranes: a Langmuir film study

scientific article published on 21 January 2012

Putative role of heparan sulfate proteoglycan expression and shedding on the proliferation and survival of cells after photodynamic therapy.

scientific article published on 16 February 2007

Quantitative evaluation of experimental choroidal neovascularization by confocal scanning laser ophthalmoscopy: fluorescein angiogram parallels heparan sulfate proteoglycan expression.

scientific article

Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.

scientific article

Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide

scientific article published on 13 January 2011

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells

scientific article

Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii

scientific article published on 6 September 2017

Schistosomiasis mansoni: ultrasound-evaluated hepatic fibrosis and serum concentrations of hyaluronic acid.

scientific article

Serum hyaluronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis

scientific article published on 01 November 2002

Stimulation of heparan sulfate proteoglycan synthesis and secretion during G1 phase induced by growth factors and PMA

scientific article published on 01 September 1998

Structural and inhibitory properties of a plant proteinase inhibitor containing the RGD motif.

scientific article published on 26 May 2006

Structural and pharmacological profile of generic enoxaparins used in Brazil

scientific article published on 05 March 2012

Structural differences of heparan sulfates according to the tissue and species of origin ⬇️

scientific article published on March 29, 1983

Structural features and anticoagulant activities of a novel natural low molecular weight heparin from the shrimp Penaeus brasiliensis.

scientific article

Structural studies and "in vivo" and "in vitro" pharmacological activities of heparin fractions and fragments prepared by chemical and enzymic depolimerization

Sulfated glycosaminoglycans of the periurethral tissue in women with and without stress urinary incontinence, according to genital prolapse stage

scientific article published on 28 November 2005

Sulfation of intrinsic glycoproteins of the rabbit vitreous

scientific article published on 01 September 1998

Syndecan-2 is upregulated in colorectal cancer cells through interactions with extracellular matrix produced by stromal fibroblasts ⬇️

scientific article published on May 25, 2013

THE M-RNA, EXPRESSION OF SERCA2 AND NCX1 IN THE PROCESS OF PHARMACOLOGICAL CELL PROTECTION IN EXPERIMENTAL ACUTE PANCREATITIS INDUCED BY TAUROCHOLATE.

scientific article published on 21 June 2018

Testing for urinary hyaluronate improves detection and grading of transitional cell carcinoma

scientific article published on 04 December 2009

The Profile of Heparanase Expression Distinguishes Differentiated Thyroid Carcinoma from Benign Neoplasms

scientific article published on 21 October 2015

The binding of heparin to the extracellular matrix of endothelial cells up-regulates the synthesis of an antithrombotic heparan sulfate proteoglycan.

scientific article

The critical interaction of the metallopeptidase PHEX with heparan sulfate proteoglycans.

scientific article published on 8 June 2008

The effect of brown spider venom on endothelial cell morphology and adhesive structures.

scientific article published on 10 March 2006

The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome.

scientific article published on December 2014

The expression of glycosaminoglycans and proteoglycans in the uterine cervix of albino rats after local hyaluronidase infusion

scientific article

The heterogeneity of heparan sulfate from beef-lung tissue; p.m.r.-spectral evidence ⬇️

scientific article published on May 1, 1975

The identification of proteoglycans and glycosaminoglycans in archaeological human bones and teeth

scientific article

The involvement of proteoglycans in the human plasma prekallikrein interaction with the cell surface.

scientific article

The natural cell-penetrating peptide crotamine targets tumor tissue in vivo and triggers a lethal calcium-dependent pathway in cultured cells.

scientific article published on 23 December 2011

The renal and hepatic distribution of Bence Jones proteins depends on glycosylation: a scintigraphic study in rats ⬇️

scientific article published on 01 July 1997

Tissue hyaluronan expression, as reflected in the sputum of lung cancer patients, is an indicator of malignancy

scientific article published on 8 May 2015

Trisulfate Disaccharide Decreases Calcium Overload and Protects Liver Injury Secondary to Liver Ischemia/Reperfusion

scientific article

Trypanosoma cruzi heparin-binding proteins and the nature of the host cell heparan sulfate-binding domain.

scientific article published on 22 October 2007

Trypanosoma cruzi heparin-binding proteins mediate the adherence of epimastigotes to the midgut epithelial cells of Rhodnius prolixus.

scientific article published on 7 February 2012

Trypanosoma cruzi heparin-binding proteins present a flagellar membrane localization and serine proteinase activity

scientific article published on 14 September 2012

Ultra-low-molecular-weight heparins: precise structural features impacting specific anticoagulant activities

scientific article published on 17 January 2013

Urinary glycosaminoglycans as biomarker for urothelial injury: is it possible to discriminate damage from recovery?

scientific article published on 7 March 2008

Urinary glycosaminoglycans excretion and the effect of dimethyl sulfoxide in an experimental model of non-bacterial cystitis.

scientific article

Urinary hyaluronan as a marker for the presence of residual transitional cell carcinoma of the urinary bladder.

scientific article published on 2 November 2005

Uterine prolapse: evaluation of glycosaminoglycans in postmenopausal women after estrogen therapy

scientific article published on 07 August 2010

Web-based learning in undergraduate medical education: development and assessment of an online course on experimental surgery.

scientific article published in September 2004

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