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List of works by Robert J Williams

(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.

scientific article published on 7 February 2007

A series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles

scientific article published on 19 August 2020

AMPA receptor activation promotes non-amyloidogenic amyloid precursor protein processing and suppresses neuronal amyloid-β production

scientific article

Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors

scientific article published on 9 February 2007

Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons.

scientific article published in November 2007

Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons

scientific article published on April 2005

Advanced glycation end products modulate amyloidogenic APP processing and Tau phosphorylation: a mechanistic link between glycation and the development of Alzheimer's disease.

scientific article published on 31 January 2018

An excitation-energy-dependent molecular beacon detects early-stage neurotoxic Aβ aggregates in the presence of cortical neurons

scientific article published on 21 November 2018

Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis

scientific article published on 01 January 2019

Analysis of protein glycation using fluorescent phenylboronate gel electrophoresis

scientific article published on January 2013

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

scientific article

Binding sites for LH in Candida albicans: comparison with the mammalian corpus luteum LH receptor.

scientific article published in August 1991

CB2 cannabinoid receptors promote mouse neural stem cell proliferation.

scientific article

Ca(2+)-permeable AMPA receptors induce phosphorylation of cAMP response element-binding protein through a phosphatidylinositol 3-kinase-dependent stimulation of the mitogen-activated protein kinase signaling cascade in neurons

scientific article

Characterization of a factor(s) from partially purified human gonadotrophin preparations which inhibit(s) the binding of radiolabelled human LH and human chorionic gonadotrophin to Candida albicans

scientific article published on 01 January 1991

Chromatin interaction maps identify Wnt responsive cis-regulatory elements coordinating Paupar-Pax6 expression in neuronal cells

scientific article published on 01 June 2022

Chronic ethanol reduces immunologically detectable Gq alpha/11 alpha in NG108-15 cells.

scientific article published in September 1993

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts.

scientific article published in November 2001

Corrigendum: Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease.

scientific article published on 5 April 2017

Cyclin-dependent kinase 5, Munc18a and Munc18-interacting protein 1/X11alpha protein up-regulation in Alzheimer's disease.

scientific article published on 18 January 2006

Cyclothiazide unmasks an AMPA-evoked release of arachidonic acid from cultured striatal neurones.

scientific article

Decreased rabphilin 3A immunoreactivity in Alzheimer's disease is associated with Aβ burden

scientific article

Dietary (-)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing.

scientific article

Dietary flavonoid (-)epicatechin stimulates phosphatidylinositol 3-kinase-dependent anti-oxidant response element activity and up-regulates glutathione in cortical astrocytes.

scientific article published on 4 July 2008

Ethanol differentially regulates guanine nucleotide-binding protein alpha subunit expression in NG108-15 cells independently of extracellular adenosine

scientific article

Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurones.

scientific article published on December 1997

Expression of SOD1 G93A or wild-type SOD1 in primary cultures of astrocytes down-regulates the glutamate transporter GLT-1: lack of involvement of oxidative stress

scientific article published in January 2004

Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3

scientific article

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease ⬇️

scientific article published on September 17, 2011

Flavonoids: antioxidants or signalling molecules?

scientific article (publication date: April 2004)

Genes encoding multiple forms of phospholipase A2 are expressed in rat brain.

scientific article

Glial metabolism of quercetin reduces its neurotoxic potential

scientific article published on 23 July 2008

Glucose regulates glutamate-evoked arachidonic acid release from cultured striatal neurons

scientific article published on 01 July 1995

Gs alpha-dependent and -independent desensitisation of prostanoid IP receptor-activated adenylyl cyclase in NG108-15 cells.

scientific article published in July 1994

Hydrogen peroxide enhances signal-responsive arachidonic acid release from neurons: role of mitogen-activated protein kinase.

scientific article published in May 1998

Hydrogen peroxide-mediated phosphorylation of ERK1/2, Akt/PKB and JNK in cortical neurones: dependence on Ca(2+) and PI3-kinase

scientific article published in January 2002

Increased Foxo3a Nuclear Translocation and Activity is an Early Neuronal Response to βγ-Secretase-Mediated Processing of the Amyloid-β Protein Precursor: Utility of an AβPP-GAL4 Reporter Assay

scientific article published on 12 December 2017

Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones

scientific article published in March 2004

Inhibition of ADP-ribosyltransferase increases synthesis of Gsα in neuroblastoma × glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase

article

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

scientific article published in May 2003

Involvement of adenosine in ethanol-induced changes in G-protein expression in NG108-15 cells?

scientific article published on 01 January 1993

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

scientific article

Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer's Disease

scientific article

Measurement of adenylyl cyclase activity in cell membranes

scientific article published on 01 January 1995

Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

scientific article published on 24 June 2003

Neuro-nutraceuticals: Further insights into their promise for brain health.

scientific article published in May 2016

Neuro-nutraceuticals: The path to brain health via nourishment is not so distant

scientific article published on 21 August 2015

Neuroinflammation: modulation by flavonoids and mechanisms of action

scientific article

Neuroprotective actions of deferiprone in cultured cortical neurones and SHSY-5Y cells

scientific article

Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

scientific article published on 20 April 2008

Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity

scientific article published on 16 August 2012

Noxious stimulation induces Trk receptor and downstream ERK phosphorylation in spinal dorsal horn

scientific article published in December 2002

Nutrition for the ageing brain: Towards evidence for an optimal diet

scientific article

Phenolic antioxidants attenuate neuronal cell death following uptake of oxidized low-density lipoprotein.

scientific article published in December 2000

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

scientific article published in January 2002

Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions

scientific article published on April 2008

Potential Neuroprotective Actions of Dietary Flavonoids

Prion protein expression alters APP cleavage without interaction with BACE-1

scientific article published on 10 July 2012

Pro-oxidant diet enhances β/γ secretase-mediated APP processing in APP/PS1 transgenic mice.

scientific article published on 17 August 2010

Reduction of GABA and glutamate transporter messenger RNAs in the severe-seizure genetically epilepsy-prone rat.

scientific article

Serotonin transporter expression is not sufficient to confer cytotoxicity to 3,4-methylenedioxymethamphetamine (MDMA) in vitro

scientific article published on March 2006

Specific, high-affinity binding sites for human luteinizing hormone (hLH) and human chorionic gonadotrophin (hCG) in Candida species

scientific article published on 01 March 1990

Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy

scientific article published on 18 June 2017

Synaptic NMDA receptor activation stimulates alpha-secretase amyloid precursor protein processing and inhibits amyloid-beta production.

scientific article

Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease

scientific article published on 13 December 2010

Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia.

scientific article published on 3 March 2012

The 'glial' glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings

scientific article published in February 2003

The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease

scientific article published on 25 August 2020

The Library Derived 4554W Peptide Inhibits Primary Nucleation of α-Synuclein

scientific article published on 10 November 2020

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

scientific article

Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration

scientific article published in February 2010

Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage.

scientific article published in November 2004

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