Search filters

List of works by Christopher F Basler

1976 and 2009 H1N1 influenza virus vaccines boost anti-hemagglutinin stalk antibodies in humans

scientific article

2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales

scientific article published on 04 September 2020

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35-NP Interface.

scientific article

A VP35 Mutant Ebola Virus Lacks Virulence but Can Elicit Protective Immunity to Wild-Type Virus Challenge

scientific article published on 01 September 2019

A broadly neutralizing human monoclonal antibody that recognizes a conserved, novel epitope on the globular head of the influenza H1N1 virus hemagglutinin

scientific article

A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry

scientific article

A high throughput screen identifies benzoquinoline compounds as inhibitors of Ebola virus replication

scientific article published on 30 December 2017

A mutation in the Ebola virus envelope glycoprotein restricts viral entry in a host species- and cell-type-specific manner.

scientific article published on 9 January 2013

A novel mechanism of immune evasion mediated by Ebola virus soluble glycoprotein.

scientific article published on May 2013

A novel paramyxovirus?

scientific article published on January 2005

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice

scientific journal article

A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity.

scientific article

Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein

scientific article

Amino Acid Residue at Position 79 of Marburg Virus VP40 Confers Interferon Antagonism in Mouse Cells

scientific article

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions

scientific article

An upstream open reading frame modulates ebola virus polymerase translation and virus replication

scientific article

Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model

scientific article published on 13 November 2019

Assays to Measure Suppression of Type I Interferon Responses by Filovirus VP35 Proteins.

scientific article published on January 2017

Basic residues within the ebolavirus VP35 protein are required for its viral polymerase cofactor function

scientific article published on 4 August 2010

Cellular transcriptional profiling in influenza A virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza

scientific article

Characterization of the reconstructed 1918 Spanish influenza pandemic virus

scientific article

Chimeric influenza A viruses with a functional influenza B virus neuraminidase or hemagglutinin

scientific article published on September 2003

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes

scientific article published on 01 July 2018

Cooperation of the Ebola proteins VP40 and GP1,2 with BST2 to activate NF-κβ independently of virus-like particle trapping.

scientific article published on 6 September 2017

Crystallization and preliminary X-ray analysis of Ebola VP35 interferon inhibitory domain mutant proteins

scientific article

Current status of small molecule drug development for Ebola virus and other filoviruses

article

DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function

scientific article

Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection.

scientific article published on 27 March 2017

Development of RNA Aptamers Targeting Ebola Virus VP35

scientific article

Differential Regulation of Interferon Responses by Ebola and Marburg Virus VP35 Proteins

scientific article published on 10 February 2016

Dimerization Controls Marburg Virus VP24-dependent Modulation of Host Antioxidative Stress Responses

scientific article

Ebola Virus Produces Discrete Small Noncoding RNAs Independently of the Host MicroRNA Pathway Which Lack RNA Interference Activity in Bat and Human Cells

scientific article published on 28 February 2020

Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

scientific article

Ebola virus VP24 targets a unique NLS binding site on karyopherin alpha 5 to selectively compete with nuclear import of phosphorylated STAT1.

scientific article

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

scientific article

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

scientific article published on 4 March 2015

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling

scientific article

Ebola virus exploits a monocyte differentiation program to promote its entry

scientific article published on 23 January 2013

Ebola virus failure to stimulate plasmacytoid dendritic cell interferon responses correlates with impaired cellular entry.

scientific article

Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1

scientific article

Ebola virus-like particle-induced activation of NF-kappaB and Erk signaling in human dendritic cells requires the glycoprotein mucin domain.

scientific article published on 16 April 2007

Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signaling

scientific article

Ebolavirus VP35 is a multifunctional virulence factor

scientific article

Editorial overview: emerging viruses.

scientific article published on 27 March 2014

Effects of Filovirus Interferon Antagonists on Responses of Human Monocyte-Derived Dendritic Cells to RNA Virus Infection

scientific article published on 9 March 2016

Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis.

scientific article published on February 2002

Epitope-specific human influenza antibody repertoires diversify by B cell intraclonal sequence divergence and interclonal convergence

scientific article

Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus.

scientific article

Expression, purification, crystallization and preliminary X-ray studies of the Ebola VP35 interferon inhibitory domain.

scientific article published on 31 January 2009

Filoviral immune evasion mechanisms

scientific article

Filovirus Strategies to Escape Antiviral Responses

scientific article published on 8 July 2017

Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus

scientific article published on 06 October 2015

Functional replacement of the carboxy-terminal two-thirds of the influenza A virus NS1 protein with short heterologous dimerization domains.

scientific article

Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus

scientific article

Global host immune response: pathogenesis and transcriptional profiling of type A influenza viruses expressing the hemagglutinin and neuraminidase genes from the 1918 pandemic virus.

scientific article

Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies

scientific article

Henipavirus W proteins interact with 14-3-3 to modulate host gene expression

scientific article published on 22 April 2020

High-Throughput Minigenome System for Identifying Small-Molecule Inhibitors of Ebola Virus Replication

scientific article published on August 2015

Homo-oligomerization facilitates the interferon-antagonist activity of the ebolavirus VP35 protein.

scientific article

Human monoclonal antibodies to pandemic 1957 H2N2 and pandemic 1968 H3N2 influenza viruses

scientific article

ICTV Virus Taxonomy Profile: Filoviridae

scientific article published on 25 April 2019

Immunological features underlying viral hemorrhagic fevers

scientific article

Impact of Ebola mucin-like domain on antiglycoprotein antibody responses induced by Ebola virus-like particles.

scientific article

Impact of Měnglà virus proteins on human and bat innate immune pathways

scientific article published on 15 April 2020

Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses

scientific article published on 11 May 2017

In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity

scientific article

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

scientific article

Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus.

scientific article published on 21 September 2010

Influenza Human Monoclonal Antibody 1F1 Interacts with Three Major Antigenic Sites and Residues Mediating Human Receptor Specificity in H1N1 Viruses

scientific article

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

article

Innate immune evasion by filoviruses

scientific article published on 3 April 2015

Introduction of Ebola virus into a remote border district of Sierra Leone, 2014: use of field epidemiology and RNA sequencing to describe chains of transmission

article

Lloviu virus VP24 and VP35 proteins function as innate immune antagonists in human and bat cells.

scientific article published on 6 August 2015

Marburg Virus VP24 Protein Relieves Suppression of the NF-κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1.

scientific article

Marburg virus RNA synthesis is inhibited by a synthetic anti-VP35 antibody

scientific article published on 04 June 2019

Marburg virus VP40 antagonizes interferon signaling in a species-specific manner.

scientific article

Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses

scientific article

Molecular basis for ebolavirus VP35 suppression of human dendritic cell maturation.

scientific article published on 20 August 2014

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

scientific article

Molecular pathogenesis of viral hemorrhagic fever.

scientific article

Mutation of YMYL in the Nipah virus matrix protein abrogates budding and alters subcellular localization

scientific article published on 27 September 2006

Mutations Abrogating VP35 Interaction with Double-Stranded RNA Render Ebola Virus Avirulent in Guinea Pigs

scientific article

Mutual antagonism between the Ebola virus VP35 protein and the RIG-I activator PACT determines infection outcome

scientific article

Naturally occurring human monoclonal antibodies neutralize both 1918 and 2009 pandemic influenza A (H1N1) viruses.

scientific article

Neutralizing anti-influenza virus monoclonal antibodies: therapeutics and tools for discovery.

scientific article

Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis.

scientific article

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors.

scientific article

New hope in the search for Ebola virus treatments.

scientific article published on October 2014

Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins

scientific article

Newcastle disease virus V protein is a determinant of host range restriction

scientific article published on September 2003

Nipah Virus C and W Proteins Contribute to Respiratory Disease in Ferrets

scientific article published on 04 May 2016

Nipah and Hendra Virus Interactions with the Innate Immune System ⬇️

scientific article published on January 1, 2012

Nipah virus V and W proteins have a common STAT1-binding domain yet inhibit STAT1 activation from the cytoplasmic and nuclear compartments, respectively

scientific article

Nipah virus edits its P gene at high frequency to express the V and W proteins.

scientific article published on 11 February 2009

Nipah virus sequesters inactive STAT1 in the nucleus via a P gene-encoded mechanism

scientific article

Novel Cross-Reactive Monoclonal Antibodies against Ebolavirus Glycoproteins Show Protection in a Murine Challenge Model

scientific article published on 07 June 2017

Novel inhibitors of InhA efficiently kill Mycobacterium tuberculosis under aerobic and anaerobic conditions.

scientific article

Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus

scientific article

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus.

scientific article

Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice

scientific article

Phylogenetics and pathogenesis of early avian influenza viruses (H5N1), Nigeria.

scientific article

Portrait of a killer: genome of the 2014 EBOV outbreak strain.

scientific article published on October 2014

Possibility and Challenges of Conversion of Current Virus Species Names to Linnaean Binomials

scientific article

Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines.

scientific article

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication

scientific article published on 01 December 2018

Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction

scientific article published on 17 November 2014

Pyridinyl imidazole inhibitors of p38 MAP kinase impair viral entry and reduce cytokine induction by Zaire ebolavirus in human dendritic cells

scientific article

Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis

scientific article

Sensing RNA virus infections

scientific article published in January 2007

Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes

scientific article

Sequence of the immunoregulatory early region 3 and flanking sequences of adenovirus type 35.

scientific article published on May 1996

Seroprevalence of pandemic influenza viruses, New York, New York, USA, 2004.

scientific article published in November 2012

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

scientific article

Small Molecule Compounds That Inhibit Antioxidant Response Gene Expression in an Inducer-Dependent Manner

scientific article published on 15 January 2020

Structural and Functional Characterization of Reston Ebola Virus VP35 Interferon Inhibitory Domain

scientific article

Structural basis for Marburg virus VP35-mediated immune evasion mechanisms

scientific article

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

scientific article

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses.

scientific article published on 30 June 2017

Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses

scientific article published in Nature Communications

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

scientific article published in 2021

Structure of the Ebola VP35 interferon inhibitory domain

scientific article

Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus

scientific article published on 21 September 2021

Taxonomy of the order Mononegavirales: second update 2018

scientific article published on 01 April 2019

Taxonomy of the order Mononegavirales: update 2016

scientific article published in August 2016

Taxonomy of the order Mononegavirales: update 2017.

scientific article

Taxonomy of the order Mononegavirales: update 2018.

scientific article published on 11 April 2018

Taxonomy of the order Mononegavirales: update 2019

scientific article published on 01 July 2019

The Antiviral Drug Arbidol Inhibits Zika Virus.

scientific article published on 12 June 2018

The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.

scientific article

The Ebola virus VP35 protein binds viral immunostimulatory and host RNAs identified through deep sequencing

scientific article

The Ebola virus VP35 protein functions as a type I IFN antagonist.

scientific article

The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

scientific article

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication

scientific article

The L gene of J paramyxovirus plays a critical role in viral pathogenesis.

scientific article published on 25 September 2013

The Marburg virus VP24 protein interacts with Keap1 to activate the cytoprotective antioxidant response pathway

scientific article

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

scientific article

The N- and C-terminal domains of the NS1 protein of influenza B virus can independently inhibit IRF-3 and beta interferon promoter activation

scientific article published on November 2004

The VP40 protein of Marburg virus exhibits impaired budding and increased sensitivity to human tetherin following mouse adaptation

scientific article

The immunomodulating V and W proteins of Nipah virus determine disease course

scientific article published on 24 June 2015

The makings of a killer

scientific article published in September 2002

Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation.

scientific article

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

scientific article

Transcriptional analysis of lymphoid tissues from infected nonhuman primates reveals the basis for attenuation and immunogenicity of an Ebola virus encoding a mutant VP35 protein

scientific article published on 06 January 2021

VP24-Karyopherin Alpha Binding Affinities Differ between Ebolavirus Species, Influencing Interferon Inhibition and VP24 Stability.

scientific article published on 14 December 2016

Vaccine Potential of Nipah Virus-Like Particles ⬇️

scientific article published on April 6, 2011

Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets

scientific article published on 11 December 2018

Viruses and the type I interferon antiviral system: induction and evasion

scientific article

West African Ebola Virus Strains: Unstable and Ready to Invade?

scientific article

Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.

scientific article published on 22 September 2009

Paulina is supported by:

About Paulina

Help