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List of works by Ivan Špička

A dose exploration, phase I/II study of administration of continuous erythropoietin receptor activator once every 3 weeks in anemic patients with multiple myeloma receiving chemotherapy

scientific article published on 01 April 2007

A first Czech analysis of 1887 cases with monoclonal gammopathy of undetermined significance

scientific article published on 6 April 2017

A phase 2, randomized, double-blind, placebo-controlled study of siltuximab (anti-IL-6 mAb) and bortezomib versus bortezomib alone in patients with relapsed or refractory multiple myeloma.

scientific article

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients.

scientific article published on 25 November 2017

Advances in multiple myeloma therapy during two past decades

scientific article published on 11 June 2014

An overview of the VISTA trial: newly diagnosed, untreated patients with multiple myeloma ineligible for stem cell transplantation

Asymptomatic and Treatment-requiring Multiple Myeloma - Data from the Czech Registry of Monoclonal Gammopathies

scientific article published in January 2017

Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA trial

scientific article published on 5 April 2010

Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma

scientific article

Bortezomib, thalidomide and dexamethasone, with or without cyclophosphamide, for patients with previously untreated multiple myeloma: 5-year follow-up.

scientific article published on 7 July 2015

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma.

scientific article published on 20 July 2016

Carfilzomib, lenalidomide, and dexamethasone in patients with relapsed multiple myeloma categorised by age: secondary analysis from the phase 3 ASPIRE study

scientific article

Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment

scientific article

Change in ploidy status from hyperdiploid to near-tetraploid in multiple myeloma associated with bortezomib/lenalidomide resistance

scientific article published on 27 June 2014

Characterization of a new human plasma cell leukemia cell line UHKT-944.

scientific article

Complex karyotype and translocation t(4;14) define patients with high-risk newly diagnosed multiple myeloma: results of CMG2002 trial

scientific article published on 13 December 2011

Continuous Lenalidomide Treatment for Newly Diagnosed Multiple Myeloma

article

Continuous prednisolone versus conventional prednisolone with VMCP-interferon-alpha2b as first-line chemotherapy in elderly patients with multiple myeloma.

scientific article

Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma

scientific article

Distinguishing of primary mediastinal B-cell lymphoma and diffuse large B-cell lymphoma using real-time quantitative polymerase chain reaction

scientific article published on 01 January 2010

Elotuzumab Therapy for Relapsed or Refractory Multiple Myeloma

scientific article published on 2 June 2015

Elotuzumab plus lenalidomide/dexamethasone for relapsed or refractory multiple myeloma: ELOQUENT-2 follow-up and post-hoc analyses on progression-free survival and tumour growth

scientific article

Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma

article

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma.

scientific article

Gain of 1q21 is an unfavorable genetic prognostic factor for multiple myeloma patients treated with high-dose chemotherapy.

scientific article published on 18 January 2010

Health-Related Quality of Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.

scientific article published on 6 September 2016

Histone deacetylase inhibitors in plasma cell leukemia treatment: effect of bone marrow microenvironment.

scientific article published on 3 January 2017

IgM myeloma: A multicenter retrospective study of 134 patients

scientific article published on 6 April 2017

Immunotactoid glomerulonephritis as a cause of acute renal failure

scientific article published on 01 April 2004

Multicentered patient-based evidence of the role of free light chain ratio normalization in multiple myeloma disease relapse.

scientific article published on 26 March 2015

Novel human multiple myeloma cell line UHKT-893

scientific article published on January 3, 2013

Once-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin production

scientific article published on 01 August 2003

Persistent overall survival benefit and no increased risk of second malignancies with bortezomib-melphalan-prednisone versus melphalan-prednisone in patients with previously untreated multiple myeloma.

scientific article published on 10 December 2012

Phase 1/2 study of cyclin-dependent kinase (CDK)4/6 inhibitor palbociclib (PD-0332991) with bortezomib and dexamethasone in relapsed/refractory multiple myeloma.

scientific article published on 27 March 2015

Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma

scientific article

Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progression

scientific article

Risk factors for, and reversibility of, peripheral neuropathy associated with bortezomib-melphalan-prednisone in newly diagnosed patients with multiple myeloma: subanalysis of the phase 3 VISTA study.

scientific article published on 15 November 2010

Subcutaneous bortezomib in multiple myeloma patients induces similar therapeutic response rates as intravenous application but it does not reduce the incidence of peripheral neuropathy

scientific article

Thalidomide maintenance treatment increases progression-free but not overall survival in elderly patients with myeloma.

scientific article

The diagnostic performance of cardiac magnetic resonance in detection of myocardial involvement in AL amyloidosis

scientific article published on 13 November 2014

Unusual manifestation of AL amyloidosis--stenosis of inferior vena cava.

scientific article published on 28 February 2006

Whole-body low-dose computed tomography in multiple myeloma staging: Superior diagnostic performance in the detection of bone lesions, vertebral compression fractures, rib fractures and extraskeletal findings compared to radiography with similar rad

scientific article published on 13 February 2017