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List of works by Dudley W Lamming

A novel rapamycin analog is highly selective for mTORC1 in vivo

scientific article published on 19 July 2019

A radical role for TOR in longevity.

scientific article published on June 2011

A toolbox for the longitudinal assessment of healthspan in aging mice

scientific article published on 08 January 2020

ARDD 2020: from aging mechanisms to interventions

scientific article published on 30 December 2020

Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

scientific article published on 17 March 2022

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice

scientific article published in Scientific Reports

Aging and drug discovery

scientific article published on 01 November 2018

Agonist-independent Gαz activity negatively regulates β-cell compensation in a diet-induced obesity model of type 2 diabetes

scientific article published on 10 November 2020

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

scientific article published on 19 February 2016

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

scientific article

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

scientific article published on 05 June 2013

Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

scientific article published on 01 October 2019

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

scientific article

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan

scientific article (publication date: October 2014)

Diminished mTOR signaling: a common mode of action for endocrine longevity factors.

scientific article

Effects of inhaled fluticasone propionate on extrinsic tongue muscles in rats

scientific article published on 16 January 2020

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

scientific article

HST2 mediates SIR2-independent life-span extension by calorie restriction

scientific article

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

scientific article

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

scientific article published on March 2016

Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome

scientific article

Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.

scientific article published on September 1997

Hypothalamic mTORC2 is essential for metabolic health and longevity

scientific article published on 01 August 2019

Increased transport of acetyl-CoA into the endoplasmic reticulum causes a progeria-like phenotype

scientific article published on 27 July 2018

Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond

scientific article

Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

scientific article published on 19 March 2020

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

scientific article published on 7 June 2017

Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice

scientific article

Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice

scientific article published on 14 January 2021

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

scientific article published on 16 June 2016

Lysosome: The Metabolic Signaling Hub

scientific article published on 14 November 2018

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

scientific article

Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49<sup>th</sup> Annual Meeting of the American Aging Association

publication published on 29 October 2021

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

scientific article published on 13 March 2020

Molecular mechanisms of dietary restriction promoting health and longevity

scientific article published in 2021

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

scientific article published on 31 July 2017

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.

scientific article

Next Generation Strategies for Geroprotection via mTORC1 Inhibition

scientific article published on 01 January 2020

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

scientific article

Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging

scientific article published on 28 July 2020

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.

scientific article published on 9 June 2016

Pharmacologic Means of Extending Lifespan.

scientific article

Rapalogs and mTOR inhibitors as anti-aging therapeutics

scientific article

Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue

scientific article published on 8 February 2016

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance

scientific article published on July 1, 2013

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

scientific article

Rapamycin-induced metabolic defects are reversible in both lean and obese mice

scientific article

Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island.

scientific article published on 21 May 2016

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways

scientific article published on 21 November 2016

Regulation of metabolic health by essential dietary amino acids

scientific article published on 22 July 2018

Restoration of metabolic health by decreased consumption of branched-chain amino acids

scientific article published on 19 December 2017

Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model

scientific article published on 3 September 2015

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum.

scientific article

SYK kinase mediates brown fat differentiation and activation.

scientific article published on 13 December 2017

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

scientific article

Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice.

scientific article published on 7 December 2017

Short-term methionine deprivation improves metabolic health via sexually dimorphic, mTORC1-independent mechanisms.

scientific article published on 30 January 2018

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

scientific article (publication date: 11 September 2003)

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

scientific article

TORwards a Victory Over Aging

scientific article published on 01 January 2020

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

scientific article

The Metabolic Response to a Low Amino Acid Diet is Independent of Diet-Induced Shifts in the Composition of the Gut Microbiome

scientific article published in Scientific Reports

The TSC-mTOR pathway regulates macrophage polarization

scientific article published on January 2013

The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism

scientific article

The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

scientific article published on 21 April 2021

The regulation of healthspan and lifespan by dietary amino acids

scientific article published in 2021

The role of protein arginine methylation in the formation of silent chromatin

scientific article

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

scientific article published on 07 June 2013

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

scientific article

mTORC2 Puts Its Shoulder to Krebs' Wheel.

scientific article published in September 2016

mTORC2 takes the longevity stAGE.

scientific article published on September 2014