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List of works by Robert A S Ariëns

A collaborative study to establish the 1st International Standard for factor XIII plasma.

scientific article published in September 2007

A common coding polymorphism in the FXIII A-subunit gene (FXIIIVal34Leu) affects cross-linking activity

scientific article published on 01 October 1998

A fibrin biofilm covers the blood clot and protects from microbial invasion. ⬇️

scientific article

A new red cell shape helps the clot

scientific article published in March 2014

A variant in LDLR is associated with abdominal aortic aneurysm

scientific journal article

Activation markers of coagulation and fibrinolysis in twins: heritability of the prethrombotic state

scientific article published on 01 February 2002

Affimer proteins as a tool to modulate fibrinolysis, stabilize the blood clot and reduce bleeding complications ⬇️

scientific article published on 13 December 2018

Allele-specific alternative splicing; the tail of FXIII-B tells its own tale

scientific article published on 8 May 2009

Alteration of fibrin clot properties by ultrafine particulate matter

scientific article

Alterations in Fibrin Structure in Patients with Liver Diseases

scientific article published on 12 April 2016

Altered fibrin clot structure and function in the healthy first-degree relatives of subjects with intermittent claudication

scientific article published in October 2008

Altered fibrin clot structure in the healthy relatives of patients with premature coronary artery disease.

scientific article published in October 2002

An international study on the standardization of fibrin clot permeability measurement: methodological considerations and implications for healthy control values.

scientific article published in October 2012

Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis.

scientific article published on May 2001

Aspirin therapy is associated with less compact fibrin networks and enhanced fibrinolysis in patients with abdominal aortic aneurysm.

scientific article published on 12 March 2015

Assessment and determinants of whole blood and plasma fibrinolysis in patients with mild bleeding symptoms

scientific article published in February 2019

Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis.

scientific article published on 29 January 2018

Atomic force microscopy-based molecular recognition of a fibrinogen receptor on human erythrocytes

scientific article published on August 2010

BβArg448Lys polymorphism is associated with altered fibrin clot structure and fibrinolysis in type 2 diabetes ⬇️

scientific article published on 8 December 2016

CVD risk factors are related to plasma fibrin clot properties independent of total and or γ' fibrinogen concentration.

scientific article published on 29 August 2014

Cardiovascular disease and heritability of the prothrombotic state

scientific article published on 22 August 2008

Characterization of the I4399M variant of apolipoprotein(a): implications for altered prothrombotic properties of lipoprotein(a).

scientific article published on 20 June 2017

Circulating levels of coagulation factor XIII in subjects with type 2 diabetes and in their first-degree relatives

scientific article published on 01 May 2000

Clot Structure and Fibrinolysis in Thrombosis and Hemostasis ⬇️

scientific article published on 15 November 2017

Clot architecture is altered in abdominal aortic aneurysms and correlates with aneurysm size

scientific article published on 15 September 2011

Clot properties and cardiovascular disease.

scientific article published on 5 June 2014

Clot structure and fibrinolytic potential in patients with post thrombotic syndrome.

scientific article published on 10 November 2015

Coagulation factor XIII and markers of thrombin generation and fibrinolysis in patients with inflammatory bowel disease.

scientific article published in March 2002

Common FXIII and fibrinogen polymorphisms in abdominal aortic aneurysms

scientific article

Common variation in the C-terminal region of the fibrinogen beta-chain: effects on fibrin structure, fibrinolysis and clot rigidity.

scientific article published on 9 October 2007

Counting 1 fibrin molecule at a time.

scientific article published in February 2013

Denser matters.

scientific article published in November 2009

Diagnosis and classification of factor XIII deficiencies.

scientific article published in July 2011

Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all? ⬇️

scientific article published on 15 August 2018

Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management

scientific article published on 02 May 2015

Effect of aspirin and ticlopidine on plasma tissue factor levels in stable and unstable angina pectoris

scientific article published on 01 March 2000

Effects of aspirin on clot structure and fibrinolysis using a novel in vitro cellular system

scientific article published on 12 March 2009

Effects of riboflavin and amotosalen photoactivation systems for pathogen inactivation of fresh-frozen plasma on fibrin clot structure

scientific article published on 10 September 2015

Elevated fibrinogen causes thrombosis.

scientific article published in May 2011

Elimination of coagulation factor XIII from fibrinogen preparations

scientific article

Evidence that fibrinogen γ' directly interferes with protofibril growth: implications for fibrin structure and clot stiffness.

scientific article published in June 2012

Evidence that fibrinogen γ' regulates plasma clot structure and lysis and relationship to cardiovascular risk factors in black Africans

scientific article published on 19 February 2013

Ex vivo addition of fibrinogen concentrate improves the fibrin network structure in plasma samples taken during liver transplantation.

scientific article

Factor XIII A-Subunit V34L Variant Affects Thrombus Cross-Linking in a Murine Model of Thrombosis ⬇️

scientific article published on 7 January 2016

Factor XIII A-subunit concentration predicts outcome in stroke subjects and vascular outcome in healthy, middle-aged men.

scientific article published in September 2002

Factor XIII Val34Leu polymorphism, factor XIII antigen levels and activity and the risk of deep venous thrombosis

scientific article published in October 2002

Factor XIII activity and antigen levels in patients with coronary artery disease

scientific article published on 01 March 2001

Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin α-chain crosslinking

scientific article

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin

scientific article

Fibrin and D-dimer bind to monomeric GPVI

scientific article published on 15 August 2017

Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases

scientific article published on 11 August 2011

Fibrin clot structure in patients with congenital dysfibrinogenaemia. ⬇️

scientific article published on 10 November 2015

Fibrin clot structure in patients with end-stage renal disease

scientific article published on 01 August 2007

Fibrin clot structure is affected by levels of particulate air pollution exposure in patients with venous thrombosis ⬇️

scientific article published on 6 April 2016

Fibrin clot structure remains unaffected in young, healthy individuals after transient exposure to diesel exhaust

scientific article published on 16 June 2010

Fibrin(ogen) and thrombotic disease

scientific article published on June 2013

Fibrinogen and fibrin clot structure in diabetes

scientific article published in August 2004

Fibrinogen gamma-chain splice variant gamma' alters fibrin formation and structure.

scientific article published on 27 March 2003

Fibrinogen splice variation and cross-linking: Effects on fibrin structure/function and role of fibrinogen γ' as thrombomobulin II. ⬇️

scientific article

Fibrinogen αC-regions are not directly involved in fibrin polymerization as evidenced by a "Double-Detroit" recombinant fibrinogen mutant and knobs-mimic peptides

scientific article published on 29 January 2020

Fibrinogen γ' increases the sensitivity to activated protein C in normal and factor V Leiden plasma

scientific article published on 20 June 2014

Functional analysis of fibrin {gamma}-chain cross-linking by activated factor XIII: determination of a cross-linking pattern that maximizes clot stiffness

scientific article published on 13 April 2007

Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function.

scientific article published on 21 April 2003

Gender-specific alterations in fibrin structure function in type 2 diabetes: associations with cardiometabolic and vascular markers.

scientific article published on 20 September 2012

Genetic and environmental determinants of fibrin structure and function: relevance to clinical disease

scientific article

Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk.

scientific article published in April 2003

Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction

scientific article published on 27 November 2002

Genetics of fibrin clot structure: a twin study.

scientific article published on 6 November 2003

Getting to grips with complexity of disease will make genomics useful in arterial thrombosis.

scientific article published on 12 January 2007

Haemostatic and fibrinolytic factors in men with a small abdominal aortic aneurysm.

scientific article published in August 2009

High levels of tissue factor pathway inhibitor in patients with nephrotic proteinuria.

scientific article published in September 1999

Immobilized fibrinogen activates human platelets through glycoprotein VI. ⬇️

scientific article published on 22 February 2018

Impact of γ'γ' fibrinogen interaction with red blood cells on fibrin clots

article

Impaired factor XIII activation in patients with congenital afibrinogenemia ⬇️

scientific article published on 27 September 2018

Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms ⬇️

scientific article

Inhibition of thrombin-mediated factor V activation contributes to the anticoagulant activity of fibrinogen γ'.

scientific article published in September 2013

Interactions between factor XIII and the alphaC region of fibrinogen.

scientific article published on 11 January 2011

International registry on factor XIII deficiency: a basis formed mostly on European data

scientific article

Joint Linkage and Association of Six Single-Nucleotide Polymorphisms in the Factor XIII-A Subunit Gene Point to V34L As the Main Functional Locus

article

Markers of inflammation in men with small abdominal aortic aneurysm.

scientific article published in July 2010

Measurement of activated factor XII in health and disease.

scientific article

Molecular mechanisms involved in the resistance of fibrin to clot lysis by plasmin in subjects with type 2 diabetes mellitus

scientific article published on 16 March 2006

Nanoscale probing reveals that reduced stiffness of clots from fibrinogen lacking 42 N-terminal Bbeta-chain residues is due to the formation of abnormal oligomers

scientific article

Novel mechanisms that regulate clot structure/function

scientific article published on May 2016

Partial deletion of the αC-domain in the Fibrinogen Perth variant is associated with thrombosis, increased clot strength and delayed fibrinolysis

article

Plasma thrombin-antithrombin complex, prothrombin fragments 1 and 2, and D-dimer levels are elevated after endovascular but not open repair of infrarenal abdominal aortic aneurysm

scientific article published on 13 March 2013

Polyphosphate delays fibrin polymerisation and alters the mechanical properties of the fibrin network ⬇️

scientific article

Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin.

scientific article published on 12 March 2010

Procoagulant changes in fibrin clot structure in patients with cirrhosis are associated with oxidative modifications of fibrinogen ⬇️

scientific article published in February 2016

Proteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction.

scientific article published on 19 April 2011

Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm.

scientific article published in October 2006

Ranking reactive glutamines in the fibrinogen αC region that are targeted by blood coagulant factor XIII. ⬇️

scientific article

Recurrent venous thromboembolism patients form clots with lower elastic modulus than those formed by patients with non-recurrent disease

scientific article published on 08 March 2019

Regarding "Altered fibrin clot structure and function in individuals with intermittent claudication"

scientific article published on 14 January 2009

Relationship of coagulation and fibrinolytic variables with arterial structure and function in Africans

scientific article

Repeated release of the tissue factor pathway inhibitor

scientific article published on 01 August 1994

Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms

scientific article (publication date: August 2002)

Role of fibrin structure in thrombosis and vascular disease

scientific article published on January 2011

Roles of fibrin α- and γ-chain specific cross-linking by FXIIIa in fibrin structure and function.

scientific article published on 16 January 2014

Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate.

scientific article published on 6 June 2003

Subunit antigen and activity levels of blood coagulation factor XIII in healthy individuals. Relation to sex, age, smoking, and hypertension.

scientific article published in August 1999

The (Patho)physiology of Fibrinogen γ'. ⬇️

scientific article published on 12 April 2016

The 95RGD97 sequence on the Aα chain of fibrinogen is essential for binding to its erythrocyte receptor. ⬇️

scientific article published on 3 April 2018

The activation peptide cleft exposed by thrombin cleavage of FXIII-A(2) contains a recognition site for the fibrinogen α chain.

scientific article published on 9 January 2013

The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm.

scientific article published on 6 July 2014

The effect of blood coagulation factor XIII on fibrin clot structure and fibrinolysis. ⬇️

scientific article published in February 2014

The effect of dimethylbiguanide on thrombin activity, FXIII activation, fibrin polymerization, and fibrin clot formation

scientific article published in January 2002

The genetics of haemostasis: a twin study

scientific article published on 01 January 2001

The increase with age of the components of the tissue factor coagulation pathway is gender-dependent.

scientific article published in July 1995

The influence of type 2 diabetes on fibrin structure and function

scientific article published on 29 April 2005

The molecular physiology and pathology of fibrin structure/function

scientific article

The pleiotropic role of the fibrinogen gamma' chain in hemostasis

scientific article published on 17 August 2009

The prothrombotic state in paroxysmal nocturnal hemoglobinuria: a multifaceted source ⬇️

scientific article published on 15 December 2017

The quest for the Holy Grail of tissue factor pathway inhibitor deficiency has just begun.

scientific article published in April 2005

The relation between insulin resistance and hemostasis: pleiotropic genes and common environment.

scientific article

The role of activated coagulation factor XII in overall clot stability and fibrinolysis.

scientific article published on 19 June 2015

The role of barrels 1 and 2 in the enzymatic activity of factor XIII-A. ⬇️

scientific article published on 19 April 2018

Thrombin and fibrinogen γ' impact clot structure by marked effects on intrafibrillar structure and protofibril packing. ⬇️

scientific article published on 25 November 2015

Thrombosis and Hemostasis--First North Sea Conference. 12-17 June 2000, Maastricht, The Netherlands.

scientific article published in October 2000

Tissue-factor antigen and activity in human coronary atherosclerotic plaques

scientific article published on 01 March 1997

Urban Particulate Matter Induces Changes in Gene Expression in Vascular Endothelial Cells that Are Associated with Altered Clot Structure In Vitro ⬇️

scientific article published on 29 January 2018

α-α Cross-links increase fibrin fiber elasticity and stiffness

scientific article

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