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List of works by Jos Bessems

3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity

scientific article published on 01 December 1995

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

Application of toxicogenomics in hepatic systems toxicology for risk assessment: acetaminophen as a case study.

scientific article published on 21 October 2010

Biomonitoring as an Underused Exposure Assessment Tool in Occupational Safety and Health Context-Challenges and Way Forward

scientific article published on 13 August 2020

Biotransformation of 1,2-dihydronaphthalene and 1,2-dihydroanthracene by rat liver microsomes and purified cytochromes P-450. Formation of arene hydrates of naphthalene and anthracene

scientific article published on 01 November 1993

Building a European exposure science strategy

scientific article published on 02 December 2019

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment ⬇️

scientific article published on March 25, 2013

Comparison of the mouse Embryonic Stem cell Test, the rat Whole Embryo Culture and the Zebrafish Embryotoxicity Test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles.

scientific article

Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts.

scientific article published in February 1997

Development of a QSAR for worst case estimates of acute toxicity of chemically reactive compounds.

scientific article published on 15 March 2007

Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps

scientific article published on February 2008

Does EU legislation allow the use of the Benchmark dose (BMD) approach for risk assessment? ⬇️

scientific article published on July 16, 2013

ELIXIR and Toxicology: a community in development

ELIXIR and Toxicology: a community in development

scientific article published on 3 October 2023

Evaluation of semi-generic PBTK modeling for emergency risk assessment after acute inhalation exposure to volatile hazardous chemicals

scientific article published on 17 March 2015

Evaluation of three physiologically based pharmacokinetic (PBPK) modeling tools for emergency risk assessment after acute dichloromethane exposure.

scientific article published on 13 October 2014

Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis

scientific article published on 9 November 2010

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

scientific article published on 26 June 2017

Human risk assessment of dermal and inhalation exposures to chemicals assessed by route-to-route extrapolation: the necessity of kinetic data.

scientific article

Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450

scientific article published on 01 September 1998

Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment.

scientific article

Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes

scientific article published on 01 October 1994

Oral-to-inhalation route extrapolation in occupational health risk assessment: a critical assessment.

scientific article published in February 2004

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop

scientific article published on 26 November 2013

Proper knowledge on toxicokinetics improves human hazard testing and subsequent health risk characterisation. A case study approach.

scientific article published on 17 September 2013

Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol

scientific article published on 01 June 1996

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

scientific article published on 15 December 2010

Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route.

scientific article published in September 2004

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine.

scientific article

The relation between the oxidative biotransformation of hexachlorobenzene and its porphyrinogenic activity.

scientific article published in September 1989

Toxicological profile for o-benzyl-p-chlorophenol

scientific article published on 01 July 1998

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