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List of works by Eric Sorscher

8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator

scientific article published on 01 May 1997

A Comparison between Two Pathophysiologically Different yet Microbiologically Similar Lung Diseases: Cystic Fibrosis and Chronic Obstructive Pulmonary Disease

scholarly article by Daniel E Fenker et al published 2018 in International journal of respiratory and pulmonary medicine

A breath of fresh air

scientific article published on 01 August 2011

A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis

scientific article published on May 2001

A functional anatomic defect of the cystic fibrosis airway

scientific article

A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration

scientific article published in March 2003

A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA

scholarly article

A method for the rapid detection of recombinant CFTR during gene therapy in cystic fibrosis.

scientific article published on August 1996

A pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease

scientific article (publication date: 2012)

A truncated CFTR protein rescues endogenous DeltaF508-CFTR and corrects chloride transport in mice

scientific article published on 20 July 2009

A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis.

scientific article

Ablation of internalization signals in the carboxyl-terminal tail of the cystic fibrosis transmembrane conductance regulator enhances cell surface expression

scientific article published on 9 October 2002

Activation of airway cl- secretion in human subjects by adenosine.

scientific article published on 23 March 2004

Activation of chloride secretion in cystic fibrosis cells and tissues by the substituted imidazole SRI 2931.

scientific article

Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells

scientific article published on 24 April 2003

Adenoviral gene delivery elicits distinct pulmonary-associated T helper cell responses to the vector and to its transgene ⬇️

scientific article published on July 15, 1997

Affinity purification of insoluble recombinant fusion proteins containing glutathione-S-transferase.

scientific article published in April 1992

Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.

scientific article published on 3 July 2002

An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters

scientific article published on 31 October 2019

An autoregulatory mechanism governing mucociliary transport is sensitive to mucus load

scientific article published in October 2014

Analysis of cystic fibrosis-associated P67L CFTR illustrates barriers to personalized therapeutics for orphan diseases

scientific article published on September 2016

Antibodies against purified epithelial sodium channel protein from bovine renal papilla

scientific article

Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells

scientific article published on September 1991

Assessing cell-specific effects of genetic variations using tRNA microarrays

scientific article published on 16 July 2019

Assessment of CFTR localisation in native airway epithelial cells obtained by nasal brushing.

scientific article published in August 2004

Association of cystic fibrosis genetic modifiers with congenital bilateral absence of the vas deferens

scientific article published on 25 January 2010

Bioelectric effects of quinine on polarized airway epithelial cells

scientific article

Bystander killing of melanoma cells using the human tyrosinase promoter to express the Escherichia coli purine nucleoside phosphorylase gene.

scientific article

CFTR Folding Consortium: methods available for studies of CFTR folding and correction

scientific article published on January 2011

CFTR modulator theratyping: Current status, gaps and future directions

scientific article published on 20 June 2018

Channel Gating Regulation by the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) First Cytosolic Loop

scientific article

Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats

scientific article

Chlorogenic Acid Activates CFTR-Mediated Cl- Secretion in Mice and Humans: Therapeutic Implications for Chronic Rhinosinusitis.

scientific article published on 27 May 2015

Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells

scientific article

Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency

scientific article published on 01 November 2009

Clinical doses of amikacin provide more effective suppression of the human CFTR-G542X stop mutation than gentamicin in a transgenic CF mouse model

scientific article published on 16 March 2006

Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy

scientific article published on 11 March 2016

Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures

scientific article published on August 2013

Comparison of vectorial ion transport in primary murine airway and human sinonasal air-liquid interface cultures, models for studies of cystic fibrosis, and other airway diseases.

scientific article published in March 2009

Correction: Myofibroblast Differentiation and Enhanced Tgf-B Signaling in Cystic Fibrosis Lung Disease

scientific article published in PLoS ONE

Correction: Resveratrol Enhances Airway Surface Liquid Depth in Sinonasal Epithelium by Increasing Cystic Fibrosis Transmembrane Conductance Regulator Open Probability

scientific article

Correlation of microRNA levels during hypoxia with predicted target mRNAs through genome-wide microarray analysis

scientific article

Cystic fibrosis

scientific article (publication date: 12 May 2005)

Cystic fibrosis precision therapeutics: Emerging considerations

scientific article published on 01 November 2019

Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability

scientific article published on October 1998

Cystic fibrosis transmembrane conductance regulator activation by the solvent ethanol: implications for topical drug delivery.

scientific article published on 3 December 2015

Cystic fibrosis transmembrane conductance regulator modulation by the tobacco smoke toxin acrolein

scientific article published on 20 April 2012

Cystic fibrosis transmembrane conductance regulator mutations that disrupt nucleotide binding

scientific article

Cystic fibrosis: a disorder of calcium-stimulated secretion and transepithelial sodium transport?

scientific article published on 01 February 1982

Development of an airway mucus defect in the cystic fibrosis rat.

scientific article published on 11 January 2018

Development of drug targeting based on recombinant expression of the chicken avidin gene

scientific article

Diagnosis of genetic disease by primer-specified restriction map modification, with application to cystic fibrosis and retinitis pigmentosa

scientific article published on 01 May 1991

Effects of megestrol acetate on weight gain, body composition, and pulmonary function in patients with cystic fibrosis

scientific article

Efficiency of plasmid delivery and expression after lipid-mediated gene transfer to human cells in vitro

scientific article published on December 1996

Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines

scientific article published on April 2004

Elevation of hepatic sulphotransferase activities in mice with resistance to cystic fibrosis.

scientific article published in May 2002

Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones

scientific article published on March 2008

Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis

scientific article published in June 2001

Excellent in vivo bystander activity of fludarabine phosphate against human glioma xenografts that express the escherichia coli purine nucleoside phosphorylase gene

scientific article published on September 2004

Exposure to cigarette smoke condensate reduces calcium activated chloride channel transport in primary sinonasal epithelial cultures

scientific article published on July 2010

Extracellular zinc and ATP restore chloride secretion across cystic fibrosis airway epithelia by triggering calcium entry

scientific article published on 29 December 2003

Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers

scientific article published on 6 October 2005

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

scientific article published on February 2016

Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report

scientific article

Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway

scientific article published in October 1994

Gene therapy of cancer: activation of nucleoside prodrugs with E. coli purine nucleoside phosphorylase

scientific article published in April 1999

Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues

scientific article published on 22 May 2020

Hesperidin stimulates cystic fibrosis transmembrane conductance regulator-mediated chloride secretion and ciliary beat frequency in sinonasal epithelium

scientific article

Heterozygosity for the F508del mutation in the cystic fibrosis transmembrane conductance regulator anion channel attenuates influenza severity

scientific article

Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction

scientific article published on 29 April 2020

Identification of a membrane protein from T84 cells using antibodies made against a DIDS-binding peptide

scientific article published on January 1992

Immunochemical localization of amiloride-sensitive sodium channels in sodium-transporting epithelia

scientific article published on 01 June 1989

In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells

scientific article published in October 2000

Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

scientific article

Informed consent to participate in a research study -- gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway

article

Inhibitory effects of hypertonic saline on P. aeruginosa motility

scientific article published on 31 January 2008

Interaction between cystic fibrosis transmembrane conductance regulator and outwardly rectified chloride channels

scientific article published on December 1995

Interference with ubiquitination in CFTR modifies stability of core glycosylated and cell surface pools.

scientific article published on July 2014

Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator

scientific article

Intrinsic anion channel activity of the recombinant first nucleotide binding fold domain of the cystic fibrosis transmembrane regulator protein

scientific article published on March 1992

Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR

scientific article published on 25 June 2020

Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus

scientific article published on 30 December 2005

Longevity and plasticity of CFTR provide an argument for noncanonical SNP organization in hominid DNA

scientific article

Making precision medicine personal for cystic fibrosis

scientific article published on 01 July 2019

Marked repression of CFTR mRNA in the transgenic Cftr(tm1kth) mouse model

scientific article

Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography

scientific article

Micro-RNA-like effects of complete intronic sequences

scientific article published on May 2006

Molecular proximity of cystic fibrosis transmembrane conductance regulator and epithelial sodium channel assessed by fluorescence resonance energy transfer

scientific article

Mutations in the amino terminus of the cystic fibrosis transmembrane conductance regulator enhance endocytosis

scientific article

Myofibroblast differentiation and enhanced TGF-B signaling in cystic fibrosis lung disease

scientific article

Non-obstructive vas deferens and epididymis loss in cystic fibrosis rats

scientific article published on 02 November 2018

One-step affinity isolation of recombinant protein using the baculovirus/insect cell expression system

scientific article

Porcine nasal epithelial cultures for studies of cystic fibrosis sinusitis

scientific article

Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity

scientific article published on 26 January 2021

Potential role of high-mobility group box 1 in cystic fibrosis airway disease.

scientific article published on 24 July 2008

Purification of CFTR for mass spectrometry analysis: identification of palmitoylation and other post-translational modifications

scientific article published on 25 November 2011

Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis

scientific article published on September 2011

Rapid purification of recombinant baculovirus using fluorescence-activated cell sorting

scientific article

Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia

scientific article published on 22 August 2002

Recombinant synthesis of cystic fibrosis transmembrane conductance regulator and functional nucleotide-binding domains

scientific article published on January 1998

Recombinant synthesis, purification, and nucleotide binding characteristics of the first nucleotide binding domain of the cystic fibrosis gene product ⬇️

scientific article published on 01 April 1992

Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat.

scientific article published on 30 November 2017

Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

scientific article

Regulation of plasma membrane recycling by CFTR.

scientific article published on April 1992

Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators

scientific article

Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR.

scientific article published on May 1997

Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators

scientific article published on 26 July 2018

Respiratory syncytial virus infection disrupts monolayer integrity and function in cystic fibrosis airway cells

scientific article published on 19 September 2013

Restoration of W1282X CFTR activity by enhanced expression

scientific article published on 31 May 2007

Resveratrol enhances airway surface liquid depth in sinonasal epithelium by increasing cystic fibrosis transmembrane conductance regulator open probability

scientific article (publication date: 2013)

Resveratrol has salutary effects on mucociliary transport and inflammation in sinonasal epithelium

scientific article

Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect

scientific article

Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators

scientific article

Role for phospholipid interactions in the trafficking defect of Delta F508-CFTR.

scientific article published on September 2002

Role of oxygen availability in CFTR expression and function

scientific article published on 12 May 2008

S-palmitoylation regulates biogenesis of core glycosylated wild-type and F508del CFTR in a post-ER compartment

scientific article published on April 2014

SNP Formation Bias in the Murine Genome Provides Evidence for Parallel Evolution

scientific article published on 6 August 2015

Severe phenotype in mice with termination mutation in exon 2 of cystic fibrosis gene

scientific article published on 01 May 1995

Sinupret activates CFTR and TMEM16A-dependent transepithelial chloride transport and improves indicators of mucociliary clearance

scientific article

Slowing ribosome velocity restores folding and function of mutant CFTR

scientific article published on 01 December 2019

Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

scientific article published on November 1997

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

scientific article

The bioflavonoid compound, sinupret, stimulates transepithelial chloride transport in vitro and in vivo

scientific article published in May 2010

The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary

scientific article

The silent codon change I507-ATC->ATT contributes to the severity of the ΔF508 CFTR channel dysfunction

scientific article (publication date: November 2013)

The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors

scientific article published on 08 January 2020

Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications

scientific article

Transepithelial ion transport is suppressed in hypoxic sinonasal epithelium

scientific article

Transformative therapies for rare CFTR missense alleles

scientific article published on 12 October 2017

Tumor cell bystander killing in colonic carcinoma utilizing the Escherichia coli DeoD gene to generate toxic purines

scientific article published on July 1, 1994

VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level

scientific article published on 17 September 2019

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