List of works - Michael W. Chan

2,4-Diamino-Quinazoline, a Wnt Signaling Inhibitor, Suppresses Gastric Cancer Progression and Metastasis

scientific article published on 17 August 2020

A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells

scientific article

Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer.

scientific article published on 02 September 2016

Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer

scientific article

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

scientific article published in Nature Communications

Aberrant epigenetic modifications in radiation-resistant head and neck cancers

scientific article

Analysis of DNA methylation in human BK virus ⬇️

scientific article published on May 31, 2011

Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells.

scientific article

Association between cytokines and methylation of SOCS-1 in serum of patients with ankylosing spondylitis

scientific article published on 16 February 2014

CCRK-a hub for liver metastasis and cancer

scientific article published on 02 November 2020

Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.

scientific article published on February 2006

Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways.

scientific article published on 7 October 2015

DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer

scientific article published on 5 September 2017

DNA methylation profiles and biomarkers of oral squamous cell carcinoma.

scientific article

Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study

scientific article published on 01 November 2004

Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps

scientific article published on 22 March 2007

Dichotomy effects of Akt signaling in breast cancer ⬇️

scientific article published on August 24, 2012

Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine.

scientific article

Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma

scientific article published on 26 June 2017

E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness

scientific article published on 25 January 2019

Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer.

scientific article published on 29 August 2014

Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer

scientific article published on 13 February 2012

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer

scientific article published on 16 August 2016

Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment.

scientific article published on 16 October 2017

Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues.

scientific article

FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

scientific article published on 15 September 2020

FT-IR microspectrometry reveals the variation of membrane polarizability due to epigenomic effect on epithelial ovarian cancer

scientific article

Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner.

scientific article

GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells

scientific article published on 03 October 2018

Global profiling of histone modifications in the polyomavirus BK virion minichromosome

scientific article published on 15 May 2015

Growth inhibition of ovarian tumor-initiating cells by niclosamide.

scientific article

Guizhi Fuling Wan as a novel agent for intravesical treatment for bladder cancer in mouse model

scientific article published on 13 January 2016

Hard clam extracts induce atypical apoptosis in human gastric cancer cells

scientific article published on 20 June 2017

Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.

scientific article published on 8 October 2012

Hemolytic E. coli Promotes Colonic Tumorigenesis in Females

scientific article published on 24 March 2016

High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma.

scientific article

Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer.

scientific article published on October 2005

Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients.

scientific article

Identification and characterization of ovarian cancer-initiating cells from primary human tumors

scientific article

Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer.

scientific article

Irradiation enhanced risks of hospitalised pneumonopathy in lung cancer patients: a population-based surgical cohort study

scientific article published on 27 September 2017

Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation

scientific article published on 26 February 2014

Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells

scientific article

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma.

scientific article published on 22 July 2015

Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer.

scientific article published on 13 June 2019

NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression.

scientific article published on 09 September 2014

Oncogene-tumor suppressor gene feedback interactions and their control.

scientific article published in December 2015

Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma

scientific article

Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer.

scientific article

Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

scientific article

Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.

scientific article published in October 2005

Significant symptoms alleviation and tumor volume reduction after combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy in a patient with unresectable bulky hepatocellular carcinoma: A care-compliant [...]

scientific article

TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target

scientific article published on 23 April 2019

TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy.

scientific article

Unexpected close surgical margin in resected buccal cancer: very close margin and DAPK promoter hypermethylation predict poor clinical outcomes

scientific article published on 14 December 2012

ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer

scientific article published on 31 January 2019

c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma

scientific article published on 28 September 2019

List of works by Michael W. Chan

2,4-Diamino-Quinazoline, a Wnt Signaling Inhibitor, Suppresses Gastric Cancer Progression and Metastasis

A mathematical model of bimodal epigenetic control of miR-193a in ovarian cancer stem cells

Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer.

Aberrant TGFβ/SMAD4 signaling contributes to epigenetic silencing of a putative tumor suppressor, RunX1T1 in ovarian cancer

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

Aberrant epigenetic modifications in radiation-resistant head and neck cancers

Analysis of DNA methylation in human BK virus ⬇️

Anti-sense trefoil factor family-3 (intestinal trefoil factor) inhibits cell growth and induces chemosensitivity to adriamycin in human gastric cancer cells.

Association between cytokines and methylation of SOCS-1 in serum of patients with ankylosing spondylitis

CCRK-a hub for liver metastasis and cancer

Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters.

Cyproheptadine exhibits antitumor activity in urothelial carcinoma cells by targeting GSK3β to suppress mTOR and β-catenin signaling pathways.

DNA Methylation as a Noninvasive Epigenetic Biomarker for the Detection of Cancer

DNA methylation profiles and biomarkers of oral squamous cell carcinoma.

Detection of epigenetic changes in fecal DNA as a molecular screening test for colorectal cancer: a feasibility study

Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps

Dichotomy effects of Akt signaling in breast cancer ⬇️

Distinct DNA methylation epigenotypes in bladder cancer from different Chinese sub-populations and its implication in cancer detection using voided urine.

Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma

E2F6 functions as a competing endogenous RNA, and transcriptional repressor, to promote ovarian cancer stemness

Epigenetic silencing of ARNTL, a circadian gene and potential tumor suppressor in ovarian cancer.

Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer

Epigenetic silencing of the NR4A3 tumor suppressor, by aberrant JAK/STAT signaling, predicts prognosis in gastric cancer

Epigenetic silencing of the dual-role signal mediator, ANGPTL4 in tumor tissues and its overexpression in the urothelial carcinoma microenvironment.

Expression of trefoil peptides (TFF1, TFF2, and TFF3) in gastric carcinomas, intestinal metaplasia, and non-neoplastic gastric tissues.

FGF18-FGFR2 signaling triggers the activation of c-Jun-YAP1 axis to promote carcinogenesis in a subgroup of gastric cancer patients and indicates translational potential

FT-IR microspectrometry reveals the variation of membrane polarizability due to epigenomic effect on epithelial ovarian cancer

Fibroblasts isolated from common sites of breast cancer metastasis enhance cancer cell growth rates and invasiveness in an interleukin-6-dependent manner.

GATA3 as a master regulator and therapeutic target in ovarian high-grade serous carcinoma stem cells

Global profiling of histone modifications in the polyomavirus BK virion minichromosome

Growth inhibition of ovarian tumor-initiating cells by niclosamide.

Guizhi Fuling Wan as a novel agent for intravesical treatment for bladder cancer in mouse model

Hard clam extracts induce atypical apoptosis in human gastric cancer cells

Helicobacter pylori causes epigenetic dysregulation of FOXD3 to promote gastric carcinogenesis.

Hemolytic E. coli Promotes Colonic Tumorigenesis in Females

High Dickkopf-1 expression is associated with poor prognosis in patients with advanced urothelial carcinoma.

Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer.

Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients.

Identification and characterization of ovarian cancer-initiating cells from primary human tumors

Inactivation of helicase-like transcription factor by promoter hypermethylation in human gastric cancer.

Irradiation enhanced risks of hospitalised pneumonopathy in lung cancer patients: a population-based surgical cohort study

Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation

Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma.

Methylomics analysis identifies a putative STAT3 target, SPG20, as a noninvasive epigenetic biomarker for early detection of gastric cancer.

NKCC1 mediates traumatic brain injury-induced hippocampal neurogenesis through CREB phosphorylation and HIF-1α expression.

Oncogene-tumor suppressor gene feedback interactions and their control.

Promoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma

Promoter hypermethylation of tumor-related genes in gastric intestinal metaplasia of patients with and without gastric cancer.

Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma

Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer.

Significant symptoms alleviation and tumor volume reduction after combined simultaneously integrated inner-escalated boost and volumetric-modulated arc radiotherapy in a patient with unresectable bulky hepatocellular carcinoma: A care-compliant [...]

TET1 reprograms the epithelial ovarian cancer epigenome and reveals casein kinase 2α as a therapeutic target

TGF-β: friend or foe? The role of TGF-β/SMAD signaling in epigenetic silencing of ovarian cancer and its implication in epigenetic therapy.

Unexpected close surgical margin in resected buccal cancer: very close margin and DAPK promoter hypermethylation predict poor clinical outcomes

ZNF671 DNA methylation as a molecular predictor for the early recurrence of serous ovarian cancer

c-Myc Acts as a Competing Endogenous RNA to Sponge miR-34a, in the Upregulation of CD44, in Urothelial Carcinoma