List of works - Alfonso Represa

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.

scientific article

A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A

scientific journal article

A noncanonical release of GABA and glutamate modulates neuronal migration.

scientific article published in May 2005

A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus

scientific article

A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats.

scientific article

Abnormal connections in the malformed cortex of rats with prenatal treatment with methylazoxymethanol may support hyperexcitability

scientific article published on November 1999

Abnormal network activity in a targeted genetic model of human double cortex

scientific article published in January 2009

Acidic calponin cloned from neural cells is differentially expressed during rat brain development.

scientific article

An epilepsy-related ARX polyalanine expansion modifies glutamatergic neurons excitability and morphology without affecting GABAergic neurons development

scientific article published on 24 May 2012

Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats

scientific article published on 31 December 2007

Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis.

scientific article published in March 1996

Atlas of the Postnatal Rat Brain in Stereotaxic Coordinates

scientific article

Basic mechanisms of MCD in animal models

scientific article published on 10 September 2009

Beta-actin immunoreactivity in rat microglial cells: developmental pattern and participation in microglial reaction after kainate injury.

scientific article published in May 1998

Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus.

scientific article published on August 1990

Causes and consequences of gray matter heterotopia

scientific article published on 02 September 2014

Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats.

scientific article published on March 1995

Cell-autonomous and cell-to-cell signalling events in normal and altered neuronal migration

scientific article

Consensus on diagnosis and management of JME: From founder's observations to current trends.

scientific article

Correct laminar positioning in the neocortex influences proper dendritic and synaptic development

article

Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus

scientific article published on 01 August 1994

Correlative fluorescence and electron microscopy of biocytin-filled neurons with a preservation of the postsynaptic ultrastructure

scientific article

Development of high affinity kainate binding sites in human and rat hippocampi.

scientific article

Development of the cholinergic system in control and intra-uterine growth retarded rat brain.

scientific article published in May 1989

Differential expression of fibronectin, tenascin-C and NCAMs in cultured hippocampal astrocytes activated by kainate, bacterial lipopolysaccharide or basic fibroblast growth factor ⬇️

scientific article published on November 14, 1997

Distribution of caldesmon and of the acidic isoform of calponin in cultured cerebellar neurons and in different regions of the rat brain: an immunofluorescence and confocal microscopy study

scientific journal article

EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord

scientific article published on 01 August 2001

Effects of colchicine treatment on the cholinergic septohippocampal system.

scientific article published on January 1989

Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain.

scientific article published in December 1990

Effects of neonatal γ -ray irradiation on rat hippocampus—I. Postnatal maturation of hippocampal cells ⬇️

scientific article published on January 1, 1991

Effects of neonatal γ-ray irradiation on rat hippocampus—II. Development of excitatory amino acid binding sites ⬇️

scientific article published on January 1, 1991

Effects of tenascin-C in cultured hippocampal astrocytes: NCAM and fibronectin immunoreactivity changes ⬇️

scientific article published on July 1, 1997

Epilepsy induced collateral sprouting of hippocampal mossy fibers: does it induce the development of ectopic synapses with granule cell dendrites?

scientific article

Epileptogenesis and neuronal plasticity: studies on kainate receptor in the human and rat hippocampus

scientific article published on January 1, 1992

Excitatory GABA in rodent developing neocortex in vitro

scientific article published on 21 May 2008

Expression of an acidic isoform of calponin in rat brain: western blots on one- or two-dimensional gels and immunolocalization in cultured cells

scientific article

FGF-2 induces nerve growth factor expression in cultured rat hippocampal neurons.

scientific article published in June 1997

Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias

scientific article published on April 2007

GABAergic hub neurons orchestrate synchrony in developing hippocampal networks

scientific article published in December 2009

Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake

scientific article

Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells

scientific article published on 01 October 1994

Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity

scientific article published on 01 August 1995

Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons.

scientific article

Glutamate transporters prevent the generation of seizures in the developing rat neocortex.

scientific article published in March 2004

Hippocampal plasticity in childhood epilepsy

scientific article published on 01 May 1989

Hippocampal plasticity in the kindling model of epilepsy in rats

scientific article published in May 1989

Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures

scientific article

Inflammatory responses in the cerebral cortex after ischemia in the P7 neonatal Rat.

scientific article published in September 1999

Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome

scientific article published in August 2009

Interneurons set the tune of developing networks

scientific article published in July 2004

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

scientific article published on 01 August 1988

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

scientific article published on 01 March 1987

Kainate-induced apoptotic cell death in hippocampal neurons.

scientific article published in November 1994

Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region

scientific article

Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.

scientific article published on 02 October 2007

Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses

scientific article published on 21 May 2008

Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy.

scientific article published in February 1998

Long-term potentiation and sprouting of mossy fibers produced by brief episodes of hyperactivity

scientific article published on January 1, 1992

MAP2d mRNA is expressed in identified neuronal populations in the developing and adult rat brain and its subcellular distribution differs from that of MAP2b in hippocampal neurones.

scientific article published in January 1998

MAP2d promotes bundling and stabilization of both microtubules and microfilaments.

scientific article published on May 1996

Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.

scientific article

Molecular and cellular cascades in seizure-induced neosynapse formation.

scientific article published on January 1997

Molecular correlates between reactive and developmental plasticity in the rat hippocampus.

scientific article published on March 1995

Molecular mechanisms of seizure-induced cerebral plasticity.

scientific article

Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin

scientific article published in June 1993

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria

scientific article

NCAM Is Essential for Axonal Growth and Fasciculation in the Hippocampus

scientific article published on 01 January 1997

NCAM immunoreactivity on mossy fibers and reactive astrocytes in the hippocampus of epileptic rats

scientific article published on 01 October 1993

Neocortex in the hippocampus: an anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats

scientific article published in May 1998

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate

scientific article published in December 1990

Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex

scientific article

Neurotransmitters and brain maturation: early paracrine actions of GABA and glutamate modulate neuronal migration

scientific article published on June 2007

Normotopic cortex is the major contributor to epilepsy in experimental double cortex.

scientific article published on 11 August 2014

Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons.

scientific article published in June 2006

Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation

scientific article

Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene

scientific journal article

Process formation results from the imbalance between motor-mediated forces.

scientific article

Proliferative astrocytes may express fibronectin-like protein in the hippocampus of epileptic rats

scientific article published on 01 October 1994

Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation

scientific article (publication date: February 1999)

Reactive astrocytes in the kainic acid-damage hippocampus have the phenotypic features of type-2 astrocytes.

scientific article

Recurrent CA1 collateral axons in developing rat hippocampus.

scientific article

Recurrent mossy fibers establish aberrant kainate receptor-operated synapses on granule cells from epileptic rats.

scientific article

Seizure-induced molecular changes, sprouting and synaptogenesis of hippocampal mossy fibers.

scientific article published on January 1996

Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses

scientific article published on May 2008

Selective destruction of mossy fibers and granule cells with preservation of the GABAergic network in the inferior region of the rat hippocampus after colchicine treatment

scientific article published in July 1989

Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

scientific article

Spared cognitive and behavioral functions prior to epilepsy onset in a rat model of subcortical band heterotopia

scientific article published on 25 January 2019

Spatiotemporal expression of noncatalytic TrkC NC2 isoform during early and late CNS neurogenesis: a comparative study with TrkC catalytic and p75NTR receptors.

scientific article published in September 2000

Spontaneous epileptic manifestations in a DCX knockdown model of human double cortex

scientific article published on 17 February 2010

Spontaneous epileptiform activity in a rat model of bilateral subcortical band heterotopia

scientific article published on 30 December 2018

Subcellular distribution of calponin and caldesmon in rat hippocampus

scientific journal article

Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency.

scientific article published in September 2007

TBC1D24 regulates neuronal migration and maturation through modulation of the ARF6-dependent pathway

scientific journal article

The Establishment of GABAergic and Glutamatergic Synapses on CA1 Pyramidal Neurons is Sequential and Correlates with the Development of the Apical Dendrite

scientific article published on 01 December 1999

The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission

scientific article

The right neuron at the wrong place: biology of heterotopic neurons in cortical neuronal migration disorders, with special reference to associated pathologies.

scientific article

Transient cerebral ischemia induces changes in SRIF mRNA in the fascia dentata ⬇️

scientific article published on July 1, 1991

Transient increase of NMDA-binding sites in human hippocampus during development.

scientific article

Transient increased density of NMDA binding sites in the developing rat hippocampus

scientific article published on 01 October 1988

Trophic actions of GABA on neuronal development

scientific article

Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero

scientific article published on 5 July 2013

Ultrastructural morphology of neuronal death following reversible focal ischemia in the rat

scientific article published on 01 March 1998

List of works by Alfonso Represa

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations.

A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A

A noncanonical release of GABA and glutamate modulates neuronal migration.

A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus

A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats.

Abnormal connections in the malformed cortex of rats with prenatal treatment with methylazoxymethanol may support hyperexcitability

Abnormal network activity in a targeted genetic model of human double cortex

Acidic calponin cloned from neural cells is differentially expressed during rat brain development.

An epilepsy-related ARX polyalanine expansion modifies glutamatergic neurons excitability and morphology without affecting GABAergic neurons development

Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats

Apoptosis and necrosis after reversible focal ischemia: an in situ DNA fragmentation analysis.

Atlas of the Postnatal Rat Brain in Stereotaxic Coordinates

Basic mechanisms of MCD in animal models

Beta-actin immunoreactivity in rat microglial cells: developmental pattern and participation in microglial reaction after kainate injury.

Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus.

Causes and consequences of gray matter heterotopia

Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats.

Cell-autonomous and cell-to-cell signalling events in normal and altered neuronal migration

Consensus on diagnosis and management of JME: From founder's observations to current trends.

Correct laminar positioning in the neocortex influences proper dendritic and synaptic development

Correlation between reactive sprouting and microtubule protein expression in epileptic hippocampus

Correlative fluorescence and electron microscopy of biocytin-filled neurons with a preservation of the postsynaptic ultrastructure

Development of high affinity kainate binding sites in human and rat hippocampi.

Development of the cholinergic system in control and intra-uterine growth retarded rat brain.

Differential expression of fibronectin, tenascin-C and NCAMs in cultured hippocampal astrocytes activated by kainate, bacterial lipopolysaccharide or basic fibroblast growth factor ⬇️

Distribution of caldesmon and of the acidic isoform of calponin in cultured cerebellar neurons and in different regions of the rat brain: an immunofluorescence and confocal microscopy study

EGF-responsive neural stem cells are a transient population in the developing mouse spinal cord

Effects of colchicine treatment on the cholinergic septohippocampal system.

Effects of kainic acid-induced seizures and ischemia on c-fos-like proteins in rat brain.

Effects of neonatal γ -ray irradiation on rat hippocampus—I. Postnatal maturation of hippocampal cells ⬇️

Effects of neonatal γ-ray irradiation on rat hippocampus—II. Development of excitatory amino acid binding sites ⬇️

Effects of tenascin-C in cultured hippocampal astrocytes: NCAM and fibronectin immunoreactivity changes ⬇️

Epilepsy induced collateral sprouting of hippocampal mossy fibers: does it induce the development of ectopic synapses with granule cell dendrites?

Epileptogenesis and neuronal plasticity: studies on kainate receptor in the human and rat hippocampus

Excitatory GABA in rodent developing neocortex in vitro

Expression of an acidic isoform of calponin in rat brain: western blots on one- or two-dimensional gels and immunolocalization in cultured cells

FGF-2 induces nerve growth factor expression in cultured rat hippocampal neurons.

Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias

GABAergic hub neurons orchestrate synchrony in developing hippocampal networks

Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake

Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells

Gliosis and axonal sprouting in the hippocampus of epileptic rats are associated with an increase of tenascin-C immunoreactivity

Glutamate acting on AMPA but not NMDA receptors modulates the migration of hippocampal interneurons.

Glutamate transporters prevent the generation of seizures in the developing rat neocortex.

Hippocampal plasticity in childhood epilepsy

Hippocampal plasticity in the kindling model of epilepsy in rats

Increased levels of acidic calponin during dendritic spine plasticity after pilocarpine-induced seizures

Inflammatory responses in the cerebral cortex after ischemia in the P7 neonatal Rat.

Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome

Interneurons set the tune of developing networks

Is senile dementia of the Alzheimer type associated with hippocampal plasticity?

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

Kainate-induced apoptotic cell death in hippocampal neurons.

Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region

Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.

Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses

Long-lasting enhanced expression in the rat hippocampus of NMDAR1 splice variants in a kainate model of epilepsy.

Long-term potentiation and sprouting of mossy fibers produced by brief episodes of hyperactivity

MAP2d mRNA is expressed in identified neuronal populations in the developing and adult rat brain and its subcellular distribution differs from that of MAP2b in hippocampal neurones.

MAP2d promotes bundling and stabilization of both microtubules and microfilaments.

Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.

Molecular and cellular cascades in seizure-induced neosynapse formation.

Molecular correlates between reactive and developmental plasticity in the rat hippocampus.

Molecular mechanisms of seizure-induced cerebral plasticity.

Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of alpha-tubulin

Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria

NCAM Is Essential for Axonal Growth and Fasciculation in the Hippocampus

NCAM immunoreactivity on mossy fibers and reactive astrocytes in the hippocampus of epileptic rats

Neocortex in the hippocampus: an anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats

Neurogranin: immunocytochemical localization of a brain-specific protein kinase C substrate

Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex

Neurotransmitters and brain maturation: early paracrine actions of GABA and glutamate modulate neuronal migration

Normotopic cortex is the major contributor to epilepsy in experimental double cortex.

Ongoing epileptiform activity in the post-ischemic hippocampus is associated with a permanent shift of the excitatory-inhibitory synaptic balance in CA3 pyramidal neurons.

Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation

Periventricular heterotopia in 6q terminal deletion syndrome: role of the C6orf70 gene

Process formation results from the imbalance between motor-mediated forces.

Proliferative astrocytes may express fibronectin-like protein in the hippocampus of epileptic rats

Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation