List of works - Timothy J. Stalker

A Human Vascular Injury-on-a-Chip Model of Hemostasis

scientific article published on 04 November 2020

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

scientific article published on 30 December 2011

A novel role for calpains in the endothelial dysfunction of hyperglycemia

scientific article published on 3 June 2003

A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.

scientific article

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.

scientific article

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

scientific article

A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.

scientific article published on 6 January 2016

Boundary events: contact-dependent and contact-facilitated signaling between platelets

scientific article published in August 2004

Contact-dependent signaling events that promote thrombus formation

scientific article

Coordination of platelet agonist signaling during the hemostatic response in vivo

scientific article published on 21 December 2017

Correction for Wang et al., Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

scholarly article

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

scientific article

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

scientific article

Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

scientific article

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.

scientific article

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

scientific article published on 01 January 2020

Harnessing the platelet signaling network to produce an optimal hemostatic response.

scientific article published on 11 April 2013

Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation

scientific article

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

scientific article

Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury

scientific article published on 26 September 2012

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

scientific article published on 19 August 2004

Interrelationships between structure and function during the hemostatic response to injury

scientific article published on 23 January 2019

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

scientific article published in June 2003

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

scientific article published on 23 January 2012

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

scientific article published on 2 September 2014

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

scholarly article

Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo

scientific article published in May 2002

Microcirculation as a target for the anti-inflammatory properties of statins.

scientific article

Minding the gaps to promote thrombus growth and stability

scientific article

Minding the gaps--and the junctions, too.

scientific article published on 23 April 2012

Mouse laser injury models: variations on a theme

scientific article published on 16 April 2020

Mouse models of platelet function in vivo

scientific article published on 03 April 2020

Novel therapeutic targets at the platelet vascular interface.

scientific article published on 03 January 2008

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease

scientific article

Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.

scientific article

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

scientific article published on 31 October 2017

Platelet signaling

scientific article

Platelets and hemostasis: a new perspective on an old subject

scientific article published on 22 November 2016

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

scientific journal article

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

scientific article

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists

scientific article published on 01 August 2018

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

scholarly article

Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis

scientific article published on 01 January 2017

Shaping the platelet response to vascular injury

scientific article

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.

scientific article

Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo

scientific article published on 19 September 2015

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

scientific article published on 01 April 2005

The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

scientific article published on 17 October 2017

Use of electron microscopy to study platelets and thrombi

scientific article published on 18 May 2020

List of works by Timothy J. Stalker

A Human Vascular Injury-on-a-Chip Model of Hemostasis

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

A novel role for calpains in the endothelial dysfunction of hyperglycemia

A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.

Boundary events: contact-dependent and contact-facilitated signaling between platelets

Contact-dependent signaling events that promote thrombus formation

Coordination of platelet agonist signaling during the hemostatic response in vivo

Correction for Wang et al., Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

Harnessing the platelet signaling network to produce an optimal hemostatic response.

Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

Interrelationships between structure and function during the hemostatic response to injury

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo

Microcirculation as a target for the anti-inflammatory properties of statins.

Minding the gaps to promote thrombus growth and stability

Minding the gaps--and the junctions, too.

Mouse laser injury models: variations on a theme

Mouse models of platelet function in vivo

Novel therapeutic targets at the platelet vascular interface.

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease

Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Platelet signaling

Platelets and hemostasis: a new perspective on an old subject

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis

Shaping the platelet response to vascular injury

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.

Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

Use of electron microscopy to study platelets and thrombi