List of works - A. Ganesan

A 'triflate-like' tetrafluoroarylsulfonate linker for multifunctional solid-phase organic synthesis

scientific article published on 29 July 2004

A Decade of Antifungal Leads from Natural Products: 2010-2019

scientific article published on 12 December 2019

Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor

scientific article published on 13 October 2009

Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis.

scientific article published on November 2006

Cellular analysis of the action of epigenetic drugs and probes

scientific article published on 10 January 2017

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

scientific article

Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).

scientific article

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

scientific article

Current strategies to target the anti-apoptotic Bcl-2 protein in cancer cells.

scientific article published on April 2004

Cyclative cleavage strategies for the solid-phase synthesis of heterocycles and natural products

scientific article published on 01 January 2003

Determination of Molecular Torsion Angles Using Nuclear Singlet Relaxation

scientific article published on 01 June 2010

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

scientific article published on 13 February 2011

Enzymatic synthesis of an indole diterpene by an oxidosqualene cyclase: mechanistic, biosynthetic, and phylogenetic implications.

scientific article published in July 2003

Epigenetic drug discovery: a success story for cofactor interference

scientific article published on 01 June 2018

Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat

scientific article published on 14 February 2020

Epigenetic polypharmacology: from combination therapy to multitargeted drugs

scientific article

Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery.

scientific article published on December 2009

Epigenetics: the first 25 centuries.

scientific article published in June 2018

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin

scientific article (publication date: 2013)

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

scientific article published on 29 March 2017

Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors.

scientific article

Identification of a chemical probe for NAADP by virtual screening

scientific article

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.

scientific article published on 22 September 2015

Ionic liquid acceleration of solid-phase suzuki-miyaura cross-coupling reactions

scientific article published on 01 September 2002

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

scientific article published on 5 June 2018

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

scientific article

Modular three-component solid-phase synthesis of unsymmetrical guanidines via resin capture of carbodiimides

scientific article published on 01 January 2004

Multitarget Drugs: an Epigenetic Epiphany.

scientific article published on 18 February 2016

Natural products as a hunting ground for combinatorial chemistry.

scientific article

New tools for parallel automated chemistry

scientific article published on 01 March 2001

Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule.

scientific article

PS-COD and PS-9-BBN: polymer-supported reagents for solution-phase parallel synthesis

scientific article published on 01 March 2005

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

scientific article published on 01 July 2020

Pictet-spengler reaction using ion-exchange resin as a catalyst and support for 'catch and release' purification

scientific article published on 07 February 2011

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

scientific article

Rapid deprotection of N-Boc amines by TFA combined with freebase generation using basic ion-exchange resins.

scientific article published in January 2005

Recent developments in combinatorial organic synthesis.

scientific article

Regioselective synthesis of 3-alkylindoles mediated by zinc triflate.

scientific article

Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via theN-Acyliminium Pictet−Spengler Reaction and Cyclative Cleavage

scientific article published on 01 November 2002

Solid-phase synthesis in the twenty-first century.

scientific article

Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone

scientific article published on 01 March 1998

Solid-phase total synthesis of kahalalide A and related analogues.

scientific article published on March 2005

Structure Revision of Similanamide to PF1171C by Total Synthesis.

scientific article published on 8 September 2015

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.

scientific article

Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation.

scientific article published in August 2002

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

scientific article

Targeting protein-protein interactions: the HIV protease

scientific article published on 01 August 1999

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

scientific article

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

scientific article

The impact of natural products upon modern drug discovery.

scientific article published on June 2008

The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin

scientific journal article

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

scientific article published on 18 August 2009

Total Synthesis of (+)-okaramine J featuring an exceptionally facile N-reverse-prenyl to C-prenyl aza-Claisen rearrangement

scientific article published on 01 August 2003

Total synthesis and biological evaluation of PF1171A, C, F, and G, cyclic hexapeptides with insecticidal activity.

scientific article published on 20 August 2014

Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor.

scientific article

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

scientific article published on 21 February 2007

Total synthesis of debromoflustramine B via biomimetic alkylative cyclization

scientific article published on 01 May 2003

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

scientific article published on 17 February 2011

Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor

scientific article published on 01 February 2004

Total synthesis of the fumiquinazoline alkaloids: solution-phase studies

scientific article published on 01 February 2000

Total synthesis, structural, and biological evaluation of stylissatin A and related analogs

scientific article published on September 2016

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

scientific article published on 19 August 2008

cis-Cyclopropylamines as mechanism-based inhibitors of monoamine oxidases

scientific article

List of works by A. Ganesan

A 'triflate-like' tetrafluoroarylsulfonate linker for multifunctional solid-phase organic synthesis

A Decade of Antifungal Leads from Natural Products: 2010-2019

Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor

Azumamides A-E: histone deacetylase inhibitory cyclic tetrapeptides from the marine sponge Mycale izuensis.

Cellular analysis of the action of epigenetic drugs and probes

Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.

Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).

Comparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.

Current strategies to target the anti-apoptotic Bcl-2 protein in cancer cells.

Cyclative cleavage strategies for the solid-phase synthesis of heterocycles and natural products

Determination of Molecular Torsion Angles Using Nuclear Singlet Relaxation

Enantioselective synthesis of tranylcypromine analogues as lysine demethylase (LSD1) inhibitors.

Enzymatic synthesis of an indole diterpene by an oxidosqualene cyclase: mechanistic, biosynthetic, and phylogenetic implications.

Epigenetic drug discovery: a success story for cofactor interference

Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat

Epigenetic polypharmacology: from combination therapy to multitargeted drugs

Epigenetic therapy: histone acetylation, DNA methylation and anti-cancer drug discovery.

Epigenetics: the first 25 centuries.

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin

Fluorinated tranylcypromine analogues as inhibitors of lysine-specific demethylase 1 (LSD1, KDM1A).

Hologram quantitative structure-activity relationship and comparative molecular interaction field analysis of aminothiazole and thiazolesulfonamide as reversible LSD1 inhibitors.

Identification of a chemical probe for NAADP by virtual screening

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore.

Ionic liquid acceleration of solid-phase suzuki-miyaura cross-coupling reactions

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

Macrolactamization versus macrolactonization: total synthesis of FK228, the depsipeptide histone deacetylase inhibitor.

Modular three-component solid-phase synthesis of unsymmetrical guanidines via resin capture of carbodiimides

Multitarget Drugs: an Epigenetic Epiphany.

Natural products as a hunting ground for combinatorial chemistry.

New tools for parallel automated chemistry

Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule.

PS-COD and PS-9-BBN: polymer-supported reagents for solution-phase parallel synthesis

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni

Pictet-spengler reaction using ion-exchange resin as a catalyst and support for 'catch and release' purification

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

Rapid deprotection of N-Boc amines by TFA combined with freebase generation using basic ion-exchange resins.

Recent developments in combinatorial organic synthesis.

Regioselective synthesis of 3-alkylindoles mediated by zinc triflate.

Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via theN-Acyliminium Pictet−Spengler Reaction and Cyclative Cleavage

Solid-phase synthesis in the twenty-first century.

Solid-phase synthesis of peptidomimetic oligomers with a phosphodiester backbone

Solid-phase total synthesis of kahalalide A and related analogues.

Structure Revision of Similanamide to PF1171C by Total Synthesis.

Synthesis and evaluation of tryprostatin B and demethoxyfumitremorgin C analogues.

Synthesis of functionalized 1,5-cyclooctadienes by LICKOR metalation.

TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+

Targeting protein-protein interactions: the HIV protease

The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor

The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.

The impact of natural products upon modern drug discovery.

The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin

Thioflavin S (NSC71948) interferes with Bcl-2-associated athanogene (BAG-1)-mediated protein-protein interactions.

Total Synthesis of (+)-okaramine J featuring an exceptionally facile N-reverse-prenyl to C-prenyl aza-Claisen rearrangement

Total synthesis and biological evaluation of PF1171A, C, F, and G, cyclic hexapeptides with insecticidal activity.

Total synthesis and stereochemical assignment of burkholdac B, a depsipeptide HDAC inhibitor.

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Total synthesis of debromoflustramine B via biomimetic alkylative cyclization

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor

Total synthesis of the fumiquinazoline alkaloids: solution-phase studies

Total synthesis, structural, and biological evaluation of stylissatin A and related analogs

Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

cis-Cyclopropylamines as mechanism-based inhibitors of monoamine oxidases