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List of works by Steven A Johnsen

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.

scientific article

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

scientific article published on 19 June 2019

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

scientific article published on 06 June 2019

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

scientific article

Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice

scientific article published on 20 January 2009

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells.

scientific article published on 22 March 2018

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.

scientific article published on 19 September 2016

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells

scientific article

Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription

scientific article published on 10 July 2014

CDK4 inhibition diminishes p53 activation by MDM2 antagonists

scholarly article by Anusha Sriraman et al published 11 September 2018 in Cell Death and Disease

CDK9 and H2B monoubiquitination: a well-choreographed dance.

scientific article

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

scientific article published on 07 January 2021

CHD1 regulates cell fate determination by activation of differentiation-induced genes

scientific article published on 5 May 2017

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

scientific article published on 15 August 2017

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

scientific article published on 21 August 2020

Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

scientific article published on 7 February 2017

Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

article

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

scientific article

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.

scientific article

EZH2 regulates pancreatic cancer subtype identity and tumor progression via transcriptional repression of GATA6

scientific article published on 09 September 2020

Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer

scientific article

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

scientific article

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

scientific article published on 09 August 2019

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

scientific article published on 17 February 2022

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.

scientific article

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

scientific article

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

scientific article

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.

scientific article published on March 2015

HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.

scientific article published on 17 August 2015

Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation

scientific article published on 13 February 2016

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.

scientific article published on 27 March 2017

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.

scientific article

Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing

scientific article

Interfering with the dynamics of estrogen receptor-regulated transcription

scientific article published on 01 January 2006

Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism

scientific article published on March 2017

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

scientific article published on 5 September 2016

Loss of RNF40 decreases NF-κB activity in colorectal cancer cells and reduces colitis burden in mice

article

Loss of causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

scientific article published on 01 October 2018

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

scientific article

Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.

scientific article

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

scientific article

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy

scholarly article

No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.

scientific article published on April 2016

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

scientific article published on 19 October 2019

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

scientific article published in April 2015

Perturbing Enhancer Activity in Cancer Therapy.

scientific article published on 7 May 2019

Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function ⬇️

scientific article published on June 1, 2012

RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease

scientific article published on 04 June 2021

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk

scientific article published on 08 September 2020

RNF40 regulates gene expression in an epigenetic context-dependent manner.

scientific article published on 16 February 2017

Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.

scientific article published on 12 July 2005

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

scientific article published on 8 February 2016

Role of TIEG1 in biological processes and disease states.

scientific article

SIRT2 directs the replication stress response through CDK9 deacetylation.

scientific article published on 29 July 2013

STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer

scientific article published on 12 January 2021

SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.

scientific article published on 20 January 2014

Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation

scientific article

Super enhancers - new analyses and perspectives on the low hanging fruit

scientific article

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

scientific article

TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.

scientific article

Targeted therapy of epigenomic regulatory mechanisms controlling the epithelial to mesenchymal transition during tumor progression.

scientific article published on 17 May 2014

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.

scientific article

The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming

scientific article published on 27 April 2020

The enigmatic role of H2Bub1 in cancer ⬇️

scientific article published on April 13, 2012

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.

scientific article published on 08 July 2008

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells

scientific article

The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis

scientific article published on 17 October 2020

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

scientific article

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

scientific article published on 07 January 2019

The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

scientific article

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

scientific article published on April 2017

Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.

scientific article

Twist1 induces distinct cell states depending on TGFBR1-activation

scientific article

USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity

scientific article published on 17 September 2019

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

scientific article published on 18 May 2021

USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer

scientific article published on 04 December 2019

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

scientific article published on 25 September 2015

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