List of works - Nathan Brown

A chemoinformatics analysis of hit lists obtained from high-throughput affinity-selection screening

scientific article

A graph-based genetic algorithm and its application to the multiobjective evolution of median molecules.

scientific article published in May 2004

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells

scientific article

Chemoinformatics—an introduction for computer scientists

scientific article (publication date: February 2009)

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

scientific article

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

scientific article published on 12 July 2012

Evaluation of germline BMP4 mutation as a cause of colorectal cancer

scientific article

Fragment-based hit identification: thinking in 3D.

scientific article

Introducing the consensus modeling concept in genetic algorithms: application to interpretable discriminant analysis.

scientific article published in September 2006

Knowledge-based virtual screening: application to the MDM4/p53 protein-protein interaction

scientific article

MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation

scientific article published on 9 June 2015

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

scientific article

Relationships between Molecular Complexity, Biological Activity, and Structural Diversity

scientific article

Revealing important Molecular Fragments in Drug Discovery Using Time Trend Analyses

abstract from 2018

Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors

scientific article

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

scientific article

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

scientific article

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library

scientific article (publication date: 11 April 2016)

The de novo design of median molecules within a property range of interest

scientific article published in December 2004

List of works by Nathan Brown

A chemoinformatics analysis of hit lists obtained from high-throughput affinity-selection screening

A graph-based genetic algorithm and its application to the multiobjective evolution of median molecules.

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells

Chemoinformatics—an introduction for computer scientists

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

Druggability analysis and structural classification of bromodomain acetyl-lysine binding sites

Evaluation of germline BMP4 mutation as a cause of colorectal cancer

Fragment-based hit identification: thinking in 3D.

Introducing the consensus modeling concept in genetic algorithms: application to interpretable discriminant analysis.

Knowledge-based virtual screening: application to the MDM4/p53 protein-protein interaction

MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation

Optimization of Imidazo[4,5- b ]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate for the Treatment of Acute Myeloid Leukemia

Relationships between Molecular Complexity, Biological Activity, and Structural Diversity

Revealing important Molecular Fragments in Drug Discovery Using Time Trend Analyses

Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors

Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library

The de novo design of median molecules within a property range of interest