List of works - Jakub Hofman

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

scientific article published on 10 July 2018

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

scientific article published on 14 May 2014

Brivanib Exhibits Potential for Pharmacokinetic Drug-Drug Interactions and the Modulation of Multidrug Resistance through the Inhibition of Human ABCG2 Drug Efflux Transporter and CYP450 Biotransformation Enzymes

scientific article published on 21 October 2019

Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3

scientific article published on 28 January 2019

Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters

scientific article published on 28 February 2019

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

scientific article published on 03 November 2015

In vitro transfection mediated by dendrigraft poly(L-lysines): the effect of structure and molecule size.

scientific article published on 11 December 2012

Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.

scientific article published on 7 January 2016

Interactions of Alectinib with Human ATP-Binding Cassette Drug Efflux Transporters and Cytochrome P450 Biotransformation Enzymes: Effect on Pharmacokinetic Multidrug Resistance

scientific article published on 08 May 2019

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

scientific article published on 24 April 2014

Nitric oxide is involved in light-specific responses of tomato during germination under normal and osmotic stress conditions

scientific article published on 9 July 2012

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

scientific article

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1)

scientific article (publication date: 2013)

Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.

scientific article published on 15 May 2015

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

scientific article

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro