List of works - A Johnston

22 again: IL-22 as a risk gene and important mediator in psoriasis

scientific article published on 01 June 2014

Age-Associated Increase in Skin Fibroblast-Derived Prostaglandin E2 Contributes to Reduced Collagen Levels in Elderly Human Skin

scientific article

Alteration of the EphA2/Ephrin-A Signaling Axis in Psoriatic Epidermis ⬇️

scientific article published on November 29, 2012

Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models

scientific article

CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

scientific article

Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era

scientific article

Current understanding of the genetic basis of psoriasis

scientific article published on 01 July 2009

Cytokines in psoriasis

scientific article

Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells

scientific article

Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients

scientific article

EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner

scientific article

Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling

scientific article

Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture

scientific article

Evidence for altered Wnt signaling in psoriatic skin.

scientific article

Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.

scientific article

HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.

scientific article

Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis

scientific article

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.

scientific article published on 30 December 2016

Immunopathogenic mechanisms in psoriasis.

scientific article published on January 2004

Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants

scientific article published on 09 April 2012

In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity

scientific article published in November 2016

Isolation of mononuclear cells from tonsillar tissue

scientific article published on 01 August 2009

Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature

scientific article

Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin.

scientific article published on January 2010

Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin

scientific article

Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation

scientific article

Mouse models of psoriasis.

scientific article published on 12 April 2007

Narrowband-UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells

scientific article published on 12 May 2005

Novel systemic drugs under investigation for the treatment of psoriasis.

scientific article published on 02 February 2012

Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation.

scientific article published on 28 June 2008

Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells

scientific article published on 01 October 2004

Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.

scientific article published on 4 August 2015

Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans

scientific article published on 28 October 2014

Psoriasis and the MAITing game: a role for IL-17A+ invariant TCR CD8+ T cells in psoriasis?

scientific article

Psoriasis--as an autoimmune disease caused by molecular mimicry

scientific article

Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite

scientific article published in October 2017

Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation ⬇️

scientific article published on February 5, 2013

Still waters run deep: latent cytokine activity in nonlesional psoriasis skin

scientific article published on 01 January 2016

The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis

scientific article published on May 2017

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

scientific article published in February 2005

The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells

scientific article published on 07 October 2011

The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.

scientific article published in October 2013

The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

scientific article

The role of the palatine tonsils in the pathogenesis and treatment of psoriasis

scientific article

The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis

scientific article published in PLoS ONE

Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice

scientific article

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms

scientific article

List of works by A Johnston

22 again: IL-22 as a risk gene and important mediator in psoriasis

Age-Associated Increase in Skin Fibroblast-Derived Prostaglandin E2 Contributes to Reduced Collagen Levels in Elderly Human Skin

Alteration of the EphA2/Ephrin-A Signaling Axis in Psoriatic Epidermis ⬇️

Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models

CYR61/CCN1: A Novel Mediator of Epidermal Hyperplasia and Inflammation in Psoriasis?

Cellular dissection of psoriasis for transcriptome analyses and the post-GWAS era

Current understanding of the genetic basis of psoriasis

Cytokines in psoriasis

Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells

Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients

EGFR and IL-1 signaling synergistically promote keratinocyte antimicrobial defenses in a differentiation-dependent manner

Early tissue responses in psoriasis to the antitumour necrosis factor-α biologic etanercept suggest reduced interleukin-17 receptor expression and signalling

Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture

Evidence for altered Wnt signaling in psoriatic skin.

Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.

HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement after tonsillectomy: A prospective case series.

Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis

IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.

Immunopathogenic mechanisms in psoriasis.

Improvement of psoriasis after tonsillectomy is associated with a decrease in the frequency of circulating T cells that recognize streptococcal determinants and homologous skin determinants

In the Red: Deficits in Immune Regulation Underlie Psoriasis Severity

Isolation of mononuclear cells from tonsillar tissue

Meta-profiles of gene expression during aging: limited similarities between mouse and human and an unexpectedly decreased inflammatory signature

Metalloproteinase-mediated, context-dependent function of amphiregulin and HB-EGF in human keratinocytes and skin.

Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte-associated antigen and the numbers of mononuclear leucocytes in psoriatic skin

Modulation of epidermal transcription circuits in psoriasis: new links between inflammation and hyperproliferation

Mouse models of psoriasis.

Narrowband-UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells

Novel systemic drugs under investigation for the treatment of psoriasis.

Obesity in psoriasis: leptin and resistin as mediators of cutaneous inflammation.

Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells

Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance.

Proteomics of skin proteins in psoriasis: from discovery and verification in a mouse model to confirmation in humans

Psoriasis and the MAITing game: a role for IL-17A+ invariant TCR CD8+ T cells in psoriasis?

Psoriasis--as an autoimmune disease caused by molecular mimicry

Resolving Inflammation by Targeting an Ancient Innate Immune Sensor with a Bacterial Metabolite

Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation ⬇️

Still waters run deep: latent cytokine activity in nonlesional psoriasis skin

The Molecular Revolution in Cutaneous Biology: The Era of Global Transcriptional Analysis

The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules

The anti-microbial peptide LL-37 modulates immune responses in the palatine tonsils where it is exclusively expressed by neutrophils and a subset of dendritic cells

The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.

The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells.

The role of the palatine tonsils in the pathogenesis and treatment of psoriasis

The small molecule rhodomyrtone suppresses TNF-α and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis

Transcriptional profiles of leukocyte populations provide a tool for interpreting gene expression patterns associated with high fat diet in mice

Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms