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List of works by Mei-Chuan Ko

A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates

scientific article published on 01 August 2018

A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates

scientific article published on 29 August 2016

Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.

scientific article

Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys

scientific article

Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.

scientific article

An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.

scientific article published in March 2000

Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates

scientific article published on 01 February 2020

Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys

scientific article

Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates

scientific article published on 17 August 2020

BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates

scientific article published on 01 March 2019

Central N/OFQ-NOP Receptor System in Pain Modulation

scientific article published on 17 December 2015

Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.

scientific article published on September 2004

Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice

scientific article published on 01 May 2021

Chronic effects of haloperidol and SCH23390 on operant and licking behaviors in the rat.

scientific article published in January 1995

Cocaine esterase: interactions with cocaine and immune responses in mice

scientific article published on 17 November 2006

Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.

scientific article

Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain

scientific article

Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys

scientific article

Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys ⬇️

scientific article published on May 1, 1998

Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.

scientific article

Effect of opioid receptor antagonists on hypothalamic–pituitary–adrenal activity in rhesus monkeys ⬇️

scientific article published on May 1, 2003

Effects of NOP-Related Ligands in Nonhuman Primates

scientific article published on 01 January 2019

Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.

scientific article

Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates

scientific article

Effects of butorphanol on morphine-induced itch and analgesia in primates.

scientific article

Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.

scientific article published on 9 June 2006

Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.

scientific article published on 5 March 2008

Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/μ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain

scientific article published on 07 May 2013

Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys

scientific article published on 10 April 2019

Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.

scientific article

Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits

scientific article

Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects

scientific article

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

scientific article

Gangrenous Clostridium perfringens infection and subsequent wound management in a rhesus macaque (Macaca mulatta).

scientific article published in July 2007

How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches.

scientific article

Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys

scientific article

Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.

scientific article

Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.

scientific article

Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats

scientific article published on 12 October 2011

Most efficient cocaine hydrolase designed by virtual screening of transition states

scientific article

Neuraxial opioid-induced itch and its pharmacological antagonism

scientific article published on January 2015

Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons

scientific article published on 01 May 2019

PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity

scientific article

Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice

scientific article

Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).

scientific article

Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

scientific article published on 30 April 2007

Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice

scientific article

Relative reinforcing effects of three opioids with different durations of action.

scientific article published in May 2002

Repeated Administration of a Mutant Cocaine Esterase: Effects on Plasma Cocaine Levels, Cocaine-Induced Cardiovascular Activity, and Immune Responses in Rhesus Monkeys ⬇️

scientific article published on April 19, 2012

Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates

scientific article

Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice

scientific article published on 15 December 2015

Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys

scientific article published on 12 May 2015

Structural analysis of thermostabilizing mutations of cocaine esterase

scientific article

Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys.

scientific article published on 3 April 2003

Subunit Stabilization and Polyethylene Glycolation of Cocaine Esterase Improves In Vivo Residence Time ⬇️

scientific article published on September 2, 2011

Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.

scientific article published on 24 April 2015

TC-2559, an α4β2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1β through STAT3 inhibition in cultured murine macrophages

scientific article published on 08 May 2015

The Therapeutic Potential of Nociceptin/Orphanin FQ Receptor Agonists as Analgesics without Abuse Liability ⬇️

scientific article published on November 6, 2012

The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys

scientific article

The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.

scientific article published on August 1999

The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination

scientific article published on 11 October 2011

The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats

scientific article

The role of central mu opioid receptors in opioid-induced itch in primates.

scientific article

The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys ⬇️

scientific article published on July 1, 1998

The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.

scientific article published on June 2008

Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse

scientific article published on 07 April 2020

Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity

scientific article

Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.

scientific article

[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.

scientific article published on January 2013

kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception ⬇️

scientific article published on May 1, 1998

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