List of works - Robert V. Stahelin

A Conserved Tryptophan in the Ebola Virus Matrix Protein C-Terminal Domain Is Required for Efficient Virus-Like Particle Formation

scientific article published on 22 May 2020

A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

scientific article published on 18 January 2018

A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress

scientific article

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

scientific article (publication date: 30 April 2015)

A new model of interfacial kinetics for phospholipases

scientific article published on July 2013

Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms.

scientific article

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

scientific article

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

scientific article published on 16 June 2015

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.

scientific article

Bright red-emitting pyrene derivatives with a large Stokes shift for nucleus staining

scientific article published on 16 May 2017

C2 domain membrane penetration by group IVA cytosolic phospholipase A₂ induces membrane curvature changes

scientific article

Cellular and molecular interactions of phosphoinositides and peripheral proteins

scientific article published on 17 February 2014

Cellular membranes and lipid-binding domains as attractive targets for drug development

scientific article published on August 2008

Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

scientific article

Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis

scientific article

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A

scientific article published on 20 August 2020

Computer Modeling of the Membrane Interaction of FYVE Domains

article

Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains

scientific article (publication date: August 2003)

Could the Ebola virus matrix protein VP40 be a drug target?

scientific article

Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

scientific article published on 9 December 2015

Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry

scientific article

Ebola virus matrix protein VP40 hijacks the host plasma membrane to form the virus envelope

scientific article published on 15 April 2020

Editorial [Hot Topic: Peripheral Proteins as Drug Targets (Guest Editor: Robert V. Stahelin) ]

article

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism

scientific article published on 22 February 2020

Emerging methodologies to investigate lipid-protein interactions

scientific article

Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell

scientific article published on January 2012

Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface

scientific article

Genome-wide structural analysis reveals novel membrane binding properties of AP180 N-terminal homology (ANTH) domains.

scientific article

Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments.

scientific article published on 13 September 2017

Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites

scientific article

Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization

scientific article

Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis

scientific article

Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40.

scientific article published on 30 December 2015

Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate.

scientific article published on 15 June 2016

Lipid binding domains: more than simple lipid effectors.

scientific article

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly

scientific article published on 01 January 2021

MeTaDoR: a comprehensive resource for membrane targeting domains and their host proteins.

scientific article published on 25 August 2007

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization

scientific article published on 20 July 2022

Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine

scientific article published on 17 April 2019

Membrane binding and bending in Ebola VP40 assembly and egress

scientific article published in 2014

Membrane binding and subcellular targeting of C2 domains

scientific article published on 26 July 2006

Membrane binding assays for peripheral proteins.

scientific article

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox

scientific article published on 29 January 2003

Membrane insertion of the FYVE domain is modulated by pH

scientific article

Membrane-protein interactions in cell signaling and membrane trafficking

scientific article

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

scientific article

Modular synthesis of biologically active phosphatidic acid probes using click chemistry.

scientific article

Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1

scientific article published on 04 February 2020

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

scientific article

Molecular mechanism of membrane docking by the Vam7p PX domain

scientific article

Monitoring peripheral protein oligomerization on biological membranes

scientific article

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

scientific article published on 24 April 2020

Notes and tips for improving quality of lipid-protein overlay assays

scientific article published on 11 October 2016

Orientation and Penetration Depth of Monolayer-Bound p40phox-PX†

article

PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte

scientific article published on 22 July 2012

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

scientific article published on 10 May 2002

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

scientific article published in 2022

Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer.

scientific article published on April 2017

Ready, set, go! How protein kinase C manages dynamic signaling.

scientific article

Red-emitting pyrene-benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect

scientific article published on 01 March 2019

Roles of calcium ions in the membrane binding of C2 domains.

scientific article published in November 2001

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

scientific article

SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles

scientific article published on 19 November 2020

SARS-CoV-2 viral budding and entry can be modeled using virus-like particles

scientific article published on 01 October 2020

SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.

scientific article published on 5 June 2017

Selection of DNA ligands for protein kinase C-delta.

scientific article published on 23 June 2006

Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein

scientific article

Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity

scientific article

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

scientific article

Surface plasmon resonance: a useful technique for cell biologists to characterize biomolecular interactions.

scientific article published on April 2013

Synthesis and Convenient Functionalization of Azide-Labeled Diacylglycerol Analogues for Modular Access to Biologically Active Lipid Probes

article

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress.

scientific article

The Ebola Virus: From Basic Research to a Global Health Crisis

scientific article published on 13 August 2015

The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes

scientific article

The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress

scientific article published on May 2013

The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress

scientific article published on 6 January 2013

The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P2 lipids in the plasma membrane.

scientific article

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties

scientific article published on 08 August 2020

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding

scientific article published on 13 July 2020

The molecular basis of ceramide-1-phosphate recognition by C2 domains.

scientific article published on 31 December 2012

The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.

scientific article published on 16 January 2003

The molecular basis of the differential subcellular localization of FYVE domains.

scientific article published on 27 September 2004

The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

scientific article

Time to Fold: Tom1 Uses New Tricks to Regulate Lipid Binding of Tollip.

scientific article published in October 2015

Using Surface Plasmon Resonance to Quantitatively Assess Lipid-Protein Interactions.

scientific article published in January 2016

X-ray reflectivity studies of cPLA2{alpha}-C2 domains adsorbed onto Langmuir monolayers of SOPC

scientific article

pH-dependent binding of the Epsin ENTH domain and the AP180 ANTH domain to PI(4,5)P2-containing bilayers.

scientific article

List of works by Robert V. Stahelin

A Conserved Tryptophan in the Ebola Virus Matrix Protein C-Terminal Domain Is Required for Efficient Virus-Like Particle Formation

A cationic, C-terminal patch and structural rearrangements in Ebola virus matrix VP40 protein control its interactions with phosphatidylserine.

A loop region in the N-terminal domain of Ebola virus VP40 is important in viral assembly, budding, and egress

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

A new model of interfacial kinetics for phospholipases

Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms.

Binding of the PX domain of p47(phox) to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid is masked by an intramolecular interaction

Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation

Biophysical and computational studies of membrane penetration by the GRP1 pleckstrin homology domain.

Bright red-emitting pyrene derivatives with a large Stokes shift for nucleus staining

C2 domain membrane penetration by group IVA cytosolic phospholipase A₂ induces membrane curvature changes

Cellular and molecular interactions of phosphoinositides and peripheral proteins

Cellular membranes and lipid-binding domains as attractive targets for drug development

Ceramide 1-phosphate acts as a positive allosteric activator of group IVA cytosolic phospholipase A2 alpha and enhances the interaction of the enzyme with phosphatidylcholine.

Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis

Characterization of the Relationship between the Chaperone and Lipid-Binding Functions of the 70-kDa Heat-Shock Protein, HspA1A

Computer Modeling of the Membrane Interaction of FYVE Domains

Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains

Could the Ebola virus matrix protein VP40 be a drug target?

Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression

Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry

Ebola virus matrix protein VP40 hijacks the host plasma membrane to form the virus envelope

Editorial [Hot Topic: Peripheral Proteins as Drug Targets (Guest Editor: Robert V. Stahelin) ]

Effects of Manganese Porphyrins on Cellular Sulfur Metabolism

Emerging methodologies to investigate lipid-protein interactions

Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell

Eukaryotic virulence determinants utilize phosphoinositides at the ER and host cell surface

Genome-wide structural analysis reveals novel membrane binding properties of AP180 N-terminal homology (ANTH) domains.

Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments.

Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites

Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization

Investigation of Ebola VP40 assembly and oligomerization in live cells using number and brightness analysis

Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40.

Investigation of the biophysical properties of a fluorescently modified ceramide-1-phosphate.

Lipid binding domains: more than simple lipid effectors.

Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly

MeTaDoR: a comprehensive resource for membrane targeting domains and their host proteins.

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization

Membrane Localization of HspA1A, a Stress Inducible 70-kDa Heat-Shock Protein, Depends on Its Interaction with Intracellular Phosphatidylserine

Membrane binding and bending in Ebola VP40 assembly and egress

Membrane binding and subcellular targeting of C2 domains

Membrane binding assays for peripheral proteins.

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox

Membrane insertion of the FYVE domain is modulated by pH

Membrane-protein interactions in cell signaling and membrane trafficking

Metabolically stabilized derivatives of phosphatidylinositol 4-phosphate: synthesis and applications.

Modular synthesis of biologically active phosphatidic acid probes using click chemistry.

Molecular Analysis of Membrane Targeting by the C2 Domain of the E3 Ubiquitin Ligase Smurf1

Molecular Basis of Phosphatidylinositol 4-Phosphate and ARF1 GTPase Recognition by the FAPP1 Pleckstrin Homology (PH) Domain

Molecular mechanism of membrane docking by the Vam7p PX domain

Monitoring peripheral protein oligomerization on biological membranes

Mutation of Hydrophobic Residues in the C-Terminal Domain of the Marburg Virus Matrix Protein VP40 Disrupts Trafficking to the Plasma Membrane

Notes and tips for improving quality of lipid-protein overlay assays

Orientation and Penetration Depth of Monolayer-Bound p40phox-PX†

PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte

Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs.

Phosphatidylserine clustering by the Ebola virus matrix protein is a critical step in viral budding

Plasma membrane association facilitates conformational changes in the Marburg virus protein VP40 dimer.

Ready, set, go! How protein kinase C manages dynamic signaling.

Red-emitting pyrene-benzothiazolium: unexpected selectivity to lysosomes for real-time cell imaging without alkalinizing effect

Roles of calcium ions in the membrane binding of C2 domains.

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

SARS-CoV-2 viral budding and entry can be modeled using BSL-2 level virus-like particles

SARS-CoV-2 viral budding and entry can be modeled using virus-like particles

SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.

Selection of DNA ligands for protein kinase C-delta.

Single-particle tracking demonstrates that actin coordinates the movement of the Ebola virus matrix protein

Structural and membrane binding analysis of the Phox homology domain of Bem1p: basis of phosphatidylinositol 4-phosphate specificity

Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha.

Surface plasmon resonance: a useful technique for cell biologists to characterize biomolecular interactions.

Synthesis and Convenient Functionalization of Azide-Labeled Diacylglycerol Analogues for Modular Access to Biologically Active Lipid Probes

The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress.

The Ebola Virus: From Basic Research to a Global Health Crisis

The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes

The Ebola virus matrix protein deeply penetrates the plasma membrane: an important step in viral egress

The Ebola virus matrix protein penetrates into the plasma membrane: a key step in viral protein 40 (VP40) oligomerization and viral egress

The Ebola virus protein VP40 hexamer enhances the clustering of PI(4,5)P2 lipids in the plasma membrane.

The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity andcontributes to membrane binding