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List of works by John E. Ladbury

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus

scientific article

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

scientific article published on 18 April 2019

A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain

scientific article published on 01 April 2001

A complex of Shc and Ran-GTPase localises to the cell nucleus

scientific article published on 01 February 2009

A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme

scientific article published on 01 November 1992

A landscape of driver mutations in melanoma

scientific article

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. ⬇️

scientific article published on 20 March 2015

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

scientific article

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

scientific article published in December 2014

A survey of the year 2002 literature on applications of isothermal titration calorimetry

scientific article published on November 2003

A survey of the year 2003 literature on applications of isothermal titration calorimetry

scientific article published in November 2004

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

scientific article published on 19 April 2015

Adding calorimetric data to decision making in lead discovery: a hot tip

article

Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†

article

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

scientific article published on 04 March 2016

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

scientific article

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

article

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

scientific article published on 18 November 2011

Biophysical characterization of VEGF-aHt DNA aptamer interactions

scientific article

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

scientific article published on August 2013

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

scientific article published on August 2010

Catalysis and regulation

article

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

scientific article published on 7 June 2012

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion ⬇️

scientific article published on 19 January 2014

Conformational changes in the AAA ATPase p97-p47 adaptor complex

scientific article published on 3 May 2006

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

scientific article

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

scientific article published on 3 August 2015

Counting the calories to stay in the groove.

scientific article published on July 1995

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48

scientific article published in Journal of Biological Chemistry

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

scientific article published on 25 August 2020

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

scientific article

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX

scientific article

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors

scientific article

Editorial

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

scientific article published on February 2009

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

scientific article

Erythropoietin Stimulates Tumor Growth via EphB4.

scientific article published on 14 October 2015

Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator

scientific article (publication date: 5 June 2001)

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma ⬇️

scientific article published on 15 September 2015

Extent of enthalpy-entropy compensation in protein-ligand interactions.

scientific article

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

scientific article published on July 2008

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

article

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

article published in the Proceedings of the National Academy of Sciences of the United States of America

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

scientific article published in February 2006

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

scientific article published on February 2013

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer ⬇️

scientific article

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function ⬇️

scientific article published on 24 June 2015

H-NS forms a superhelical protein scaffold for DNA condensation

scientific article

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

scientific article

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein

scientific article

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing ⬇️

article

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer ⬇️

scientific article published on 11 November 2014

Heat capacity effects of water molecules and ions at a protein-DNA interface

scientific article

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

scientific article published on 01 December 1994

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes

scientific article published on 27 July 2020

INTERACTION OF PORPHYRIN WITH G-QUADRUPLEX STRUCTURES

scientific article published on 01 January 2005

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

scientific article

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

scientific article

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

scientific article published in June 2007

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

scientific article published on December 2008

Inhibition of basal FGF receptor signaling by dimeric Grb2

scientific article

Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.

scientific article published in June 2001

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli ⬇️

scientific article

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat

scientific article

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria

scientific article published on 8 June 2009

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

scientific article published on July 2000

Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction

scientific article

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

scientific article

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

scientific article

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

scientific article

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

scientific article published on 2 August 2008

NMR Assignment of the Apo and Peptide-bound SH2 Domain from the Rous Sarcoma Viral Protein Src

article

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. ⬇️

scientific article published on 23 July 2016

Noise in cellular signaling pathways: causes and effects ⬇️

scientific article published on February 15, 2012

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity ⬇️

scientific article

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications

scientific article

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

scientific article

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

scientific article published on 16 November 2015

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands

scientific article

Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.

scientific article published on January 2006

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression ⬇️

scientific article

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. ⬇️

scientific article published on 2 December 2017

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity

scientific article (publication date: 2014)

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

scientific article published on 3 June 2015

Probing cocaine-antibody interactions in buffer and human serum

scientific article

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

scientific article

Redox-State-Dependent Complex Formation between Pseudoazurin and Nitrite Reductase

article

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy

scientific article published in May 2002

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

scientific article

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation ⬇️

scientific article published on 09 August 2013

Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice

scientific article published on December 2004

Specific DNA Recognition by the Type II Restriction Endonuclease MunI: The Effect of pH ⬇️

scientific article published on December 11, 2001

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies ⬇️

scientific article published on August 15, 1997

Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry 1 1Edited by P. E. Wright

article

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling

scientific article

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.

scientific article

StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI. ⬇️

scientific article

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

scientific article published on 14 January 2016

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

scientific article published on 21 July 2009

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

scientific article published on 26 April 2013

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design

scientific article

Substitution of Charged Residues into the Hydrophobic Core of Escherichia coli Thioredoxin Results in a Change in Heat Capacity of the Native Protein

scientific article published on 01 February 1995

Survey of the year 2004: literature on applications of isothermal titration calorimetry

scientific article

Survey of the year 2005: literature on applications of isothermal titration calorimetry

scientific article published on January 2007

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

scientific article published on 25 March 2010

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

scientific article

T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation

scientific article published on 27 May 2010

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling

scientific article published on 14 May 2019

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

scientific article published on 27 October 2015

Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

scientific article published on 01 September 2000

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

article

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein

scientific article

The binding stoichiometry of CIN85 SH3 domain A and cbl-b

scientific article published on September 2008

The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon ⬇️

scientific article published on May 29, 1998

The extended interface: measuring non-local effects in biomolecular interactions

scientific article published in October 2004

The hidden thermodynamics of a zinc finger

scientific article

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

scientific article

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

scientific article

The thermodynamics of formation of a three-strand, DNA three-way junction complex.

scientific article published on June 1994

The toolbox is open, but who should pay for the job?

scientific article published on 01 July 2014

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.

scientific article

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

scientific article published on 17 May 2019

Turning Up the Heat On Rational Drug Design

scientific article published on 01 November 1994

Two EGF molecules contribute additively to stabilization of the EGFR dimer

scientific article

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity

scientific article

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