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List of works by Shaun P Jackson

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

scientific article published on 27 September 2016

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

scientific article

A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

scientific article published on 25 February 2008

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

scientific article published on 01 January 2012

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

scientific article published on 14 December 2006

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

scientific article published on 01 January 2013

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

scientific article

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

scientific article published on 01 June 2009

An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

scientific article published on 25 March 2019

An investigation on platelet transport during thrombus formation at micro-scale stenosis

scientific article

Antiplatelet therapy: in search of the 'magic bullet'.

scientific article published on October 2003

Antiplatelet therapy: present status and future prospects ⬇️

scientific article published on August 1, 2007

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

scientific article

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

scientific article published in Nature Communications

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

scientific article published on 29 June 2017

Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

scientific article published on 01 January 2007

Arterial thrombosis—insidious, unpredictable and deadly ⬇️

scientific article published on November 7, 2011

Autoregulation of von Willebrand factor function by a disulfide bond switch.

scientific article published on 28 February 2018

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

scientific article

Bcl-xL–inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function ⬇️

scientific article published on 01 February 2012

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots

scientific article published on 01 January 1997

Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction

scientific article published on 01 August 1997

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

scientific article

Class I phosphoinositide 3-kinases.

scientific article

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

scientific article published on 01 April 2011

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets

scientific article published on 14 March 2018

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization

scientific article published on 13 July 2006

Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading

scientific article published on 04 June 2007

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 30 August 2017

Differentiating haemostasis from thrombosis for therapeutic benefit

scientific article published on 15 August 2013

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

scientific article

Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.

scientific article published on 16 November 2001

Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets

scientific article published on 01 October 1997

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

scientific article

Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species.

scientific article published on 27 October 2017

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

scientific article

Dynamics of platelet thrombus formation.

scientific article published on July 2009

Endogenous fibrinolysis facilitates clot retraction in vivo

scientific article

Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury

scientific article

Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin αIIbβ3 ⬇️

scientific article published on January 1, 2002

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

scientific article published on June 2007

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

scientific article

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant

scientific article published on 26 October 2015

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

scientific article published in February 2010

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

scientific article published on 01 March 1999

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction

scientific article

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

scientific article published on 21 September 2006

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

scientific article

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

scientific article published on 02 August 2007

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.

scientific article published on May 2005

Imaging signaling processes in platelets.

scientific article

Improved analogs and novel delivery systems for somatostatin octapeptides.

scientific article published on August 1996

Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform

scientific article

Interaction between Platelet Glycoprotein Ibα and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear ⬇️

scientific article published on November 7, 2001

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

scientific article published on 21 May 2018

Is thrombin the problem or (dis)solution?

scientific article published on 01 June 2009

Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor.

scientific article published on 14 June 2006

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

scientific article published in February 2013

Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.

scientific article

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

scientific article

Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles

scientific article published in Nature Communications

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

scientific article

New insights into the haemostatic function of platelets.

scientific article

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

scientific article published on 8 October 2009

Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction

scientific article published on 20 January 2011

PI 3-kinase p110beta: a new target for antithrombotic therapy

scientific journal article

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

article

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

scientific article published on 25 July 2010

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

scientific article published on 19 March 2012

Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation

scientific article published on 25 September 2008

Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations.

scientific article

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

scientific article

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

scientific article

Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.

scientific article

Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton

scientific journal article

Procoagulant platelets: are they necrotic?

scientific article published on 10 June 2010

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

scientific article published on 01 June 1993

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

scientific article

Raised Plasma Soluble P-Selectin in Peripheral Arterial Occlusive Disease Enhances Leukocyte Adhesion

scientific article published on 08 December 2005

Rapid assembly and profiling of an anticoagulant sulfoprotein library

scientific article published on 20 June 2019

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

scientific article published on 5 February 2002

Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets

scientific article published on 21 August 2009

SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.

scientific article

SR-BI and fatty platelets

scientific article published on 01 September 2010

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

scientific article

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

scientific article

Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics

scientific article published on 29 December 2005

Shear-dependent tether formation during platelet translocation on von Willebrand factor

scientific article published on 01 January 2002

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

scientific article

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication

scholarly article

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

scientific article published on 01 April 2011

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3. Studies in human platelets ans transfected Chinese hamster ovary cells

scientific article published on 01 December 2000

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

scientific article published on 4 September 2007

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

scientific article

The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi ⬇️

scientific article published on April 2, 2013

The Role of Platelets in Atherothrombosis ⬇️

scientific article published on January 1, 2011

The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.

scientific article published on October 1996

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

scientific article published on 5 November 2010

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

scientific article

The clot thickens--oxidized lipids and thrombosis

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions

scientific article published on 21 December 2011

The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

scientific article published on 30 September 2006

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells.

scientific article

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency

scientific article published on 03 January 2006

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

scientific article

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

scientific article published on 14 January 2019

Thromboinflammatory Functions of Platelets in Ischemia-Reperfusion Injury and Its Dysregulation in Diabetes

scientific article

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 22 April 2009

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

scientific article

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

scientific article published on 5 October 2016

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