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List of works by Karl Insogna

24,25 Dihydroxyvitamin D supplementation corrects hyperparathyroidism and improves skeletal abnormalities in X-linked hypophosphatemic rickets--a clinical research center study

scientific article published on 01 June 1996

A clinician's guide to X-linked hypophosphatemia

scientific article

A patient with hypophosphatemia, a femoral fracture, and recurrent kidney stones: report of a novel mutation in SLC34A3.

scientific article published on October 2008

A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis

scientific article published on 03 April 2002

A role for interleukin-6 in parathyroid hormone-induced bone resorption in vivo

scientific article published on 01 October 1999

Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts

scientific article published on 01 September 2006

Adequate dietary protein is associated with better physical performance among post-menopausal women 60-90 years

scientific article published on January 2014

AgRP Neurons Regulate Bone Mass.

scientific article published on 22 September 2015

An aerobic weight-loaded pilot exercise intervention for breast cancer survivors: bone remodeling and body composition outcomes

scientific article published on July 2008

An investigation of the association between omega 3 FA and bone mineral density among older adults: results from the National Health and Nutrition Examination Survey years 2005–2008.

scientific article published on March 2014

Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy

scientific article published on 01 March 1984

Bone Health and Osteoporosis

scientific article published on 01 September 2015

Bone densities in patients receiving isotretinoin for cystic acne

scientific article published on 01 August 1999

Boning up on estrogen: new options, new concerns

scientific article published on 01 November 1996

Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting protein

scientific journal article

Breast cancer-associated gene 3 interacts with Rac1 and augments NF-κB signaling in vitro, but has no effect on RANKL-induced bone resorption in vivo

scientific article published on 04 August 2017

Burosumab Improved Histomorphometric Measures of Osteomalacia in Adults with X-Linked Hypophosphatemia: A Phase 3, Single-Arm, International Trial

scientific article published on 01 October 2019

Burosumab for the Treatment of Tumor-induced Osteomalacia

scientific article published on 18 December 2020

CSF-1 induces fos gene transcription and activates the transcription factor Elk-1 in mature osteoclasts

scientific article published on 11 April 2005

Calcium and kidney stones

scientific article published on 01 August 1993

Calcium intake in the United States from dietary and supplemental sources across adult age groups: new estimates from the National Health and Nutrition Examination Survey 2003-2006.

scientific article published on May 2011

Can serum pentosidine levels predict risk of vertebral fracture in patients with type 2 diabetes mellitus?

scientific article published on 6 May 2008

Changes in bone turnover in young women consuming different levels of dietary protein

scientific article published on 01 March 1999

Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption--a clinical research center study

scientific article published on 01 October 1996

Circulating levels of interleukin-6 soluble receptor predict rates of bone loss in patients with primary hyperparathyroidism.

scientific article published in November 2002

Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian variance, effects of treatment, and relationship to parathyroid status

scientific article

Claudins, dietary milk proteins, and intestinal barrier regulation.

scientific article published on January 2013

Colony-Stimulating Factor-1 Increases Osteoclast Intracellular pH and Promotes Survival via the Electroneutral Na/HCO3Cotransporter NBCn1

scientific article published on 26 October 2006

Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts ⬇️

scientific article published on November 15, 1997

Control of bone formation by the serpentine receptor Frizzled-9 ⬇️

scientific journal article

Conventional Therapy in Adults With X-Linked Hypophosphatemia: Effects on Enthesopathy and Dental Disease

scientific article

Cross-cultural association between dietary animal protein and hip fracture: A hypothesis ⬇️

scientific article published on January 1, 1992

Deletion of Rac in Mature Osteoclasts Causes Osteopetrosis, an Age-Dependent Change in Osteoclast Number, and a Reduced Number of Osteoblasts In Vivo.

scientific article published on 23 October 2015

Denosumab for treatment of hypercalcemia of malignancy.

scientific article

Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures

scientific article

Dietary acid load is associated with lower bone mineral density in men with low intake of dietary calcium.

scientific article published on February 2014

Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation.

scientific article published on 12 April 2017

Dietary protein and skeletal health: a review of recent human research.

scientific article

Dietary protein-induced increases in urinary calcium are accompanied by similar increases in urinary nitrogen and urinary urea: a controlled clinical trial

scientific article published in March 2013

Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.

scientific article

Effect of 25(OH) vitamin D reference method procedure (RMP) alignment on clinical measurements obtained with the IDS-iSYS chemiluminescent-based automated analyzer.

scientific article

Effect of a randomized controlled exercise trial on bone outcomes: influence of adjuvant endocrine therapy.

scientific article published on 5 February 2016

Effect of age on serum immunoreactive parathyroid hormone and its biological effects.

scientific article published in November 1981

Effect of four monthly doses of a human monoclonal anti-FGF23 antibody (KRN23) on quality of life in X-linked hypophosphatemia

scientific article published on 13 May 2016

Effect of paricalcitol on circulating parathyroid hormone in X-linked hypophosphatemia: a randomized, double-blind, placebo-controlled study

scientific article

Effect of short-term somatostatin and long-term triiodothyronine administration in a child with nontumorous inappropriate thyrotropin secretion

scientific article published on 01 January 1988

Effects of continuous glucocorticoid infusion on bone metabolism in the rat

scientific article published on 01 September 1996

Effects of glucose-dependent insulinotropic peptide on osteoclast function

scientific article published on 26 September 2006

Elevated production rate of 1,25-dihydroxyvitamin D in patients with absorptive hypercalciuria

scientific article published on 01 September 1985

Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia.

scientific article published in January 1985

Enhanced production rate of 1,25-dihydroxyvitamin D in sarcoidosis

scientific article published on 01 January 1988

Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells

scientific article published on 01 October 1994

Estrogen modulates parathyroid hormone-induced interleukin-6 production in vivo and in vitro

scientific article published on 01 July 2000

Evidence for disordered control of 1,25-dihydroxyvitamin D production in absorptive hypercalciuria.

scientific article published on July 1984

Evidence that the IL-6/IL-6 soluble receptor cytokine system plays a role in the increased skeletal sensitivity to PTH in estrogen-deficient women

scientific article published on 01 June 2002

Expression and synthesis of bone morphogenetic proteins by osteoclasts: a possible path to anabolic bone remodeling.

scientific article published on 3 March 2008

Frequency and partial characterization of adenylate cyclase-stimulating activity in tumors associated with humoral hypercalcemia of malignancy

scientific article published on 01 June 1986

Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass

scientific article published on 20 January 2007

Glucose-dependent insulinotropic polypeptide receptor knockout mice have altered bone turnover

scientific article published on 10 October 2005

Human granulosa-luteal cells secrete parathyroid hormone-related protein in vivo and in vitro.

scientific article

Humoral hypercalcemia of malignancy in canine lymphosarcoma.

scientific article published in February 1988

Immunoaffinity purification of parathyroid hormone-related protein from bovine milk and human keratinocyte-conditioned medium

scientific article published on 01 March 1991

Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis.

scientific article

Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets.

scientific article published on June 1983

Increased bone resorption during tenofovir plus lopinavir/ritonavir therapy in Chinese individuals with HIV

scientific article

Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.

scientific article published on 27 February 2013

Influence of pregnancy on immunoreactive parathyroid hormone levels

scientific article published on 01 January 1982

Isolation of 16,000-dalton parathyroid hormone-like proteins from two animal tumors causing humoral hypercalcemia of malignancy.

scientific article

Isotretinoin does have an adverse effect on bone mineral density.

scientific article published in July 2005

L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells.

scientific article published on 16 June 2005

LIM kinase 1 deficient mice have reduced bone mass ⬇️

scientific article published on September 24, 2012

Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz among individuals with HIV.

scientific article

Low dietary protein and low bone density

scientific article published on 01 April 2000

Macrophage colony-stimulating factor release and receptor expression in bone cells

scientific article published on 01 December 1993

Measurement of plasma, serum, and platelet serotonin in individuals with high bone mass and mutations in LRP5

scientific article published on April 2014

Mutations in SLC34A3/NPT2c are associated with kidney stones and nephrocalcinosis

scientific article

Nocturnal hyperparathyroidism: a frequent feature of X-linked hypophosphatemia

scientific article published on 01 June 1994

Nuclear factor-kappaB p50 is required for tumor necrosis factor-alpha-induced colony-stimulating factor-1 gene expression in osteoblasts

scientific article published on 01 August 2000

Optimizing bone health in older adults: the importance of dietary protein.

scientific article

Orthopaedic management improves the rate of early osteoporosis treatment after hip fracture. A randomized clinical trial.

scientific article published in November 2008

Osteoclasts lacking Rac2 have defective chemotaxis and resorptive activity.

scientific article

Osteomalacia and weakness from excessive antacid ingestion

scientific article published on 01 December 1980

Osteoporosis knowledge, self-efficacy, and health beliefs among Chinese individuals with HIV.

scientific article

Parameters of high bone-turnover predict bone loss in renal transplant patients: a longitudinal study

scientific article published on 01 July 2001

Parathyroid hormone increases circulating levels of fibronectin in vivo: modulating effect of ovariectomy

scientific article published on 01 September 1997

Parathyroid hormone-related protein induces spontaneous osteoclast formation via a paracrine cascade

scientific article

Parathyroid hormone-related protein stimulates prostaglandin E2 release from human osteoblast-like cells: modulating effect of peptide length

scientific article published on August 1, 1992

Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing

scientific article published on 01 June 1994

Pharmacokinetics and pharmacodynamics of a human monoclonal anti-FGF23 antibody (KRN23) in the first multiple ascending-dose trial treating adults with X-linked hypophosphatemia.

scientific article

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

scientific article

Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing.

scientific article

Pioglitazone and Risk for Bone Fracture: Safety Data From a Randomized Clinical Trial

scientific article

Posttransplant bone disease: evidence for a high bone resorption state

scientific article published on 01 December 2000

Prolonged Correction of Serum Phosphorus in Adults With X-Linked Hypophosphatemia Using Monthly Doses of KRN23.

scientific article published on 28 April 2015

Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia

scientific article published on 24 February 2014

Secondary hyperparathyroidism in patients with ichthyosis is not caused by vitamin D deficiency or ingestion of retinoids

scientific article published on 01 May 1993

Selective deletion of the membrane-bound colony stimulating factor 1 isoform leads to high bone mass but does not protect against estrogen-deficiency bone loss.

scientific article

Selective deletion of the soluble Colony-Stimulating Factor 1 isoform in vivo prevents estrogen-deficiency bone loss in mice.

scientific article

Sensitivity of the parathyroid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism.

scientific article published in October 1985

Serum levels of sclerostin, Dickkopf-1, and secreted frizzled-related protein-4 are not changed in individuals with high bone mass causing mutations in LRP5.

scientific article

Serum parathyroid hormone level is elevated in some patients with disorders of keratinization

scientific article published on 01 July 1992

Skin-derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins.

scientific article

Supplementing a low-protein diet with dibasic amino acids increases urinary calcium excretion in young women.

scientific article

Survey of the enthesopathy of X-linked hypophosphatemia and its characterization in Hyp mice

scientific article

Synthetic and partially-purified adenylate cyclase-stimulating proteins from tumors associated with humoral hypercalcemia of malignancy inhibit phosphate transport in a PTH-responsive renal cell line

scientific article published on 01 February 1988

Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats.

scientific article published on February 1988

Synthetic parathyroid hormone-like protein (1-74) is anabolic for bone in vivo

scientific article published on July 1, 1992

Synthetic parathyroid hormone-like protein-(1-74): biochemical and physiological characterization

scientific article published on 01 February 1989

The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial

scientific article

The Effect of a Whey Protein Supplement on Bone Mass in Older Caucasian Adults.

scientific article published on 6 April 2015

The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes

scientific article

The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo

scientific journal article

The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells.

scientific article published on February 1998

The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone

scientific article published on 23 December 2004

The effect of dietary protein on intestinal calcium absorption in rats.

scientific article

The effects of dietary protein and amino acids on skeletal metabolism

scientific article published on 02 April 2015

The expanding role of PI3-kinase in bone.

scientific article published on January 2004

The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women

scientific article published on 16 November 2004

The liver throws the skeleton a bone (resorption factor).

scientific article published on 16 June 2016

The relative potency of a human tumor-derived PTH-like adenylate cyclase-stimulating preparation in three bioassays

scientific article published on 01 February 1987

The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis

scientific article

Torus palatinus: a new anatomical correlation with bone density in postmenopausal women.

scientific article

Treatment of humoral hypercalcemia of malignancy in rats with inhibitors of carbonic anhydrase.

scientific article published on October 1990

Treatment of sarcoidosis-associated hypercalcemia with ketoconazole.

scientific article published in December 1991

Two species of adenylate cyclase-stimulating activity in a murine squamous carcinoma model of humoral hypercalcemia of malignancy

scientific article published on 01 May 1986

Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia

scientific article published on 01 October 1984

Vitamin D metabolism in chronic childhood hypoparathyroidism: evidence for a direct regulatory effect of calcium

scientific article published on 01 February 1990

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

scientific article

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